Patents by Inventor Mariano Stivanello

Mariano Stivanello has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210040051
    Abstract: The present invention relates to a non-hygroscopic salt of the compound 2-(3-(4-propylheptyl)morpholino)ethan-1-ol having the INN name delmopinol. In particular, the invention relates to the citrate salt of delmopinol. The present invention also relates to pharmaceutical compositions comprising the citrate salt of delmopinol depicted below.
    Type: Application
    Filed: August 23, 2018
    Publication date: February 11, 2021
    Inventors: Carla De Faveri, Mariano Stivanello
  • Patent number: 10894778
    Abstract: The present invention relates to a new process for producing 2-(3-(4-propylheptyl)morpholino)ethan-1-ol with the INN name Delmopinol. The invention also relates to three key intermediates 1-chloro-4-propylhept-3-ene, 1-iodo-4-propylhept-3-ene and 2-(3-(4-propylhept-3-en-1-yl)morpholino)ethan-1-ol.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: January 19, 2021
    Assignee: Lundbeck Pharmaceuticals Italy S.P.A.
    Inventors: Carla De Faveri, Mariano Stivanello
  • Patent number: 10815251
    Abstract: The present invention relates to a method for the manufacture of 2-(3-(alkyl or alkenyl)morpholino)-ethan-1-ols by reduction of 8a-(alkyl or alkenyl)hexahydrooxazolo[2,3-c][1,4]oxazines encompassing a process for producing 2-(3-(4-propylheptyl)morpholino)ethan-1-ol with the INN name delmopinol. The invention also relates to 1-chloro-4-propylhept-3-ene, 1-iodo-4-propylhept-3-ene, 8a-(4-propylheptyl)hexahydrooxazolo[2,3-c][1,4]oxazine, 8a-(4-propylhept-3-en-1-yl)hexahydrooxazolo[2,3-c][1,4]oxazine and 2-(3-(4-propylhept-3-en-1-yl)morpholino)ethan-1-ol which are intermediates in the delmopinol process.
    Type: Grant
    Filed: February 14, 2020
    Date of Patent: October 27, 2020
    Assignee: Lundbeck Pharmaceuticals Italy S.P.A.
    Inventors: Carla De Faveri, Mariano Stivanello
  • Patent number: 10717747
    Abstract: The present invention relates to a method for the manufacture of 2-(3-(alkyl or alkenyl)morpholino)-ethan-1-ols by reduction of 8a-(alkyl and alkenyl)hexahydrooxazolo[2,3-c][1,4]oxazines encompassing a process for producing 2-(3-(4-propylheptyl)morpholino)ethan-1-ol with the INN name delmopinol. The invention also relates to 1-chloro-4-propylhept-3-ene, 1-iodo-4-propylhept-3-ene, 8a-(4-5 propylheptyl)hexahydrooxazolo[2,3-c][1,4]oxazine, 8a-(4-propylhept-3-en-1-yl)hexahydrooxazolo[2,3-c][1,4]oxazine and 2-(3-(4-propylhept-3-en-1-yl)morpholino)ethan-1-ol which are intermediates in the delmopinol process.
    Type: Grant
    Filed: December 20, 2017
    Date of Patent: July 21, 2020
    Assignee: Lundbeck Pharmaceuticals Italy S.P.A.
    Inventors: Carla De Faveri, Mariano Stivanello
  • Publication number: 20200181167
    Abstract: The present invention relates to a method for the manufacture of 2-(3-(alkyl or alkenyl)morpholino)-ethan-1-ols by reduction of 8a-(alkyl and alkenyl)hexahydrooxazolo[2,3-c][1,4]oxazines encompassing a process for producing 2-(3-(4-propylheptyllmorpholino)ethan-1-ol with the INN name delmopinol. The invention also relates to 1-chloro-4-propylhept-3-ene, 1-iodo-4-propylhept-3-ene, 8a-(4-5 propylheptyl)hexahydrooxazolo[2,3-c] [1,4]oxazine, 8a-(4-propylhept-3-en-1-yl)hexahydrooxazo-lo[2,3-c][1,4]oxazine and 2-(3-(4-propylhept-3-en-1-yl)morpholino)ethan-1-ol which are intermediates in the delmopinol process.
    Type: Application
    Filed: February 14, 2020
    Publication date: June 11, 2020
    Applicant: Lundbeck Pharmaceuticals Italy S.p.A.
