Patents by Inventor Margo Roberts

Margo Roberts has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MODIFIED PLURIPOTENT STEM CELLS AND METHODS OF MAKING AND USE
    Publication number: 20210040449
    Abstract: The disclosure provides a method of generating modified T cells from engineered stem cells for use in an autologous or allogeneic setting for engineered immunotherapy. The knockout of endogenous TCR or HLA expression allows for engineering of modified pluripotent stem cells that reduce or eliminate the risk of Graft versus Host Disease (GVHD), provide resistance to elimination by a recipient's T cells and NK cells, and allow for controllable T cell activity. Thus, this method allows the development of T cells with reduced immune reactivity.
    Type: Application
    Filed: February 15, 2019
    Publication date: February 11, 2021
    Inventors: Eric GSCHWENG, Rajul JAIN, Yong OUYANG, Arianne PEREZ GARCIA, Margo ROBERTS, Ruben ALVAREZ RODRIGUEZ, Drake SMITH, Xingliang ZHOU
  • Cancer-associated antigens and methods of their identification and use
    Patent number: 7645587
    Abstract: The present invention provides novel, isolated, tumor-associated antigens, and methods for identifying such antigens in a biological sample, and of screening for the presence of such an antigen in a biological specimen, wherein the tumor antigen identified reacts with serum from a subject treated with a vaccine comprising a cytokine and proliferation-incompetent tumor cells which express the tumor-associated antigen. Also provided are kits for carrying out the methods of the invention.
    Type: Grant
    Filed: May 2, 2007
    Date of Patent: January 12, 2010
    Assignees: BioSante Pharmaceuticals, Inc., John Hopkins University
    Inventors: James McArthur, Ju-Fay Chang, Dale Ando, Margo Roberts, Jonathan Simons, William Nelson
  • Novel cancer-associated antigens and methods of their identification and use
    Publication number: 20070212739
    Abstract: The present invention provides novel, isolated, tumor-associated antigens, and methods for identifying such antigens in a biological sample, and of screening for the presence of such an antigen in a biological specimen, wherein the tumor antigen identified reacts with serum from a subject treated with a vaccine comprising a cytokine and proliferation-incompetent tumor cells which express the tumor-associated antigen. Also provided are kits for carrying out the methods of the invention.
    Type: Application
    Filed: May 2, 2007
    Publication date: September 13, 2007
    Applicant: Cell Genesys, Inc.
    Inventors: James McArthur, Ju-Fay Chang, Dale Ando, Margo Roberts, Jonathan Simons, William Nelson
  • Cancer-associated antigens and methods of their identification and use
    Patent number: 7226606
    Abstract: The present invention provides novel, isolated, tumor-associated antigens, and methods for identifying such antigens in a biological sample, and of screening for the presence of such an antigen in a biological specimen, wherein the tumor antigen identified reacts with serum from a subject treated with a vaccine comprising a cytokine and proliferation-incompetent tumor cells which express the tumor-associated antigen. Also provided are kits for carrying out the methods of the invention.
    Type: Grant
    Filed: November 16, 2005
    Date of Patent: June 5, 2007
    Assignee: Cell Genesys, Inc.
    Inventors: James McArthur, Ju-Fay Chang, Dale Ando, Margo Roberts, Jonathan Simons, William Nelson
  • Cancer-associated antigens and methods of their identification and use
    Patent number: 7217421
    Abstract: The present invention provides novel, isolated, tumor-associated antigens, and methods for identifying such antigens in a biological sample, and of screening for the presence of such an antigen in a biological specimen, wherein the tumor antigen identified reacts with serum from a subject treated with a vaccine comprising a cytokine and proliferation-incompetent tumor cells which express the tumor-associated antigen. Also provided are kits for carrying out the methods of the invention.
    Type: Grant
    Filed: July 6, 2000
    Date of Patent: May 15, 2007
    Assignee: Cell Genesys, Inc.
    Inventors: James McArthur, Ju-Fay Chang, Dale Ando, Margo Roberts, Jonathan Simons, William Nelson
  • Novel cancer-associated antigens and methods of their identification and use
    Publication number: 20060078544
    Abstract: The present invention provides novel, isolated, tumor-associated antigens, and methods for identifying such antigens in a biological sample, and of screening for the presence of such an antigen in a biological specimen, wherein the tumor antigen identified reacts with serum from a subject treated with a vaccine comprising a cytokine and proliferation-incompetent tumor cells which express the tumor-associated antigen. Also provided are kits for carrying out the methods of the invention.
    Type: Application
    Filed: November 16, 2005
    Publication date: April 13, 2006
    Inventors: James McArthur, Ju-Fay Chang, Dale Ando, Margo Roberts, Jonathan Simons, William Nelson