Patents by Inventor Maria Belen Rubio

Maria Belen Rubio has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

Targeted polymeric prodrugs containing multifunctional linkers

Patent number: 8367065

Abstract: The present invention provides single chain antibody-directed polymeric prodrugs containing multifunctional linkers. Methods of making the polymeric delivery systems and methods of treating mammals using the same are also disclosed.

Type: Grant

Filed: March 12, 2009

Date of Patent: February 5, 2013

Assignee: Enzon Pharmaceuticals, Inc.

Inventors: Hong Zhao, Prasanna Reddy, Maria Belen Rubio
Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers

Patent number: 8299089

Abstract: A four arm-polyethylene glycol-7-ethyl-10-hydroxycamptothecin conjugate, such as, is disclosed. Methods of making the conjugates and methods of treating mammals using the same are also disclosed.

Type: Grant

Filed: April 19, 2010

Date of Patent: October 30, 2012

Assignee: Enzon Pharmaceuticals, Inc.

Inventors: Hong Zhao, Maria Belen Rubio, Dechun Wu, Puja Sapra
TARGETED POLYMERIC PRODRUGS CONTAINING MULTIFUNCTIONAL LINKERS

Publication number: 20100233190

Abstract: The present invention provides single chain antibody-directed polymeric prodrugs containing multifunctional linkers. Methods of making the polymeric delivery systems and methods of treating mammals using the same are also disclosed.

Type: Application

Filed: March 12, 2009

Publication date: September 16, 2010

Applicant: ENZON PHARMACEUTICALS, INC.

Inventors: Hong ZHAO, Maria Belen RUBIO, Pasanna Reddy
MULTI-ARM POLYMERIC CONJUGATES OF 7-ETHYL-10-HYDROXYCAMPTOTHECIN FOR TREATMENT OF BREAST, COLORECTAL, PANCREATIC, OVARIAN AND LUNG CANCERS

Publication number: 20100204261

Abstract: A four arm-polyethylene glycol-7-ethyl-10-hydroxycamptothecin conjugate, such as, is disclosed. Methods of making the conjugates and methods of treating mammals using the same are also disclosed.

Type: Application

Filed: April 19, 2010

Publication date: August 12, 2010

Applicant: ENZON PHARMACEUTICALS, INC.

Inventors: Hong ZHAO, Maria Belen RUBIO, Dechun WU, Puja Sapra
Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers

Patent number: 7723351

Abstract: A four arm-polyethylene glycol-7-ethyl-10-hydroxycamptothecin conjugate, such as, is disclosed. Methods of making the conjugates and methods of treating mammals using the same are also disclosed.

Type: Grant

Filed: November 20, 2008

Date of Patent: May 25, 2010

Assignee: Enzon Pharmaceuticals, Inc.

Inventors: Hong Zhao, Maria Belen Rubio, Dechun Wu, Puja Sapra
MULTI-ARM POLYMERIC CONJUGATES OF 7-ETHYL-10-HYDROXYCAMPTOTHECIN FOR TREATMENT OF BREAST, COLORECTAL, PANCREATIC, OVARIAN AND LUNG CANCERS

Publication number: 20090074706

Abstract: A four arm-polyethylene glycol-7-ethyl-10-hydroxycamptothecin conjugate, such as, is disclosed. Methods of making the conjugates and methods of treating mammals using the same are also disclosed.

Type: Application

Filed: November 20, 2008

Publication date: March 19, 2009

Applicant: ENZON PHARMACEUTICALS, INC.

Inventors: Hong ZHAO, Maria Belen RUBIO, Dechun WU, Puja SAPRA
Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers

Patent number: 7462627

Abstract: A four arm-polyethylene glycol-7-ethyl-10-hydroxycamptothecin conjugate, such as, is disclosed. Methods of making the conjugates and methods of treating mammals using the same are also disclosed.

Type: Grant

Filed: February 9, 2007

Date of Patent: December 9, 2008

Assignee: Enzon Pharmaceuticals, Inc.

Inventors: Hong Zhao, Maria Belen Rubio, Dechun Wu, Puja Sapra

Targeted polymeric prodrugs containing multifunctional linkers

Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers

TARGETED POLYMERIC PRODRUGS CONTAINING MULTIFUNCTIONAL LINKERS

MULTI-ARM POLYMERIC CONJUGATES OF 7-ETHYL-10-HYDROXYCAMPTOTHECIN FOR TREATMENT OF BREAST, COLORECTAL, PANCREATIC, OVARIAN AND LUNG CANCERS

Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers

MULTI-ARM POLYMERIC CONJUGATES OF 7-ETHYL-10-HYDROXYCAMPTOTHECIN FOR TREATMENT OF BREAST, COLORECTAL, PANCREATIC, OVARIAN AND LUNG CANCERS

Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers