Patents by Inventor Maria Scarselli

Maria Scarselli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel Antigens
    Publication number: 20240115688
    Abstract: The present invention is directed to novel, modified FimH polypeptides, nucleic acids encoding them, and the use of the polypeptides and nucleic acids in the treatment and/or prevention of disease, in particular, urinary tract infection (UTI).
    Type: Application
    Filed: November 30, 2021
    Publication date: April 11, 2024
    Applicant: GLAXOSMITHKLINE BIOLOGICALS SA
    Inventors: Roberto ADAMO, Roberta COZZI, Adele FANTONI, Sanjay PHOGAT, Roberto ROSINI, Maria SCARSELLI, Newton WAHOME
  • Modified meningococcal fHbp polypeptides
    Patent number: 11932671
    Abstract: Modified meningococcal fHbp polypeptides with increased stability.
    Type: Grant
    Filed: April 30, 2021
    Date of Patent: March 19, 2024
    Assignee: GLAXOSMITHKLINE BIOLOGICALS SA
    Inventors: Matthew Bottomley, Enrico Malito, Manuele Martinelli, Maria Scarselli
  • Modified meningococcal FHBP polypeptides
    Patent number: 11708394
    Abstract: The present invention provides mutated fHbp polypeptides and fusion proteins comprising said mutated fHbp polypeptides that are useful as components of immunogenic compositions for immunizing against Neisseria meningitidis infection.
    Type: Grant
    Filed: August 9, 2019
    Date of Patent: July 25, 2023
    Assignee: GlaxoSmithKline Biologicals SA
    Inventors: Maria Scarselli, Daniele Veggi
  • QUANTIFICATION OF BIOCONJUGATE GLYCOSYLATION
    Publication number: 20220257751
    Abstract: The present invention provides analytical tools for the characterisation of bioconjugates, in particular for the measurement of glycosylation levels, and methods for absolute quantification of glycosylation sequences, as well as sequences and glycosylation sites for use in such methods.
    Type: Application
    Filed: July 21, 2020
    Publication date: August 18, 2022
    Applicant: GLAXOSMITHKLINE BIOLOGICALS SA
    Inventors: Massimilliano BIAGINI, Lucia Eleonora FONTANA, Anna GALEA, Nathalie NORAIS, Maria SCARSELLI
  • MODIFIED MENINGOCOCCAL FHBP POLYPEPTIDES
    Publication number: 20210277069
    Abstract: The present invention provides mutated fHbp polypeptides and fusion proteins comprising said mutated fHbp polypeptides that are useful as components of immunogenic compositions for immunizing against Neisseria meningitidis infection.
    Type: Application
    Filed: August 9, 2019
    Publication date: September 9, 2021
    Inventors: Maria SCARSELLI, Daniele VEGGI
  • MODIFIED MENINGOCOCCAL FHBP POLYPEPTIDES
    Publication number: 20210253647
    Abstract: Modified meningococcal fHbp polypeptides with increased stability.
    Type: Application
    Filed: April 30, 2021
    Publication date: August 19, 2021
    Applicant: GLAXOSMITHKLINE BIOLOGICALS SA
    Inventors: Matthew BOTTOMLEY, Enrico MALITO, Manuele MARTINELLI, Maria Scarselli
  • Modified meningococcal FHBP polypeptides
    Patent number: 11021522
    Abstract: Modified meningococcal fHbp polypeptides with increased stability.
    Type: Grant
    Filed: July 1, 2019
    Date of Patent: June 1, 2021
    Assignee: GLAXOSMITHKLINE BIOLOGICALS SA
    Inventors: Matthew Bottomley, Enrico Malito, Manuele Martinelli, Maria Scarselli
  • PSEUDOMONAS ANTIGENS AND ANTIGEN COMBINATIONS
    Publication number: 20200360504
    Abstract: An effective Pseudomonas aeruginosa vaccine may require one or several antigenic components, and so various antigens of P. aeruginosa are identified for use in immunisation. These polypeptides may optionally be used in combination with other nosocomial antigens.
