Patents by Inventor Marco Alpegiani

Marco Alpegiani has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8101758
    Abstract: A stereoselective process for preparing 7-[(E)-t-butyloxyiminomethyl]-camptothecin (also known as gimatecan) is herein disclosed. With the addition of further dissolution and precipitation steps carried out in appropriate different solvent mixtures, four new crystalline forms of gimatecan are also obtainable by using the same stereoselective process.
    Type: Grant
    Filed: August 17, 2010
    Date of Patent: January 24, 2012
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Paolo Carminati, Maria Ornella Tinti, Mauro Marzi, Fabrizio Giorgi, Walter Cabri, Marco Alpegiani, Domenico Vergani, Paolo Ghetti
  • Publication number: 20110137026
    Abstract: A solid DMSO solvate of a compound of formula (I) is described, which is a useful intermediate for preparing the broad spectrum antibiotics Ceftobiprole and Ceftobiprole Medocaril.
    Type: Application
    Filed: April 14, 2009
    Publication date: June 9, 2011
    Applicant: BASILEA PHARMACEUTICA AG
    Inventors: Marco Alpegiani, Walter Cabri, Markus Heubes, Davide Longoni, Michael Schleimer
  • Publication number: 20100311784
    Abstract: A stereoselective process for preparing 7-[(E)-t-butyloxyiminomethyl]-camptothecin (also known as gimatecan) is herein disclosed. With the addition of further dissolution and precipitation steps carried out in appropriate different solvent mixtures, four new crystalline forms of gimatecan are also obtainable by using the same stereoselective process.
    Type: Application
    Filed: August 17, 2010
    Publication date: December 9, 2010
    Applicant: SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITIE SPA
    Inventors: Paolo Carminati, Maria Ornella Tinti, Mauro Marzi, Fabrizio Giorgi, Walter Cabri, Marco Alpegiani, Domenico Vergani, Paolo Ghetti
  • Publication number: 20100311783
    Abstract: A stereoselective process for preparing 7-[(E)-t-butyloxyiminomethyl]-camptothecin (also known as gimatecan) is herein disclosed. With the addition of further dissolution and precipitation steps carried out in appropriate different solvent mixtures, four new crystalline forms of gimatecan are also obtainable by using the same stereoselective process.
    Type: Application
    Filed: August 17, 2010
    Publication date: December 9, 2010
    Applicant: SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITIE SPA
    Inventors: Paolo Carminati, Maria Ornella Tinti, Mauro Marzi, Fabrizio Giorgi, Walter Cabri, Marco Alpegiani, Domenico Vergani, Paolo Ghetti
  • Patent number: 7799921
    Abstract: A stereoselective process for preparing 7-[(E)-t-butyloxyiminomethyl]-camptothecin (also known as gimatecan) is herein disclosed. With the addition of further dissolution and precipitation steps carried out in appropriate different solvent mixtures, four new crystalline forms of gimatecan are also obtainable by using the same stereoselective process.
    Type: Grant
    Filed: December 16, 2005
    Date of Patent: September 21, 2010
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Paolo Carminati, Maria Ornella Tinti, Mauro Marzi, Fabrizio Giorgi, Walter Cabri, Marco Alpegiani, Domenico Vergani, Paolo Ghetti
  • Publication number: 20100179180
    Abstract: Disclosed is a crystalline form of irinotecan hydrochloride (I) and processes for the preparation thereof from crude irinotecan hydrochloride or another polymorphic form of irinotecan. Said crystalline form is particularly suitable for industrial use, because it is easily filtered and possesses characteristics of high stability and purity.
    Type: Application
    Filed: November 10, 2009
    Publication date: July 15, 2010
    Applicant: ANTIBIOTICOS S.p.A.
