Abstract: The present invention establishes a molecular therapy for glycogen storage disease type Ia. The present invention provides an oligonucleotide of 15-30 bases comprising a nucleotide sequence complementary to die cDNA of G6PC gene with c.648G>T mutation, wherein the oligonucleotide comprises a sequence complementary to a region comprising any site between the 82nd to the 92nd nucleotide from the 5? end of exon 5 of the G6PC gene with c.648C>T mutation, a pharmacologically acceptable salt or solvate thereof. Also provided is a pharmaceutical drug comprising the oligonucleotide, a pharmacologically acceptable salt or solvate thereof (e.g., therapeutic drug for glycogen storage disease type Ia).

Abstract: A powder magnetic core according to an aspect of the present disclosure is a powder magnetic core in which a magnetic powder is bonded via a binder layer. The powder magnetic core contains 88 volume % or more of magnetic powder, and when a cross-sectional photograph of the powder magnetic core is taken, an area of the cross-sectional photograph having a size of 10000 ?m2 is divided into unit areas, one or more of the unit areas in which the size of a cross-sectional area of a binder accounts for 50% or more of the unit area are extracted as specific unit areas, and the percentage of the number of specific unit areas with respect to the total number of unit areas is equal to or larger than 0.2% but equal to or smaller than 3.0%.

Abstract: A powder magnetic core capable of achieving a low loss in a high frequency range is provided. A powder magnetic core according to the present disclosure is a powder magnetic core in which a magnetic powder is bonded via a binder layer. A volume filling percentage of the magnetic powder included in the powder magnetic core is 85 volume % or higher, and a value obtained by dividing a BET specific surface area (m2/g) of the powder magnetic core by a specific surface area (m2/g) calculated using outer dimensions of the powder magnetic core is 5000 or less.

Abstract: A reverse osmosis treatment apparatus includes a membrane unit including an osmosis membrane module. The membrane unit includes a plurality of banks connected in series, each bank including an osmosis membrane module. At least one of the banks includes a treatment water pipe valve and a concentrated water pipe valve, and a bypass pipe capable of diverting the water to be treated, which is to be supplied to the bank, around the bank and draining the water to be treated and a chemical cleaning pipe capable of supplying the reverse osmosis membrane module disposed in the bank with chemical cleaning water are connected. A reverse osmosis treatment method is for cleaning intermittently a bank having the treatment water pipe valve and the concentrated water pipe valve while continuing the reverse osmosis treatment using the remaining bank.

Abstract: An oil content measurement device includes a fluid device which mixes water to be treated containing oil content with a solvent and extracts the oil content into the solvent, a sensor unit which has a casing storing a quartz crystal oscillator therein with a ring-like spacer in between, a dispensing nozzle which is disposed above the oscillator at a predetermined gap there between and feeds a predetermined amount of the solvent after the oil content has been extracted on the oscillator, a sensor circuit which measures a resonance frequency of the oscillator, and controller which controls at least the fluid device and the sensor circuit. Provided is a arithmetic logical unit, based on a change amount of the received resonance frequency of the oscillator in the sensor unit to which the solvent after the oil content has been extracted has been fed, measures the oil content remaining on the oscillator.

Abstract: A catheter balloon exhibiting improved pressure resistance of the entire membrane is formed of a membrane as a laminate of at least two layers including a polyamide elastomer layer and a polyamide layer, in which the polyamide elastomer layer is disposed at the inner side of the polyamide layer, a refractive index nr1 in the circumferential direction of a cross-section perpendicular to the axis in the inner side surface of the polyamide layer is greater than a refractive index nr2 in the circumferential direction of a cross-section perpendicular to the axis in the inner side surface of the polyamide elastomer layer, and the difference between the refractive index nr1 and the refractive index nr2 is 0.01 or greater.

