Patents by Inventor Marian J. Drohan

Marian J. Drohan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHOD OF PRODUCING RECOMBINANT VITAMIN K DEPENDENT PROTEINS
    Publication number: 20120276079
    Abstract: Methods for producing cell lines with high levels of biologically active recombinant vitamin K dependent proteins are described. The transfected cell lines do not include heterologous genes for processing enzymes and are not subject to selection pressure such as methotrexate resistance. Cell lines producing Factor VII/VIIa and Factor IX are described. These cell lines can be used for isolation of Factor VII/VIIa and/or Factor IX for treatment of Hemophilia.
    Type: Application
    Filed: April 30, 2012
    Publication date: November 1, 2012
    Applicant: Inspiration Biopharmaceuticals, Inc.
    Inventors: William N. Drohan, Marian J. Drohan, Michael J. Griffith
  • RECOMBINANT VITAMIN K DEPENDENT PROTEINS WITH HIGH SIALIC ACID CONTENT AND METHODS OF PREPARING SAME
    Publication number: 20100081187
    Abstract: Methods of isolating highly sialylated recombinant vitamin K dependent proteins, particularly Factor IX, by chromatographic methods are described. The highly sialylated recombinant proteins are characterized. The improved Factor IX has at least 62% N-glycosylation with 3 or 4 sialic acid residues and improved bioavailability and pharmokinetic properties.
    Type: Application
    Filed: April 28, 2008
    Publication date: April 1, 2010
    Inventors: Michael J. Griffith, William N. Drohan, Marian J. Drohan