Patents by Inventor Manish J. Butte

Manish J. Butte has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210079104
    Abstract: Methods are described for treating systemic fungal and mycobacterial infections by treatment to enhances a Th1 response, reduces a Th2 response, or the combination thereof. Agents that antagonize the IL-4, the IL-13 receptor, or the combination thereof achieve the desired results.
    Type: Application
    Filed: September 15, 2020
    Publication date: March 18, 2021
    Applicant: The Regents of the University of California
    Inventors: Manish J. BUTTE, Maria I. GARCIA-LLORET
  • Publication number: 20210077503
    Abstract: Methods for treating pediatric patients with systemic mastocytosis are described by administering midostaurin.
    Type: Application
    Filed: September 15, 2020
    Publication date: March 18, 2021
    Applicant: The Regents of the University of California
    Inventors: Manish J. BUTTE, Maria I. Garcia-Lloret, Lisa A. Kohn, Mona M. Liu
  • Patent number: 10426403
    Abstract: A method of testing for specificity and strength of an allergic reaction is performed by penetrating the skin of an individual with the microneedle array comprising a plurality of epitopes and determining the response of the skin to the allergens. The response can be measured with a thermal imaging device. Analysis, and optionally treatment, can be provided to the individual.
    Type: Grant
    Filed: May 8, 2014
    Date of Patent: October 1, 2019
    Assignee: The Board of Trustees of The Leland Stanford Junior University
    Inventors: Manish J. Butte, Jayakumar Rajadas
  • Patent number: 9664679
    Abstract: Embodiments of the invention provide lateral flow and flow-through bioassay devices based on patterned porous media, methods of making same, and methods of using same. Under one aspect, an assay device includes a porous, hydrophilic medium; a fluid impervious barrier comprising polymerized photoresist, the barrier substantially permeating the thickness of the porous, hydrophilic medium and defining a boundary of an assay region within the porous, hydrophilic medium; and an assay reagent in the assay region.
    Type: Grant
    Filed: November 19, 2015
    Date of Patent: May 30, 2017
    Assignee: President and Fellows of Harvard College
    Inventors: George M. Whitesides, Scott T. Phillips, Andres W. Martinez, Manish J. Butte, Amy Wong, Samuel W. Thomas, Hayat Sindi, Sarah J. Vella, Emanuel Carrilho, Katherine A. Mirica, Yanyan Liu
  • Publication number: 20160274105
    Abstract: Embodiments of the invention provide lateral flow and flow-through bioassay devices based on patterned porous media, methods of making same, and methods of using same. Under one aspect, an assay device includes a porous, hydrophilic medium; a fluid impervious barrier comprising polymerized photoresist, the barrier substantially permeating the thickness of the porous, hydrophilic medium and defining a boundary of an assay region within the porous, hydrophilic medium; and an assay reagent in the assay region.
    Type: Application
    Filed: November 19, 2015
    Publication date: September 22, 2016
    Inventors: George M. WHITESIDES, Scott T. PHILLIPS, Andres W. MARTINEZ, Manish J. BUTTE, Amy WONG, Samuel W. THOMAS, Hayat SINDI, Sarah J. VELLA, Emanuel CARRILHO, Katherine A. MIRICA, Yanyan LIU
  • Publication number: 20160058377
    Abstract: A method of testing for specificity and strength of an allergic reaction is performed by penetrating the skin of an individual with the microneedle array comprising a plurality of epitopes and determining the response of the skin to the allergens. The response can be measured with a thermal imaging device. Analysis, and optionally treatment, can be provided to the individual.
