Patents by Inventor Makoto Kakinuma

Makoto Kakinuma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7223882
    Abstract: A process for a preparation of Compound (V), a pharmaceutically acceptable salt or a solvate thereof, said process comprising the steps represented by the following formula: wherein R1 and R2 are each independently C1–C8 alkyl.
    Type: Grant
    Filed: March 18, 2003
    Date of Patent: May 29, 2007
    Assignee: Shionogi & Co., Ltd.
    Inventors: Haruo Koike, Katsuo Oda, Yutaka Nishino, Makoto Kakinuma
  • Patent number: 6987187
    Abstract: A process for producing amidine derivatives represented by the following reaction scheme, characterized in that the reactions of steps 1 and 3 are conducted in acetonitrile and the reaction of step 2 is conducted in acetone.
    Type: Grant
    Filed: July 15, 2002
    Date of Patent: January 17, 2006
    Assignee: Shionogi & Co., Ltd.
    Inventors: Toshiaki Masui, Kyozo Kawata, Takayuki Kasai, Makoto Kakinuma
  • Publication number: 20050143596
    Abstract: A process for a preparation of Compound (V), a pharmaceutically acceptable salt or a solvate thereof, said process comprising the steps represented by the following formula: wherein R1 and R2 are each independently C1-C8 alkyl
    Type: Application
    Filed: March 18, 2003
    Publication date: June 30, 2005
    Applicant: Shionogi & Co. Ltd.
    Inventors: Haruo Koike, Katsuo Oda, Yutaka Nishino, Makoto Kakinuma
  • Publication number: 20020156297
    Abstract: A process for preparing a compound having PGD2 antagonism represented by the formula (I), or a pharmaceutically acceptable salt or hydrate thereof, which process comprises reacting an amino alcohol of the formula (II) or its salt with a compound of the formula (III) or its reactive derivative, oxidizing the product with halo oxoacid in the presence of 2,2,6,6-tetramethylpiperidine-1-oxyls, reacting the product with an ylide under the conditions for Wittig reaction, and optionally deprotecting the product.
    Type: Application
    Filed: April 29, 2002
    Publication date: October 24, 2002
    Inventors: Tetsuo Okada, Makoto Kakinuma
  • Patent number: 6462241
    Abstract: A process for preparing a compound having PGD2 antagonism represented by the formula (I), or a pharmaceutically acceptable salt or hydrate thereof, which process comprises reacting an amino alcohol of the formula (II) or its salt with a compound of the formula (III) or its reactive derivative, oxidizing the product with halo oxoacid in the presence of 2,2,6,6-tetramethylpiperidine-1-oxyls, reacting the product with an ylide under the conditions for Wittig reaction, and optionally deprotecting the product.
    Type: Grant
    Filed: April 29, 2002
    Date of Patent: October 8, 2002
    Assignee: Shionogi & Co., Ltd.
    Inventors: Tetsuo Okada, Makoto Kakinuma
  • Patent number: 6455741
    Abstract: A process for preparing a compound having PGD2 antagonism represented by the formula (I), or a pharmaceutically acceptable salt or hydrate thereof, which process comprises reacting an amino alcohol of the formula (II) or its salt with a compound of the formula (III) or its reactive derivative, oxidizing the product with halo oxoacid in the presence of 2,2,6,6-tetramethylpiperidine-1-oxyls, reacting the product with an ylide under the conditions for Wittig reaction, and optionally deprotecting the product.
    Type: Grant
    Filed: April 29, 2002
    Date of Patent: September 24, 2002
    Assignee: Shionogi & Co., Ltd.
    Inventors: Tetsuo Okada, Makoto Kakinuma
  • Publication number: 20020115871
    Abstract: A process for preparing a compound having PGD2 antagonism represented by the formula (I), or a pharmaceutically acceptable salt or hydrate thereof, which process comprises reacting an amino alcohol of the formula (II) or its salt with a compound of the formula (III) or its reactive derivative, oxidizing the product with halo oxoacid in the presence of 2,2,6,6-tetramethylpiperidine-1-oxyls, reacting the product with an ylide under the conditions for Wittig reaction, and optionally deprotecting the product.
    Type: Application
    Filed: April 29, 2002
    Publication date: August 22, 2002
    Inventors: Tetsuo Okada, Makoto Kakinuma
  • Patent number: 6399788
    Abstract: A process for preparing a compound having PGD2 antagonism represented by the formula (I), or a pharmaceutically acceptable salt or hydrate thereof, which process comprises reacting an amino alcohol of the formula (II) or its salt with a compound of the formula (III) or its reactive derivative, oxidizing the product with halo oxoacid in the presence of 2,2,6,6-tetramethylpiperidine-1-oxyls, reacting the product with an ylide under the conditions for Wittig reaction, and optionally deprotecting the product.
    Type: Grant
    Filed: September 29, 2000
    Date of Patent: June 4, 2002
    Assignee: Shionogi & Co., Ltd.
    Inventors: Tsunetoshi Honma, Yoshiharu Hiramatsu, Tetsuo Okada, Makoto Kakinuma