Patents by Inventor Margaret Taylor
Margaret Taylor has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240117064Abstract: CD37-specific bispecific antibody molecules binding to different epitopes of the human CD37 antigen which bispecific antibody molecules have enhanced Fc-Fc interactions upon binding to CD37 on the cell surface. The invention also relates to the monoclonal parental antibodies from which the first or the second binding region of the bispecific antibody molecules is obtained. The invention also relates to pharmaceutical compositions containing these molecules and the treatment of cancer and other diseases using these compositions.Type: ApplicationFiled: October 27, 2022Publication date: April 11, 2024Inventors: Simone OOSTINDIE, Frank BEURSKENS, Esther BREIJ, Edward VAN DEN BRINK, Andreas HOLLENSTEIN, Marije OVERDIJK, Margaret LINDORFER, Ronald TAYLOR, Paul PARREN, Hilma VAN DER HORST, Martine E.D. CHAMULEAU, Tuna MUTIS
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Publication number: 20240076397Abstract: CD37-specific bispecific antibody molecules binding to different epitopes of the human CD37 antigen which bispecific antibody molecules have enhanced Fc-Fc interactions upon binding to CD37 on the cell surface. The invention also relates to the monoclonal parental antibodies from which the first or the second binding region of the bispecific antibody molecules is obtained. The invention also relates to pharmaceutical compositions containing these molecules and the treatment of cancer and other diseases using these compositions.Type: ApplicationFiled: October 27, 2023Publication date: March 7, 2024Inventors: Simone OOSTINDIE, Frank BEURSKENS, Esther BREIJ, Edward VAN DEN BRINK, Andreas HOLLENSTEIN, Marije OVERDIJK, Margaret LINDORFER, Ronald TAYLOR, Paul PARREN, Hilma VAN DER HORST, Martine E.D. CHAMULEAU, Tuna MUTIS
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Publication number: 20230321326Abstract: A catheter configured to provide inherent antimicrobial properties includes a polyhydroxyalkanoate (PHA). In some embodiments, an extruded catheter body is fabricated of a PHA. In some embodiments, an extruded catheter body has an exterior layer containing PHA, an interior layer containing PHA, or both exterior and interior layers containing PHA. The PHA layer may be co-extruded with the catheter body. The PHA layer may be coating applied to the catheter body. Useful PHA materials to provide inherent antimicrobial properties include poly-4-hydroxybutyrate (P4HB) and copolymers of P4HB. The catheter may be an IV catheter, a urinary catheter, a dialysis catheter, or any other catheter introduced into a body lumen.Type: ApplicationFiled: April 11, 2022Publication date: October 12, 2023Inventors: Amit Limaye, Margaret Taylor
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Patent number: 11738150Abstract: A drug delivery device (100) for administering a low dose of a medicament includes a housing (111) and a drug reservoir (101) disposed in the housing (111). A needle (135) is connected to the drug reservoir (101). A pressure applying member (113) is movably connected to the housing (111) and is movable between first and second positions. The pressure applying member (113) does not apply pressure to the drug reservoir (101) in the first position and applies pressure to the drug reservoir (101) in the second position to dispense medicament stored in the drug reservoir (101). A method of administering a low dose of insulin to simulate a first-phase insulin response of a pancreas is also disclosed.Type: GrantFiled: December 16, 2020Date of Patent: August 29, 2023Assignee: Becton, Dickinson and CompanyInventors: Margaret Taylor, James Bates, Roman Tunkel, Jay Butterbrodt, Gary Searle, Joshua Horvath, Keith Knapp, II, Edward Gillen
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Patent number: 11315674Abstract: Improved systems and methods for medicine delivery, and in particular, improved insulin pen needles and related devices are provided. Smart injection devices record and transfer data including medicine level, delivered dose, dose confirmation, and dose time and date. Additional data captured may include glucose concentration, insulin level, carbohydrates ingested, stress level, exercise, blood pressure, and glucose high and low excursion events. Various means of data collection and analysis are provided and systems can identify and flag patients who require intervention. Smart sleeves and add sensing capability to standard insulin pens. Pen needles are provided with sensing capability to confirm and measure doses delivered by insulin pen. A two-part pen cap include a primary sleeve that connects to the insulin pen and an end cap that provides for capturing the time of dose delivery, and monitoring the hold time for a dose delivery after plunger movement.Type: GrantFiled: October 20, 2015Date of Patent: April 26, 2022Assignee: BECTON, DICKINSON AND COMPANYInventors: Keith Knapp, Neil McCaffrey, Jay Butterbrodt, Margaret Taylor, Ruth Markowitz, Gary Searle, Michael Gibney, James Salemme, James Walker, Sean Sullivan, Ernest Elgin, Rita Saltiel-Berzin
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Publication number: 20210100956Abstract: A drug delivery device (100) for administering a low dose of a medicament includes a housing (111) and a drug reservoir (101) disposed in the housing (111). A needle (135) is connected to the drug reservoir (101). A pressure applying member (113) is movably connected to the housing (111) and is movable between first and second positions. The pressure applying member (113) does not apply pressure to the drug reservoir (101) in the first position and applies pressure to the drug reservoir (101) in the second position to dispense medicament stored in the drug reservoir (101). A method of administering a low dose of insulin to simulate a first-phase insulin response of a pancreas is also disclosed.Type: ApplicationFiled: December 16, 2020Publication date: April 8, 2021Applicant: Becton, Dickinson and CompanyInventors: Margaret TAYLOR, James BATES, Roman TUNKEL, Jay BUTTERBRODT, Gary SEARLE, Joshua HORVATH, Keith KNAPP, II, Edward GILLEN
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Patent number: 10898648Abstract: A drug delivery device (100) for administering a low dose of a medicament includes a housing (111) and a drug reservoir (101) disposed in the housing (111). A needle (135) is connected to the drug reservoir (101). A pressure applying member (113) is movably connected to the housing (111) and is movable between first and second positions. The pressure applying member (113) does not apply pressure to the drug reservoir (101) in the first position and applies pressure to the drug reservoir (101) in the second position to dispense medicament stored in the drug reservoir (101). A method of administering a low dose of insulin to simulate a first-phase insulin response of a pancreas is also disclosed.Type: GrantFiled: November 30, 2017Date of Patent: January 26, 2021Assignee: Becton, Dickinson and CompanyInventors: Margaret Taylor, James Bates, Roman Tunkel, Jay Butterbrodt, Gary Searle, Joshua Horvath, Keith Knapp, II, Edward Gillen
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Patent number: 10688240Abstract: A needle changing device for use on a medication delivery device includes an engagement element that is configured to engage the medication delivery device and pierce a septum of the medication delivery device, a needle holder connected to the engagement element, the needle holder having a needle changing septum having a reservoir, the reservoir being in continuous fluid communication with the engagement element, and a plurality of needles configured to pierce the needle changing septum, wherein when the needle holder is in a first position, the plurality of needles are disengaged from the reservoir of the needle changing septum, and when the needle holder is in a second position, one of the plurality of needles enters into fluid communication with the reservoir of the needle changing septum and is partially exposed outside the needle changing device for medicament delivery.Type: GrantFiled: December 30, 2016Date of Patent: June 23, 2020Assignee: Becton, Dickinson and CompanyInventors: Michel Bruehwiler, Cole Constantineau, Ryan Schoonmaker, James Bates, Robert Banik, Margaret Taylor
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Patent number: 10626398Abstract: The oligonucleotide compositions of the present invention make use of combinations of oligonucleotides. In one aspect, the invention features an oligonucleotide composition including at least 2 different oligonucleotides targeted to a target gene. This invention also provides methods of inhibiting protein synthesis in a cell and methods of identifying oligonucleotide compositions that inhibit synthesis of a protein in a cell.Type: GrantFiled: January 21, 2019Date of Patent: April 21, 2020Assignee: LIFE TECHNOLOGIES CORPORATIONInventors: Tod Woolf, Margaret Taylor
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Publication number: 20190316138Abstract: The oligonucleotide compositions of the present invention make use of combinations of oligonucleotides. In one aspect, the invention features an oligonucleotide composition including at least 2 different oligonucleotides targeted to a target gene. This invention also provides methods of inhibiting protein synthesis in a cell and methods of identifying oligonucleotide compositions that inhibit synthesis of a protein in a cell.Type: ApplicationFiled: January 21, 2019Publication date: October 17, 2019Inventors: Tod Woolf, Margaret Taylor
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Patent number: 10398852Abstract: Smart sensors are employed to determine one or more of drug identification, dose, flow rate, concentration, agglomeration, and degradation and/or other characteristics of drug administration that can be detected via sensing technology. A smart sensor(s) can be coupled to or retrofitted onto injection pen injectors and/or drug delivery cartridges and/or infusion sets or cannulae, enabling infusion sets, pen injector systems or drug delivery cartridges to improve tracking of drug self-administration and stop medication errors that occur primarily through self or automated injection (e.g., due to incorrect or incomplete dosing, excessive dose or rate, incorrect drug, or drug degradation).Type: GrantFiled: March 14, 2014Date of Patent: September 3, 2019Assignee: Becton, Dickinson and CompanyInventors: Margaret Taylor, David Feygin, Elizabeth Nelson, Bart Peterson, Karthik Ranganathan, Richard Byrd
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Patent number: 10369271Abstract: An apparatus is disclosed for storing and changing needles for connection with a medicament delivery device, comprising an inner housing, a reservoir disposed within the inner housing, and a needle holder disposed within the inner housing, for fluidly connecting a medicament container of the medicament delivery device with the reservoir. The apparatus also includes a plurality of patient needles displaceably disposed on the needle holder, and an outer housing displaceably disposed about the inner housing and providing a user interface to individually select one of the plurality of patient needles, connect the selected needle with the reservoir, expose the selected needle outside of the apparatus for injection, and store the selected needle.Type: GrantFiled: June 23, 2017Date of Patent: August 6, 2019Assignee: Becton, Dickinson and CompanyInventors: Michel Bruehwiler, Cole Constantineau, Ryan Schoonmaker, James Bates, Robert Banik, Margaret Taylor