    Inventors: Carla De Faveri, Mariano Stivanello
  • Publication number: 20190375722
    Abstract: The present invention relates to a new process for producing 2-(3-(4-propylheptyl)morpholino)ethan-1-ol with the INN name Delmopinol. The invention also relates to three key intermediates 1-chloro-4-propylhept-3-ene, 1-iodo-4-propylhept-3-ene and 2-(3-(4-propylhept-3-en-1-yl)morpholino)ethan-1-ol.
    Type: Application
    Filed: December 20, 2017
    Publication date: December 12, 2019
    Inventors: Carla De Faveri, Mariano Stivanello
  • Publication number: 20190359632
    Abstract: The present invention relates to a method for the manufacture of 2-(3-(alkyl or alkenyl)morpholino)-ethan-1-ols by reduction of 8a-(alkyl and alkenyl)hexahydrooxazolo[2,3-c][1,4]oxazines encompassing a process for producing 2-(3-(4-propylheptyl)morpholino)ethan-1-ol with the INN name delmopinol. The invention also relates to 1-chloro-4-propylhept-3-ene, 1-iodo-4-propylhept-3-ene, 8a-(4-5 propylheptyl)hexahydrooxazolo[2,3-c][1,4]oxazine, 8a-(4-propylhept-3-en-1-yl)hexahydrooxazolo[2,3-c][1,4]oxazine and 2-(3-(4-propylhept-3-en-1-yl)morpholino)ethan-1-ol which are intermediates in the delmopinol process.
    Type: Application
    Filed: December 20, 2017
    Publication date: November 28, 2019
    Inventors: Carla De Faveri, Mariano Stivanello
  • Patent number: 10385020
    Abstract: Methods are provided for the synthesis of key intermediates for the synthesis of Argatroban monohydrate, ethyl (2R,4R)-1-[(2S)-2-amino-5-[[imino(nitroamino)methyl]amino]-1-oxopentyl]-4-methylpiperidine-2-carboxylate compounded with HCl. Such intermediates are also provided.
    Type: Grant
    Filed: May 11, 2018
    Date of Patent: August 20, 2019
    Assignee: LUNDBECK PHARMACEUTICALS ITALY S.P.A.
    Inventors: Mariano Stivanello, Florian Anton Martin Huber, Antonio Ricci
  • Publication number: 20180258041
    Abstract: Methods are provided for the synthesis of key intermediates for the synthesis of Argatroban monohydrate, ethyl (2R,4R)-1-[(2S)-2-amino-5-[[imino(nitroamino)methyl]amino]-1-oxopentyl]-4-methylpiperidine-2-carboxylate compounded with HCl. Such intermediates are also provided.
    Type: Application
    Filed: May 11, 2018
    Publication date: September 13, 2018
    Applicant: LUNDBECK PHARMACEUTICALS ITALY S.p.A.
    Inventors: Mariano Stivanello, Florian Anton Martin HUBER, Antonio RICCI
  • Patent number: 9994526
    Abstract: Methods are provided for the synthesis of key intermediates for the synthesis of Argatroban monohydrate, ethyl (2R,4R)-1-[(2S)-2-amino-5-[[imino(nitroamino)methyl]amino]-1-oxopentyl]-4-methylpiperidine-2-carboxylate compounded with HCl. Such intermediates are also provided.
    Type: Grant
    Filed: August 12, 2016
    Date of Patent: June 12, 2018
    Assignee: LUNDBECK PHARMACEUTICALS ITALY S.p.A.
    Inventors: Mariano Stivanello, Florian Anton Martin Huber, Antonio Ricci
  • Publication number: 20160347711
    Abstract: Methods are provided for the synthesis of key intermediates for the synthesis of Argatroban monohydrate, ethyl (2R,4R)-1-[(2S)-2-amino-5-[[imino(nitroamino)methyl]amino]-1-oxopentyl]-4-methylpiperidine-2-carboxylate compounded with HCl. Such intermediates are also provided.
    Type: Application
    Filed: August 12, 2016
    Publication date: December 1, 2016
    Applicant: LUNDBECK PHARMACEUTICALS ITALY S.p.A.
    Inventors: Mariano Stivanello, Florian Anton Martin HUBER, Antonio RICCI
  • Publication number: 20140296525
    Abstract: The present invention relates to an improved process for recovery of nalmefene hydrochloride [17-(cyclopropylmethyl)-4,5- alpha-epoxy-6-methylenemorphinan-3,14-diol hydrochloride] from an aqueous composition containing nalmefene and certain impurities.
