Patents by Inventor Makoto Adachi

Makoto Adachi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6756376
    Abstract: The present invention provides a compound having sPLA2 inhibiting activity. The compound represented by the formula (I): wherein E is N or C—R4; G is N or C—R25; R1 is a carbocyclic group, heterocyclic group or the like; one of R3 and R4 is —(L2)-(acidic group), the other is a hydrogen atom, wherein L2 is a group connecting with an acid group; A ring is optionally substituted 5-8 membered cyclohexane ring or cyclohexene ring; R24 and R25 are a hydrogen atom or the like, its prodrug, their pharmaceutically acceptable salt, or hydrate thereof.
    Type: Grant
    Filed: May 9, 2002
    Date of Patent: June 29, 2004
    Assignee: Shionogi & Co., Ltd.
    Inventors: Masahiro Fuji, Tetsuo Okada, Makoto Adachi
  • Patent number: 6703385
    Abstract: The present invention provides a compound having sPLA2 inhibiting activity. The compound represented by the formula (I): wherein R1 is (a) C1 to C20 alkyl, C2 to C20 alkenyl, C2 to C20 alkynyl, carbocyclic groups, heterocyclic groups or the like; R2 is COCONH2 or the like; Q1 is a nitrogen atom or C—R4; one of R3 and R4 is —(L2)-(acidic group) wherein L2 is a group connecting with an acid group and the length of the connecting groups 1 to 5 atoms, and the other is a hydrogen atom; R21 and R22 are hydrogen atoms or the like; X is —CR23R24— or the like wherein R23 and R24 are hydrogen atoms or the like; Y is —CR25R26— or the like wherein R25 and R26 are hydrogen atoms or the like; Z is CH2 or the like; a broken line ( - - - ) represents the presence or absence of a bond, its prodrug, their pharmaceutically acceptable salt, or solvate thereof.
    Type: Grant
    Filed: January 22, 2002
    Date of Patent: March 9, 2004
    Assignee: Shionogi & Co., Ltd.
    Inventors: Mitsuaki Ohtani, Masahiro Fuji, Makoto Adachi, Tomoyuki Ogawa
  • Patent number: 6673781
    Abstract: The present invention provides a compound having sPLA2 inhibiting activity. The compound represented by the formula (I): wherein R1 is (a) C1 to C20 alkyl, C2 to C20 alkenyl, C2 to C20 alkynyl, carbocyclic groups, heterocyclic groups or the like; R2 is CONH2 or CONHNH2; one of R3 and R4 is —(L2)-(acidic group) wherein L2 is a group connecting with an acid group and the length of the connecting groups 1 to 5 atoms, and the other is a hydrogen atom; its prodrug, their pharmaceutically acceptable salt, or solvate thereof.
    Type: Grant
    Filed: February 1, 2002
    Date of Patent: January 6, 2004
    Assignee: Shionogi & Co., Ltd.
    Inventors: Mitsuaki Ohtani, Masahiro Fuji, Tetsuo Okada, Makoto Adachi, Tomoyuki Ogawa
  • Publication number: 20030236295
    Abstract: Having an affinity against serotonine receptors, compound (I) shown below is useful as a therapeutic agent against various kinds of diseases of central nervous systems.
    Type: Application
    Filed: December 31, 2002
    Publication date: December 25, 2003
    Inventors: Yoshikazu Fukui, Makoto Adachi, Takashi Sasatani
  • Publication number: 20030097989
    Abstract: A vapor deposition crucible includes a crucible main body which is open to upper and lower sides and has a cavity in which a sintered pellet as a vapor deposition material is stored. The cavity of the crucible main body has two cavity portions. A first cavity portion connected to an opening open to the lower side is formed to make the sintered pellet to be stored fit in the first cavity portion. A second cavity portion connected to an opening open to the upper side is formed to form a gap between the second cavity portion and the sintered pellet to be stored. A step like portion is at least partially formed at a connection portion between the first cavity portion and the second cavity portion.
