Patents by Inventor Mannching Sherry Ku

Mannching Sherry Ku has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210015752
    Abstract: Disclosed herein are particles of an active ingredient, a composition comprising the same, and a method for producing the same. The method disclosed herein comprises the steps of, (a) forming a first solution by dissolving the active ingredient in a first solvent; (b) forming the particles of the active ingredient by mixing a second solvent with the first solution to produce an emulsified solution. Moreover, the second solvent is miscible with the first solvent, but is immiscible with the first solution.
    Type: Application
    Filed: June 14, 2018
    Publication date: January 21, 2021
    Applicant: Savior Lifetec Corporation
    Inventors: Yan-Ming CHEN, Shih-Hsie PAN, Mannching Sherry KU, Chia-Hsin LIN
  • Publication number: 20190380967
    Abstract: Disclosed herein is a method for producing microparticles of an active ingredient via an in-line recirculating mixing system, wherein the in-line recirculating mixing system comprises a mixer and a conduit couple to the mixer. The method disclosed herein comprises the steps of: (a) forming a continuous phase of a medium in the in-line recirculating mixing system; (b) allowing the continuous phase of the medium of the step (a) to come into contact with a first mixture of the active ingredient, a polymer and a solvent at a site in the conduit, thereby forming a second mixture, in the conduit; and (c) allowing the second mixture of the step (b) to enter the mixer and circulate in the in-line recirculating mixing system until the microparticles of the active ingredient are formed.
    Type: Application
    Filed: January 23, 2018
    Publication date: December 19, 2019
    Applicant: Savior Lifetec Corporation
    Inventors: Amy LIU, Alex CHOU, Shih-Hsie PAN, Mannching Sherry KU
  • Publication number: 20190352365
    Abstract: Disclosed herein are expression constructs and methods for producing a protein of interest. According to some examples, an expression construct includes a nucleotide sequence encoding a fusion protein. To produce the protein of interest, the expression construct is transformed into a host cell, which is cultured under conditions that allow the expression of the fusion protein. The fusion protein has at least one expression unit; each expression unit has, sequentially, an affinity tag moiety, a spacer moiety, an enzymatic cleavage site, and a protein of interest moiety. The fusion protein is isolated from the host cell, solubilized, and refolded. The refolded fusion protein is cleaved to release the protein of interest.
    Type: Application
    Filed: January 18, 2018
    Publication date: November 21, 2019
    Applicant: Savior Lifetec Corporation
    Inventors: Shu-Ping YANG, Hong-Zhang WANG, Chi-Chao HU, Jia-Hau SHIU, Shih-Hsie PAN, Mannching Sherry KU
  • Patent number: 10035788
    Abstract: The present invention relates to maleate salt forms of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide, methods of preparing crystalline maleate salt forms, the associated compounds, and pharmaceutical compositions containing the same. The maleate salts are useful in treating cancers, particularly those affected by kinases of the epidermal growth factor receptor family.
    Type: Grant
    Filed: March 20, 2017
    Date of Patent: July 31, 2018
    Assignee: WYETH LLC
    Inventors: Qinghong Lu, Mannching Sherry Ku, Warren Chew, Gloria Cheal, Anthony F. Hadfield, Mahmoud Mirmehrabi
  • Publication number: 20170320852
    Abstract: The present invention relates to maleate salt forms of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinollnyl}-4-(dimethylamino)-2-butenamide, methods of preparing crystalline maleate salt forms, the associated compounds, and pharmaceutical compositions containing the same. The maleate salts are useful in treating cancers, particularly those affected by kinases of the epidermal growth factor receptor family.
    Type: Application
    Filed: March 20, 2017
    Publication date: November 9, 2017
    Inventors: Quinhong Lu, Mannching Sherry Ku, Warren Chew, Gloria Cheal, Anthony F. Hadfield, Mahmoud Mirmehrabi
  • Patent number: 9630946
    Abstract: The present invention relates to maleate salt forms of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide, methods of preparing crystalline maleate salt forms, the associated compounds, and pharmaceutical compositions containing the same. The maleate salts are useful in treating cancers, particularly those affected by kinases of the epidermal growth factor receptor family.
    Type: Grant
    Filed: August 13, 2015
    Date of Patent: April 25, 2017
    Assignee: WYETH LLC
    Inventors: Quinhong Lu, Mannching Sherry Ku, Warren Chew, Gloria Cheal, Anthony F. Hadfield, Mahmoud Mirmehrabi
  • Publication number: 20160068511
    Abstract: The present invention relates to maleate salt forms of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide, methods of preparing crystalline maleate salt forms, the associated compounds, and pharmaceutical compositions containing the same. The maleate salts are useful in treating cancers, particularly those affected by kinases of the epidermal growth factor receptor family.
