Patents by Inventor Manuela Teresa Raimondi

Manuela Teresa Raimondi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220177837
    Abstract: A method for culturing cells on a substrate capable of inducing pluripotency is provided. The method includes plating cells on a nichoid-type substrate, allowing cultured cells to proliferate for a certain period of time, detaching cells from the nichoid-type substrate, and, once cells have been detached, culturing cells in suspension or under adhesion.
    Type: Application
    Filed: March 9, 2020
    Publication date: June 9, 2022
    Inventors: Stefania CARELLI, Manuela Teresa RAIMONDI, Anna Maria DI GIULIO, Toniella GIALLONGO, Alfredo GORIO, Giulio Nicola CERULLO, Roberto OSELLAME
  • Patent number: 11273023
    Abstract: An implantable medical device obtained by means of two-photon laser polymerisation of a resin to form a three-dimensional matrix, wherein: said three-dimensional matrix comprises a number of levels distributed in height; and said three-dimensional matrix comprises reference means designed to uniquely identify the height of each level from a pre-set reference, by means of a multi-photon fluorescence-excitation microscope; said implantable medical device being characterised in that said reference means comprise a solid having a cross section that varies with height.
    Type: Grant
    Filed: December 18, 2018
    Date of Patent: March 15, 2022
    Assignees: POLITECNICO DI MILANO, UNIVERSITA' DEGLI STUDI DI MILANO-BICOCCA, CONSIGLIO NAZIONALE DELLE RICERCHE
    Inventors: Manuela Teresa Raimondi, Giulio Cerullo, Claudio Conci, Tommaso Zandrini, Roberto Osellame, Giuseppe Chirico
  • Patent number: 11111469
    Abstract: A device for cell culture comprising: a main body (11); said main body (11) comprises a plurality of circular portions (21-23); said device comprises a plurality of caps (51-53); each of said plurality of caps (51-53) comprises a base structure (58) having a circular hole (57), housing an upper slide (54) and an elastomeric layer (56) secured to said slide (54); said elastomeric layer (56) has a rectangular hole (59); said plurality of caps (51-53) being adapted to cooperate with said plurality of circular portions (21-23); each of said plurality of circular portions (21-23) each comprise an inlet hole (64-66) and an outlet hole (67-69) aligned with the long side of said rectangular hole (59), to perfuse the culture chamber (12-14) located in said rectangular hole (59) of said elastomeric layer (56).
    Type: Grant
    Filed: May 5, 2017
    Date of Patent: September 7, 2021
    Assignee: POLITECNICO DI MILANO
    Inventors: Manuela Teresa Raimondi, Matteo Lagana
  • Patent number: 11027045
    Abstract: The present invention relates to a supermatrix of synthetic niches comprising at least two matrices of niches wherein each matrix comprises n×m niches and wherein the distance (d) between a matrix and the other is greater than zero and wherein in each matrix every synthetic niche has one or more walls in common with the others synthetic niches of the matrix. A support for the culture of cells that includes at least one supermatrix and the use of said supermatrix or support for the in vitro culture of cells, in particular stem cells, or for the in vivo implant in a subject in order to promote tissue or organ regeneration through cell repopulation are also within the scope of the present invention.
    Type: Grant
    Filed: August 31, 2016
    Date of Patent: June 8, 2021
    Assignees: POLITECNICO DI MILANO, CONSIGLIO NAZIONALE DELLE RICERCHE, FONDAZIONE CARIPLO
    Inventors: Manuela Teresa Raimondi, Giulio Cerullo, Roberto Osellame, Andrea Remuzzi
  • Publication number: 20200337824
    Abstract: An implantable medical device obtained by means of two-photon laser polymerisation of a resin to form a three-dimensional matrix, wherein: said three-dimensional matrix comprises a number of levels distributed in height; and said three-dimensional matrix comprises reference means designed to uniquely identify the height of each level from a pre-set reference, by means of a multi-photon fluorescence-excitation microscope; said implantable medical device being characterised in that said reference means comprise a solid having a cross section that varies with height.
    Type: Application
    Filed: December 18, 2018
    Publication date: October 29, 2020
    Inventors: Manuela Teresa Raimondi, Giulio Cerullo, Claudio Conci, Tommaso Zandrini, Roberto Osellame, Giuseppe Chirico
  • Publication number: 20200046881
    Abstract: The present invention relates to a supermatrix of synthetic niches comprising at least two matrices of niches wherein each matrix comprises n×m niches and wherein the distance (d) between a matrix and the other is greater than zero and wherein in each matrix every synthetic niche has one or more walls in common with the others synthetic niches of the matrix. A support for the culture of cells that includes at least one supermatrix and the use of said supermatrix or support for the in vitro culture of cells, in particular stem cells, or for the in vivo implant in a subject in order to promote tissue or organ regeneration through cell repopulation are also within the scope of the present invention.
    Type: Application
    Filed: August 31, 2016
    Publication date: February 13, 2020
    Inventors: Manuela Teresa RAIMONDI, Giulio CERULLO, Roberto OSELLAME, Andrea REMUZZI
  • Publication number: 20190144810
    Abstract: A device for cell culture comprising: a main body (11); said main body (11) comprises a plurality of circular portions (21-23); said device comprises a plurality of caps (51-53); each of said plurality of caps (51-53) comprises a base structure (58) having a circular hole (57), housing an upper slide (54) and an elastomeric layer (56) secured to said slide (54); said elastomeric layer (56) has a rectangular hole (59); said plurality of caps (51-53) being adapted to cooperate with said plurality of circular portions (21-23); each of said plurality of circular portions (21-23) each comprise an inlet hole (64-66) and an outlet hole (67-69) aligned with the long side of said rectangular hole (59), to perfuse the culture chamber (12-14) located in said rectangular hole (59) of said elastomeric layer (56).
    Type: Application
    Filed: May 5, 2017
    Publication date: May 16, 2019
    Inventors: Manuela Teresa Raimondi, Matteo Lagana
  • Publication number: 20100049205
    Abstract: A surgical instrument (10) is described for the implanting of acetabular components of hip prostheses. The instrument comprises a main stem (12) which acts as a dynamometric impactor for obtaining the implantation of the acetabular component and which comprises at least one torsional dynamometer (14), coaxial to the main stem (12), for the application and measuring of a torsional moment on the acetabular component implanted. The instrument also comprises a side mechanism (16), which includes a secondary stem (18), parallel to the main stem (12), a handle (20) and at least one axial dynamometer (22), orthogonal to the stem (18), which connects the secondary stem (18) to the handle (20) for the application and measuring of a destabilizing force on the acetabular component implanted.
    Type: Application
    Filed: December 21, 2007
    Publication date: February 25, 2010
    Applicant: Istituto Ortopedico Galeazzi S.P.A
    Inventors: Roberto Giacometti, Manuela Teresa Raimondi, Ariana Colombini