    Type: Application
    Filed: August 30, 2002
    Publication date: May 29, 2003
    Inventors: Ken-ichi Shinde, Makoto Adachi, Takeshi Imizu, Takeshi Mitsuishi
  • Publication number: 20030013473
    Abstract: In a system including the first terminal and the second terminal. A communication method at the first terminal includes the steps of preparing its own device name, detecting a request for connection with the second terminal, rewriting the device name in response to the request, and transmitting the changed device name to the second terminal. A communication method at the second terminal includes the steps of receiving device names from a plurality of first terminals, displaying the device names for the user of the second terminal to recognize a changed device name easier than unchanged device names, and communicating with the first terminal specified by a device name selected by the user.
    Type: Application
    Filed: July 10, 2002
    Publication date: January 16, 2003
    Inventors: Makoto Adachi, Tadami Tanabe, Hiroyoshi Toda
  • Patent number: 6472389
    Abstract: The present invention provides a compound having sPLA2 inhibiting activity. The compound represented by the formula (I): wherein R1 is —(L1)—R6 wherein L1 is a divalent linking group of 1 to 18 atoms or the like, and R6 is a carbocyclic ring substituted by at least one non-interfering substituent or the like; R2 is C1 to C3 alkyl or the like; R3 is —(L2)-(acidic group); R4 and R5 are hydrogen atoms, non-interfering substituents, carbocyclic groups or the like; X is independently oxygen atom of sulfur atom; and RA is —C(═X)—C(═X)—NH2 or the like; the prodrugs thereof, their pharmaceutically acceptable salts, or their solvates, and a composition for inhibiting sPLA2 containing them as effective ingredients.
    Type: Grant
    Filed: October 18, 2000
    Date of Patent: October 29, 2002
    Assignee: Shionogi & Co., Ltd.
    Inventors: Mitsuaki Ohtani, Masahiro Fuji, Yoshikazu Fukui, Makoto Adachi
  • Publication number: 20010033575
    Abstract: Disclosed is an interface apparatus in a communication network for converting a frame, which has been received from a digital transmission line and has overhead and a payload, to ATM cells, assembling a frame using ATM cells that have been received from an ATM network, and sending the assembled frame to a digital transmission line. The apparatus includes cell conversion zone specifying means for defining, as a cell conversion zone, the smallest possible portion of a frame that contains the overhead data and payload, and generating a signal that specifies the cell conversion zone; pointer creation means for creating a pointer which specifies a predetermined position of the cell conversion zone as a reference position; and cell conversion means for converting data in the cell conversion zone into cells based upon the signal that specifies the cell conversion zone, and for inserting this pointer, which indicates the reference position of the cell conversion zone, in a prescribed cell.
    Type: Application
    Filed: January 19, 2001
    Publication date: October 25, 2001
    Applicant: FUJITSU LIMITED
    Inventors: Akira Shimamura, Yoshihiro Uchida, Makoto Adachi, Yoshiyuki Tokoi, Hirotoshi Mori, Hajime Yamashita
  • Patent number: 6049571
    Abstract: An encoding circuit with a function of zero continuous-suppression in a data transmission system according to the present invention includes an EXZ detecting unit, a NRZ pulse generating unit and an output control unit. The EXZ detecting unit receives serial data indicating a NRZ signal and binary information indicating a code rule, and outputs EXZ pulses and delay data. The NRZ pulse generating unit receives the EXZ pulses from the EXZ detecting unit, and outputs an EXZ detecting signal, bipolar rule pulses and violation pulses. The output control unit receives the EXZ detecting signal, the bipolar rule pulses and the violation pulses, these are output from the NRZ pulse generating unit, and the delay data from the EXZ detecting unit, and outputs P-pole pulses and N-pole pulses to an external stage, and an odd signal to the NRZ pulse generating unit.
    Type: Grant
    Filed: December 9, 1998
    Date of Patent: April 11, 2000
    Assignee: Fujitsu Limited
    Inventors: Hitoshi Hasegawa, Makoto Adachi, Makoto Yamada
  • Patent number: 5684958
    Abstract: A cell dropout preventing system includes a memory for temporarily storing cells which are obtained by dividing transmitting data into cells having a fixed length, an address generating part for generating a read address signal of the memory, a controlling part for controlling the address generating part based on a timing signal received from a line side and for transmitting to the line side the cell read from the memory by the read address signal generated from the address generating part, and a read completion detecting part for outputting a detection signal when it is detected that one cell is read completely from the memory. The controlling part controls the address generating part so that a cell which is the same as a previous cell is read from the memory and transmitted to the line side when no detection signal is received from the read completion detecting part.
