Patents by Inventor Manal MEHIBEL

Manal MEHIBEL has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220249522
    Abstract: Methods for treating a cancer are provided, the methods comprising administering to an individual an effective amount of a hypoxia targeting composition, such as a hypoxia-activated drug or a prodrug thereof, and combinations thereof with an effective amount of a poly(ADP-ribose) polymerase (PARP) inhibitor. In some instances, one or more of a homology recombination (HR) efficiency status, an IDH mutation status, and a hypoxia status of a cancer is used as a basis for selecting an individual for a treatment disclosed herein. Also provided are compositions (such as pharmaceutical formulations), medicine, kits, and unit dosages useful for the methods described herein.
    Type: Application
    Filed: December 6, 2019
    Publication date: August 11, 2022
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Manal Mehibel, Amato J. Giaccia
  • Publication number: 20190282701
    Abstract: The present invention relates to a polymer-drug conjugate wherein the polymer is hyaluronic acid and the drug is an anticancer compound. The anticancer compound is covalently linked to the hyaluronic acid by a pH-labile boronic acid-containing linkage. These conjugates can be used for the treatment of cancer.
    Type: Application
    Filed: July 25, 2017
    Publication date: September 19, 2019
    Inventors: Nicola TIRELLI, Vincenzo QUAGLIARIELLO, Alfonso BARBARISI, Francesco ROSSO, Som Akshay JAIN, Manlio BARBARISI, Rosario Vincenzo LAFFAIOLI, Ian James STRATFORD, Muna OQAL, Manal MEHIBEL