    Type: Application
    Filed: May 8, 2014
    Publication date: March 3, 2016
    Inventors: Manish J. BUTTE, Jayakumar RAJADAS
  • Patent number: 9267963
    Abstract: A high-bandwidth AFM probe having a diffraction grating characterized by a diffraction characteristic that monotonically changes along the length of the diffraction grating is disclosed. AFM probes in accordance with the present invention are capable of high-sensitivity performance over a broad range of operating conditions, such as operating wavelength and measurement media. A method for estimating at least one physical property of a surface based on high-frequency signal components in the output signal from a high-bandwidth AFM probe is also disclosed. The method enables determination of tip-surface interaction forces based on the relationship between a first motion of the base of the AFM probe and a second motion of the tip of the AFM probe.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: February 23, 2016
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Antonio A. Gellineau, Olav Solgaard, Karthik Vijayraghavan, Andrew Y J Wang, Manish J. Butte
  • Patent number: 9193988
    Abstract: Embodiments of the invention provide lateral flow and flow-through bioassay devices based on patterned porous media, methods of making same, and methods of using same. Under one aspect, an assay device includes a porous, hydrophilic medium; a fluid impervious barrier comprising polymerized photoresist, the barrier substantially permeating the thickness of the porous, hydrophilic medium and defining a boundary of an assay region within the porous, hydrophilic medium; and an assay reagent in the assay region.
    Type: Grant
    Filed: November 21, 2013
    Date of Patent: November 24, 2015
    Assignee: President and Fellows of Harvard College
    Inventors: George M. Whitesides, Scott T. Phillips, Andres W. Martinez, Manish J. Butte, Amy Wong, Samuel W. Thomas, Hayat Sindi, Sarah J. Vella, Emanuel Carrilho, Katherine A. Mirica, Yanyan Liu
  • Publication number: 20140234881
    Abstract: Embodiments of the invention provide lateral flow and flow-through bioassay devices based on patterned porous media, methods of making same, and methods of using same. Under one aspect, an assay device includes a porous, hydrophilic medium; a fluid impervious barrier comprising polymerized photoresist, the barrier substantially permeating the thickness of the porous, hydrophilic medium and defining a boundary of an assay region within the porous, hydrophilic medium; and an assay reagent in the assay region.
    Type: Application
    Filed: November 21, 2013
    Publication date: August 21, 2014
    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: George M. WHITESIDES, Scott T. PHILLIPS, Andres W. MARTINEZ, Manish J. BUTTE, Amy WONG, Samuel W. THOMAS, Hayat SINDI, Sarah J. VELLA, Emanuel CARRILHO, Katherine A. MIRICA, Yanyan LIU
  • Patent number: 8750652
    Abstract: A microfluidic detection device is provided that includes a planar waveguide, or an ion-exchange planar waveguide, a microfluidic channel disposed on the planar waveguide, a light source, such as a laser, LED or incandescent light, directed through the planar waveguide, a labeled cell disposed in the microfluidic channel, where the labeled cell lies in an evanescent field extending from the planar waveguide, and a light detector disposed to receive light from the light source through the planar waveguide. The evanescent field interacts with the labeled cell, where the light through the planar waveguide is altered according to a presence of the labeled cell in the microfluidic channel.
    Type: Grant
    Filed: October 12, 2011
    Date of Patent: June 10, 2014
    Assignees: The Board of Trustees of the Leland Stanford Junior University, The Charles Stark Draper Laboratory, Inc.
    Inventors: Manish J. Butte, John J. LeBlanc
  • Patent number: 8603832
    Abstract: Embodiments of the invention provide lateral flow and flow-through bioassay devices based on patterned porous media, methods of making same, and methods of using same. Under one aspect, an assay device includes a porous, hydrophilic medium; a fluid impervious barrier comprising polymerized photoresist, the barrier substantially permeating the thickness of the porous, hydrophilic medium and defining a boundary of an assay region within the porous, hydrophilic medium; and an assay reagent in the assay region.