    Type: Grant
    Filed: October 7, 1996
    Date of Patent: November 4, 1997
    Assignee: Fujitsu Limited
    Inventors: Makoto Adachi, Tetsuo Tachibana
  • Patent number: 5677305
    Abstract: An oxopyridinylquinoxaline derivative represented by the following Formula I or pharmaceutically acceptable salts thereof: ##STR1## wherein R.sup.1 is hydrogen, halogen, nitro, or trihalomethyl; R.sup.2 is hydrogen, halogen, nitro, cyano, trihalomethyl, carbamoyl, carbamoyl substituted with lower alkyl, sulfamoyl, or sulfamoyl substituted with lower alkyl; R.sup.3 is hydrogen, nitro, or halogen; R.sup.4 is hydrogen, lower alkyl, substituted lower alkyl, lower cycloalkyl, or substituted lower cycloalkyl; R.sup.5 's are substituents independently selected from the group consisting of halogen, nitro, cyano, lower alkyl, carbamoyl, and carbamoyl substituted with lower alkyl; and n is an integer of 0 to 4. The derivative works as an antagonistic agent against both the NMDA receptors and the AMPA receptors, so that it is effective as a therapeutic agent for neurological disorders caused by excitatory amino acids binding to the receptors.
    Type: Grant
    Filed: April 7, 1995
    Date of Patent: October 14, 1997
    Assignee: Shionogi & Co., Ltd.
    Inventors: Susumu Takada, Nobuo Chomei, Makoto Adachi, Masami Eigyo, Kazuo Kawasaki
  • Patent number: 5509013
    Abstract: A multiplexer control system is used to control multiplexing of data of a plurality of channels including channels having different transmission speeds. The multiplexer control system includes a bit map memory storing, in a bit map format, bits indicating existence of output timings respectively corresponding to different transmission speeds, a rate setting memory in which identification numbers indicating the transmission speeds are set in correspondence with the channels, and a controlling part for outputting an output timing signal depending on the transmission speed of the corresponding channel, based on the bit which indicates the existence of the output timing and is read by making access to the bit map memory and the identification number read by making access to the rate setting memory. The output timing signal determines the multiplexing of the data of the plurality of channels.
    Type: Grant
    Filed: March 30, 1994
    Date of Patent: April 16, 1996
    Assignee: Fujitsu Limited
    Inventors: Makoto Adachi, Tetsuo Tachibana
  • Patent number: 5477336
    Abstract: A video signal recording and reproducing apparatus in accordance with the present invention includes A/D converters, a shuffling circuit and magnetic heads. The A/D converters A/D-convert a luminance signal Y and color difference signals P.sub.B and P.sub.R included in a video signal. The shuffling circuit divides each A/D converted data into first and second channels and further divides the first and second channels into data of a first segment including the color difference signal P.sub.R and data of a second segment including the color difference signal P.sub.B.
    Type: Grant
    Filed: May 18, 1994
    Date of Patent: December 19, 1995
    Assignee: Sharp Kabushiki Kaisha
    Inventor: Makoto Adachi
  • Patent number: 5461062
    Abstract: A compound of the formula: ##STR1## wherein R is an optionally substituted phenyl group, 5-membered; the A ring is a 5 to 7 membered alicyclic group in which said A ring may have an alkyl group as a substituent, or a pharmaceutically acceptable salt thereof, and is useful as a psychotropic agent.
    Type: Grant
    Filed: August 30, 1994
    Date of Patent: October 24, 1995
    Assignee: Shionogi & Co., Ltd.
    Inventors: Susumu Takada, Takashi Sasatani, Nobuo Chomei, Makoto Adachi, Akira Matsushita
  • Patent number: 5406382
    Abstract: A video signal recording-reproduction device is provided with a recording device for applying time base extension of N-times to an input video signal to form a recording signal and recording the signal on a recording medium by dividing it into a plurality of channels the number of which is given by N or integral multiples of N. The recording device includes a line memory control circuit for shifting a phase of a signal such that the phase shift between adjacent channels is a 1/N horizontal scanning period. The video signal recording-reproduction device is also provided with a reproduction device for forming an output video signal by reproducing a recording signal from each channel and by making a separated sync signal of the recording signal of each channel to coincide with a horizontal synchronizing signal of the input video signal.