    Type: Application
    Filed: August 13, 2015
    Publication date: March 10, 2016
    Inventors: Quinhong Lu, Mannching Sherry Ku, Warren Chew, Gloria Cheal, Anthony F. Hadfield, Mahmoud Mirmehrabi
  • Patent number: 9139558
    Abstract: The present invention relates to maleate salt forms of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide, methods of preparing crystalline maleate salt forms, the associated compounds, and pharmaceutical compositions containing the same. The maleate salts are useful in treating cancers, particularly those affected by kinases of the epidermal growth factor receptor family.
    Type: Grant
    Filed: February 12, 2013
    Date of Patent: September 22, 2015
    Assignee: Wyeth LLC
    Inventors: Quinhong Lu, Mannching Sherry Ku, Warren Chew, Gloria Cheal, Anthony F. Hadfield, Mahmoud Mirmehrabi
  • Patent number: 8865689
    Abstract: Methods and compositions for treating and/or preventing hyperuricemia or metabolic disorders associated with hyperuricemia comprising administering to a patient in need a therapeutically effective amount of diacerein, rhein, or a pharmaceutically acceptable salt, an analog, a prodrug, or an active metabolite thereof.
    Type: Grant
    Filed: March 7, 2012
    Date of Patent: October 21, 2014
    Assignee: TWi Biotechnology, Inc.
    Inventors: Mannching Sherry Ku, Chih-Kuang Chen, Wei-Shu Lu, I-Yin Lin
  • Patent number: 8846758
    Abstract: Methods for treating abnormal glycosylated hemoglobin (HbA1c) levels in a patient in need thereof, wherein the provided methods comprise administering to a patient in need a therapeutically effective amount of an Interleukin-1? modulator. Also, the invention provides compositions comprising at least one lipid modifying agent and an IL-1? modulator.
    Type: Grant
    Filed: July 19, 2012
    Date of Patent: September 30, 2014
    Assignee: TWi Biotechnology, Inc.
    Inventors: Mannching Sherry Ku, Chih-Kuang Chen, Wei-Shu Lu, Chih-Ming Chen, I-Yin Lin
  • Patent number: 8536152
    Abstract: The present invention provides methods of treating type II diabetes using combinations of diacerein or its derivatives with other antidiabetic agents. The methods may also allow improving glycemic control of type II diabetes patients and/or reducing side effects and/or cardiovascular risks of antidiabetic agents.
    Type: Grant
    Filed: April 7, 2011
    Date of Patent: September 17, 2013
    Assignee: TWi Biotechnology, Inc.
    Inventors: Mannching Sherry Ku, Danchen Gao, Wei-Shu Lu, Chih-Ming Chen, I-Yin Lin
  • Patent number: 8394959
    Abstract: The present invention relates to maleate salt forms of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide, methods of preparing crystalline maleate salt forms, the associated compounds, and pharmaceutical compositions containing the same. The maleate salts are useful in treating cancers, particularly those affected by kinases of the epidermal growth factor receptor family.
    Type: Grant
    Filed: April 6, 2012
    Date of Patent: March 12, 2013
    Assignee: Wyeth LLC
    Inventors: Qinghong Lu, Mannching Sherry Ku, Warren Chew, Gloria Cheal, Anthony F. Hadfield, Mahmoud Mirmehrabi
  • Patent number: 8372995
    Abstract: Crystalline solid forms of tigecycline, Form I, Form II, Form III, Form IV, and Form V, compositions comprising these crystalline solid forms, and processes for preparing these crystalline solid forms are described herein.
    Type: Grant
    Filed: May 25, 2006
    Date of Patent: February 12, 2013
    Assignee: Wyeth LLC
    Inventors: Lalitha Krishnan, Subodh S. Deshmukh, W. James Huang, Mannching Sherry Ku
  • Publication number: 20130022610
    Abstract: Methods for treating abnormal glycosylated hemoglobin (HbA1c) levels in a patient in need thereof, wherein the provided methods comprise administering to a patient in need a therapeutically effective amount of an Interleukin-1? modulator. Also, the invention provides compositions comprising at least one lipid modifying agent and an IL-1? modulator.
