Patents by Inventor Manuel Romero Bernárdez

Manuel Romero Bernárdez has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Peptide with quorum-sensing inhibitory activity, polynucleotide that encodes said peptide, and the uses thereof
    Patent number: 10316302
    Abstract: The invention relates to the cloning, sequencing and characterization of the gene responsible for Quorum Quenching (QQ) activity against Quorum Sensing (QS) signals of the Tenacibaculum sp. strain 20J (CECT7426). Said gene encodes a peptide having at least lactonase activity with a percentage of identity less than 38% with the lactonases described up until now for other species, as well as the sequences of the homologous genes present in other species of the genus Tenacibaculum. Said peptide shows a broad spectrum of activity degrading optionally substituted N-acyl-homoserine lactones (AHLs) of 4-14 carbon atoms in the side chain thereof, is active at pH comprised between 3 and 9, proteinase K- and chymotrypsin-resistant and does not interact with ?-lactam antibiotics.
    Type: Grant
    Filed: July 10, 2014
    Date of Patent: June 11, 2019
    Assignees: UNIVERSIDADE DE SANTIAGO DE COMPOSTELA, FUNDACIÓN PEDRO BARRIÉ DE LA MAZA, CONDE DE FENOSA
    Inventors: Ana María Otero Casal, Manuel Romero Bernárdez, Celia Mayer Mayer
  • PEPTIDE WITH QUORUM-SENSING INHIBITORY ACTIVITY, POLYNUCLEOTIDE THAT ENCODES SAID PEPTIDE, AND THE USES THEREOF
    Publication number: 20160244735
    Abstract: The invention relates to the cloning, sequencing and characterization of the gene responsible for Quorum Quenching (QQ) activity against Quorum Sensing (QS) signals of the Tenacibaculum sp. strain 20J (CECT7426). Said gene encodes a peptide having at least lactonase activity with a percentage of identity less than 38% with the lactonases described up until now for other species, as well as the sequences of the homologous genes present in other species of the genus Tenacibaculum. Said peptide shows a broad spectrum of activity degrading optionally substituted N-acyl-homoserine lactones (AHLs) of 4-14 carbon atoms in the side chain thereof, is active at pH comprised between 3 and 9, proteinase K- and chymotrypsin-resistant and does not interact with ?-lactam antibiotics.
    Type: Application
    Filed: July 10, 2014
    Publication date: August 25, 2016
    Inventors: Ana Maria OTERO CASAL, Manuel ROMERO BERNÁRDEZ, Celia MAYER MAYER
  • Use of bacteria of the genus for quorum quenching
    Patent number: 8586343
    Abstract: Use of bacterial cells of the genus Tenacibaculum, from the crude cellular extract or from its cultivation supernatants, capable of degrading N-acyl homoserine lactones, for quorum quenching, for treatment of infectious bacterial illnesses or to inhibit formation of biofilms.
    Type: Grant
    Filed: July 23, 2009
    Date of Patent: November 19, 2013
    Assignee: Universidade de Santiago de Compostela
    Inventors: Ana Maria Otero Casal, Manuel Romero Bernárdez, Arturo Roca Rivada
  • USE OF BACTERIA OF THE GENUS TENACIBACULUM FOR QUORUM QUENCHING
    Publication number: 20110195051
    Abstract: Use of bacterial cells of the genus Tenacibaculum, from the crude cellular extract or from its cultivation supernatants, capable of degrading N-acyl homoserine lactones, for quorum quenching, for treatment of infectious bacterial illnesses or to inhibit formation of biofilms.
    Type: Application
    Filed: July 23, 2009
    Publication date: August 11, 2011
    Applicant: UNIVERSIDADE DE SANTIAGO DE COMPOSTELA
    Inventors: Ana Maria Otero Casal, Manuel Romero Bernárdez, Arturo Roca Rivada