Abstract: The present invention is directed to antibodies and antigen binding fragments thereof having binding specificity for PACAP. The antibodies and antigen binding fragments thereof comprise the sequences of the VH, VL, and CDR polypeptides described herein, and the polynucleotides encoding them. Antibodies and antigen binding fragments described herein bind to and/or compete for binding to the same linear or conformational epitope(s) on human PACAP as an anti-PACAP antibody. The invention contemplates conjugates of anti-PACAP antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. Methods of making said anti-PACAP antibodies and antigen binding fragments thereof are also contemplated.

Abstract: An improved jewelry finding (20) has a first member (21) provided with a first opening (24) therethrough, and a second member (22) provided with a second opening (25) therethrough. The two members are fixed to one another such that the axes (y1—y1, y2—y2) of the first and second openings are oriented at an acute included angle (&thgr;) with respect to one another when seen along a line joining the center of these members. The finding may include a third member (e.g., 33 or 43). The center of the third member may be on this imaginary line, or the center of the three members may be arranged at the apices of an imaginary triangle. A multi-strand necklace formed by passing stylets through the member openings will have a generally twisted or intertwined appearance.

Abstract: A springless jewelry finding (25) includes an hinge plate (26) and an ear-wire (28) having one marginal end portion (34) secured to the hinge plate, having an intermediate arcuate portion (35) and having a distal marginal end portion (36). A lever-paddle (29) has one marginal end portion (38) pivotally mounted on the hinge and has another marginal end portion (39) mounted for arcuate movement toward and away from the ear-wire distal marginal end portion. The lever-paddle other marginal end portion has a concave surface that is adapted to selectively embrace the ear-wire distal marginal end portion and has a detent (40) that is so configured and dimensioned with respect to the ear-wire distal marginal end portion as to require that the ear-wire distal marginal end portion be forcibly passed through the detent as the lever-paddle is moved between opened and closed positions relative to the ear-wire.