Patents by Inventor Makoto Ogura
Makoto Ogura has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11597414Abstract: A method of assembling a railcar bogie includes: a positioning step of locking a wheelbase fixing jig to a pair of axle box devices to position the pair of axle box devices such that a wheelbase between a pair of wheelsets supported by the respective axle box devices becomes a predetermined designed value, the pair of axle box devices being arranged away from each other in a car longitudinal direction, the wheelbase fixing jig extending in the car longitudinal direction; a plate spring arranging step of making the pair of axle box devices support a plate spring extending in the car longitudinal direction; and a bogie frame arranging step of making a longitudinal direction middle portion of the plate spring support a bogie frame and coupling the bogie frame to the pair of axle box devices.Type: GrantFiled: March 14, 2017Date of Patent: March 7, 2023Assignee: KAWASAKI RAILCAR MANUFACTURING CO., LTD.Inventors: Fumikazu Kounoike, Toshiaki Iwanaga, Makoto Ogura, Takuya Nakao
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Publication number: 20200269886Abstract: A method of assembling a railcar bogie includes: a positioning step of locking a wheelbase fixing jig to a pair of axle box devices to position the pair of axle box devices such that a wheelbase between a pair of wheelsets supported by the respective axle box devices becomes a predetermined designed value, the pair of axle box devices being arranged away from each other in a car longitudinal direction, the wheelbase fixing jig extending in the car longitudinal direction; a plate spring arranging step of making the pair of axle box devices support a plate spring extending in the car longitudinal direction; and a bogie frame arranging step of making a longitudinal direction middle portion of the plate spring support a bogie frame and coupling the bogie frame to the pair of axle box devices.Type: ApplicationFiled: March 14, 2017Publication date: August 27, 2020Applicant: KAWASAKI JUKOGYO KABUSHIKI KAISHAInventors: Fumikazu KOUNOIKE, Toshiaki IWANAGA, Makoto OGURA, Takuya NAKAO
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Patent number: 10589077Abstract: A microneedle device system includes a microneedle device having a sheet-like microneedle having a sheet in which one surface is a skin contact surface and the other surface is a rear surface, and in which a plurality of microneedles are formed substantially along a surface of the sheet, and in which the microneedles in the skin piercing region are raised from the skin contact surface so as to be capable of piercing skin if the sheet is bent in a thickness direction, an adhesive layer that is disposed on the sheet-like microneedle, and a liner that is attached to the adhesive layer so as to be releasable therefrom, and an auxiliary tool having a bending portion which bends the microneedle device in the thickness direction, and on which the microneedle device is mounted so as to be movable along the bending portion.Type: GrantFiled: December 4, 2015Date of Patent: March 17, 2020Assignee: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Makoto Ogura, Naoki Yamamoto, Takashi Kumon
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Publication number: 20190015652Abstract: A microneedle sheet according to an embodiment comprises a plurality of microneedles formed on a sheet substantially along a principal surface of the sheet. The sheet is bent to raise the microneedles from the principal surface, and the raised microneedles pierce a skin.Type: ApplicationFiled: September 18, 2018Publication date: January 17, 2019Inventors: Kazuya KOMINAMI, Shinpei NISHIMURA, Seiji TOKUMOTO, Makoto OGURA, Toshiyuki MATSUDO, Naoki YAMAMOTO
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Patent number: 10086183Abstract: An applicator is configured to transfer an active ingredient into a body through skin by a puncture in the skin with microneedles. The applicator includes a piston plate that is provided with a first protrusion part and second protrusion parts on a lower surface side of a main body of the piston plate. The microneedles are provided on a surface of the first protrusion part. The second protrusion parts are provided in a periphery of the first protrusion part while spaced apart from the first protrusion part.Type: GrantFiled: November 4, 2014Date of Patent: October 2, 2018Assignee: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Shunsuke Arami, Shinpei Nishimura, Seiji Tokumoto, Makoto Ogura
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Patent number: 10039911Abstract: An applicator of one aspect for applying microneedles to skin includes a resistive portion configured to apply resistance against movement of a microneedle sheet having the plurality of microneedles formed along a main surface of the sheet, and a bending portion configured to bend the microneedle sheet passed through the resistive portion to raise the microneedle from the main surface.Type: GrantFiled: June 17, 2014Date of Patent: August 7, 2018Assignee: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Naoki Yamamoto, Makoto Ogura
