Abstract: A drape for use in surgical procedures having a base sheet of a liquid-repellent material and including a generally U-shaped fenestration with a layer of adhesive surrounding the fenestration and providing for varying the dimensions of the fenestration. The adhesive is protected by a plurality of cover strips which permit the drape to be applied in a folded condition to the patient and unfolded with reduced danger of contamination. In a preferred embodiment the drape also includes a foam-film laminate layer on the top surface thereof around the fenestration for placement of instruments, increased protection against liquid strike-through, reduced glare, and controlled absorbency. In use, the drape of the invention may be combined with other drapes, and an application is described including a stocking and a bar sheet for complete protection in complicated procedures such as knee or hip surgery. An improved method of folding the drape of the invention for increased safety and convenience is also described.