Abstract: An oil content measurement device includes a fluid device which mixes water to be treated containing oil content with a solvent and extracts the oil content into the solvent, a sensor unit which has a casing storing a quartz crystal oscillator therein with a ring-like spacer in between, a dispensing nozzle which is disposed above the oscillator at a predetermined gap there between and feeds a predetermined amount of the solvent after the oil content has been extracted on the oscillator, a sensor circuit which measures a resonance frequency of the oscillator, and controller which controls at least the fluid device and the sensor circuit. Provided is a arithmetic logical unit, based on a change amount of the received resonance frequency of the oscillator in the sensor unit to which the solvent after the oil content has been extracted has been fed, measures the oil content remaining on the oscillator.

Abstract: A means for restraining hardening of silicone rubber is provided. In one form, a silicone rubber composition is provided that contains an antioxidant dispersed therein. In addition, a method for preparing the silicone rubber composition is provided that includes: a step of mixing a silicone rubber precursor and the antioxidant and curing the obtained mixture; or a step of wetting the silicone rubber with a liquid antioxidant. A method of manufacturing a medical device is also provided, including: a step of incorporating into a medical device the silicone rubber composition obtained in the preparation method outlined above; a step of seal packaging the obtained medical device; and a step of irradiating the seal-packaged medical device with radiation.

Abstract: A balloon including a laminated film of at least two layers including a polyamide elastomer layer and a polyamide layer wherein the polyamide elastomer layer is formed at the inner side of the polyamide layer and a molecular weight distribution of the polymers as a whole of the balloon (weight-average molecular weight MW/number-average molecular weight Mn) ranges from 3 to 10.

Abstract: A hydrophilic material having a hydrophilic nature and being biocompatible and processable into nanoparticles wherein a hydrophilic monomer such as threitol or a hydrophilic polymer such as polyethylene glycol is attached to the ?position of an ?,?-unsaturated carboxyl group of a (co)polymer comprising an aromatic compound such as 4-hydroxycinnamic acid in which an aromatic ring is substituted by the ?,?-unsaturated carboxyl group and one or more hydroxyl groups. In particular, a hydrophilic material having a nanoparticle size which is highly dispersible in water, can well migrate into the blood and is useful as a drug carrier, a medical material and a sustained drug release material.

Abstract: A catheter balloon exhibiting improved pressure resistance of the entire membrane is formed of a membrane as a laminate of at least two layers including a polyamide elastomer layer and a polyamide layer, in which the polyamide elastomer layer is disposed at the inner side of the polyamide layer, a refractive index nr1 in the circumferential direction of a cross-section perpendicular to the axis in the inner side surface of the polyamide layer is greater than a refractive index nr2 in the circumferential direction of a cross-section perpendicular to the axis in the inner side surface of the polyamide elastomer layer, and the difference between the refractive index nr1 and the refractive index nr2 is 0.01 or greater.

Abstract: A sewage treatment apparatus includes a membrane separation active-sludge treating section which performs a biological treatment on a part of sewage, which is introduced by a water introducing section while flowing through a sewer trunk line, to generate first treated sewage; a membrane highly treating section which performs a membrane high treatment on the first treated sewage to generate second treated sewage; a membrane treating tank which stores the first treated sewage; a membrane highly treating tank which stores the second treated sewage; water level sensors which respectively measure water level of the membrane treating tank and the membrane highly treating tank; and a power-control section which controls water introducing quantity of the water introducing section on the basis of the water level data measured by the water level sensors.

Abstract: A sewage reuse system distributes a plurality of reuse water supply sections, each including a water introducing opening formed in a sewer trunk line; a treated sewage tank for storing reuse water; and a water level sensor for measuring a water level of the treated sewage tank, in a demand area of reuse water along the sewer trunk line. The system includes a movable sewage treatment section which moves to any of the plurality of water introducing openings; performs the sewage treatment to generate reuse water; and supplies the generated reuse water to the treated sewage tank, a communication section which transmits the water level data measured by the water level sensor, and a central control section which controls a water storing quantity of the treated sewage tank on the basis of the demand information of reuse water and the water level data.