    Type: Grant
    Filed: December 28, 2012
    Date of Patent: December 10, 2013
    Assignee: President and Fellows of Harvard College
    Inventors: George M. Whitesides, Scott T. Phillips, Andreas W. Martinez, Manish J. Butte, Amy Wong, Samuel W. Thomas, Hayat Sindi, Sarah J. Vella, Emanuel Carrilho, Katherine A. Mirica, Yanyan Liu
  • Publication number: 20130283486
    Abstract: Techniques for atomic force microscope manipulation of living cells include functionalizing a nanoscale tip of a microscale cantilever with a first ligand for a first receptor associated with a surface of a first type of cell. The method further comprises controlling the cantilever to cause the first ligand on the nanoscale tip to contact the first receptor on a surface of a living cell of the first type in a particular temporal pattern to induce a target response by the living cell. Other techniques for controlling an atomic force microscope comprising a nanoscale tip include controlling the cantilever to cause the nanoscale tip to contact a living cardiomyocyte at a predetermined pressure. The cantilever is also controlled to turn off vertical deflection feedback after contacting the cardiomyocyte and collecting deflection data that indicates a time series of nanoscale vertical deflections of the microscale cantilever caused by the living cardiomyocyte.
    Type: Application
    Filed: June 24, 2013
    Publication date: October 24, 2013
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Manish J. Butte, Marc Amor Bruce
  • Patent number: 8495760
    Abstract: Techniques for atomic force microscope manipulation of living cells include functionalizing a nanoscale tip of a microscale cantilever with a first ligand for a first receptor associated with a surface of a first type of cell. The method further comprises, controlling the cantilever to cause the first ligand on the nanoscale tip to contact the first receptor on a surface of a living cell of the first type in a particular temporal pattern to induce a target response by the living cell. Other techniques for controlling an atomic force microscope comprising a nanoscale tip include controlling the cantilever to cause the nanoscale tip to contact a living cardiomyocyte at a predetermined pressure. The cantilever is also controlled to turn off vertical deflection feedback after contacting the cardiomyocyte and collecting deflection data that indicates a time series of nanoscale vertical deflections of the microscale cantilever caused by the living cardiomyocyte.
    Type: Grant
    Filed: November 30, 2011
    Date of Patent: July 23, 2013
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Manish J Butte, Marc Amor Bruce, Jianwei Liu
  • Patent number: 8377710
    Abstract: Embodiments of the invention provide lateral flow and flow-through bioassay devices based on patterned porous media, methods of making same, and methods of using same. Under one aspect, an assay device includes a porous, hydrophilic medium; a fluid impervious barrier comprising polymerized photoresist, the barrier substantially permeating the thickness of the porous, hydrophilic medium and defining a boundary of an assay region within the porous, hydrophilic medium; and an assay reagent in the assay region.
    Type: Grant
    Filed: April 16, 2009
    Date of Patent: February 19, 2013
    Assignee: President and Fellows of Harvard College
    Inventors: George M. Whitesides, Scott T. Phillips, Andres W. Martinez, Manish J. Butte, Amy Wong, Samuel W. Thomas, Hayat Sindi, Sarah J. Vella, Emanuel Carrilho, Katherine A. Mirica, Yanyan Liu
  • Publication number: 20130022629
    Abstract: Disclosed are an assay to identify modulators of the PD-1:PD-L pathway and PD-1:PD-L pathway modulators, e.g., compounds and pharmaceutical compositions thereof. Methods for treating diseases influenced by modulation of the PD-1:PD-L pathway such as, for example, autoimmune diseases, inflammatory disorders, allergies, transplant rejection, cancer, immune deficiency, and other immune system-related disorders, are also disclosed.
    Type: Application
    Filed: January 3, 2011
    Publication date: January 24, 2013
    Inventors: Arlene H. Sharpe, Manish J. Butte, Shinji Oyama
  • Patent number: 8206992
    Abstract: Hydrophilic threads as platforms for inexpensive, low volume, portable diagnostic systems, and methods of making the same are described. A diagnostic system includes a hydrophilic loading thread having an inlet zone at a proximal end; a testing zone at a distal end; and an intermediate zone located between the inlet zone and the testing zone, wherein the testing zone does not directly contact the inlet zone. In another aspect, a diagnostic system includes (i) a hydrophilic loading thread that includes an inlet zone at a proximal end and an intermediate zone at a distal end; and (ii) one or more additional hydrophilic threads that contact the intermediate zone of the loading thread.
