Patents by Inventor Maria Contel

Maria Contel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibody-drug conjugates based on gold compounds
    Patent number: 11141490
    Abstract: Antibody-drug-conjugates (ADC) are provided having a structure of: wherein L is PR3 ligand. The ADC has n drug moieties bound to the Trastuzumab antibody such that the ADC has a drug-to-antibody ratio (DAR) between 2 and 4 and the drug moieties are bound to the Trastuzumab antibody through cysteine (S) or lystine (Lys) residues. The disclosed ADCs are particularly useful in treating breast cancer.
    Type: Grant
    Filed: July 5, 2019
    Date of Patent: October 12, 2021
    Assignees: Research Foundation of the City University of New York, Memorial Sloan Kettering Cancer Center
    Inventors: Maria Contel, Natalia Curado, Jason Lewis, Sophie Poty
  • ANTIBODY-DRUG CONJUGATES BASED ON GOLD COMPOUNDS
    Publication number: 20200016276
    Abstract: Antibody-drug-conjugates (ADC) are provided having a structure of: wherein L is PR3 ligand. The ADC has n drug moieties bound to the Trastuzumab antibody such that the ADC has a drug-to-antibody ratio (DAR) between 2 and 4 and the drug moieties are bound to the Trastuzumab antibody through cysteine (S) or lystine (Lys) residues. The disclosed ADCs are particularly useful in treating breast cancer.
    Type: Application
    Filed: July 5, 2019
    Publication date: January 16, 2020
    Inventors: Maria Contel, Natalia Curado, Jason Lewis, Sophie Poty
  • Arene ruthenium (II) derivatives containing iminophosphorane ligands and their use in cancer therapy
    Patent number: 9555049
    Abstract: A method for providing a therapeutic benefit for a subject having a cancer is provided. A compound with an arene ruthenium (II) compound with an iminophosphorane ligand is administered to the subject.
    Type: Grant
    Filed: May 28, 2015
    Date of Patent: January 31, 2017
    Assignee: Research Foundation of the City University of New York
    Inventors: Maria Contel, Isabel Marzo, Malgorzata Frik, Benelita T. Elie
  • Titanocene-gold derivatives comprising thiolato ligands
    Patent number: 9315531
    Abstract: Titanocene-gold compounds are provided that are useful for treating cancers.
    Type: Grant
    Filed: June 5, 2015
    Date of Patent: April 19, 2016
    Assignees: Research Foundation of the City University of New York, University of Hawaii
    Inventors: Maria Contel, Jacob Fernandez-Gallardo, Benelita T. Elie, Joe W. Ramos
  • ARENE RUTHENIUM (II) DERIVATIVES CONTAINING IMINOPHOSPHORANE LIGANDS AND THEIR USE IN CANCER THERAPY
    Publication number: 20150374724
    Abstract: A method for providing a therapeutic benefit for a subject having a cancer is provided. A compound with an arene ruthenium (II) compound with an iminophosphorane ligand is administered to the subject.
    Type: Application
    Filed: May 28, 2015
    Publication date: December 31, 2015
    Inventors: Maria Contel, Isabel Marzo, Malgorzata Frik, Benelita T. Elie
  • TITANOCENE-GOLD DERIVATIVES COMPRISING THIOLATO LIGANDS
    Publication number: 20150353591
    Abstract: Titanocene-gold compounds are provided that are useful for treating cancers.
    Type: Application
    Filed: June 5, 2015
    Publication date: December 10, 2015
    Inventors: Maria Contel, Jacob Fernandez-Gallardo, Benelita T. Elie, Joe W. Ramos