Patents by Inventor Marinella G. Callow

Marinella G. Callow has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PHOSPHOSPECIFIC PAK ANTIBODIES AND DIAGNOSTIC KITS
    Publication number: 20120045775
    Abstract: The present invention relates to the use of phosphorylated p21-activated protein kinases (PAK), especially PAK4, as biomarkers of tumorogenesis. The present invention contemplates the use of phosphospecific antibodies for detecting phosphorylated PAK from mammalian biopsies, as well as screening assays for identifying compounds that modulate PAK activity. Also contemplated is a method for determining a subset of a given population that is amenable to treatment with a compound that modulates PAK activity.
    Type: Application
    Filed: August 18, 2011
    Publication date: February 23, 2012
    Inventors: Tod R. SMEAL, Marinella G. CALLOW, Bahija JALLAL
  • GEF-H1b: BIOMARKERS, COMPLEXES, ASSAYS AND THERAPEUTIC USES THEREOF
    Publication number: 20110159532
    Abstract: The present invention relates to diagnosing abnormal cell proliferation in biological samples and screening for drugs which inhibit, reduce or abolish cell growth, especially tumorigenic cell growth, by detecting a phosphovariant isoform of a guanine nucleotide exchange factor biomarker, such as the novel GEF-H1S.
    Type: Application
    Filed: November 30, 2010
    Publication date: June 30, 2011
    Applicant: SUGEN, INC.
    Inventors: Tod R. Smeal, Marinella G. Callow, Bahija Jallal, Sergey Zozulya, Mikhail L. Gishizky
  • GEF-H1b: biomarkers, complexes, assays and therapeutic uses thereof
    Patent number: 7871786
    Abstract: The present invention relates to diagnosing abnormal cell proliferation in biological samples and screening for drugs which inhibit, reduce or abolish cell growth, especially tumorigenic cell growth, by detecting a phosphovariant isoform of a guanine nucleotide exchange factor biomarker, such as the novel GEF-H1S.
    Type: Grant
    Filed: September 11, 2008
    Date of Patent: January 18, 2011
    Assignee: Sugen, Inc.
    Inventors: Tod R. Smeal, Marinella G. Callow, Bahija Jallal, Sergey Zozulya, Mikhail L. Gishizky
  • Phosphospecific PAK antibodies and diagnostic kits
    Publication number: 20090215063
    Abstract: The present invention relates to the use of phosphorylated p21-activated protein kinases (PAK), especially PAK4, as biomarkers of tumorogenesis. The present invention contemplates the use of phosphospecific antibodies for detecting phosphorylated PAK from mammalian biopsies, as well as screening assays for identifying compounds that modulate PAK activity. Also contemplated is a method for determining a subset of a given population that is amenable to treatment with a compound that modulates PAK activity.
    Type: Application
    Filed: February 11, 2009
    Publication date: August 27, 2009
    Inventors: TOD R. SMEAL, MARINELLA G. CALLOW, BAHIJA JALLAL
  • GEF-H1b: biomarkers, complexes, assays and therapeutic uses thereof
    Publication number: 20090130695
    Abstract: The present invention relates to diagnosing abnormal cell proliferation in biological samples and screening for drugs which inhibit, reduce or abolish cell growth, especially tumorigenic cell growth, by detecting a phosphovariant isoform of a guanine nucleotide exchange factor biomarker, such as the novel GEF-H1S.
    Type: Application
    Filed: September 11, 2008
    Publication date: May 21, 2009
    Inventors: Tod R. Smeal, Marinella G. Callow, Bahija Jallal, Sergey Zozulya, Mikhail L. Gishizky
  • GEF-H1b: biomarkers, complexes assays and therapeutic uses thereof
    Patent number: 7439329
    Abstract: The present invention relates to diagnosing abnormal cell proliferation in biological samples and screening for drugs which inhibit, reduce or abolish cell growth, especially tumorigenic cell growth, by detecting a phosphovariant isoform of a guanine nucleotide exchange factor biomarker, such as the novel GEF-H1S.
    Type: Grant
    Filed: July 2, 2003
    Date of Patent: October 21, 2008
    Assignee: Sugen, Inc.
    Inventors: Tod R. Smeal, Marinella G. Callow, Bahija Jallal, Sergey Zozulya, Mikhail L. Gishizky
  • GEF-H1b: biomarkers, complexes assays and therapeutic uses thereof
    Publication number: 20040091907
    Abstract: The present invention relates to diagnosing abnormal cell proliferation in biological samples and screening for drugs which inhibit, reduce or abolish cell growth, especially tumorigenic cell growth, by detecting a phosphovariant isoform of a guanine nucleotide exchange factor biomarker, such as the novel GEF-H1S.
    Type: Application
    Filed: July 2, 2003
    Publication date: May 13, 2004
    Applicant: Sugen, Inc.
    Inventors: Tod R. Smeal, Marinella G. Callow, Bahija Jallal, Sergey Zozulya, Mikhail L. Gishizky