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Patent number: 10196640Abstract: The oligonucleotide compositions of the present invention make use of combinations of oligonucleotides. In one aspect, the invention features an oligonucleotide composition including at least 2 different oligonucleotides targeted to a target gene. This invention also provides methods of inhibiting protein synthesis in a cell and methods of identifying oligonucleotide compositions that inhibit synthesis of a protein in a cell.Type: GrantFiled: June 21, 2018Date of Patent: February 5, 2019Assignee: LIFE TECHNOLOGIES CORPORATIONInventors: Tod Woolf, Margaret Taylor
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Publication number: 20190017051Abstract: The oligonucleotide compositions of the present invention make use of combinations of oligonucleotides. In one aspect, the invention features an oligonucleotide composition including at least 2 different oligonucleotides targeted to a target gene. This invention also provides methods of inhibiting protein synthesis in a cell and methods of identifying oligonucleotide compositions that inhibit synthesis of a protein in a cell.Type: ApplicationFiled: June 21, 2018Publication date: January 17, 2019Inventors: Tod WOOLF, Margaret TAYLOR
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Patent number: 10036025Abstract: The oligonucleotide compositions of the present invention make use of combinations of oligonucleotides. In one aspect, the invention features an oligonucleotide composition including at least 2 different oligonucleotides targeted to a target gene. This invention also provides methods of inhibiting protein synthesis in a cell and methods of identifying oligonucleotide compositions that inhibit synthesis of a protein in a cell.Type: GrantFiled: October 3, 2017Date of Patent: July 31, 2018Assignee: LIFE TECHNOLOGIES CORPORATIONInventors: Tod Woolf, Margaret Taylor
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Publication number: 20180087056Abstract: The oligonucleotide compositions of the present invention make use of combinations of oligonucleotides. In one aspect, the invention features an oligonucleotide composition including at least 2 different oligonucleotides targeted to a target gene. This invention also provides methods of inhibiting protein synthesis in a cell and methods of identifying oligonucleotide compositions that inhibit synthesis of a protein in a cell.Type: ApplicationFiled: October 3, 2017Publication date: March 29, 2018Inventors: Tod WOOLF, Margaret TAYLOR
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Publication number: 20180085527Abstract: A drug delivery device (100) for administering a low dose of a medicament includes a housing (111) and a drug reservoir (101) disposed in the housing (111). A needle (135) is connected to the drug reservoir (101). A pressure applying member (113) is movably connected to the housing (111) and is movable between first and second positions. The pressure applying member (113) does not apply pressure to the drug reservoir (101) in the first position and applies pressure to the drug reservoir (101) in the second position to dispense medicament stored in the drug reservoir (101). A method of administering a low dose of insulin to simulate a first-phase insulin response of a pancreas is also disclosed.Type: ApplicationFiled: November 30, 2017Publication date: March 29, 2018Applicant: Becton, Dickinson and CompanyInventors: Margaret TAYLOR, James BATES, Roman TUNKEL, Jay BUTTERBRODT, Gary SEARLE, Joshua HORVATH, Keith KNAPP, II, Edward GILLEN
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Patent number: 9849247Abstract: A drug delivery device (100) for administering a low dose of a medicament includes a housing (111) and a drug reservoir (101) disposed in the housing (111). A needle (135) is connected to the drug reservoir (101). A pressure applying member (113) is movably connected to the housing (111) and is movable between first and second positions. The pressure applying member (113) does not apply pressure to the drug reservoir (101) in the first position and applies pressure to the drug reservoir (101) in the second position to dispense medicament stored in the drug reservoir (101). A method of administering a low dose of insulin to simulate a first-phase insulin response of a pancreas is also disclosed.Type: GrantFiled: January 31, 2011Date of Patent: December 26, 2017Assignee: Becton, Dickinson and CompanyInventors: Margaret Taylor, James Bates, Roman Tunkel, Jay Butterbrodt, Gary Searle, Joshua Horvath, Keith Knapp, II, Edward Gillen
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Publication number: 20170321219Abstract: The oligonucleotide compositions of the present invention make use of combinations of oligonucleotides. In one aspect, the invention features an oligonucleotide composition including at least 2 different oligonucleotides targeted to a target gene. This invention also provides methods of inhibiting protein synthesis in a cell and methods of identifying oligonucleotide compositions that inhibit synthesis of a protein in a cell.Type: ApplicationFiled: July 17, 2017Publication date: November 9, 2017Inventors: Tod WOOLF, Margaret Taylor
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Patent number: 9796978Abstract: The oligonucleotide compositions of the present invention make use of combinations of oligonucleotides. In one aspect, the invention features an oligonucleotide composition including at least 2 different oligonucleotides targeted to a target gene. This invention also provides methods of inhibiting protein synthesis in a cell and methods of identifying oligonucleotide compositions that inhibit synthesis of a protein in a cell.Type: GrantFiled: July 17, 2017Date of Patent: October 24, 2017Assignee: LIFE TECHNOLOGIES CORPORATIONInventors: Tod Woolf, Margaret Taylor