Abstract: A method for predicting a benefit from inclusion of taxane in a chemotherapy regimen in a patient suffering from or at risk of developing recurrent neoplastic disease, in particular breast cancer.

Abstract: The present invention describes a three-way-catalyst system comprising a first three-way catalyst on an inert catalyst support which is a double-layer catalyst comprising a first layer on the inert catalyst support, comprising active alumina, a cerium/zirconium mixed oxide and palladium and a second layer applied to the first layer and in direct contact with the exhaust gas to be purified, comprising active alumina and rhodium and being free of cerium and cerium containing materials and a second three-way-catalyst located upstream of the first three-way catalyst.

Abstract: An implant includes a humidity sensor for generating a signal indicative of humidity within the implant. A controller within the implant receives the signal indicative of humidity, and controls the implant based on the signal indicative of humidity.

Abstract: An implant includes a humidity sensor for generating a signal indicative of humidity within the implant. A controller within the implant receives the signal indicative of humidity, and controls the implant based on the signal indicative of humidity.

Abstract: The present invention relates to a process for the hydrogenation, in particular selective hydrogenation of at least one unsaturated hydrocarbon compound comprising reacting the at least one unsaturated hydrocarbon compound with hydrogen in the presence of a hydrogenation catalyst, wherein the hydrogenation catalyst comprises a mixture of an ordered intermetallic compound and an inert material. According to another aspect, the present invention is concerned with the use of a mixture of at least one ordered intermetallic compound and at least one inert material, as a catalyst. The mixtures for use as a catalyst in the present invention can be prepared easily and achieve a superior activity in relation to the prior art, while preserving the high selectivity to the target compounds, e.g. in the selective hydrogenation of acetylene to ethylene.

Abstract: Devices with both electrical and mechanical signal transducers can be used for improving sound perception by individuals with severe to profound hearing loss or tinnitus.

Abstract: An implantable fixation structure includes a c-shape bone fixation clip adapted to fit over and attach to a bony bridge element in the middle ear of a patient. A c-shape electrode fixation clip is adapted to fit over and attach to an electrode array element in the middle ear of the patient. A connecting bar has a first end connected to the bone fixation clip and a second end connected to the electrode fixation clip. A coupling clip is connected to the connecting bar between the first end and the second end and adapted to fit over and attach to a cochlear implant element and hold the cochlear implant element in a desired position relative to the middle ear of the patient.

Abstract: The present invention relates to methods for prediction of an outcome of neoplastic disease or cancer. More specifically, the present invention relates to a method for the prediction of breast cancer by determining in a biological sample from said patient an expression level of a plurality of genes selected from the group consisting of ACTG1, CA12, CALM2, CCND1, CHPT1, CLEC2B, CTSB, CXCL13, DCN, DHRS2, EIF4B, ERBB2, ESR1, FBXO28, GABRP, GAPDH, H2AFZ, IGFBP3, IGHG1, IGKC, KCTD3, KIAA0101, KRT17, MLPH, MMP1, NAT1, NEK2, NR2F2, OAZ1, PCNA, PDLIM5, PGR, PPIA, PRC1, RACGAP1, RPL37A, SOX4, TOP2A, UBE2C and VEGF.

Abstract: The present invention relates to methods for prediction of an outcome of neoplastic disease or cancer. More specifically, the present invention relates to a method for the prediction of breast cancer by determining in a biological sample from said patient an expression level of a plurality of genes selected from the group consisting of ACTG1, CA12, CALM2, CCND1, CHPT1, CLEC2B, CTSB, CXCL13, DCN, DHRS2, EIF4B, ERBB2, ESR1, FBXO28, GABRP, GAPDH, H2AFZ, IGFBP3, IGHG1, IGKC, KCTD3, KIAA0101, KRT17, MLPH, MMP1, NAT1, NEK2, NR2F2, OAZ1, PCNA, PDLIM5, PGR, PPIA, PRC1, RACGAP1, RPL37A, SOX4, TOP2A, UBE2C and VEGF.

