Abstract: Microsclerotia of entomopathogenic fungi, including Metarhizium species, Beauveria species, and Lecanicillium species, may be produced. These microsclerotia are effective for the control of a wide variety of insect pests, particularly soil-dwelling insect pests.

Abstract: Systems, methods, and computer-readable media are provided to assist users to locate content of interest based on viewer ratings. First information enabling unique identification of a first user may be processed. Indications of ratings of television programming may be processed, the indications being received from a first media device associated with the first user. Ratings information associated with the first user may be retained in repositories, the ratings information being based on the indications. The first user may be matched to a category that represents a classification of a set of viewers and/or of a set of content based on a set of attributes. Descriptive content indicative of the first user and/or content rated by the first user may be selected and may be transmitted via the network to a second media device associated with a second user.

Abstract: The invention relates to a method and system that implements a payment initialization input that receives an electronic payment; the payment initialization input generates a payment context with an execution plan; a payments topology comprising a stage router, coupled to the payment initialization input and further in communication with a transform-to-external component and de-duplication component; and the stage router routes the payment context in accordance with the execution plan to a plurality of stages, the plurality of stages comprising a validation stage, an enrichment stage, a controls stage and a clearing stage where after each stage, the payment context is routed back to the stage router before being routed to a subsequent stage.

Abstract: The invention relates to compounds comprising a substituted pyrrolo-, indolino- or tetrahydroisoquinoline-benzodiazepines alkylating moiety linked via the A-ring to aromatic groups of formula (Ia), and to pharmaceutically acceptable salts thereof, which are useful as medicaments, in particular as anti-proliferative agents.

Abstract: Compositions and methods for treatment of conditions affecting skin and/or mucosal surfaces of a subject that make use of an imidazoquinoline compound and a retinoid agent are described.

Abstract: ACD Mesh Network: A method, computer program product, and computing system for maintaining an automated clinical documentation mesh network that includes a plurality of end point devices; receiving content within the automated clinical documentation mesh network; processing the content to identify a routing rule for the content; and routing the content to one or more endpoint devices based, at least in part, upon the routing rule.

Abstract: The invention relates to pyrridinobenzodiazepines (PDDs) comprising three fused 6-7- 6-membered rings and to benzopyrridodiazecines (BPDs) comprising three fused 6-8- 6-membered rings and, in particular, to PDD or BPD dimers linked together or PDD and BPD monomers linked to aromatic groups, and pharmaceutically acceptable salts thereof, which are useful as medicaments, such as anti-proliferative agents.

Abstract: A medical accessory holder (10) is provided, for use during reprocessing and/or conditioning of medical equipment. The holder comprises a planar base portion (11). At least one recess (12, 13, 14) is provided in the planar base portion, and is adapted to receive a medical accessory (15, 16, 17) firmly engaged therein. The holder (10) further comprises retaining means (22) associated with the base portion (11) and adapted to engage therewith. Once engaged, the retaining means (22) cannot be disengaged, and the medical accessory (15, 16, 17) cannot be removed from the recess (12, 13, 14), without breaking the retaining means (22), thereby rendering the holder suitable only for single use. Attachment means (26) are further provided to enable the holder (10) to be secured to an article of medical equipment with which the medical accessory (15, 16, 17) is associated, during reprocessing thereof.

Abstract: Novel tools and techniques are provided for implementing digital currency, and, more particularly, to methods, systems, and apparatuses for implementing digital currency tied to physical precious metals. In various embodiments, a computing system might receive a request from a user for a digital currency transaction; might validate a blockchain containing a hash of a first block, the first block comprising a first identifier associated with a first piece of a precious metal; might add a block to the blockchain, the added block comprising a second identifier associated with the user and a timestamp of the transaction; might encrypt the added block with a cryptographic hash; and might update the blockchain across a plurality of digital currency data stores. In some cases, the computing system might generate a first block of a blockchain by adding received identifier associated with the first piece of the precious metal.

Abstract: The present disclosure relates generally to generation of a recombinant enzyme with cyclization activity and its use for generating cyclic peptides as well as linear peptide conjugates.

