Abstract: The disclosure relates to tube with a tube head (4) and a container (5) made of resilient material, wherein the tube head (4) is connected to the container (5), wherein the tube head (4) comprises a female Luer lock fitting (7) with a flow passage (17), the female Luer lock fitting (7) being designed for sealingly receiving a male Luer lock fitting (9) of a syringe (2), wherein a tamper-evident closure (11, 12, 13, 14) is arranged at the inner surface of the female Luer lock fitting (7) such that it closes the flow passage (17) in a closed state of the tube (1).

Abstract: The invention relates to a tip cap assembly for closing a distal opening of a receptacle like a syringe body or a tube in a sealed manner, and to a method for producing the tip cap. A cap assembly according to the invention comprises a frangible tip of a receptacle, preferably a pre-filled receptacle. An upper portion of the tip closes the receptacle respectively a lower tip portion comprising a passage as known from the state of the art. Hence, the receptacle is reliably sealed to prevent contamination or loss of the medication. Compared with the state of the art, a receptacle has a more effectively sealed tip. It is necessary to break the upper tip portion away in order to open the receptacle. A cap element protects the tip on one side. On the other side, unscrewing the cap breaks the upper portion away without hurting a person.

Abstract: The invention relates to a one-way valve (1; 1?) for discharge regulation of a tube, the one-way valve (1; 1?) comprising a sealing means (9) and a ring support (8), with the sealing means (9) being at least partially inserted in the ring support (8), wherein the sealing means (9) comprises a sealing element (11) and a support element (12) that has at least one opening (10), wherein the sealing element (11) is connected to the support element (12) by anchoring means (13) and rests on the ring support (12) in a closed state of the one-way valve (1; 1?) thereby covering the at least one opening (10), and wherein the sealing element (11) is of lower bending stiffness than the support element (12) and the ring support (8). The invention furthermore relates to a tube with a tube head (2; 2?) and a container (6), wherein such a one-way valve (1; 1?) is inserted in the neck (4) of the tube head (2; 2?). Moreover the invention relates to a method for manufacturing such a one-way valve (1; 1?).

Abstract: The disclosure relates to tube with a tube head (4) and a container (5) made of resilient material, wherein the tube head (4) is connected to the container (5), wherein the tube head (4) comprises a female Luer lock fitting (7) with a flow passage (17), the female Luer lock fitting (7) being designed for sealingly receiving a male Luer lock fitting (9) of a syringe (2), wherein a tamper-evident closure (11; 12, 13, 14) is arranged at the inner surface of the female Luer lock fitting (7) such that it closes the flow passage (17) in a closed state of the tube (1).

Abstract: The invention relates to a one-way valve (1; 1?) for discharge regulation of a tube, the one-way valve (1; 1?) comprising a sealing means (9) and a ring support (8), with the sealing means (9) being at least partially inserted in the ring support (8), wherein the sealing means (9) comprises a sealing element (11) and a support element (12) that has at least one opening (10), wherein the sealing element (11) is connected to the support element (12) by anchoring means (13) and rests on the ring support (12) in a closed state of the one-way valve (1; 1?) thereby covering the at least one opening (10), and wherein the sealing element (11) is of lower bending stiffness than the support element (12) and the ring support (8). The invention furthermore relates to a tube with a tube head (2; 2?) and a container (6), wherein such a one-way valve (1; 1?) is inserted in the neck (4) of the tube head (2; 2?). Moreover the invention relates to a method for manufacturing such a one-way valve (1; 1?).

Abstract: The invention relates to a tip cap assembly for closing a distal opening of a receptacle like a syringe body or a tube in a sealed manner, and to a method for producing the tip cap. A cap assembly according to the invention comprises a frangible tip of a receptacle, preferably a pre-filled receptacle. An upper portion of the tip closes the receptacle respectively a lower tip portion comprising a passage as known from the state of the art. Hence, the receptacle is reliably sealed to prevent contamination or loss of the medication. Compared with the state of the art, a receptacle has a more effectively sealed tip. It is necessary to break the upper tip portion away in order to open the receptacle. A cap element protects the tip on one side. On the other side, unscrewing the cap breaks the upper portion away without hurting a person.