Abstract: The present invention relates to a method for predicting a response of a tumor in a patient suffering from or at risk of developing recurrent gynecologic cancer towards a chemotherapeutic agent, said method comprising the steps of: a) obtaining a biological sample from said patient; b) determining the pattern of expression level of at least one gene of the group comprising AKR1C1, MLPH, ESR1, PGR, COMP, DCN, IGKC, CCL5, FBN1 and/or UBE2C, or of genes coregulated therewith, in said sample; c) comparing the pattern of expression levels determined in (b) with one or several reference pattern (s) of expression levels; d) identifying at least one marker gene; e) determining a molecular subtype for said sample on the basis of (d); and f) predicting from said molecular subtype response of a tumor for a chemotherapeutic agent, wherein the molecular subtype is selected from the group comprising the subtypes basal, stromal-high, stromal-low, luminal A, immune system-high, immune system-low, proliferation-high and/or pr

Abstract: An implantable fixation structure includes a c-shape bone fixation clip adapted to fit over and attach to a bony bridge element in the middle ear of a patient. A c-shape electrode fixation clip is adapted to fit over and attach to an electrode array element in the middle ear of the patient. A connecting bar has a first end connected to the bone fixation clip and a second end connected to the electrode fixation clip. A coupling clip is connected to the connecting bar between the first end and the second end and adapted to fit over and attach to a cochlear implant element and hold the cochlear implant element in a desired position relative to the middle ear of the patient.

Abstract: The present invention relates to a process for the hydrogenation, in particular selective hydrogenation of at least one unsaturated hydrocarbon compound comprising reacting the at least one unsaturated hydrocarbon compound with hydrogen in the presence of a hydrogenation catalyst, wherein the hydrogenation catalyst comprises a mixture of an ordered intermetallic compound and an inert material. According to another aspect, the present invention is concerned with the use of a mixture of at least one ordered intermetallic compound and at least one inert material, as a catalyst. The mixtures for use as a catalyst in the present invention can be prepared easily and achieve a superior activity in relation to the prior art, while preserving the high selectivity to the target compounds, e.g. in the selective hydrogenation of acetylene to ethylene.

Abstract: The present invention pertains to methods of preparing optionally supported, ordered intermetallic palladium gallium compounds, and the corresponding, optionally supported, intermetallic palladium gallium compounds obtainable by these methods. The present invention also pertains to the use of the optionally supported ordered intermetallic palladium gallium compounds as catalysts, such as in selective hydrogenations of alkynes, in particular ethyne, to give the corresponding alkenes. The optionally supported, ordered intermetallic palladium gallium compounds were found to be highly active and selective catalysts in the above hydrogenation reactions.

Abstract: An implantable fixation structure includes at least one implantable holding element. The holding element is connected to an implantable cochlear implant element and maintains the cochlear implant element in a desired position relative to the middle ear of a patient user.

Abstract: A double-layer three-way catalyst is presented, which is formed from a catalytic coating applied directly to an inert honeycomb and a catalytically active coating thereon, and is suitable especially for cleaning of exhaust gases of motor vehicles with gasoline-operated internal combustion engines. The catalyst contains, in each layer, an active aluminum oxide and a cerium/zirconium mixed oxide, both of which are catalytically activated by palladium. The second layer on the gas side contains not only palladium but also rhodium, which is applied to the active aluminum oxide and the cerium/zirconium mixed oxide of the second layer in addition to the palladium. The cerium/zirconium mixed oxide of the second layer has a higher zirconium oxide content than the cerium/zirconium mixed oxide of the first layer. The catalyst is notable for exceptional activity coupled with outstanding aging stability.

Abstract: A system may include reception of an internet electronic mail message associated with a standards-compliant groupware object, and conversion of the internet electronic mail message to a message associated with the standards-compliant groupware object and compliant with a Web service message interface.

Abstract: An implant includes a humidity sensor for generating a signal indicative of humidity within the implant. A controller within the implant receives the signal indicative of humidity, and controls the implant based on the signal indicative of humidity.

Abstract: An implantable fixation structure includes at least one implantable holding element. The holding element is connected to an implantable cochlear implant element and maintains the cochlear implant element in a desired position relative to the middle ear of a patient user.

Abstract: The present invention relates to implantable medical devices for improving sound perception by individuals with severe to profound hearing loss or tinnitus. In particular, the present invention provides methods and devices for stimulating structures of the ear via multiple signal transducers.

Abstract: The present invention relates to implantable medical devices for improving sound perception by individuals with severe to profound hearing loss or tinnitus. In particular, the present invention provides methods and devices for stimulating structures of the ear via multiple signal transducers.