Abstract: The present invention is directed to indazole compounds which are potent inhibitors of LRRK2 kinase and useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which LRRK-2 kinase is involved.

Abstract: The present invention is directed to indazole compounds which are potent inhibitors of LRRK2 kinase and useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which LRRK-2 kinase is involved.

Abstract: The system of the present invention is used to execute data consolidation to combine data from Google, MSN and Yahoo, at least. The user does not need anymore to combine by himself data in spreadsheets. The system allows creating consolidated campaigns that span across search providers, letting the user effortlessly build reports that previously took hours to create each month. The system of the present invention is particularly suited for agencies. A tool designed for agencies needs to allow for management at the client level as well as the agency level. The system client center gives each member of the team a summary view of the client accounts that they're responsible for, along with emerging trend indicators for every major metric.

Abstract: Processes useful for the preparation of a Compound of Formula I: Formula (I). Intermediates useful for the preparation of the compound of Formula I, and processes useful for preparing said intermediates are disclosed.

Abstract: The present invention relates to synthetic processes useful in the preparation of compounds of Formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease and have application in the treatment of conditions caused by HCV. In particular, the present invention relates to novel oxidation processes useful for preparing compounds of Formula (I) and related compounds, including pharmaceutically acceptable salts, hydrates and solvates thereof, and including stereoisomers thereof.

Abstract: This application discloses a novel process to synthesize 8-[{1-(3,5-Bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds, which may be used, for example, as NK-1 inhibitor compounds in pharmaceutical preparations, intermediates useful in said process, and processes for preparing said intermediates; also disclosed is a process for removal of metals from N-heterocyclic carbine metal complexes.

Abstract: This application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center.

Abstract: The disclosure is directed at a method and system for improving situational awareness and accuracy of a user with a firearm. The system includes a blank firing laser attachment which is mounted to an end of the firearm and emits a laser when the trigger is pulled.

Abstract: The system of the present invention is used to optimize the returns of advertising campaigns on the internet. The system allows to create portfolios of keywords and to optimize these portfolios. Moreover, the system allows to classify the keywords in the portfolios according to their past data and to agitate the keywords which held a stagnant position over a pre-set period of time. The system support different implementations of the keyword classification in portfolios, different implementations of keyword bids agitation and different implementations of optimization. The various implementations can meet the specific aspects of different industries and/or the distinctive optimization approach of different agencies. The system can leverage the cloud computing whereby shared data, process and information are provided to computers and other devices on-demand. The delivery model involves the provision of dynamically scalable and virtualized resources as a service over the Internet.

Abstract: This application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center.

Abstract: This application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center.

Abstract: Processes useful for the preparation of a Compound of Formula I: Formula (I). Intermediates useful for the preparation of the compound of Formula I, and processes useful for preparing said intermediates are disclosed.

Abstract: Historical data from keywords in a pay-per-click internet advertising campaign are used to predict performance of other keywords with the goal of optimizing a keyword portfolio to maximize returns from the advertising campaign. A computing system receives the keyword portfolio for the advertising campaign, and classifies the keywords based on whether or not sufficient historical data exist to generate acceptable predictions about the performance of the keywords in the advertising campaign. Historical data are then used to make performance predictions for keywords having sufficient data. For keywords without sufficient historical data, generic prediction functions are created based on a generic change rate obtained from keywords with sufficient historical data. These generic prediction functions are then used to predict keyword performance in the advertising campaign. Predictions for keywords with and without sufficient historical data are then used to optimize the advertising campaign.

Abstract: This application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center.

Abstract: The system of the present invention is used to execute data consolidation to combine data from Google, MSN and Yahoo, at least. The user does not need anymore to combine by himself data in spreadsheets. The system allows creating consolidated campaigns that span across search providers, letting the user effortlessly build reports that previously took hours to create each month. The system of the present invention is particularly suited for agencies. A tool designed for agencies needs to allow for management at the client level as well as the agency level. The system client center gives each member of the team a summary view of the client accounts that they're responsible for, along with emerging trend indicators for every major metric.

Abstract: This application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center.

Abstract: The system of the present invention is used to optimize the returns of advertising campaigns on the internet. The system allows to create portfolios of keywords and to optimize these portfolios. Moreover, the system allows to classify the keywords in the portfolios according to their past data and to agitate the keywords which held a stagnant position over a pre-set period of time. The system support different implementations of the keyword classification in portfolios, different implementations of keyword bids agitation and different implementations of optimization. The various implementations can meet the specific aspects of different industries and/or the distinctive optimization approach of different agencies. The system can leverage the cloud computing whereby shared data, process and information are provided to computers and other devices on-demand. The delivery model involves the provision of dynamically scalable and virtualized resources as a service over the Internet.

Abstract: This application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center.

Abstract: This application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center.

Abstract: An enantioselective process for preparing intermediates useful in the preparation of the chiral tricyclic compound of formula I is disclosed.