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Patent number: 9913970Abstract: An applicator includes a piston plate, a non-linear coil spring, a casing, a lock means and a release means. The casing includes a tubular main body part that houses therein the piston plate and the non-linear coil spring, and a cover part that is arranged on one end side of the main body part. The cover part and the piston plate sandwich the non-linear coil spring there between. The lock means locks the piston plate with the casing such that the piston plate is held at a retraction position thereof on the cover part side in a state where the cover part and the piston plate compress the non-linear coil spring. The release means releases a locked state where the piston plate is locked with the casing by the lock means and where the cover part and the piston plate compress the non-linear coil spring.Type: GrantFiled: November 27, 2013Date of Patent: March 13, 2018Assignee: HISAMITSU PHARMACEUTICAL CO., LTD.Inventors: Shunsuke Arami, Makoto Ogura, Seiji Tokumoto
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Patent number: 9909098Abstract: The current invention provides methods, as well as compositions useful in such methods, involving application of energy to a tissue of interest to generate a liquefied sample comprising tissue constituents so as to provide for rapid tissue sampling, as well as qualitative and/or quantitative detection of analytes that may be part of tissue constituents (e.g., several types of biomolecules, drugs, and microbes). Determination of tissue composition can be used in a variety of applications, including diagnosis or prognosis of local as well as systemic diseases, evaluating bioavailability of therapeutics in different tissues following drug administration, forensic detection of drugs-of-abuse, evaluating changes in the tissue microenvironment following exposure to a harmful agent, and various other applications.Type: GrantFiled: August 6, 2008Date of Patent: March 6, 2018Assignee: The Regents of the University of CaliforniaInventors: Samir M. Mitragotri, Sumit Paliwal, Makoto Ogura
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Patent number: 9849272Abstract: An applicator of one aspect for applying a sheet member to skin includes a body having a bottom surface facing the skin and a first guide configured to guide the sheet member to a space between the skin and the bottom surface, in which the sheet member is applied to the skin after being folded in the space.Type: GrantFiled: June 17, 2014Date of Patent: December 26, 2017Assignee: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Naoki Yamamoto, Makoto Ogura
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Patent number: 9848853Abstract: Disclosed are kits for at least partly liquefying tissue. The kit may include a liquefaction promoting medium (LPM). The LPM may include a non-ionic surfactant; a zwitterionic surfactant; and an abrasive material. The kit may include instructions. The instructions may direct a user to treat a tissue of a living subject by: applying the LPM together with the abrasive material to the tissue of the living subject; and transmitting energy to the tissue of the living subject through the abrasive material in the presence of the LPM effective to cause at least partial dissolution of one or more components of the tissue of the living subject.Type: GrantFiled: May 2, 2016Date of Patent: December 26, 2017Assignee: The Regents of the University of CaliforniaInventors: Samir Mitragotri, Sumit Paliwal, Makoto Ogura
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Publication number: 20170333690Abstract: A microneedle device system includes a microneedle device having a sheet-like microneedle having a sheet in which one surface is a skin contact surface and the other surface is a rear surface, and in which a plurality of microneedles are formed substantially along a surface of the sheet, and in which the microneedles in the skin piercing region are raised from the skin contact surface so as to be capable of piercing skin if the sheet is bent in a thickness direction, an adhesive layer that is disposed on the sheet-like microneedle, and a liner that is attached to the adhesive layer so as to be releasable therefrom, and an auxiliary tool having a bending portion which bends the microneedle device in the thickness direction, and on which the microneedle device is mounted so as to be movable along the bending portion.Type: ApplicationFiled: December 4, 2015Publication date: November 23, 2017Applicant: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Makoto OGURA, Naoki YAMAMOTO, Takashi KUMON
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Patent number: 9717893Abstract: A microneedle array in accordance with one embodiment comprises at least a first microneedle and a second microneedle that are inclined with respect to a support face. A tip of the first microneedle points in a first direction, and a tip of the second microneedle points in a second direction different from the first direction. The first microneedle in contact with skin is stuck into the skin while being moved along a surface of the skin in the first direction. The second microneedle in contact with the skin is stuck into the skin while being moved along the surface of the skin in the second direction.Type: GrantFiled: February 12, 2014Date of Patent: August 1, 2017Assignee: HISAMITSU PHARMACEUTICAL CO., LTD.Inventors: Ryusuke Fudoji, Makoto Ogura