    Type: Application
    Filed: December 6, 2012
    Publication date: October 2, 2014
    Inventors: Carla De Faveri, Mariano Stivanello
  • Patent number: 8841452
    Abstract: The present invention relates to an improved process for recovery of nalmefene hydrochloride[17-(cyclopropylmethyl)-4,5-alpha-epoxy-6-methylenemorphinan-3,14-diol hydrochloride] from an aqueous composition containing nalmefene and certain impurities.
    Type: Grant
    Filed: December 6, 2012
    Date of Patent: September 23, 2014
    Assignee: H. Lundbeck A/S
    Inventors: Carla De Faveri, Mariano Stivanello
  • Publication number: 20140155608
    Abstract: The present invention relates to a new process for producing naltrexone [17-(cyclopropylmethyl)-4,5?-epoxy-3,14-dihydroxy-morphinan-6-one] from noroxymorphone [4,5-?-epoxy-3,14-dihydroxy-morphinan-6-one] by alkylation with a cyclopropylmethyl halide.
    Type: Application
    Filed: May 2, 2013
    Publication date: June 5, 2014
    Inventors: Carla De Faveri, Mariano Stivanello, Florian Anton Martin Huber
  • Publication number: 20140088310
    Abstract: Methods are provided for the synthesis of key intermediates for the synthesis of Argatroban monohydrate, ethyl (2R,4R)-1-[(2S)-2-amino-5-[[imino(nitroamino)methyl]amino]-1-oxopentyl]-4-methylpiperidine-2-carboxylate compounded with HCl. Such intermediates are also provided.
    Type: Application
    Filed: March 26, 2012
    Publication date: March 27, 2014
    Applicant: LUNDBECK PHARMACEUTICALS ITALY S.P.A.
    Inventors: Mariano Stivanello, Florian Anton Martin Huber, Antonio Ricci
  • Patent number: 8580963
    Abstract: The present invention relates to an improved process for producing naltrexone[17-(cyclopropylmethyl)-4,5?-epoxy-3,14-dihydroxy-morphinan-6-one] from noroxymorphone[4,5-?-epoxy-3,14-dihydroxy-morphinan-6-one] by alkylation with a cyclopropylmethyl halide.
    Type: Grant
    Filed: November 2, 2011
    Date of Patent: November 12, 2013
    Assignee: H. Lundbeck A/S
    Inventors: Carla De Faveri, Florian Anton Martin Huber, Mariano Stivanello
  • Patent number: 8334381
    Abstract: It is the object of the present invention a process for the preparation of 4-methyl-N3-[4-(3-pyridinyl)-2-pyrimidinyl]-1,3-benzenediamine and analogues thereof, intermediates useful for the synthesis of Imatinib, or 4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide.
    Type: Grant
    Filed: May 20, 2010
    Date of Patent: December 18, 2012
    Assignee: F.I.S. Fabbrica Italiana Sintetici S.p.A.
    Inventors: Alessandro Falchi, Ennio Grendele, Riccardo Motterle, Mariano Stivanello
  • Publication number: 20120116085
    Abstract: The present invention relates to an improved process for producing naltrexone[17-(cyclopropylmethyl)-4,5?-epoxy-3,14-dihydroxy-morphinan-6-one] from noroxymorphone[4,5-?-epoxy-3,14-dihydroxy-morphinan-6-one] by alkylation with a cyclopropylmethyl halide.
    Type: Application
    Filed: November 2, 2011
    Publication date: May 10, 2012
    Applicant: H. Lundbeck A/S
    Inventors: Carla De Faveri, Florian Anton Martin Huber, Mariano Stivanello
  • Patent number: 8168787
    Abstract: A process for the preparation of 4-methyl-N3-[4-(3-pyridinyl)-2-pyrimidinyl]-1,3-benzenediamine and analogues thereof, intermediates useful for the synthesis of Imatinib, or 4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide.
    Type: Grant
    Filed: November 15, 2007
    Date of Patent: May 1, 2012
    Assignee: F.I.S. Fabbrica Italiana Sintetici S.p.A.
    Inventors: Alessandro Falchi, Ennio Grendele, Riccardo Motterle, Mariano Stivanello
  • Patent number: 7838704
    Abstract: The present invention relates to a synthetic method for terbinafine and analogues thereof using metal catalysts, preferably Ni(II) salts and/or complexes.
    Type: Grant
    Filed: March 4, 2005
    Date of Patent: November 23, 2010
    Assignee: F.I.S. Fabbrica Italiana Sintetici S.p.A.
    Inventors: Federico Della Negra, Cristiano Grandini, Mariano Stivanello