Abstract: The invention provides a method of inspecting bacteria by using an outer membrane vesicle of the bacteria, which is useful for easily diagnosing a periodontopathic bacteria with high precision. An outer membrane vesicle of bacteria to be detected is previously arranged in a measuring portion of a measuring appliance, a specimen material collected from a test subject is brought into contact with the measuring portion, and an anti-outer membrane vesicle antibody corresponding to the outer membrane vesicle in the specimen material is detected on the basis of an antigen antibody reaction. A measuring appliance for executing the inspecting method of the bacteria is structured such that the outer membrane vesicle of the bacteria to be detected is previously arranged in the measuring portion.

Abstract: A bioabsorbable stent has a relatively high radial force and can be placed directly at the lesion without the possibility or reducing the possibility of occluding the lesion again after placement. The bioabsorbable stent is formed from a mixture composed of a bioabsorbable aliphatic polyester and an aromatic compound having one or more aromatic rings.

Abstract: A medical device wherein a metal base and a surface lubricating layer are fixed with each other more firmly. The medical device permanently exhibits excellent surface lubricity when in use. A medical device which has a lubricating surface when wet, is characterized by comprising a base layer which is composed of a metal material, an intermediate layer which covers at least a part of the base layer and is composed of a compound that has a plurality of thiol groups in each molecule, and a surface lubricating layer which covers the surface of the intermediate layer and is composed of a hydrophilic polymer that has a reactive functional group. The medical device is also characterized in that the surface lubricating layer is bonded to the base layer via the intermediate layer by reacting the compound having thiol groups with the hydrophilic polymer.

Abstract: A bioabsorbable material which is flexible and degradable at a controlled rate, and an in-vivo indwelling device made thereof. The bioabsorbable material is a copolymer composed of an aromatic compound having an ?,?-unsaturated carboxylic group and at least one hydroxyl group as substituents on the aromatic ring, and a polycarbonate or a monomer constituting polycarbonate. Alternatively, it is a copolymer composed of, as the first component, an aromatic compound having an ?,?-unsaturated carboxylic group and at least one hydroxyl group as substituents on the aromatic ring, as the second component, an aromatic compound having an ?,?-unsaturated carboxylic group and at least two hydroxyl groups as substituents on the aromatic ring, and, as the third component, a polycarbonate or a monomer constituting polycarbonate.

Abstract: A medical device wherein a metal base and a surface lubricating layer are fixed with each other more firmly. The medical device permanently exhibits excellent surface lubricity when in use. A medical device which has a lubricating surface when wet, is characterized by comprising a base layer which is composed of a metal material, an intermediate layer which covers at least a part of the base layer and is composed of a compound that has a plurality of thiol groups in each molecule, and a surface lubricating layer which covers the surface of the intermediate layer and is composed of a hydrophilic polymer that has a reactive functional group. The medical device is also characterized in that the surface lubricating layer is bonded to the base layer via the intermediate layer by reacting the compound having thiol groups with the hydrophilic polymer.

Abstract: A hydrophilic material having a hydrophilic nature and being biocompatible and processable into nanoparticles wherein a hydrophilic monomer such as threitol or a hydrophilic polymer such as polyethylene glycol is attached to the ?position of an ?, ?-unsaturated carboxyl group of a (co)polymer comprising an aromatic compound such as 4-hydroxycinnamic acid in which an aromatic ring is substituted by the ?, ?-unsaturated carboxyl group and one or more hydroxyl groups. In particular, a hydrophilic material having a nanoparticle size which is highly dispersible in water, can well migrate into the blood and is useful as a drug carrier, a medical material and a sustained drug release material.

Abstract: The wastewater treatment system according to the present invention includes a plurality of reaction sequences including a first sedimentation tank, a reaction tank, a final sedimentation tank, a first channel which connects the first sedimentation tank and the reaction tank and a second channel which connects the reaction tank and the final sedimentation tank. In one reaction sequence of the plurality of reaction sequences, the reaction tank has a membrane separation tank including a carrier, a membrane unit, and activated sludge and in which an MLSS concentration of the activated sludge is in a range of 500 mg/L to 7000 mg/L, and wastewater is supplied to the reaction tank via the first channel, and wastewater in a quantity exceeding a treatment capacity of the reaction tank is supplied to the final sedimentation tank via the second channel.