Abstract: A screen is provided. The screen includes: a substrate; an adhesive affixed to the substrate; and a mixture of reflective beads and transparent beads affixed by the adhesive to the substrate.

Abstract: Compositions and methods for treatment of conditions affecting skin and/or mucosal surfaces of a subject that make use of an imidazoquinoline compound and a retinoid agent are described.

Abstract: The invention relates to compound of formula (I): A-X1-L-X2—B?? (I) and salts, solvates and tautomers thereof, which are useful as medicaments, in particular as anti-proliferative agents and for use as a drug in an antibody-drug conjugate; wherein A is a group selected from: X1 and X2 are independently selected from O, S, NR28, CR28R29, CR28R29O, C(?O), C(?O)NR28, NR28C(?O), C(O)—RA—C(O)—NH, C(O)—RA—NH—C(O), C(O)—NH—RA—C(O), NH—C(O)—RA—C(O), NH—C(O)—RA—C(O)—NH, NH—C(O)—RA—NH—C(O), C(O)—NH—RA—NH—C(O), C(O)—NH—RA—C(O)—NH, O—C(O) and C(O)—O or is absent; L is selected from an amino acid, a peptide chain having from 2 to 12 amino acids, a paraformaldehyde chain —(OCH2)1-24—, a polyethylene glycol chain —(OCH2CH2)1-12— and —(CH2)m—Y6—(CH2)n— wherein Y6 is selected from —(CH2)z— and a group (L1) a group (L1) that is selected from arylene, monocyclic heteroarylene, monocyclic cycloalkylene, monocyclic cycloalkenylene and monocyclic heterocyclylene groups optionally substituted with up to three optional subst

Abstract: The invention relates to pyrridinobenzodiazepines (PDDs) comprising three fused 6-7-6-membered rings linked to aromatic groups, and pharmaceutically acceptable salts thereof, which are useful as medicaments, such as anti-proliferative agents.

Abstract: The invention relates to pyrridinobenzodiazepines (PDDs) comprising three fused 6-7-6-membered rings linked to aromatic groups, and pharmaceutically acceptable salts thereof, which are useful as medicaments, such as anti-proliferative agents.

Abstract: Techniques for providing access control in environments that may become disconnected, as a whole, from other networks (e.g., on-board a vehicle) may include locally storing access control information within the dis-connectable environment, and locally providing discovery and authentication/authorization services. Local services and/or applications may be registered and authenticated and client applications may be authenticated and/or authorized to one or more locally provided services and/or applications even when the environment is in a disconnected state. Local access control information may be synchronized with source access control information stored externally to the environment (e.g., on the ground).

Abstract: The invention relates to pyrrolo[2,1-c][1,4]benzodiazepines (PBDs) of formula (I) and in particular to PBD dimers linked through the C1 position, and PBD monomers linked through the C1 position to aromatic groups, and pharmaceutically acceptable salts thereof, which are useful as medicaments, in particular as anti-proliferative agents.

Abstract: The invention relates to pyrridinobenzodiazepines (PDDs) comprising three fused 6-7-6-membered rings and to benzopyrridodiazecines (BPDs) comprising three fused 6-8-6-membered rings and, in particular, to PDD or BPD dimers linked together or PDD and BPD monomers linked to aromatic groups, and pharmaceutically acceptable salts thereof, which are useful as medicaments, such as anti-proliferative agents.

Abstract: Systems, methods, and computer-readable media are provided to assist users to locate content of interest based on viewer ratings. First information enabling unique identification of a first user may be processed. Indications of ratings of television programming may be processed, the indications being received from a first media device associated with the first user. Ratings information associated with the first user may be retained in repositories, the ratings information being based on the indications. The first user may be matched to a category that represents a classification of a set of viewers and/or of a set of content based on a set of attributes. Descriptive content indicative of the first user and/or content rated by the first user may be selected and may be transmitted via the network to a second media device associated with a second user.

Abstract: Neutralizing PCSK9 variants that interact with low density lipoprotein receptor (LDLR) are described. Methods and compositions for treating disorders by administering a pharmaceutically effective amount of a neutralizing PCSK9 variant are described.