Patents by Inventor Maria Rotaru

Maria Rotaru has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20160051679
    Abstract: The invention provides stable formulations of pemetrexed for infusion. The formulations are based on using pemetrexed diacid and certain selected suitable stabilising basic amine compounds that provide counter ions to the pemetrexed diacid, forming base addition salts. The formulations can be dried powder formulations to be reconstituted as liquid concentrate formulations or directly in ready-to-use infusion solutions, or they can be liquid formulations, most suitably concentrates to be diluted in infusion solution prior to use. The suitable basic amine addition compounds according to the invention are one or more of diethanolamine, tris-(hydroxymethyl)aminomethane and meglumine.
    Type: Application
    Filed: April 14, 2014
    Publication date: February 25, 2016
    Inventor: Maria ROTARU
  • Patent number: 8398860
    Abstract: A method of purifying a surfactant for use in a pharmaceutical formulation, which comprises mixing the surfactant with a solvent and bringing said mixture into contact with a semi-permeable membrane so as to allow impurities present in the surfactant and having a molecular weight lower than the molecular weight cut-off of the membrane to pass through the membrane, whilst retaining the purified surfactant.
    Type: Grant
    Filed: February 10, 2006
    Date of Patent: March 19, 2013
    Assignee: Sindan Pharma SRL
    Inventors: Constantin Busoi, Maria Rotaru, Bogdan-Mihai Oghina, Mariana Surmeian
  • Publication number: 20080287524
    Abstract: A method of purifying a surfactant for use in a pharmaceutical formulation, which comprises mixing the surfactant with a solvent and bringing said mixture into contact with a semi-permeable membrane so as to allow impurities present in the surfactant and having a molecular weight lower than the molecular weight cut-off of the membrane to pass through the membrane, whilst retaining the purified surfactant.
    Type: Application
    Filed: February 10, 2006
    Publication date: November 20, 2008
    Inventors: Constantin Busoi, Maria Rotaru, Bogdan-Mihai Oghina, Mariana Surmeian