Patents by Inventor Makoto Hirasawa

Makoto Hirasawa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240239778
    Abstract: The present invention addresses the problem of providing a compound for prophylaxis and/or treatment of central inflammatory diseases, or a pharmacologically acceptable salt thereof. The present invention addresses a compound of a general formula (I) or a pharmacologically acceptable salt thereof as a means to solve the problem.
    Type: Application
    Filed: January 16, 2024
    Publication date: July 18, 2024
    Applicant: Daiichi Sankyo Company, Limited
    Inventors: Keiji Saito, Katsuyoshi Nakajima, Yasuyuki Ogawa, Mitsuhiro Makino, Kaori Ito, Seiko Nagata, Makoto Hirasawa
  • Patent number: 11993593
    Abstract: The present invention addresses the problem of providing a compound for prophylaxis and/or treatment of central inflammatory diseases, or a pharmacologically acceptable salt thereof. The present invention addresses a compound of a general formula (I) or a pharmacologically acceptable salt thereof as a means to solve the problem. [R1: a C1-C6 alkyl group or the like, R2: a C1-C6 alkyl group or the like, A: a 5-membered aromatic hetero-ring or the like, R3, R3?: a C1-C6 alkyl group or the like].
    Type: Grant
    Filed: June 21, 2022
    Date of Patent: May 28, 2024
    Assignee: Daiichi Sankyo Company, Limited
    Inventors: Keiji Saito, Katsuyoshi Nakajima, Yasuyuki Ogawa, Mitsuhiro Makino, Kaori Ito, Seiko Nagata, Makoto Hirasawa
  • Publication number: 20220411416
    Abstract: The present invention addresses the problem of providing a compound for prophylaxis and/or treatment of central inflammatory diseases, or a pharmacologically acceptable salt thereof. The present invention addresses a compound of a general formula (I) or a pharmacologically acceptable salt thereof as a means to solve the problem.
    Type: Application
    Filed: June 21, 2022
    Publication date: December 29, 2022
    Applicant: Daiichi Sankyo Company, Limited
    Inventors: Keiji Saito, Katsuyoshi Nakajima, Yasuyuki Ogawa, Mitsuhiro Makino, Kaori Ito, Seiko Nagata, Makoto Hirasawa
  • Patent number: 11407746
    Abstract: The present invention addresses the problem of providing a compound for prophylaxis and/or treatment of central inflammatory diseases, or a pharmacologically acceptable salt thereof. The present invention addresses a compound of a general formula (I) or a pharmacologically acceptable salt thereof as a means to solve the problem. [R1: a C1-C6 alkyl group or the like, R2: a C1-C6 alkyl group or the like, A: a 5-membered aromatic hetero-ring or the like, R3, R3?: a C1-C6 alkyl group or the like.
    Type: Grant
    Filed: September 28, 2018
    Date of Patent: August 9, 2022
    Assignee: Daiichi Sankyo Company, Limited
    Inventors: Keiji Saito, Katsuyoshi Nakajima, Yasuyuki Ogawa, Mitsuhiro Makino, Kaori Ito, Seiko Nagata, Makoto Hirasawa
  • Patent number: 9675964
    Abstract: A method of producing a composite nanoparticle (M-AxOy), having: generating, in an inert gas, an alloy (A-M) nanoparticle, which contains 0.1 at. % to 30 at. % of a noble metal (M), with the balance being a base metal (A) and inevitable impurities, and which has a particle size of 1 nm to 100 nm, to heat the alloy (A-M) nanoparticle and to bring the alloy (A-M) nanoparticle into contact with a supplied oxidizing gas during transportation of the alloy (A-M) nanoparticle with the inert gas, to oxidize the base metal component (A) in the floating alloy (A-M) nanoparticle, and to phase separate into the thus-oxidized base metal component (AxOy) and the noble metal component (M), to thereby obtain a composite nanoparticle (M-AxOy) having one noble metal particle (M) combined to the surface of a particulate base metal oxide (AxOy).
