Abstract: Provided herein are antibody-drug conjugates that bind EGFR, in particular human EGFR, their methods of making, and their uses to treat patients having cancer.

Abstract: Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.

Abstract: A system for identifying a user of a controller includes a controller having one or more sensors configured to detect interaction with the controller by the user and a transmitter configured to transmit telemetry data based on outputs of one or more of the sensors, a user profile unit configured to obtain user profile data for one or more user profiles, where each user profile corresponds to a respective user and the user profile data for a user profile comprises data indicative of one or more characteristic interactions by the user with the controller, and a user profile selection unit configured to select a user profile from the one or more user profiles in dependence upon a degree of match between one or more properties of the transmitted telemetry data and the data of each respective user profile, and configured to modify an output of the system responsive to the selection.

Abstract: A managing information handling system may dynamically update a user interface and transmit the updated user interface to a client information handling system. The user interface may be dynamically updated when an update to a user interface configuration is detected by the managing information handling system. The dynamically updated user interface may include dependency functionality so that when a master policy indicator is adjusted multiple policies that depend from the master policy are updated.

Abstract: Active comfort controlled bedding systems and processes of operating the bedding systems generally include a variable firmness control. The active comfort controlled bedding system can include a control unit in electrical communication with a signal generating layer configured to generate heat and alter a firmness property of at least one viscoelastic foam layer, wherein the amount of heat is based on a decrease of the glass transition temperature as a function of the percentage of humidity in the environment. In other embodiments, the bedding system is provided with at least one foam layer comprising a phase change material stratified in a foam structure of the at least one foam layer; and the at least one foam layer is heated to a temperature greater than a melt temperature of the paraffin wax to soften the at least one foam layer. In other embodiments, ambient humidity conditions can be changed.

Abstract: An inflatable life preserver uses a novel packing method with a lightweight inflatable film that allows it to integrate with equipment so that it is not noticeable to the user in the uninflated condition and does not impede the user's operations. In the uninflated state, the bladder is folded and rolled in a way that minimizes the device footprint. The device can be attached to a MOLLE vest or other garment. In the inflated condition, the inflatable bladder material is unsupported and is constrained to provide buoyancy distribution to turn a user face-up at the water line.

Abstract: Provided herein are antibody-drug conjugates that bind EGFR, in particular human EGFR, their methods of making, and their uses to treat patients having cancer.

Abstract: Cysteine engineered monospecific and bispecific EGFR and/or c-Met FN3 domain containing molecules comprising one or more free cysteine amino acids are prepared by mutagenizing a nucleic acid sequence of a parent molecule and replacing one or more amino acid residues by cysteine to encode the cysteine engineered FN3 domain containing monospecific or bispecific molecules; expressing the cysteine engineered FN3 domain containing molecules; and recovering the cysteine engineered FN3 domain containing molecule. Isolated cysteine engineered monospecific or bispecific FN3 domain containing molecules may be covalently attached to a detection label or a drug moiety and used therapeutically.

Abstract: The present invention relates to a dispenser module for converting preexisting analog systems into a customizable digital system. According to an illustrative embodiment of the present disclosure, a user can utilize preexisting analog equipment to operate and control a dispenser module. A squib is electrically connected to a logic circuit such that the normal “firing” of the original payload at that location will cause a change in the state of the electrical circuit. Because there are multiple payload allocations within one module, this allows electrical communication with individual/select payload devices by an operator. Payloads in the module can be quickly swapped in and out without making any changes to the vehicle.

Abstract: Disclosed herein are systems and methods for converting physical input signals into bitstreams using syntax trees regardless of the physical input signal's protocol. Using declarative language definitions within a protocol declaration, a test and measurement system can compile a syntax tree that automatically translates the input data into a proper bitstream output. The declarative language definitions within the protocol declaration allow custom or standard protocol rules to be written for multiple or arbitrary input protocols without writing unsafe functions, having to access memory, or debugging more complex language codes.

Abstract: A pizza oven is disclosed for cooking pizza or other food items on a barbecue grill. The pizza oven includes a top wall and a sidewall that together define an interior space sized and shaped to receive the food item to be cooked. The top wall includes one or more projections extending from an inner surface of the top wall into the interior space. When the pizza oven is positioned on the grates of a heated grill, heated air from the grill enters the interior space through a gap between the side walls and the food item. The heated air then contacts the one or more projections and passes over the top surface of the food item to cook the food item by convection. The one or more projections are sized and shaped to cause the heated air to move in a rotational pattern in the interior space. The rotational pattern allows the food item to be cooked faster and more evenly.