    Inventors: Giovanni POZZI, Paolo Ghetti, Gaetano Balsamo, Ettore Negri, Marco Alpegiani, Angelo Bedeschi, Roberta Pizzocaro
  • Publication number: 20090275766
    Abstract: The invention relates to processes for the preparation of tigecycline (I): a wide spectrum antibiotic belonging to the tetracycline family, in stable amorphous form, by freeze-drying, antisolvent precipitation and nebulization.
    Type: Application
    Filed: May 4, 2009
    Publication date: November 5, 2009
    Inventors: Giovanni POZZI, Marco Alpegiani, Angelo Bedeschi, Roberta Pizzocaro
  • Publication number: 20090239893
    Abstract: A stereoselective process for preparing 7-[(E)-t-butyloxyiminomethyl]-camptothecin (also known as gimatecan) is herein disclosed. With the addition of further dissolution and precipitation steps carried out in appropriate different solvent mixtures, four new crystalline forms of gimatecan are also obtainable by using the same stereoselective process.
    Type: Application
    Filed: December 16, 2005
    Publication date: September 24, 2009
    Applicant: SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A.
    Inventors: Paolo Carminati, Maria Ornella Tinti, Mauro Marzi, Fabrizio Giorgi, Walter Cabri, Marco Alpegiani, Domenico Vergani, Paolo Ghetti
  • Publication number: 20090192184
    Abstract: The invention relates to two novel crystalline form of Topotecan hydrochloride (Ia) Herein referred to as forms ? and ?, characterized by high purity and whose preparation is advantageous from the industrial point of view. Form ? can be in fact conveniently prepared starting from 10-hydroxy-camptothecin, whereas form ? can be prepared starting from form ?.
    Type: Application
    Filed: December 3, 2008
    Publication date: July 30, 2009
    Applicant: ANTIBIOTICOS S.p.A.
    Inventors: Giovanni Pozzi, Paolo Ghetti, Gaetano Balsamo, Ettore Negri, Andrea Mazzoni, Marco Alpegiani, Angelo Bedeschi, Roberta Pizzocaro
  • Publication number: 20090036672
    Abstract: Disclosed are salts of the general formula (I) wherein R1, R2 and B are as defined in the description and methods for the preparation thereof. These salts are useful intermediates for the preparation of cefdinir.
    Type: Application
    Filed: July 29, 2008
    Publication date: February 5, 2009
    Applicant: ANTIBIOTICOS S.p.A.
    Inventors: Giovanni Pozzi, Patricio Martin Gomez, Marco Alpegiani, Walter Cabri
  • Patent number: 7405294
    Abstract: Disclosed are salts of the general formula (I) wherein R1, R2 and B are defined in the description. These salts are useful intermediates for the preparation of cefdinir. Also, disclosed are processes for the preparation thereof from the compounds of the general formula (II) and (III). Further, disclosed is a method of producing cefdinir from the salts of the general formula (I) including the steps of removing protecting groups.
    Type: Grant
    Filed: September 26, 2003
    Date of Patent: July 29, 2008
    Assignee: Antibioticos S.p.A.
    Inventors: Giovanni Pozzi, Patricio Martin Gomez, Marco Alpegiani, Walter Cabri
  • Publication number: 20080076915
    Abstract: A process for the epoxidation of 17-oxo-15,16-methylene steroids, in particular of drospirenone precursors, comprising the use of sulfoxonium ylides, in particular of dimethylsulfoxonium methyl ylide. The process allows to prepare in good yields 17-spiro epoxides, which can be easily transformed into 17-spironolacto-steroids.
    Type: Application
    Filed: September 21, 2007
    Publication date: March 27, 2008
    Applicant: ANTIBIOTICOS S.P.A.
    Inventors: Walter Cabri, Fabio Benedetti, Marco Alpegiani, Manuela Rodriquez, Cinzia Bottai
  • Publication number: 20080033169
    Abstract: The invention relates to crystalline Cefdinir ammonium salt of formula (I) and to a process for the preparation thereof. This salt is particularly advantageous in that it allows to prepare highly pure Cefdinir.