    Type: Grant
    Filed: February 2, 2012
    Date of Patent: June 13, 2017
    Assignee: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
    Inventors: Kenji Koga, Makoto Hirasawa, Hiroaki Sakurai, Naoto Koshizaki
  • Publication number: 20150209765
    Abstract: A method of continuously generating a joined structure: comprising a cube- or quadratic prism-shaped rock salt-type oxide nanoparticle and a metal nanoparticle, and having high crystallinity, in a gas phase, the method is characterized in that alloy nanoparticles composed of a noble metal and a base metal and having a particle size of 1 to 100 nm are generated in an inert gas; and brought into contact with a hot oxidizing gas, while the nanoparticles are heated at a high temperature together with the inert gas, to oxidize a base metal component in the alloy nanoparticles floating in the gas, and to simultaneously allow phase separation of the metal component, whereby the joined structure.
    Type: Application
    Filed: July 26, 2013
    Publication date: July 30, 2015
    Applicant: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
    Inventors: Kenji Koga, Makoto Hirasawa
  • Publication number: 20150052973
    Abstract: A protector (42) of a full-range-air-fuel-ratio sensor (2) is made of a material having an Ni content of 30.0 to 35.0 wt %, a Cr content of 19.0 to 23.0 wt %, an Al content of 0.15 to 0.60 wt %, and containing at least Fe as balance. The material of the protector may further contain Ti in an amount of 0.15 to 0.60 wt %.
    Type: Application
    Filed: August 13, 2014
    Publication date: February 26, 2015
    Applicant: NGK SPARK PLUG CO., LTD.
    Inventors: Takashi NAKASHIMA, Kensuke MIZUTANI, Makoto HIRASAWA
  • Publication number: 20140038815
    Abstract: A method of producing a composite nanoparticle (M-AxOy), having: generating, in an inert gas, an alloy (A-M) nanoparticle, which contains 0.1 at. % to 30 at. % of a noble metal (M), with the balance being a base metal (A) and inevitable impurities, and which has a particle size of 1 nm to 100 nm, to heat the alloy (A-M) nanoparticle and to bring the alloy (A-M) nanoparticle into contact with a supplied oxidizing gas during transportation of the alloy (A-M) nanoparticle with the inert gas, to oxidize the base metal component (A) in the floating alloy (A-M) nanoparticle, and to phase separate into the thus-oxidized base metal component (AxOy) and the noble metal component (M), to thereby obtain a composite nanoparticle (M-AxOy) having one noble metal particle (M) combined to the surface of a particulate base metal oxide (AxOy).
    Type: Application
    Filed: February 2, 2012
    Publication date: February 6, 2014
    Applicant: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY
    Inventors: Kenji Koga, Makoto Hirasawa, Hiroaki Sakurai, Naoto Koshizaki
  • Patent number: 8021616
    Abstract: A gas sensor including: a gas detection element; a metal shell extending in an axial direction; and a metal cylinder extending in an axial direction, wherein a leading end portion of the metal cylinder surrounds a base end portion of the metal shell and is fixed to the metal shell via a circumferential welded portion. The metal shell includes: Fe in an amount equal to or more than 50.0 mass %; C in an amount of 0.02 mass % to 0.15 mass %; Cr in an amount of 11.5 mass % to 18.0 mass %; and Nb in an amount equal to or more than twice amount of C in mass %.
    Type: Grant
    Filed: February 25, 2009
    Date of Patent: September 20, 2011
    Assignee: NGK Spark Plug Co., Ltd.
    Inventors: Daisuke Miyata, Makoto Hirasawa, Yoshiaki Matsubara
  • Patent number: 7965487
    Abstract: A neutralization apparatus comprising an ion generation element employing a novel, high efficiency discharge system capable of generating high concentration ions with a low ozone concentration. In the neutralization apparatus, the ion generation element is a minute electrode ion generation element consisting of a discharge electrode and an induction electrode having minute protrusions arranged in one direction on a plane, and a thin dielectric film sandwiched between them.
