Patents by Inventor Marianne Brüggemann

Marianne Brüggemann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10194645
    Abstract: The present invention provides in a first aspect a mouse in which the ? (lambda) light chain locus has been functionally silenced. In one embodiment, the mouse ? light chain locus was functional silenced by deletion of gene segments coding for the ? light chain locus. In a further aspect, a mouse containing functionally silenced ? and ? (kappa) L chain loci was produced. The invention is useful for the production of antibodies, for example heterologous antibodies, including heavy chain only antibodies.
    Type: Grant
    Filed: August 8, 2016
    Date of Patent: February 5, 2019
    Assignee: Crescendo Biologics Limited
    Inventors: Marianne Brüggemann, Xiangang Zou
  • Publication number: 20180362666
    Abstract: The invention relates to nucleic acid constructs for expression in mice for the production of heavy chain only antibodies and VH domains, transgenic mice, related methods and uses.
    Type: Application
    Filed: October 22, 2014
    Publication date: December 20, 2018
    Applicant: Crescendo Biologics Limited
    Inventors: Yumin Teng, Joyce Young, Brian McGuinness, Mike Romanos, Marianne Brueggemann
  • Publication number: 20170049083
    Abstract: The present invention provides in a first aspect a mouse in which the ? (lambda) light chain locus has been functionally silenced. In one embodiment, the mouse ? light chain locus was functional silenced by deletion of gene segments coding for the ? light chain locus. In a further aspect, a mouse containing functionally silenced ? and ? (kappa) L chain loci was produced. The invention is useful for the production of antibodies, for example heterologous antibodies, including heavy chain only antibodies.
    Type: Application
    Filed: August 8, 2016
    Publication date: February 23, 2017
    Applicant: Crescendo Biologics Limited
    Inventors: Marianne Brüggemann, Xiangang Zou
  • Patent number: 9439405
    Abstract: The present invention provides in a first aspect a mouse in which the ? (lambda) light chain locus has been functionally silenced. In one embodiment, the mouse ? light chain locus was functional silenced by deletion of acne segments coding for the ? light chain locus. In a further aspect, a mouse containing functionally silenced ? and ? (kappa) L chain loci was produced. The invention is useful for the production of antibodies, for example heterologous antibodies, including heavy chain only antibodies.
    Type: Grant
    Filed: October 17, 2012
    Date of Patent: September 13, 2016
    Assignee: Crescendo Biologics Limited
    Inventors: Marianne Brüggemann, Xiangang Zou
  • Patent number: 8367888
    Abstract: The present invention provides in a first aspect a mouse in which the ? (lambda) light chain locus has been functionally silenced. In one embodiment, the mouse ? light chain locus was functional silenced by deletion of gene segments coding for the ? light chain locus. In a further aspect, a mouse containing functionally silenced ? and ? (kappa) L chain loci was produced. The invention is useful for the production of antibodies, for example heterologous antibodies, including heavy chain only antibodies.
    Type: Grant
    Filed: June 1, 2009
    Date of Patent: February 5, 2013
    Assignee: Crescendo Biologics Limited
    Inventors: Marianne Brüggemann, Xiangang Zou
  • Publication number: 20100122358
    Abstract: The invention relates to mice having functionally silenced endogenous lambda (?) and kappa (?) L-chain loci, comprising antibody-producing cells in which the CH1 domain is functionally silenced, either via spontaneous processes in somatic antibody-producing cells or due to germline deletion of the CH1 domain. Mice of the invention are capable of producing H-chain-only antibody lacking a functional CH1 domain; transgenic human heavy-chain-only antibodies lacking a functional CH1 domain can be produced following insertion into the mouse of an artificial locus with human heavy chain V, D and J segments and a constant region, which is preferably a modified constant region with alterations in, around or upstream of a CH1 domain and/or removal of a CH1 domain.
    Type: Application
    Filed: June 8, 2009
    Publication date: May 13, 2010
    Applicant: Crescendo Biologics Limited
    Inventors: Marianne Brüggemann, Xiangang Zou, Louise Matheson, Michael Osborn
  • Patent number: 7029910
    Abstract: This invention relates to a control region in human immunoglobulins, to parts thereof and to their use.
    Type: Grant
    Filed: February 20, 2002
    Date of Patent: April 18, 2006
    Assignee: The Babraham Institute
    Inventors: Cornelia Anna Mundt, Marianne Brueggemann
  • Publication number: 20020132373
    Abstract: This invention relates to a control region in human immunoglobulins, to parts thereof and to their use.
    Type: Application
    Filed: February 20, 2002
    Publication date: September 19, 2002
    Inventors: Cornelia Anna Mundt, Marianne Brueggemann