    Type: Application
    Filed: October 24, 2005
    Publication date: February 7, 2008
    Inventors: Giovanni Pozzi, Paolo Ghetti, Gaetano Balsamo, Marco Alpegiani, Walter Cabri
  • Patent number: 7173126
    Abstract: Cefdinir crystalline salts of formula (I), in which n ranges from 1 to 3, the preparation and use thereof for the preparation and purification of cefdinir are herein disclosed. The salts of formula (I) can be obtained from cefdinir intermediates or crude cefdinir by treatment with phosphoric acid.
    Type: Grant
    Filed: December 1, 2003
    Date of Patent: February 6, 2007
    Assignee: Antibioticos S.p.A.
    Inventors: Giovanni Pozzi, Patricio Martin Gomez, Marco Alpegiani, Walter Cabri
  • Publication number: 20060111566
    Abstract: Disclosed are salts of the general formula (I) wherein R1, R2 and as defined in the description and a process for the preparation thereof. These salts are useful intermediates for the preparation of cefdinir.
    Type: Application
    Filed: September 26, 2003
    Publication date: May 25, 2006
    Applicant: Antibioticos S.p.A.
    Inventors: Giovanni Pozzi, Patricio Martinez Gomez, Marco Alpegiani, Walter Cabri
  • Publication number: 20060074236
    Abstract: Cefdinir crystalline salts of formula (I), in which n ranges from 1 to 3, the preparation and use thereof for the preparation and purification of cefdinir is herein disclosed. The salts of formula (I) can be obtained from cefdinir intermediates or crude cefdinir by treatement with phosphoric acid.
    Type: Application
    Filed: December 1, 2003
    Publication date: April 6, 2006
    Applicant: ANTIBIOTICOS S.p.A.
    Inventors: Giovanni Pozzi, Patricio Martin Gomez, Marco Alpegiani, Walter Cabri
  • Publication number: 20050272934
    Abstract: The invention relates to a process for the preparation of thalidomide (I) comprising the reaction between glutamine (II) and a phthaloylating agent, preferably phthalic anhydride, to give N-phthaloyl-glutamine, which is directly transformed in thalidomide.
    Type: Application
    Filed: May 31, 2005
    Publication date: December 8, 2005
    Applicant: ANTIBIOTICOS S.p.A.
    Inventors: Marco Alpegiani, Andrea Mazzoni, Domenico Vergani, Walter Cabri
  • Publication number: 20050032771
    Abstract: A process for the preparation Cefixime, namely 7-[2-(2-aminothiazol-4-yl)-2-(carboxymethoxyimino)acetamido]-3-vinyl-3-cephem-4-carboxylic acid, via alkyl- or aryl- sulfonates, of general formula (IA).
    Type: Application
    Filed: October 11, 2002
    Publication date: February 10, 2005
    Inventors: Walter Cabri, Marco Alpegiani, Giovanni Pozzi, Gomez Martin, Francesco Oliva
  • Publication number: 20040242864
    Abstract: The present invention relates to a process for the preparation of crystalline cefuroxime axetil with high purity lecel and optimal diastereomeric ratio. Said process, which comprises the use of a dimethyl carbonate for isolating crystallizing cefuroxime axetil, is particularly suitable for implementing on an industrial scale.
    Type: Application
    Filed: March 11, 2004
    Publication date: December 2, 2004
    Inventors: Davide Longoni, Marco Alpegiani, Walter Cabri, Claudio Felisi
  • Publication number: 20040210050
    Abstract: A process for the preparation of highly pure cefuroxime axetil is herein described. The process makes use of a treatment, which allows removing an impurity present in the reagent 1-acetoxyethyl bromide and responsible for the formation of cefuroxime dimeric derivatives. The removal of said impurity makes it easier to recover crystalline, cefuroxime axetil and allows obtaining an exceptional-quality product.
    Type: Application
    Filed: June 9, 2004
    Publication date: October 21, 2004
    Inventors: Claudio Felisi, Davide Longoni, Marco Alpegiani, Walter Cabri