Patents by Inventor Mark A. Guadliana

Mark A. Guadliana has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6372781
    Abstract: Spirolaxine, the compound of formula (I) wherein R is H, and the novel compounds of formula (I) wherein R is (C1-C5) alkyl or CH3(CH2)nCO and n is 1, 2, 3 or 4 are useful in treating gastroduodenal diseases such as gastric ulcers, duodenal ulcers and gastric cancer caused by Helicobacter pylori. Spirolaxine and spirolaxine methyl ether are isolated from the fermentation of Sporotrichum pruinosum ATCC 74278. Spirolaxine and the compounds of formula (I) are also useful in combination with H2 antagonist, colloidal bismuth subcitrate and other antibiotics.
    Type: Grant
    Filed: June 7, 2000
    Date of Patent: April 16, 2002
    Assignee: Pfizer Inc.
    Inventors: Mark A. Guadliana, Liang H. Huang, Takushi Kaneko, Paul C. Watts
  • Patent number: 6174710
    Abstract: Spirolaxine, the compound of formula (I) wherein R is H, and the novel compounds of formula (I) wherein R is (C1-C6)alkyl or CH3(CH2)nCO and n is 1, 2, 3 or 4 are useful in treating gastroduodenal diseases such as gastric ulcers, duodenal ulcers and gastric cancer caused by Helicobacter pylori. Spirolaxine and spirolaxine methyl ether are isolated from the fermentation of Sporotrichum pruinosum ATCC 74278. Spirolaxine and the compounds of formula (I) are also useful in combination with H2 antagonist colloidal bismuth subcitrate and other antibiotics.
    Type: Grant
    Filed: January 16, 1997
    Date of Patent: January 16, 2001
    Assignee: Pfizer Inc.
    Inventors: Mark A. Guadliana, Liang H. Huang, Takushi Kaneko, Paul C. Watts
  • Patent number: 6074855
    Abstract: Processes for preparing spirolaxine and spirolaxine methyl ether, the compounds of formulas (I) and (II) respectively, ##STR1## comprising fermenting fungi selected from the group consisting of Sporotrichum pruinosum FD 29585, ATCC 74327; Sporotrichum pruinosum FD 29454, ATCC 74329; Sporotrichun pruinosum FD 29586, ATCC 74328; and Phanerochaete chrysosporiun LN 3576, ATCC 74326. This invention also relates to a process for preparing spirolaxine comprising fermenting Sporotrichum pruinosum FD 29458, ATCC 74330.
    Type: Grant
    Filed: August 14, 1997
    Date of Patent: June 13, 2000
    Assignee: Pfizer Inc.
    Inventors: Mark A. Guadliana, Liang H. Huang, Takushi Kaneko
  • Patent number: 5849730
    Abstract: A compound of the formula (IV) ##STR1## and a process for preparing the compound of formula (IV). Also disclosed is a process for preparing C-16-demethylrapamycin and C-39-demethylrapamycin. The process of this invention comprises fermenting Actinoplanes sp. ATCC 63771 in the presence of rapamycin and isolating the products produced thereby.
    Type: Grant
    Filed: January 16, 1997
    Date of Patent: December 15, 1998
    Assignee: Pfizer Inc.
    Inventors: Mark A. Guadliana, Susan J. Truesdell
  • Patent number: 5494820
    Abstract: A compound of the formula ##STR1## is a novel immunosuppressant agent prepared by fermenting Steptomyces braeaensis subsp. pulcherrimus, ATCC 55150, or another compound of the formula I producing strain and extracting the compound of the formula I from the fermentation medium. The compound is useful in treating transplant rejection and autoimmune diseases.
    Type: Grant
    Filed: January 24, 1994
    Date of Patent: February 27, 1996
    Assignee: Pfizer Inc.
    Inventors: Walter P. Cullen, Mark A. Guadliana, Liang H. Huang, Keiji Kaneda, Nakao Kojima, Gloria Kostek, Satoshi Nishiyama, Yuji Yamauchi, Yasuhiro Kojima
  • Patent number: 4382085
    Abstract: 4"-Epi erythromycin A and 9-dihydro-4"-epi erythromycin A and derivatives thereof as useful antibacterial agents.
    Type: Grant
    Filed: March 1, 1982
    Date of Patent: May 3, 1983
    Assignee: Pfizer Inc.
    Inventors: Frank C. Sciavolino, Mark A. Guadliana