Abstract: There are provided a microchemical system capable of acquiring a highly accurate TLM output value and a method for calculating TLM output thereof. A microchemical system 1 comprises: a microchemical chip having a channel with a depth t in which a sample flows; an exciting light source 13 adapted to irradiate the sample with an exciting light through an objective lens 10 with a numerical aperture NA; a detecting light source 14 adapted to irradiate the sample with a detecting light coaxially with the exciting light through the objective lens 10; and a PD adapted to receive a transmitted light when the detecting light transmits the sample before and after formation of a thermal lens 12. When a TLM output is calculated in the microchemical system 1 on the basis of a received light amount of the PD, the depth t (?m) is set to the range of 75?t?300, the numerical aperture NA is set to the range of 0.04?NA?0.

Abstract: A desktop thermal lens microscope apparatus can detect a chemical reaction in a micro spatial region within a glass chip, or the like, more conveniently and at any given place. The desktop thermal lens microscope apparatus has small laser light sources such as semiconductor lasers as an excitation light source and a probe light source. Since an excitation light source system (P), a probe light source (Q), and a thermal lens microscope optical system (R, S, T) are integrally provided in a single housing, the size of the desktop thermal lens microscope is as small as that of a desktop microscope.

Abstract: An enzyme immunoassay chip having, as micro channels, a reaction liquid leading-in flow passage part, a reaction flow passage part, and detection flow passage part sequentially disposed on a substrate continuously to each other, comprising an installed part for bead-bodies supporting antibodies and the bead-body flow stopping part formed in the micro channel of the reaction flow passage part, wherein enzyme reactive product flowing beyond the flow stopping part can be analyzed by using the chip.

Abstract: A microchemical system is provided, which can improve the working efficiency of the user. In the microchemical system 1, a plate-shaped element 10 that constitutes an optical unit 1a has an optical wave guide path 20, which acts as an optical path for exciting light and detecting light. An irradiation lens 30 is disposed at an end of the optical wave guide path 20 downstream in the direction of travel of the exciting light and the detecting light, and a channel 40 is located downstream of the irradiation lens 30, through which a liquid containing a sample flows. A detector 50 is disposed at an end of the plate-shaped element 10 downstream of the channel 40 and detects the detecting light for analysis of the sample.

Abstract: A small and portable microscope for ultramicroanalysis has an excellent spatial resolution and fixed position analyzing ability. The microscope has at least a part of an excitation light source, a part of a probe light source and a part of a thermal lens microscope optical system arranged integrally in a device body. The device body also includes an analyzing cell and substrates supporting the analyzing cell.

Abstract: It is an object to provide a photothermal conversion spectroscopic analysis method that enables measurement to be carried out with high sensitivity, and a photothermal conversion spectroscopic analysis apparatus that carries out the method. The photothermal conversion spectroscopic analysis apparatus is comprised of an exciting light source 111, a chopper 112 that is disposed close to the exciting light source 111 in the optical path of exciting light emitted from the exciting light source 111, a mirror 114 that changes the direction of travel of the exciting light, a detecting light source 120, a dichroic mirror 113 that has detecting light from the detecting light source 120 incident thereon and makes the exciting light and the detecting light coaxial, a lens 10 that has a suitable amount of chromatic aberration, and a holder 15 that holds the lens 10 such as to enable adjustment along three axes.

Abstract: For enlarging the application range of samples capable of being treated, decreasing the amount of samples used, preventing deterioration of samples by a change with the passage of time and preventing mixing of samples by diffusion, a micro fluidics system according to the present invention comprises a sample server which stores plural samples and which has sample efflux portions, a microchip for feeding samples to a treating portion through plural sample introducing portions communicating with the sample efflux portions and further through a microchannel, allowing the samples to be subjected to a predetermined treatment, and a sample feeder for feeding the samples stored in the sample server to the sample introducing portions through the sample efflux portions.

Abstract: A small and portable microscope for ultramicroanalysis having an excellent spatial resolution and a fixed position analyzing ability in which at least a part of an excitation light source (3), a part of a probe light source (4) and a part of a thermal lens microscope optical system are arranged integrally in a device body comprising an analyzing cell (1) and substrates (2A), (2B) supporting the analyzing cell (1).

Abstract: A microchemical system is provided, which can improve the working efficiency of the user and can be designed compact in size. The microchemical system is provided with an optical fiber 10 with a gradient index rod lens 102 mounted on an end thereof. The lens-possessing optical fiber 10 is comprised of an optical fiber 101 that transmits exciting light and detecting light in the single mode, and a ferrule 103 for expanding the outer diameter of the optical fiber 101 to the same value as that of the gradient index rod lens 102. The gradient index rod lens 102 and the optical fiber 101 are rigidly joined together by means of a sleeve 104.

