Patents by Inventor Marie J. Delaney
Marie J. Delaney has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9739714Abstract: A particle identification system includes: a cartridge for containing a sample with fluorescently labeled particles; illumination for illuminating a region within the cartridge to stimulate emission from particles; imager for generating wavelength-filtered electronic images of the emission within at least one measurement field of the region; and particle identifier for processing the electronic images to determine a superset of particles of interest, and fluorescently labeled particles within the superset based on properties of the particles in the at least one measurement field.Type: GrantFiled: March 15, 2013Date of Patent: August 22, 2017Assignee: MBio Diagnostics, Inc.Inventors: Kevin D. Moll, Marie J. Delaney, Kurt R. Vogel, Michael J. Lochhead, Jeffrey Ives, John S. Dunn, Keagan B. Rowley
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Publication number: 20170189906Abstract: A cartridge for detecting a target analyte in a sample includes (a) a capillary channel with a detection region configured for detection of the target analyte, (b) an inlet port configured to hold the sample before entering the capillary channel and including a dried reagents for rehydrating into the sample, the inlet port and the capillary channel being shaped in part by a common structure, and (c) a vent having a frangible seal configured to prevent flow of the sample into the capillary channel until the frangible seal is broken, the capillary channel being airtight between the inlet port and the vent.Type: ApplicationFiled: March 17, 2017Publication date: July 6, 2017Inventors: Kevin D. Moll, Marie J. Delaney, Kurt R. Vogel, Michael J. Lochhead, Jeffrey Ives, John S. Dunn, Keagan B. Rowley
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Patent number: 9658222Abstract: A cartridge for processing a sample includes (a) a planar waveguide with upper and lower planar surfaces defining an optical axis therebetween, wherein the upper planar surface has a plurality of capture molecules bound thereto, (b) a lens portion, coupled to the planar waveguide, for focusing and refracting a light beam propagating parallel to, but offset from, the optical axis such that the light beam couples into the planar waveguide and propagates therein along the optical axis at a non-zero, internal propagation angle ? relative to the upper planar surface, and (c) a sample chamber for positioning the sample in contact with the plurality of capture molecules such that a target analyte of the sample is detectable through (i) an assay involving the target analyte and the capture molecules and (ii) evanescent illumination of the assay using the light beam within the planar waveguide.Type: GrantFiled: December 14, 2015Date of Patent: May 23, 2017Assignee: Mbio Diagnostics, Inc.Inventors: Kevin D. Moll, Kurt R. Vogel, Marie J. Delaney, Michael J. Lochhead, Christopher J. Myatt
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Publication number: 20160187333Abstract: A cartridge for processing a sample includes (a) a planar waveguide with upper and lower planar surfaces defining an optical axis therebetween, wherein the upper planar surface has a plurality of capture molecules bound thereto, (b) a lens portion, coupled to the planar waveguide, for focusing and refracting a light beam propagating parallel to, but offset from, the optical axis such that the light beam couples into the planar waveguide and propagates therein along the optical axis at a non-zero, internal propagation angle ? relative to the upper planar surface, and (c) a sample chamber for positioning the sample in contact with the plurality of capture molecules such that a target analyte of the sample is detectable through (i) an assay involving the target analyte and the capture molecules and (ii) evanescent illumination of the assay using the light beam within the planar waveguide.Type: ApplicationFiled: December 14, 2015Publication date: June 30, 2016Inventors: Kevin D. Moll, Kurt R. Vogel, Marie J. Delaney, Michael J. Lochhead, Christopher J. Myatt
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Patent number: 9212995Abstract: A rapid diagnostic system that delivers a panel of serologic assay results using a small amount of blood, serum, or plasma is described. The system includes a disposable cartridge, including an integral lens portion coupled to a planar waveguide, and a reader instrument, based on planar waveguide imaging technology. The cartridge incorporates a microarray of recombinant antigens and antibody controls in a fluidic channel, providing multiple parallel fluorescence assay results for a single sample.Type: GrantFiled: March 15, 2013Date of Patent: December 15, 2015Assignee: MBio Diagnostics, Inc.Inventors: Kevin D. Moll, Kurt R. Vogel, Marie J. Delaney, Michael J. Lochhead, Christopher J. Myatt, Keagan B. Rowley
