Patents by Inventor Mai Li

Mai Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12088654
    Abstract: A system and/or method that can reduce impact of network latency can be provided. Information associated with a user device participating in an online meeting can be determined, for user devices connecting to the online meeting. Based on the information, the user devices can be grouped. For each of the user devices in a group, network quality associated with network connection between a user device in the group and a server managing the online meeting can be evaluated. Based on the network quality, at least one user device in the group can be designated to operate as a sharer device to at least one other user device in the group. The sharer device can be caused to stream data directly from the server during the online meeting. That one other user device can be caused to connect with and stream data from the sharer device.
    Type: Grant
    Filed: June 9, 2023
    Date of Patent: September 10, 2024
    Assignee: International Business Machines Corporation
    Inventors: Xiang Yu Xue, Hui Wang, Yu Mei Dai, Mai Zeng, Xiao Chen Huang, Wei Li
  • Patent number: 12037258
    Abstract: The invention provides a method for continuously producing composite nanoparticles, the method comprising heating a precursor mixture with supercritical water, wherein the mixture contains a first compound capable of transitioning from a monoclinic to a tetragonal rutile crystal state; cooling the heated mixture to obtain core particles of a predetermined shape and size; encapsulating the core particle with a second precursor to create a core-shell construct; and encapsulating the construct with an organic material. Also provided is a device for continuously synthesizing composite nanoparticles, the device comprising a water supply and a precursor supply; a means for heating the water, a continuous flow hydrothermal reaction chamber adapted to receive the heated water and precursor, a means for chilling the heated water and precursor, and a capping agent supply positioned downstream of the reaction chamber.
    Type: Grant
    Filed: February 2, 2021
    Date of Patent: July 16, 2024
    Assignee: UCHICAGO ARGONNE, LLC
    Inventors: Jie Li, Mai Kim Tran, Ralph T. Muehleisen
  • Publication number: 20240190815
    Abstract: The present disclosure relates to: a) crystalline forms of N—((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide; b) pharmaceutical compositions comprising one or more crystalline forms of N—((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide, and, optionally, one or more pharmaceutically acceptable carriers; c) methods of treating a tumor a cancer, or a Rasopathy disorder by administering one or more crystalline forms of N—((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide to a subject in need thereof; and methods of producing essentially pure Form IV of N—((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide.
    Type: Application
    Filed: January 16, 2024
    Publication date: June 13, 2024
    Inventors: Kristin PATTERSON, Jiping LIU, Ricky Wayne COUCH, Peter Gregory VARLASHKIN, Mai LI, Yonghong GAN
  • Patent number: 11884610
    Abstract: The present disclosure relates to: a) crystalline forms of N—((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide; b) pharmaceutical compositions comprising one or more crystalline forms of N—((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide, and, optionally, one or more pharmaceutically acceptable carriers; c) methods of treating a tumor a cancer, or a Rasopathy disorder by administering one or more crystalline forms of N—((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide to a subject in need thereof; and methods of producing essentially pure Form IV of N—((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide.
    Type: Grant
    Filed: June 14, 2022
    Date of Patent: January 30, 2024
    Assignee: SPRINGWORKS THERAPEUTICS, INC.
    Inventors: Kristin Patterson, Jiping Liu, Ricky Wayne Couch, Peter Gregory Varlashkin, Mai Li, Yonghong Gan
  • Publication number: 20230032403
    Abstract: The present disclosure relates to: a) crystalline forms of N-((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide; b) pharmaceutical compositions comprising one or more crystalline forms of N-((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide, and, optionally, one or more pharmaceutically acceptable carriers; c) methods of treating a tumor a cancer, or a Rasopathy disorder by administering one or more crystalline forms of N-((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide to a subject in need thereof; and methods of producing essentially pure Form IV of N-((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide.
    Type: Application
    Filed: June 14, 2022
    Publication date: February 2, 2023
    Applicant: SpringWorks Therapeutics Inc.
    Inventors: Kristin PATTERSON, Jiping LIU, Ricky Wayne COUCH, Peter Gregory VARLASHKIN, Mai LI, Yonghong GAN
  • Patent number: 11427534
    Abstract: The present disclosure relates to: a) crystalline forms of N—((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide, h) pharmaceutical compositions comprising one or more crystalline forms of N—((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide, and, optionally, one or more pharmaceutically acceptable carriers; c) methods of treating a tumor a cancer, or a Rasopathy disorder by administering one or more crystalline forms of N—((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide to a subject in need thereof; and methods of producing essentially pure Form IV of N—((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide.
    Type: Grant
    Filed: August 3, 2021
    Date of Patent: August 30, 2022
    Assignee: SpringWorks Therapeutics, Inc.