Abstract: In a microfluid system it is intended to expand the application range of samples capable of being treated, decrease the amount of samples used, and prevent deterioration of samples with the lapse of time. In a microfluid system having a microchip for feeding plural samples to a treating portion and performing predetermined treatments, plural sample servers for storage of the samples therein are provided in the microchip, the sample servers and the treating portion are connected with each other through capillary channels provided respectively on outlet sides of the sample servers, and a pressurizing device for pressurizing the samples stored in the sample servers and feeding them to the treating portion is provided.

Abstract: An enzyme immunoassay chip having, as micro channels, a reaction liquid leading-in flow passage part, a reaction flow passage part, and detection flow passage part sequentially disposed on a substrate continuously to each other, comprising an installed part for bead-bodies supporting antibodies and the bead-body flow stopping part formed in the micro channel of the reaction flow passage part, wherein enzyme reactive product flowing beyond the flow stopping part can be analyzed by using the chip.

Abstract: A microchemical system chip and a microchemical system that can be reduced in size while improving measurement sensitivity. The microchemical system chip 1 is comprised of a plate-shaped glass substrate 10, and the glass substrate 10 has a U-shaped channel 11 therein. The U-shaped channel 11 is comprised of a longitudinal channel 11a, and a pair of transverse channels 11b and 11c that are connected to the two ends of the longitudinal channel 11a. The glass substrate 10 has therein two voids provided coaxially with the longitudinal channel 11a near the two ends of the longitudinal channel 11a, and gradient index rod lenses 14 and 15 are housed respectively in the two voids. An optical fiber 16 that propagates detecting light emitted from a light source is connected to the gradient index rod lens 14, and an optical fiber 17 that leads detecting light received by the gradient index rod lens 15 to a detector is connected to the gradient index rod lens 15.

Abstract: A microchemical system is provided, which can improve the working efficiency of the user. In the microchemical system 1, a plate-shaped element 10 that constitutes an optical unit la has an optical wave guide path 20, which acts as an optical path for exciting light and detecting light. An irradiation lens 30 is disposed at an end of the optical wave guide path 20 downstream in the direction of travel of the exciting light and the detecting light, and a channel 40 is located downstream of the irradiation lens 30, through which a liquid containing a sample flows. A detector 50 is disposed at an end of the plate-shaped element 10 downstream of the channel 40 and detects the detecting light for analysis of the sample.

Abstract: A microchemical system is provided, which can improve the working efficiency of the user and can be designed compact in size. The microchemical system is provided with an optical fiber 10 with a gradient index rod lens 102 mounted on an end thereof. The lens-possessing optical fiber 10 is comprised of an optical fiber 101 that transmits exciting light and detecting light in the single mode, and a ferrule 103 for expanding the outer diameter of the optical fiber 101 to the same value as that of the gradient index rod lens 102. The gradient index rod lens 102 and the optical fiber 101 are rigidly joined together by means of a sleeve 104.

Abstract: It is an object to provide a photothermal conversion spectroscopic analysis method that enables measurement to be carried out with high sensitivity, and a photothermal conversion spectroscopic analysis apparatus that carries out the method. The photothermal conversion spectroscopic analysis apparatus is comprised of an exciting light source 111, a chopper 112 that is disposed close to the exciting light source 111 in the optical path of exciting light emitted from the exciting light source 111, a mirror 114 that changes the direction of travel of the exciting light, a detecting light source 120, a dichroic mirror 113 that has detecting light from the detecting light source 120 incident thereon and makes the exciting light and the detecting light coaxial, a lens 10 that has a suitable amount of chromatic aberration, and a holder 15 that holds the lens 10 such as to enable adjustment along three axes.

Abstract: An integrated structure of multilayer flow microchannel, which comprises a plurality of microchannels in which parallel multilayer flow that involves the interface of fluids is formed, arranged on various positions of a substrate, wherein each of the multilayer flow microchannels is communicated with another multilayer flow microchannel. A plurality of unit operations can be carried out continuously with high efficiency on a microchip, enabling high-degree microanalysis or precise chemical synthesis using the highly integrated structure of multilayer flow microchannel.

Abstract: There is provided a chip element for microchemical systems that renders adjustments between the focal positions of exciting light and detecting light and the position of a solution sample every time a measurement is taken unnecessary and thus enables work efficiency to be increased, and moreover enables a microchemical system such as an analyzer to be made smaller in size. The chip element is comprised of a channel-possessing plate-shaped element having a channel through which the liquid containing the sample is passed. A lens, which is preferably a gradient refractive index lens, is fixed to the channel-possessing plate-shaped element in a position facing the channel.

Abstract: A small and portable microscope for ultramicroanalysis having an excellent spatial resolution and a fixed position analyzing ability in which at least a part of an excitation light source (3), a part of a probe light source (4) and a part of a thermal lens microscope optical system are arranged integrally in a device body comprising an analyzing cell (1) and substrates (2A), (2B) supporting the analyzing cell (1).