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Publication number: 20170049695Abstract: A microneedle sheet according to an embodiment includes a plurality of microneedles formed on a sheet generally along a principal surface of the sheet. The material of the microneedles is selected from among hydroxypropyl methylcellulose, hydroxypropyl cellulose, polyvinyl alcohol, and a graft copolymer of polyvinyl alcohol and polyethylene glycol. The microneedles are raised from the principal surface by bending the sheet, and the raised microneedles pierce skin.Type: ApplicationFiled: February 19, 2015Publication date: February 23, 2017Inventors: Naoki YAMAMOTO, Makoto OGURA
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Patent number: 9498611Abstract: An active agent is effectively administered without giving fear to the user when the microneedles are applied. An applicator 10 includes a transmission member that transmits biasing force of a biasing member to a microneedle array including micro projections (microneedles) with a needle density of 500 needles/cm2 or more. The transmission member has a mass of 1.5 g or less, and the transmission member activated by the biasing force of the biasing member has a momentum of from 0.0083 (N·s) to 0.015 (N·s).Type: GrantFiled: October 2, 2012Date of Patent: November 22, 2016Assignee: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Seiji Tokumoto, Makoto Ogura
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Publication number: 20160263363Abstract: An applicator is configured to transfer an active ingredient into a body through skin by a puncture in the skin with microneedles. The applicator includes a piston plate that is provided with a first protrusion part and second protrusion parts on a lower surface side of a main body of the piston plate. The microneedles are provided on a surface of the first protrusion part. The second protrusion parts are provided in a periphery of the first protrusion part while spaced apart from the first protrusion part.Type: ApplicationFiled: November 4, 2014Publication date: September 15, 2016Inventors: Shunsuke ARAMI, Shinpei NISHIMURA, Seiji TOKUMOTO, Makoto OGURA
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Publication number: 20160235392Abstract: Disclosed are kits for at least partly liquefying tissue. The kit may include a liquefaction promoting medium (LPM). The LPM may include a non-ionic surfactant; a zwitterionic surfactant; and an abrasive material. The kit may include instructions. The instructions may direct a user to treat a tissue of a living subject by: applying the LPM together with the abrasive material to the tissue of the living subject; and transmitting energy to the tissue of the living subject through the abrasive material in the presence of the LPM effective to cause at least partial dissolution of one or more components of the tissue of the living subject.Type: ApplicationFiled: May 2, 2016Publication date: August 18, 2016Inventors: Samir Mitragotri, Sumit Paliwal, Makoto Ogura
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Publication number: 20160206866Abstract: A microneedle sheet in an embodiment of the present invention includes a plurality of microneedles formed on a sheet generally along a principal surface of the sheet. The microneedles are configured to rise from the principal surface when the sheet is bent, and the raised microneedles pierce skin. At least some of the microneedles each have a region for exposing a tear formed in the skin in a needle inserted state.Type: ApplicationFiled: September 3, 2014Publication date: July 21, 2016Inventors: Naoki YAMAMOTO, Makoto OGURA
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Publication number: 20160144160Abstract: An applicator of one aspect for applying microneedles to skin includes a resistive portion configured to apply resistance against movement of a microneedle sheet having the plurality of microneedles formed along a main surface of the sheet, and a bending portion configured to bend the microneedle sheet passed through the resistive portion to raise the microneedle from the main surface.Type: ApplicationFiled: June 17, 2014Publication date: May 26, 2016Inventors: Naoki YAMAMOTO, Makoto OGURA
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Publication number: 20160136405Abstract: An applicator of one aspect for applying a sheet member to skin includes a body having a bottom surface facing the skin and a first guide configured to guide the sheet member to a space between the skin and the bottom surface, in which the sheet member is applied to the skin after being folded in the space.Type: ApplicationFiled: June 17, 2014Publication date: May 19, 2016Inventors: Naoki YAMAMOTO, Makoto OGURA
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Patent number: D778434Type: GrantFiled: August 21, 2014Date of Patent: February 7, 2017Assignee: HISAMITSU PHARMACEUTICAL CO., INC.Inventors: Shunsuke Arami, Makoto Ogura