    Inventors: Kristin Patterson, Jiping Liu, Ricky Wayne Couch, Peter Gregory Varlashkin, Mai Li, Yonghong Gan
  • Publication number: 20220267257
    Abstract: The present disclosure relates to: a) crystalline forms of N—((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide; b) pharmaceutical compositions comprising one or more crystalline forms of N—((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide, and, optionally, one or more pharmaceutically acceptable carriers; c) methods of treating a tumor a cancer, or a Rasopathy disorder by administering one or more crystalline forms of N—((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide to a subject in need thereof; and methods of producing essentially pure Form IV of N—((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide.
    Type: Application
    Filed: August 3, 2021
    Publication date: August 25, 2022
    Applicant: SpringWorks Therapeutics Inc.
    Inventors: Kristin PATTERSON, Jiping LIU, Ricky Wayne COUCH, Peter Gregory VARLASHKIN, Mai LI, Yonghong GAN
  • Patent number: 11084780
    Abstract: The present disclosure relates to a) crystalline forms of N—((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide; b) pharmaceutical compositions comprising one or more crystalline forms of N—((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide, and, optionally, one or more pharmaceutically acceptable carriers; c) methods of treating a tumor a cancer, or a Rasopathy disorder by administering one or more crystalline forms of N—((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide to a subject in need thereof, and methods of producing essentially pure Form IV of N—((R)-2,3-dihydroxypropoxy)-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-benzamide.
    Type: Grant
    Filed: February 17, 2021
    Date of Patent: August 10, 2021
    Assignee: SpringWorks Therapeutics, Inc.
    Inventors: Kristin Patterson, Jiping Liu, Ricky Wayne Couch, Peter Gregory Varlashkin, Mai Li, Yonghong Gan
  • Patent number: 10465212
    Abstract: There is provided a recombinant bacterium comprising at least one overexpressed acyl-ACP thioesterase gene, and wherein at least one gene from the tricarboxylic acid cycle or glycolysis or both is inactivated. There is also provided a method for producing fatty acids, said method comprising culturing bacteria comprising at least one overexpressed acyl-ACP thioesterase gene in a growth medium in a container having walls; allowing said bacteria to secrete fatty acids; and collecting said fatty acids. Acid supplementation is also shown to increase productivity.
    Type: Grant
    Filed: March 18, 2016
    Date of Patent: November 5, 2019
    Assignee: William Marsh Rice University
    Inventors: Ka-Yiu San, Mai Li, Xiujun Zhang
  • Publication number: 20190142340
    Abstract: A system for monitoring physiological condition includes a device for collecting readings and a monitoring device. The collecting device includes a number of collecting units configured to be selected human body. Based on different requirements, different numbers of collecting units can be selected to be attached to different portions of the living subject to collect readings. The selected collecting units transmit the readings to the monitoring device via wireless communication networks. The monitoring device can analyze the readings and generate a report.
    Type: Application
    Filed: November 30, 2017
    Publication date: May 16, 2019
    Inventors: MING-SHIUNG CHANG, KO-MAI LI
  • Publication number: 20180228378
    Abstract: A device for measuring blood measure measures variations in electrical charges on the body as a result of heart activity. A method using the same is also described. The method acquires ECG signal collected by a collection unit of the device for measuring blood measure, processes the ECG signal, extracts feature from the ECG signal, and computes blood pressure according to the feature extracted from the ECG signal.
    Type: Application
    Filed: July 19, 2017
    Publication date: August 16, 2018
    Inventor: KO-MAI LI
  • Patent number: 9598696
    Abstract: The present invention discloses a process for increasing the production of free fatty acids at high yield (close to maximum theoretical yield), with various fatty acid compositions and various percentage of fatty acids accumulated intracellularly. This invention will enable the efficient production of other products derived from free fatty acids and/or products that can be branched out from the fatty acid synthesis pathways.
    Type: Grant
    Filed: October 16, 2012
    Date of Patent: March 21, 2017
    Assignee: William Marsh Rice University
    Inventors: Ka-Yiu San, Mai Li
  • Patent number: 9579021
    Abstract: A wearable electronic device includes a signal capturing assembly and a holder. The holder includes a case defining a receiving slot configured for receiving the signal capturing assembly, a first connecting electrode, and a second connecting electrode. The first and second connecting electrodes protrude from a bottom surface of the case and are electronically connected to the signal capturing assembly. The first and second connecting electrodes detect vital signs of a user and transmit the detected vital signs to the signal capturing assembly.