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Publication number: 20140120556Abstract: A particle identification system includes: a cartridge for containing a sample with fluorescently labeled particles; illumination for illuminating a region within the cartridge to stimulate emission from particles; imager for generating wavelength-filtered electronic images of the emission within at least one measurement field of the region; and particle identifier for processing the electronic images to determine a superset of particles of interest, and fluorescently labeled particles within the superset based on properties of the particles in the at least one measurement field.Type: ApplicationFiled: March 15, 2013Publication date: May 1, 2014Applicant: MBIO DIAGNOSTICS, INC.Inventors: Kevin D. Moll, Marie J. Delaney, Kurt R. Vogel, Michael J. Lochhead, Jeffrey Ives, John S. Dunn, Keagan B. Rowley
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Patent number: 8606066Abstract: An apparatus for illuminating a sample includes a planar waveguide. The planar waveguide includes a first substrate, including a first outer surface and a first inner surface, and a second substrate, including a second outer surface and a second inner surface. The first and second inner surfaces of the first and second substrates, respectively, are spaced apart from each other and partly define a volume for confining the sample therein. The apparatus also includes a light source for providing light directed toward the planar waveguide, such that the light is optically coupled to and contained within the planar waveguide between the outer surfaces of the first and second substrates, while illuminating at least a portion of the sample confined within the volume.Type: GrantFiled: December 4, 2012Date of Patent: December 10, 2013Assignee: MBio Diagnostics, Inc.Inventors: Marie J. Delaney, Kevin D. Moll
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Patent number: 8586347Abstract: A rapid diagnostic system that delivers a panel of serologic assay results using a small amount of blood, serum, or plasma is described. The system includes a disposable cartridge and a reader instrument, based on planar waveguide imaging technology. The cartridge incorporates a microarray of recombinant antigens and antibody controls in a fluidic channel, providing multiple parallel fluorescence assay results for a single sample.Type: GrantFiled: September 15, 2011Date of Patent: November 19, 2013Assignee: MBio Diagnostics, Inc.Inventors: Michael J. Lochhead, Jeffrey Ives, Kathryn Todorof, Charles Greef, Marie J. Delaney, Kevin D. Moll, Kurt R. Vogel, Keagan B. Rowley, Evelyn S. Woodruff, John S. Dunn, Christopher J. Myatt, Daniel T. Nieuwlandt
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Patent number: 8331751Abstract: An apparatus for illuminating a sample includes a planar waveguide. The planar waveguide includes a first substrate, including a first outer surface and a first inner surface, and a second substrate, including a second outer surface and a second inner surface. The first and second inner surfaces of the first and second substrates, respectively, are spaced apart from each other and partly define a volume for confining the sample therein. The apparatus also includes a light source for providing light directed toward the planar waveguide, such that the light is optically coupled to and contained within the planar waveguide between the outer surfaces of the first and second substrates, while illuminating at least a portion of the sample confined within the volume.Type: GrantFiled: November 9, 2010Date of Patent: December 11, 2012Assignee: mBio Diagnositcs, Inc.Inventors: Marie J. Delaney, Kevin D. Moll
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Patent number: 8300993Abstract: A sample can be illuminated for analysis using apparatus including a light source, a planar waveguide, and a refractive volume. The light source provides light along a propagation vector. The planar waveguide is oriented such that the propagation vector is perpendicular to the normal vector of the planar waveguide and offset from the planar waveguide in a direction parallel to the normal vector of the planar waveguide. The refractive volume is positioned proximate to the planar waveguide and can optically coupling light provided by the light source to the planar waveguide.Type: GrantFiled: November 12, 2009Date of Patent: October 30, 2012Assignee: MBio Diagnostics, Inc.Inventors: Kevin D. Moll, Kurt R. Vogel, Marie J. Delaney, Michael J. Lochhead, Christopher J. Myatt