    Type: Grant
    Filed: March 3, 2006
    Date of Patent: June 21, 2011
    Assignees: FISA Corporation, National Institute of Advanced Industrial Science and Technology
    Inventors: Takafumi Seto, Makoto Hirasawa, Masaaki Tsuji, Akira Okuyama, Susumu Saito
  • Publication number: 20100263434
    Abstract: A gas sensor extending along an axial direction, the gas sensor including: a housing having a through hole, the through hole including an expanding portion at a leading end thereof; a gas sensing element inserted into the housing, having a closed leading end, and provided with a sensor electrode on an outer surface of the leading end side thereof; a heater inserted into the gas sensor, and including a contact portion where the heater contacts an inner surface; an protector fixed on the leading end side of the housing and having an outer protector including an outer air hole and an inner protector being positioned within the outer protector and spaced apart from the outer protector in the radial direction; and an inner air vent provided between the inner protector and the leading end of the housing.
    Type: Application
    Filed: April 15, 2010
    Publication date: October 21, 2010
    Applicant: NGK SPARK PLUG CO., LTD.
    Inventors: Shigeki Aoki, Daisuke Miyata, Makoto Hirasawa, Takayoshi Atsumi, Yasuhiro Fujita
  • Patent number: 7706120
    Abstract: An ion generating element capable of cost reduction and space saving while exhibiting a high generation efficiency of positive ions and negative ions and stabilized generation capacity with less variation, and an ion generator and a neutralizer employing it. The ion generating element comprises a dielectric body having at least two faces, at least two discharge electrodes arranged on the at least two faces of the dielectric body, and an induction electrode arranged in the dielectric body and subjected to the action of the at least two discharge electrodes and is characterized in that positive ions and negative ions are generated on the body, and ions are generated from the at least two faces of the dielectric body through discharge generated because of the potential difference between the discharge electrode of the ion generating element and the induction electrode when a drive voltage is applied between them.
    Type: Grant
    Filed: February 20, 2006
    Date of Patent: April 27, 2010
    Assignees: National Institute of Advanced Industrial Science and Technology, FISA Corporation
    Inventors: Takafumi Seto, Makoto Hirasawa, Masaaki Tsuji, Akira Okuyama, Susumu Saito
  • Patent number: 7612981
    Abstract: The present invention is relating to an ion generator and an ionizer, in which the ion generator can obtain stable ion generation even if the electrode and the power supply slightly change, satisfies voltage and frequency conditions for realizing an ozone concentration less than 50 ppb as an allowable concentration.
    Type: Grant
    Filed: January 31, 2008
    Date of Patent: November 3, 2009
    Assignees: National Institute of Advanced Industrial Science & Technology, FISA Corporation
    Inventors: Takafumi Seto, Makoto Hirasawa, Yasufumi Hozumi, Masaaki Tsuji, Akira Okuyama, Susumu Saito
  • Publication number: 20090214389
    Abstract: A gas sensor including: a gas detection element; a metal shell extending in an axial direction; and a metal cylinder extending in an axial direction, wherein a leading end portion of the metal cylinder surrounds a base end portion of the metal shell and is fixed to the metal shell via a circumferential welded portion. The metal shell includes: Fe in an amount equal to or more than 50.0 mass %; C in an amount of 0.02 mass % to 0.15 mass %; Cr in an amount of 11.5 mass % to 18.0 mass %; and Nb in an amount equal to or more than twice amount of C in mass %.
    Type: Application
    Filed: February 25, 2009
    Publication date: August 27, 2009
    Applicant: NGK SPARK PLUG CO., LTD.
    Inventors: Daisuke MIYATA, Makoto HIRASAWA, Yoshiaki MATSUBARA
  • Publication number: 20090207548
    Abstract: An ion generating element capable of cost reduction and space saving while exhibiting a high generation efficiency of positive ions and negative ions and stabilized generation capacity with less variation, and an ion generator and a neutralizer employing it. The ion generating element comprises a dielectric body having at least two faces, at least two discharge electrodes arranged on the at least two faces of the dielectric body, and an induction electrode arranged in the dielectric body and subjected to the action of the at least two discharge electrodes and is characterized in that positive ions and negative ions are generated on the body, and ions are generated from the at least two faces of the dielectric body through discharge generated because of the potential difference between the discharge electrode of the ion generating element and the induction electrode when a drive voltage is applied between them.