    Type: Application
    Filed: July 19, 2012
    Publication date: January 24, 2013
    Inventors: Mannching Sherry Ku, Chih-Kuang Chen, Wei-Shu Lu, Chih-Ming Chen, I-Yin Lin
  • Publication number: 20120289545
    Abstract: The present invention relates to maleate salt forms of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide, methods of preparing crystalline maleate salt forms, the associated compounds, and pharmaceutical compositions containing the same. The maleate salts are useful in treating cancers, particularly those affected by kinases of the epidermal growth factor receptor family.
    Type: Application
    Filed: April 6, 2012
    Publication date: November 15, 2012
    Inventors: Qinghong Lu, Mannching Sherry Ku, Warren Chew, Gloria Cheal, Anthony F. Hadfield, Mahmoud Mirmehrabi
  • Publication number: 20120232044
    Abstract: Methods and compositions for treating and/or preventing hyperuricemia or metabolic disorders associated with hyperuricemia comprising administering to a patient in need a therapeutically effective amount of diacerein, rhein, or a pharmaceutically acceptable salt, an analog, a prodrug, or an active metabolite thereof.
    Type: Application
    Filed: March 7, 2012
    Publication date: September 13, 2012
    Applicant: TWi Biotechnology, Inc.
    Inventors: Mannching Sherry Ku, Chih-Kuang Chen, Wei-Shu Lu, I-Yin Lin
  • Patent number: 8183201
    Abstract: The invention provides disintegrin variants, and more specifically to disintegrin variants which are selective ?v?3 integrin antagonists for treatment and prevention of ?v?3 integrin-associated diseases. The present invention also relates to pegylated proteins, including proteins comprising a disintegrin variant having an RGD motif variant 48ARLDDL53. The invention also relates to the use of the polypeptides of the invention for the treatment and prevention of ?v?3 integrin-associated diseases.
    Type: Grant
    Filed: February 25, 2011
    Date of Patent: May 22, 2012
    Assignees: National Cheng Kung University, National Taiwan University
    Inventors: Woei-Jer Chuang, Wen-Mei Fu, Mannching Sherry Ku, Yen-Lun Huang
  • Publication number: 20120115858
    Abstract: Tanaproget polymorph Form II, processes for preparing tanaproget polymorph Form II, pharmaceutical compositions including tanaproget polymorph Form II, micronized tanaproget polymorph Form II, and processes for converting Form II to tanaproget Form I are provided. Also provided are methods of contraception, hormone replacement therapy, stimulation of food intake and treating or preventing uterine myometrial fibroids, benign prostatic hypertrophy, benign and malignant neoplastic disease, dysfunctional bleeding, uterine leiomyomata, endometriosis, polycystic ovary syndrome, or carcinomas and adenocarcinomas comprising administering polymorph Form II to a mammalian subject.
    Type: Application
    Filed: January 10, 2012
    Publication date: May 10, 2012
    Applicant: Wyeth LLC
    Inventors: Marc Sadler Tesconi, Mannching Sherry Ku, Yan Xu
  • Patent number: 8173814
    Abstract: The present invention relates to maleate salt forms of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide, methods of preparing crystalline maleate salt forms, the associated compounds, and pharmaceutical compositions containing the same. The maleate salts are useful in treating cancers, particularly those affected by kinases of the epidermal growth factor receptor family.
    Type: Grant
    Filed: July 12, 2011
    Date of Patent: May 8, 2012
    Assignee: Wyeth LLC
    Inventors: Qinghong Lu, Mannching Sherry Ku, Warren Chew, Gloria Cheal, Anthony F. Hadfield, Mahmoud Mirmehrabi
  • Patent number: 8114869
    Abstract: Tanaproget polymorph Form II, processes for preparing tanaproget polymorph Form II, pharmaceutical compositions including tanaproget polymorph Form II, micronized tanaproget polymorph Form II, and processes for converting Form II to tanaproget Form I are provided. Also provided are methods of contraception, hormone replacement therapy, stimulation of food intake and treating or preventing uterine myometrial fibroids, benign prostatic hypertrophy, benign and malignant neoplastic disease, dysfunctional bleeding, uterine leiomyomata, endometriosis, polycystic ovary syndrome, or carcinomas and adenocarcinomas comprising administering polymorph Form II to a mammalian subject.
    Type: Grant
    Filed: May 12, 2011
    Date of Patent: February 14, 2012
    Assignee: Wyeth LLC
    Inventors: Marc Sadler Tesconi, Mannching Sherry Ku, Yan Xu