    Type: Application
    Filed: August 7, 2020
    Publication date: November 19, 2020
    Applicants: GlaxoSmithKline Biologicals SA, Ospedale San Raffaele Srl
    Inventors: Vega MASIGNANI, Maria SCARSELLI, Roberto PETRACCA, Irene BIANCONI, Alessandra BRAGONZI, Beatriz ALCALA' FRANCO
  • Adjuvanted combinations of meningococcal factor H binding proteins
    Patent number: 10596246
    Abstract: The M01573 sequence of meningococcal fHbp offers poor coverage in a vaccine. The invention addresses this poor coverage in two ways. In a first aspect, a fHbp-based vaccine includes two family I fHbp sequences, one which is more closely related to MC58 than to M01573, and vice versa. In a second aspect, a multi-family fHbp-based vaccine uses a family I fHbp sequence which is more closely related to MC58 than to M01573, in combination with a family III fHbp sequence. The compositions are adjuvanted with an aluminium phosphate adjuvant.
    Type: Grant
    Filed: December 29, 2011
    Date of Patent: March 24, 2020
    Assignee: GLAXOSMITHKLINE BIOLOGICAL SA
    Inventors: Beatrice Maria Arico, Brunella Brunelli, Maurizio Comanducci, Mariagrazia Pizza, Silvana Savino, Maria Scarselli
  • Combinations of meningococcal factor H binding proteins
    Patent number: 10478483
    Abstract: The M01573 sequence of meningococcal fHbp offers poor coverage in a vaccine. The invention addresses this poor coverage in two ways. In a first aspect, a fHbp-based vaccine includes two family I fHbp sequences, one which is more closely related to MC58 than to M01573, and vice versa. In a second aspect, a multi-family fHbp-based vaccine uses a family I fHbp sequence which is more closely related to MC58 than to M01573, in combination with a family III fHbp sequence.
    Type: Grant
    Filed: June 24, 2011
    Date of Patent: November 19, 2019
    Assignee: GLAXOSMITHKLINE BIOLOGICALS SA
    Inventors: Maria Aricò, Brunella Brunelli, Maurizio Comanducci, Mariagrazia Pizza, Silvana Savino, Maria Scarselli
  • Nucleic acids and proteins from streptococcus groups A and B
    Patent number: 10428121
    Abstract: The invention provides proteins from group B streptococcus (Streptococcus agalactiae) and group A streptococcus (Streptococcus pyogenes), including amino acid sequences and the corresponding nucleotide sequences. Data are given to show that the proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics. The proteins are also targets for antibiotics.
    Type: Grant
    Filed: November 7, 2017
    Date of Patent: October 1, 2019
    Assignees: Novartis AG, J. Craig Venter Institute, Inc.
    Inventors: John Telford, Vega Masignani, Maria Scarselli, Guido Grandi, Herve Tettelin, Claire Fraser
  • ANTIGENS AND ANTIGEN COMBINATIONS
    Publication number: 20190290748
    Abstract: NTHI protein antigens have been identified and found to be conserved across several Haemophilus influenzae pathogenic strains. They have been isolated, cloned from a reference strain and tested for immunogenicity. Methods for immunization and vaccines derived thereof are also disclosed.
    Type: Application
    Filed: March 25, 2019
    Publication date: September 26, 2019
    Applicant: GLAXOSMITHKLINE BIOLOGICALS SA
    Inventors: Marco SORIANI, Maria SCARSELLI, Nathalie NORAIS, Danilo GOMES MORIEL, Silvia ROSSI PACCANI
  • Modified meningococcal fHbp polypeptides
    Patent number: 10392424
    Abstract: Modified meningococcal fHbp polypeptides with increased stability.
    Type: Grant
    Filed: February 27, 2015
    Date of Patent: August 27, 2019
    Assignee: GLAXOSMITHKLINE BIOLOGICALS SA
    Inventors: Matthew Bottomley, Enrico Malito, Manuele Martinelli, Maria Scarselli
  • Mutant staphylococcal antigens
    Patent number: 10328140
    Abstract: Mutant protein A of Staphylococcus aureus (SpA) with decreased affinity for the Fc? portion of human IgG is provided.