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Publication number: 20120088230Abstract: A system for enumeration of objects such as cells in a sample is disclosed. The system uses a low-cost cartridge and a reader instrument, based on planar waveguide imaging technology. Cells of a blood sample may be stained with fluorescence-tagged antibodies and are loaded onto the cartridge where the differentially labeled cells may be distinguished and quantified.Type: ApplicationFiled: October 11, 2011Publication date: April 12, 2012Inventors: Monique Givens, Jeffrey Ives, Michael J. Lochhead, Marie J. Delaney, Kevin D. Moll, Keagan B. Rowley, Kurt R. Vogel, Christopher J. Myatt
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Publication number: 20120071342Abstract: A rapid diagnostic system that delivers a panel of serologic assay results using a small amount of blood, serum, or plasma is described. The system includes a disposable cartridge and a reader instrument, based on planar waveguide imaging technology. The cartridge incorporates a microarray of recombinant antigens and antibody controls in a fluidic channel, providing multiple parallel fluorescence assay results for a single sample.Type: ApplicationFiled: September 15, 2011Publication date: March 22, 2012Applicant: MBIO DIAGNOSTICS, INC.Inventors: Michael J. Lochhead, Jeffrey Ives, Kathryn Todorof, Charles Greef, Marie J. Delaney, Kevin D. Moll, Kurt R. Vogel, Keagan B. Rowley, Evelyn S. Woodruff, John S. Dunn, Christopher J. Myatt, Daniel T. Nieuwlandt
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Publication number: 20110049388Abstract: An apparatus for illuminating a sample includes a planar waveguide. The planar waveguide includes a first substrate, including a first outer surface and a first inner surface, and a second substrate, including a second outer surface and a second inner surface. The first and second inner surfaces of the first and second substrates, respectively, are spaced apart from each other and partly define a volume for confining the sample therein. The apparatus also includes a light source for providing light directed toward the planar waveguide, such that the light is optically coupled to and contained within the planar waveguide between the outer surfaces of the first and second substrates, while illuminating at least a portion of the sample confined within the volume.Type: ApplicationFiled: November 9, 2010Publication date: March 3, 2011Applicant: mBio Diagnostics, Inc.Inventors: Marie J. Delaney, Kevin D. Moll
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Publication number: 20110012026Abstract: An apparatus for illuminating a sample includes a planar waveguide. The planar waveguide includes a first substrate, including a first outer surface and a first inner surface, and a second substrate, including a second outer surface and a second inner surface. The first and second inner surfaces of the first and second substrates, respectively, are spaced apart from each other and partly define a volume for confining the sample therein. The apparatus also includes a light source for providing light directed toward the planar waveguide, such that the light is optically coupled to and contained within the planar waveguide between the outer surfaces of the first and second substrates, while illuminating at least a portion of the sample confined within the volume.Type: ApplicationFiled: September 16, 2010Publication date: January 20, 2011Applicant: MBIO DIAGNOSTICS, INC.Inventors: Kevin D. Moll, Kurt R. Vogel, Marie J. Delaney, Michael J. Lochhead, Christopher J. Myatt
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Publication number: 20100220318Abstract: A sample can be illuminated for analysis using apparatus including a light source, a planar waveguide, and a refractive volume. The light source provides light along a propagation vector. The planar waveguide is oriented such that the propagation vector is perpendicular to the normal vector of the planar waveguide and offset from the planar waveguide in a direction parallel to the normal vector of the planar waveguide. The refractive volume is positioned proximate to the planar waveguide and can optically coupling light provided by the light source to the planar waveguide.Type: ApplicationFiled: November 12, 2009Publication date: September 2, 2010Inventors: Kevin D. Moll, Kurt R. Vogel, Marie J. Delaney, Michael J. Lochhead, Christopher I. Myatt