    Type: Grant
    Filed: May 12, 1993
    Date of Patent: April 11, 1995
    Assignee: Sharp Kabushiki Kaisha
    Inventor: Makoto Adachi
  • Patent number: 5394276
    Abstract: A video signal recording apparatus is provided with first and second channels for transmitting an input video signal. The first channel has a line memory for conducting a 1H delay on data and a time-base-extension line memory for conducting time base extension on the data with the 1H delay. The data subjected to the time base extension undergoes D/A conversion to be an output of the first channel. On the other hand, the second channel does not have a line memory for a 1H delay, and the video signal without delay is subjected to time base extension and undergoes D/A conversion to be an output of the second channel. In the arrangement, odd lines and even lines respectively contained in adjoining two frames in each channel are reversed such that in a certain frame, odd lines of the input video signal are transmitted through the first channel with even lines through the second channel. In the next frame, even lines are transmitted through the first channel with odd lines through the second channel.
    Type: Grant
    Filed: April 20, 1993
    Date of Patent: February 28, 1995
    Assignee: Sharp Kabushiki Kaisha
    Inventor: Makoto Adachi
  • Patent number: 5378848
    Abstract: A compound of the formula: ##STR1## wherein R is an optionally substituted aryl group or an optionally substituted aromatic heterocycle group; A ring is a 5 to 9 membered alicyclic group, in which one or more of carbon atoms constituting said A ring may be replaced by O, or S and said A ring may have alkyl as a substituent, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: February 2, 1993
    Date of Patent: January 3, 1995
    Assignee: Shionogi & Co., Ltd.
    Inventors: Susumu Takada, Takashi Sasatani, Nobuo Chomei, Makoto Adachi, Akira Matsushita
  • Patent number: 5312927
    Abstract: The present invention relates to preparation of imidazoles which are useful as pharmaceutical and agricultural chemicals. Specifically, the present invention relates to a process for preparing imidazoles of the formula (I): ##STR1## which comprises conducting condensation among an .alpha.,.alpha.-dihaloaldehyde compound of the formula (II): ##STR2## an aldehyde compound of the formula: R.sup.2 --CHO and aqueous ammonia.
    Type: Grant
    Filed: August 16, 1993
    Date of Patent: May 17, 1994
    Assignee: Shionogi & Co., Inc.
    Inventors: Susumu Takada, Makoto Adachi
  • Patent number: 5295024
    Abstract: A video signal recording apparatus is provided with first and second channels for transmitting an input video signal. The first channel has a line memory for conducting a 1H delay on data and a time-base-extension line memory for conducting time base extension on the data with the 1H delay. The data subjected to the time base extension undergoes D/A conversion to be an output of the first channel. On the other hand, the second channel does not have a line memory for a 1H delay, and the video signal without delay is subjected, to time base extension and undergoes D/A conversion to be an output of the second channel. In the arrangement, odd lines and even lines respectively contained in adjoining two frames in each channel are reversed such that in a certain frame, odd lines of the input video signal are transmitted through the first channel with even lines through the second channel. In the next frame, even lines are transmitted through the first channel with odd lines through the second channel.
    Type: Grant
    Filed: May 23, 1991
    Date of Patent: March 15, 1994
    Assignee: Sharp Kabushiki Kaisha
    Inventor: Makoto Adachi
  • Patent number: 5253076
    Abstract: A video signal recording-reproduction device is provided with a recording device for applying time base extension of N-times to an input video signal to form a recording signal and recording the signal on a recording medium by dividing it into a plurality of channels the number of which is given by N or integral multiples of N. The recording device includes a line memory control circuit for shifting a phase of a signal such that the phase shift between adjacent channels is a 1/N horizontal scanning period. The video signal recording-reproduction device is also provided with a reproduction device for forming an output video signal by reproducing a recording signal from each channel and by making a separated sync signal of the recording signal of each channel to coincide with a horizontal synchronizing signal of the input video signal.
    Type: Grant
    Filed: January 4, 1991
    Date of Patent: October 12, 1993
    Assignee: Sharp Kabushiki Kaisha
    Inventor: Makoto Adachi