Abstract: Nonaqueous redox flow batteries (RFB) hold the potential for high energy density grid scale storage, though are often limited by the solubility of the redox-active species in their electrolytes. A systematic approach enables an increase the concentration of redox-active species in electrolytes for nonaqueous RFB, starting from a metal-coordination-cation-based ionic liquid. As an example, starting with an ionic liquid consisting of a metal coordination cation (MetIL), ferrocene-containing ligands and iodide anions can be substituted into the original MetIL structure, enabling a nearly 4× increase in capacity compared to original MetIL structure. Application of this strategy to other chemistries, optimizing electrolyte melting point and conductivity could yield >10 M redox-active electrons.

Abstract: The present invention relates to antibodies specifically binding PSMA or PSMA and CD3, polynucleotides encoding the antibodies or fragments, and methods of making and using the foregoing.

Abstract: A sodium ion battery comprises a cathode having a porous redox active metal-organic framework material. The battery can be an organic electrolyte sodium ion battery wherein the electrolyte comprises a sodium salt dissolved in an organic solvent or mixture of organic solvents. Alternatively, the battery can comprise an aqueous sodium ion battery wherein the electrolyte comprises a sodium salt dissolved in an aqueous solvent. Battery performance is especially related to electrolyte and binder selection.

Abstract: A device establishes, via a first network, communications with a merchant device in a vicinity of a vehicle associated with the device, and receives, via the first network and from the merchant device, merchant information indicating goods or services available from a merchant. The device provides, via the first network and to the merchant device, order information indicating an order of a particular good or service, and receives, via the first network and from the merchant device, payment information indicating a price for the particular good or service. The device establishes, via a second network, communications with a transaction device, and provides, via the second network and to the transaction device, transaction information to be used to pay the price. The device receives, via the first network and from the merchant device information confirming payment of the price and confirming the order.

Abstract: A device, integrated within a vehicle, generates a signal identifying the device and a vehicle, and establishes, via a first network, communications with a merchant device in a vicinity of the vehicle. The device provides, to the merchant device, vehicle information identifying properties of the vehicle, and receives, from the merchant device, merchant information indicating goods or services available from a merchant. The device provides, to the merchant device, order information indicating an order of a particular good or service of the goods or services, and receives, from the merchant device, payment information indicating a price for the particular good or service. The device establishes, via a second network, communications with a transaction device, and provides, to the transaction device, transaction information to be used to pay the price. The device receives, from the merchant device, information confirming payment of the price and confirming the order.

Abstract: A managing information handling system may dynamically update a user interface and transmit the updated user interface to a client information handling system. The user interface may be dynamically updated when an update to a user interface configuration is detected by the managing information handling system. The dynamically updated user interface may include dependency functionality so that when a master policy indicator is adjusted multiple policies that depend from the master policy are updated.

Abstract: A continuous process is provided for preparing a solid gel resin selected from resorcinol-formaldehyde gel resins, phenol-formaldehyde gel resins, and phenol-resorcinol-formaldehyde gel resins, using an extruder having at least one feed zone with a first temperature and at least one reaction zone with a second temperature that is higher than the first temperature. The process comprises steps of adding ingredients to the extruder at the feed zone, mixing the ingredients under heat to effectuate reaction between the ingredients to produce a liquid product exiting the extruder, and converting the liquid product exiting the extruder to the solid gel resin. A solid gel resin produced by the continuous process is also provided.

Abstract: The present disclosure provides antibody drug conjugates that bind human cMET, their methods of making, and their uses to treat patients having cancer.

Abstract: A sodium ion battery comprises a cathode having a porous redox active metal-organic framework material. The battery can be an organic electrolyte sodium ion battery wherein the electrolyte comprises a sodium salt dissolved in an organic solvent or mixture of organic solvents. Alternatively, the battery can comprise an aqueous sodium ion battery wherein the electrolyte comprises a sodium salt dissolved in an aqueous solvent. Battery performance is especially related to electrolyte and binder selection.