    Type: Grant
    Filed: May 18, 2015
    Date of Patent: February 28, 2017
    Assignee: Rooti Labs Limited
    Inventors: Ming-Shiung Chang, Ko-Mai Li, Shu-Chen Chuang
  • Patent number: 9579022
    Abstract: A wearable electronic device includes a signal capturing assembly and a wearable assembly. The signal capturing assembly is configured for detecting and processing vital signs from a user and defines at least one port. The signal capturing assembly includes a base, a first cover, a second cover, a third cover, a first electrode, and a core module. The first, second, third covers cover the base to form a receiving chamber to accommodate the core module. The first electrode is extended through the base and electronically connected to the core module The wearable assembly is detachably connected to the signal capturing assembly through the at least one port.
    Type: Grant
    Filed: May 19, 2015
    Date of Patent: February 28, 2017
    Assignee: Rooti Labs Limited
    Inventors: Ming-Shiung Chang, Ko-Mai Li, Shu-Chen Chuang
  • Publication number: 20160265010
    Abstract: There is provided a recombinant bacterium comprising at least one overexpressed acyl-ACP thioesterase gene, and wherein at least one gene from the tricarboxylic acid cycle or glycolysis or both is inactivated. There is also provided a method for producing fatty acids, said method comprising culturing bacteria comprising at least one overexpressed acyl-ACP thioesterase gene in a growth medium in a container having walls; allowing said bacteria to secrete fatty acids; and collecting said fatty acids. Acid supplementation is also shown to increase productivity.
    Type: Application
    Filed: March 18, 2016
    Publication date: September 15, 2016
    Inventors: Ka-Yiu SUN, Mai LI, Xiujun ZHANG
  • Patent number: 9309543
    Abstract: There is provided a recombinant bacterium comprising at least one overexpressed acyl-ACP thioesterase gene, and wherein at least one gene from the tricarboxylic acid cycle or glycolysis or both is inactivated. There is also provided a method for producing fatty acids, said method comprising culturing bacteria comprising at least one overexpressed acyl-ACP thioesterase gene in a growth medium in a container having walls; allowing said bacteria to secrete fatty acids; and collecting said fatty acids. Acid supplementation is also shown to increase productivity.
    Type: Grant
    Filed: March 18, 2011
    Date of Patent: April 12, 2016
    Assignee: William Marsh Rice University
    Inventors: Ka-Yiu San, Mai Li, Xiujun Zhang
  • Publication number: 20160073882
    Abstract: A wearable electronic device includes a signal capturing assembly and a wearable assembly. The signal capturing assembly is configured for detecting and processing vital signs from a user and defines at least one port. The signal capturing assembly includes a base, a first cover, a second cover, a third cover, a first electrode, and a core module. The first, second, third covers cover the base to form a receiving chamber to accommodate the core module. The first electrode is extended through the base and electronically connected to the core module The wearable assembly is detachably connected to the signal capturing assembly through the at least one port.
    Type: Application
    Filed: May 19, 2015
    Publication date: March 17, 2016
    Inventors: MING-SHIUNG CHANG, KO-MAI LI, SHU-CHEN CHUANG
  • Publication number: 20160073881
    Abstract: A wearable electronic device includes a signal capturing assembly and a holder. The holder includes a case defining a receiving slot configured for receiving the signal capturing assembly, a first connecting electrode, and a second connecting electrode. The first and second connecting electrodes protrude from a bottom surface of the case and are electronically connected to the signal capturing assembly. The first and second connecting electrodes detect vital signs of a user and transmit the detected vital signs to the signal capturing assembly.
    Type: Application
    Filed: May 18, 2015
    Publication date: March 17, 2016
    Inventors: MING-SHIUNG CHANG, KO-MAI LI, SHU-CHEN CHUANG
  • Publication number: 20150259712
    Abstract: Methods of improving fatty acid production in bacteria, yeast, algae, and various other microbes are presented, by either supplementing the medium with millimolar amounts of magnesium, by overexpressing a magnesium transporter, or both.
    Type: Application
    Filed: March 9, 2015
    Publication date: September 17, 2015
    Inventors: Ka-Yiu SAN, SongI HAN, Wei LI, Mai LI, Zhilin LI
  • Publication number: 20150232805
    Abstract: The present invention provides a host microorganism with a deletion, disruption or mutation in one or more enzymes of a glycerol dissimilation pathway and a plasmid without an antibiotic resistance gene but carrying one or more genes encoding enzymes involved in glycerol dissimilation, wherein the plasmid is stably maintained by the host microorganism when cultured on glycerol as a carbon source. Such a plasmid maintenance system is beneficial in applications where the presence of an antibiotic resistance gene or the use of antibiotics is either prohibited or problem.
    Type: Application
    Filed: January 21, 2015
    Publication date: August 20, 2015
    Inventors: Paul Campbell, Ryan W. Black, Stephanie Doneske, Mai Li, Daniel J. Monticello