Abstract: Disclosed herein are compositions and methods for treating uterine fibroids in vivo, and methods of reducing symptoms associated with uterine fibroids, including pain, bleeding and infertility. The disclosed compositions comprise collagenase in an amount effective to cause shrinkage and/or reduce stiffness of uterine fibroids.

Abstract: Disclosed is a novel means which makes it possible to steadily mass-produce knockout individuals even in large animals. The method of the present invention is a method for producing a non-human large mammal or fish (non-human animal) that produces gametes originating in a different individual, and comprises transplanting at least one pluripotent cell derived from a second non-human animal into an embryo derived from a first non-human animal, said embryo being at a cleavage stage and having a genome in which a function of nanos3 gene is inhibited, to prepare a chimeric embryo, and allowing said chimeric embryo to develop into an individual.

Abstract: A seat system includes a seat, a controller, and a terminal. The seat includes a seat body, and a plurality of sensors configured to acquire information for use in detecting a motion of a user seated on the seat body. The controller is configured to acquire the information from the sensors. The terminal comprises a screen. The controller is configured to cause an object operated by the user to move based on the information acquired from the sensors, and to cause a movable object on the screen to move according to a motion of the object operated by the user.

Abstract: The invention relates to compositions and methods for treating uterine fibroids in vivo, wherein a uterine fibroid treatment agent comprising collagenase in an amount effective to cause shrinkage and/or reduce stiffness of uterine fibroids is injected or inserted into the uterine fibroid. The invention also relates to methods of reducing symptoms associated with uterine fibroids, including pain, bleeding and infertility.

Abstract: Disclosed is a novel means which makes it possible to steadily mass-produce knockout individuals even in large animals. The method of the present invention is a method for producing a non-human large mammal or fish (non-human animal) that produces gametes originating in a different individual, and comprises transplanting at least one pluripotent cell derived from a second non-human animal into an embryo derived from a first non-human animal, said embryo being at a cleavage stage and having a genome in which a function of nanos3 gene is inhibited, to prepare a chimeric embryo, and allowing said chimeric embryo to develop into an individual. When a pluripotent cell having a genome in which a desired gene is knocked out is used as the pluripotent cell derived from the second non-human animal, the first non-human animal capable of producing germ cells in which the desired gene is knocked out is obtained, and therefore knockout non-human animals can easily be mass-produced by mating such non-human animals.