    Type: Grant
    Filed: March 27, 2009
    Date of Patent: June 26, 2012
    Assignee: President and Fellows of Harvard College
    Inventors: Meital Reches, Michael D. Dickey, Manish J. Butte, George M. Whitesides
  • Publication number: 20120137394
    Abstract: Techniques for atomic force microscope manipulation of living cells include functionalizing a nanoscale tip of a microscale cantilever with a first ligand for a first receptor associated with a surface of a first type of cell. The method further comprises, controlling the cantilever to cause the first ligand on the nanoscale tip to contact the first receptor on a surface of a living cell of the first type in a particular temporal pattern to induce a target response by the living cell. Other techniques for controlling an atomic force microscope comprising a nanoscale tip include controlling the cantilever to cause the nanoscale tip to contact a living cardiomyocyte at a predetermined pressure. The cantilever is also controlled to turn off vertical deflection feedback after contacting the cardiomyocyte and collecting deflection data that indicates a time series of nanoscale vertical deflections of the microscale cantilever caused by the living cardiomyocyte.
    Type: Application
    Filed: November 30, 2011
    Publication date: May 31, 2012
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Manish J. Butte, Marc Amor Bruce, Jianwei Liu
  • Publication number: 20120087618
    Abstract: A microfluidic detection device is provided that includes a planar waveguide, or an ion-exchange planar waveguide, a microfluidic channel disposed on the planar waveguide, a light source, such as a laser, LED or incandescent light, directed through the planar waveguide, a labeled cell disposed in the microfluidic channel, where the labeled cell lies in an evanescent field extending from the planar waveguide, and a light detector disposed to receive light from the light source through the planar waveguide. The evanescent field interacts with the labeled cell, where the light through the planar waveguide is altered according to a presence of the labeled cell in the microfluidic channel.
    Type: Application
    Filed: October 12, 2011
    Publication date: April 12, 2012
    Inventors: Manish J. Butte, John J. LeBlanc
  • Publication number: 20110189786
    Abstract: Hydrophilic threads as platforms for inexpensive, low volume, portable diagnostic systems, and methods of making the same are described. A diagnostic system includes a hydrophilic loading thread having an inlet zone at a proximal end; a testing zone at a distal end; and an intermediate zone located between the inlet zone and the testing zone, wherein the testing zone does not directly contact the inlet zone. In another aspect, a diagnostic system includes (i) a hydrophilic loading thread that includes an inlet zone at a proximal end and an intermediate zone at a distal end; and (ii) one or more additional hydrophilic threads that contact the intermediate zone of the loading thread.
    Type: Application
    Filed: March 27, 2009
    Publication date: August 4, 2011
    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: Meital Reches, Michael D. Dickey, Manish J. Butte, George M. Whitesides
  • Publication number: 20090298191
    Abstract: Embodiments of the invention provide lateral flow and flow-through bioassay devices based on patterned porous media, methods of making same, and methods of using same. Under one aspect, an assay device includes a porous, hydrophilic medium; a fluid impervious barrier comprising polymerized photoresist, the barrier substantially permeating the thickness of the porous, hydrophilic medium and defining a boundary of an assay region within the porous, hydrophilic medium; and an assay reagent in the assay region.
    Type: Application
    Filed: April 16, 2009
    Publication date: December 3, 2009
    Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
    Inventors: George M. WHITESIDES, Scott T. PHILLIPS, Andres W. MARTINEZ, Manish J. BUTTE, Amy WONG, Samuel W. THOMAS, Hayat SINDI, Sarah J. VELLA, Emanuel CARRILHO, Katherine A. MIRICA, Yanyan LIU