    Type: Application
    Filed: February 20, 2006
    Publication date: August 20, 2009
    Applicants: National Institute of Advanced Industrial Science and Technology, FISA Corporation
    Inventors: Takafumi Seto, Makoto Hirasawa, Masaaki Tsuji, Akira Okuyama, Susumu Saito
  • Patent number: 7575782
    Abstract: An oil agent of the kind and amount suitable for a post-step is applied on a workpiece regardless of the kind and residual amount of an oil agent used in a pre-step. A workpiece on which a first oil agent is deposited is immersed in a degreasing solution, taken out of the degreasing solution and cleaned to thereby remove all the first oil agent. Then, the workpiece having all the first oil agent removed is immersed in an oil agent solution to thereby newly deposit a second oil agent of the kind and amount suitable for a post-step on the workpiece.
    Type: Grant
    Filed: December 22, 2004
    Date of Patent: August 18, 2009
    Assignee: NGK Spark Plug Co., Ltd.
    Inventors: Nobuyuki Suganuma, Mitsuyoshi Shiba, Yoshiaki Matsubara, Makoto Hirasawa
  • Patent number: 7524407
    Abstract: An oxygen sensor 10 includes an oxygen detection element 20, which assumes a hollow tubular shape extending along the axis. The oxygen detection element 20 has a closed tip end and an opened rear end. An internal electrode layer 23 is formed on an inner circumferential surface 22 of the oxygen detection element 20. The sensor 10 also has a terminal member 30 which is in contact with the internal electrode layer 23 and in electrical connection therewith. The terminal member 30 has press contact portions 34c and 34d which come into press contact with the inner circumferential surface 22 of the oxygen detection element 20 to hold the terminal member 30 in the oxygen detection element 20, and conduction portions 35b which come into press contact with the internal electrode layer 23 on the inner circumferential surface 22 of the oxygen detection element 20 and into electrical connection with the internal electrode layer 23.
    Type: Grant
    Filed: March 30, 2005
    Date of Patent: April 28, 2009
    Assignee: NGK Spark Plug Co., Ltd.
    Inventors: Makoto Hirasawa, Shohei Yoshiyasu, Yoshiaki Matsubara
  • Publication number: 20090027825
    Abstract: A neutralization apparatus comprising an ion generation element employing a novel, high efficiency discharge system capable of generating high concentration ions with a low ozone concentration. In the neutralization apparatus, the ion generation element is a minute electrode ion generation element consisting of a discharge electrode and an induction electrode having minute protrusions arranged in one direction on a plane, and a thin dielectric film sandwiched between them.
    Type: Application
    Filed: March 3, 2006
    Publication date: January 29, 2009
    Inventors: Takafumi Seto, Makoto Hirasawa, Masaaki Tsuji, Akira Okuyama, Susumu Saito
  • Publication number: 20080191146
    Abstract: The present invention is relating to an ion generator and an ionizer, in which the ion generator can obtain stable ion generation even if the electrode and the power supply slightly change, satisfies voltage and frequency conditions for realizing an ozone concentration less than 50 ppb as an allowable concentration.
    Type: Application
    Filed: January 31, 2008
    Publication date: August 14, 2008
    Inventors: Takafumi Seto, Makoto Hirasawa, Yasufumi Hozumi, Masaaki Tsuji, Akira Okuyama, Susumu Saito
  • Publication number: 20060233962
    Abstract: An oil agent of the kind and amount suitable for a post-step is applied on a workpiece regardless of the kind and residual amount of an oil agent used in a pre-step. A workpiece on which a first oil agent is deposited is immersed in a degreasing solution, taken out of the degreasing solution and cleaned to thereby remove all the first oil agent. Then, the workpiece having all the first oil agent removed is immersed in an oil agent solution to thereby newly deposit a second oil agent of the kind and amount suitable for a post-step on the workpiece.
    Type: Application
    Filed: December 22, 2004
    Publication date: October 19, 2006
    Inventors: Nobuyuki Suganuma, Mitsuyoshi Shiba, Yoshiaki Matsubara, Makoto Hirasawa