    Type: Grant
    Filed: March 24, 2015
    Date of Patent: June 25, 2019
    Assignee: GLAXOSMITHKLINE BIOLOGICALS S.A.
    Inventors: Fabio Bagnoli, Luigi Fiaschi, Maria Scarselli
  • Antigens and antigen combinations
    Patent number: 10279026
    Abstract: NTHI protein antigens have been identified and found to be conserved across several Haemophilus influenzae pathogenic strains. They have been isolated, cloned from a reference strain and tested for immunogenicity. Methods for immunization and vaccines derived thereof are also disclosed.
    Type: Grant
    Filed: April 24, 2013
    Date of Patent: May 7, 2019
    Assignee: GLAXOSMITHKLINE BIOLOGICALS SA
    Inventors: Marco Soriani, Maria Scarselli, Nathalie Norais, Danilo Gomes Moriel, Silvia Rossi Paccani
  • proteins and nucleic acids
    Patent number: 10226524
    Abstract: The invention provides proteins from Staphylococcus aureus including amino acid sequences and the corresponding nucleotide sequences. The proteins are useful for vaccines, immunogenic compositions, diagnostics, enzymatic studies and also as targets for antibiotics.
    Type: Grant
    Filed: August 17, 2017
    Date of Patent: March 12, 2019
    Assignee: GLAXOSMITHKLINE BIOLOGICALS S.A.
    Inventors: Vega Masignani, Marirosa Mora, Maria Scarselli
  • Compositions for immunising against
    Patent number: 10195263
    Abstract: An effective Staphylococcus aureus vaccine may require several antigenic components, and so various combinations of S. aureus antigens are identified for use in immunisation. These polypeptides may optionally be used in combination with S. aureus saccharides.
    Type: Grant
    Filed: May 8, 2017
    Date of Patent: February 5, 2019
    Assignee: GLAXOSMITHKLINE BIOLOGICALS S.A.
    Inventors: Fabio Bagnoli, Massimiliano Biagini, Luigi Fiaschi, Guido Grandi, Ravi Pratap Narayan Mishra, Nathalie Norais, Maria Scarselli
  • PSEUDOMONAS ANTIGENS AND ANTIGEN COMBINATIONS
    Publication number: 20180256701
    Abstract: An effective Pseudomonas aeruginosa vaccine may require one or several antigenic components, and so various antigens of P. aeruginosa are identified for use in immunisation. These polypeptides may optionally be used in combination with other nosocomial antigens.
    Type: Application
    Filed: May 11, 2018
    Publication date: September 13, 2018
    Applicants: GlaxoSmithKline Biologicals SA, Ospedale San Raffaele Srl
    Inventors: Vega MASIGNANI, Maria SCARSELLI, Roberto PETRACCA, Irene BIANCONI, Alessandra BRAGONZI, Beatriz ALCALA' FRANCO
  • antigens and antigen combinations
    Patent number: 9987344
    Abstract: An effective Pseudomonas aeruginosa vaccine may require one or several antigenic components, and so various antigens of P. aeruginosa are identified for use in immunization. These polypeptides may optionally be used in combination with other nosocomial antigens.
    Type: Grant
    Filed: November 27, 2013
    Date of Patent: June 5, 2018
    Assignees: GlaxoSmithKline Biologicals SA, Ospedale San Raffaele S.R.L.
    Inventors: Vega Masignani, Maria Scarselli, Roberto Petracca, Irene Bianconi, Alessandra Bragonzi, Beatriz Alcala′ Franco
  • NUCLEIC ACIDS AND PROTEINS FROM STREPTOCOCCUS GROUPS A AND B
    Publication number: 20180094033
    Abstract: The invention provides proteins from group B streptococcus (Streptococcus agalactiae) and group A streptococcus (Streptococcus pyogenes), including amino acid sequences and the corresponding nucleotide sequences. Data are given to show that the proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics. The proteins are also targets for antibiotics.
    Type: Application
    Filed: November 7, 2017
    Publication date: April 5, 2018
    Inventors: John TELFORD, Vega MASIGNANI, Maria SCARSELLI, Guido GRANDI, Herve TETTELIN, Claire FRASER