Patents by Inventor Marie Caroline Dieu-Nosjean

Marie Caroline Dieu-Nosjean has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NEW METHOD TO PRONOSTIC LUNG CANCER
    Publication number: 20240044901
    Abstract: The present invention relates to the field of prognostic of lung cancer. In this study, the inventors used extensive gene expression profiling and flow cytometry for an integrative analysis of the phenotypes of the B cells and CD4+ T cells from tumors and blood of NSCLC patients by TLS-B density. They showed that TIL B cells and TIL CD4+ T cells are more highly activated in tumors than in the periphery and that they express all the ligand/receptor pairs necessary for B/T interactions and two-way co-stimulation. Moreover, a high density of TLS-B cells is associated with higher frequencies of activated CD4+ T cells and lower frequencies of both immune checkpoint (ICP)-expressing CD4+ T cells and regulatory CD4+ T cells (Tregs) in the intratumor CD4+ T cell compartment. High densities of TLS-B cells together with low densities of FoxP3+ CD3+ Tregs in NSCLC tumors consistently identified the group of patients with the best clinical outcome.
    Type: Application
    Filed: February 8, 2022
    Publication date: February 8, 2024
    Inventors: Marie-Caroline DIEU-NOSJEAN, Claire GERMAIN, Scott Alan HAMMOND, Keith STEELE
  • Methods for predicting the survival time of patients suffering from a lung cancer
    Patent number: 11385231
    Abstract: The present invention relates to methods for predicting the survival time of patients suffering from a lung cancer.
    Type: Grant
    Filed: August 26, 2016
    Date of Patent: July 12, 2022
    Assignees: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE SCIENTIFIQUE), UNIVERSITE DE PARIS, SORBONNE UNIVERSITE, ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS (APHP)
    Inventors: Marie-Caroline Dieu-Nosjean, Wolf Herdman Fridman, Catherine Sautes-Fridman, Priyanka Devi
  • METHOD FOR THE PROGNOSIS OF SURVIVAL TIME OF A PATIENT SUFFERING FROM A SOLID CANCER
    Publication number: 20200041519
    Abstract: The present invention relates to an in vitro method for the prognosis of the survival time of a patient suffering from a solid cancer, comprising the quantification of the cell density of follicular B cells present in tumor-induced lymphoid structures from said patient, wherein a high density of follicular B cells indicates that the patient has a favorable prognosis and a low density of follicular B cells indicates that the patient has a poor prognosis.
    Type: Application
    Filed: September 17, 2019
    Publication date: February 6, 2020
    Inventors: Marie-Caroline Dieu-Nosjean, Wolf Herve Fridman, Romain Remark, Catherine Sautes-Fridman
  • METHODS FOR PREDICTING THE SURVIVAL TIME OF PATIENTS SUFFERING FROM A LUNG CANCER
    Publication number: 20180252720
    Abstract: The present invention relates to methods for predicting the survival time of patients suffering from a lung cancer.
    Type: Application
    Filed: August 26, 2016
    Publication date: September 6, 2018
    Inventors: Marie-Caroline DIEU-NOSJEAN, Wolf Herdman FRIDMAN, Catherine SAUTES-FRIDMAN, Priyanka DEVI
  • Method for the prognosis of survival time of a patient suffering from a solid cancer
    Patent number: 9851357
    Abstract: The present invention relates to an in vitro method for the prognosis of survival of a patient suffering from a solid cancer, comprising the quantification of the cell density of CD8+ cells and DC-LAMP+ dendritic cells present in a tumor tissue sample from said patient, wherein a high density of CD8+ cells and DC-LAMP+ dendritic cells indicates that the patient has a favorable prognosis, a high density of CD8+ cells and a low density of DC-LAMP+ dendritic cells indicates that the patient has a poor prognosis, and a low density of CD8+ cells and DC-LAMP+ dendritic cells indicates that the patient has the worst prognosis.
    Type: Grant
    Filed: July 11, 2014
    Date of Patent: December 26, 2017
    Assignees: INSERM (INSTITUTE NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, UNIVERSITE PARIS DESCARTES, UNIVERSITE PIERRE ET MARIE CURIE (PARIS6), ASSISTANCE PUBLIQUE HOPITAUX DE PARIS
    Inventors: Catherine Sautes-Fridman, Wolf-Herve Fridman, Marie-Caroline Dieu-Nosjean, Jeremy Goc
  • Method for the Prognosis of Survival Time of a Patient Suffering from a Solid Cancer
    Publication number: 20160146820
    Abstract: The present invention relates to an in vitro method for the prognosis of survival of a patient suffering from a solid cancer, comprising the quantification of the cell density of CD8+ cells and DC-LAMP+ dendritic cells present in a tumor tissue sample from said patient, wherein a high density of CD8+ cells and DC-LAMP+ dendritic cells indicates that the patient has a favorable prognosis, a high density of CD8+ cells and a low density of DC-LAMP+ dendritic cells indicates that the patient has a poor prognosis, and a low density of CD8+ cells and DC-LAMP+ dendritic cells indicates that the patient has the worst prognosis.
    Type: Application
    Filed: July 11, 2014
    Publication date: May 26, 2016
    Inventors: Catherine Sautes-Fridman, Wolf-Herve Fridman, Marie-Caroline Dieu-Nosjean, Jeremy Goc
  • METHOD FOR THE PROGNOSIS OF SURVIVAL TIME OF A PATIENT SUFFERING FROM A SOLID CANCER
    Publication number: 20150004253
    Abstract: The present invention relates to an in vitro method for the prognosis of the survival time of a patient suffering from a solid cancer, comprising the quantification of the cell density of follicular B cells present in tumor-induced lymphoid structures from said patient, wherein a high density of follicular B cells indicates that the patient has a favorable prognosis and a low density of follicular B cells indicates that the patient has a poor prognosis.
    Type: Application
    Filed: January 21, 2013
    Publication date: January 1, 2015
    Inventors: Marie-Caroline Dieu-Nosjean, Wolf Herve Fridman, Romain Remark, Catherine Sautes-Fridman
  • Chemokine uses; compositions; methods
    Publication number: 20040042998
    Abstract: Agonists or antagonists of MIP-3&agr;, and various methods of use in dermatological and related applications are provided. In particular, the method makes use of fact that the MIP-3&agr; chemokine is specifically capable of inducing migration of a skin cell subset.
    Type: Application
    Filed: August 19, 2003
    Publication date: March 4, 2004
    Inventors: Elizabeth R. Oldham, Bernhard Homey, Marie Caroline Dieu-Nosjean, Christophe Caux, Albert Zlotnik
  • Method for treating inflammatory conditions using an antibody to MIP-3&agr;
    Patent number: 6645491
    Abstract: Agonists or antagonists of MIP-3&agr;, and various methods of use in dermatological and related applications are provided. In particular, the method makes use of fact that the MIP-3&agr; chemokine is specifically capable of inducing migration of a skin cell subset.
    Type: Grant
    Filed: February 2, 2000
    Date of Patent: November 11, 2003
    Assignee: Schering Corporation
    Inventors: Elizabeth R. Oldham, Bernhard Homey, Marie Caroline Dieu-Nosjean, Christophe Caux, Albert Zlotnik