Patents by Inventor Mark L. Mathis

Mark L. Mathis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20120172909
    Abstract: The invention provides improved medical devices, therapeutic treatment systems, and treatment methods for treatment of the lung. A lung volume reduction system includes an implantable device having an elongate body that is sized and shaped for delivery via the airway system to a lung airway of a patient. The implant is inserted and positioned while the implant is in a delivery configuration, and is reconfigured to a deployed configuration so as to locally compress adjacent tissue of the lung, with portions of the elongate body generally moving laterally within the airway so as to laterally compress lung tissue. A plurality of such implants will often be used to treat a lung of a patient.
    Type: Application
    Filed: March 13, 2012
    Publication date: July 5, 2012
    Applicant: PneumRx, Inc.
    Inventors: Mark L. Mathis, David Thompson, Nathan Aronson, Patrick Wu
  • Patent number: 8182529
    Abstract: The invention is a method of delivering and deploying a tissue shaping device in a lumen within a patient, with the tissue shaping device including an anchor. In some embodiments the method includes the steps of: inserting a delivery catheter into the lumen; percutaneously delivering the device to a target site within the lumen through a delivery catheter; operating an actuator to expose an anchor; and operating the actuator to lock the anchor. In other, the method includes the steps of: inserting a delivery catheter into the lumen; moving the device from a cartridge into the delivery catheter; delivering the device to a target site within the lumen; operating an actuator to move the delivery catheter with respect to the anchor to expose the anchor; and expanding the anchor.
    Type: Grant
    Filed: September 20, 2004
    Date of Patent: May 22, 2012
    Assignee: Cardiac Dimensions, Inc.
    Inventors: Lucas S. Gordon, Mark L. Mathis, Gregory Nieminen, Leonard Kowalsky, Ryan Braxtan, Brian J. Doll
  • Publication number: 20120123532
    Abstract: A mitral valve annulus reshaping device includes at least a portion that is formed of a biocompatible shape memory alloy SMA having a characteristic temperature, Af, that is preferably below body temperature. The device is constrained in an unstable martensite (UM) state while being introduced through a catheter that passes through the venous system and into the coronary sinus of the heart. The reshaping device is deployed adjacent to the mitral valve annulus of the heart as it is forced from the catheter. When released from the constraint of the catheter, the SMA of the device at least partially converts from the UM state to an austenitic state and attempts to change to a programmed shape that exerts a force on the adjacent tissue and modifies the shape of the annulus. The strain of the SMA can be varied when the device is within the coronary sinus.
    Type: Application
    Filed: January 26, 2012
    Publication date: May 17, 2012
    Applicant: Cardiac Dimensions, Inc.
    Inventor: Mark L. Mathis
  • Patent number: 8172898
    Abstract: An intravascular support device includes a support or reshaper wire, a proximal anchor and a distal anchor. The support wire engages a vessel wall to change the shape of tissue adjacent the vessel in which the intravascular support is placed. The anchors and support wire are designed such that the vessel in which the support is placed remains open and can be accessed by other devices if necessary. The device provides a minimal metal surface area to blood flowing within the vessel to limit the creation of thrombosis. The anchors can be locked in place to secure the support within the vessel.
    Type: Grant
    Filed: March 8, 2010
    Date of Patent: May 8, 2012
    Assignee: Cardiac Dimensions, Inc.
    Inventors: Clifton A. Alferness, John M. Adams, Mark L. Mathis, David G. Reuter, Cruz Beeson, Leonard Kowalsky
  • Patent number: 8157823
    Abstract: The invention provides improved medical devices, therapeutic treatment systems, and treatment methods for treatment of the lung. A lung volume reduction system includes an implantable device having an elongate body that is sized and shaped for delivery via the airway system to a lung airway of a patient. The implant is inserted and positioned while the implant is in a delivery configuration, and is reconfigured to a deployed configuration so as to locally compress adjacent tissue of the lung, with portions of the elongate body generally moving laterally within the airway so as to laterally compress lung tissue. A plurality of such implants will often be used to treat a lung of a patient.
    Type: Grant
    Filed: September 12, 2008
    Date of Patent: April 17, 2012
    Assignee: PneumRx, Inc.
    Inventors: Nathan Aronson, Mark L. Mathis
  • Patent number: 8142455
    Abstract: A lung volume reduction system is disclosed comprising an implantable device adapted to be delivered to a lung airway of a patient in a delivery configuration and to change to a deployed configuration to bend the lung airway. The invention also discloses a method of bending a lung airway of a patient comprising inserting a device into the airway in a delivery configuration and bending the device into a deployed configuration, thereby bending the airway.
    Type: Grant
    Filed: September 12, 2008
    Date of Patent: March 27, 2012
    Assignee: PneumRx, Inc.
    Inventors: David Thompson, Patrick Wu, David Lehrberg, Mark L. Mathis, Michael Boutillette
  • Patent number: 8075608
    Abstract: A system for selectively deploying a medical device includes a cartridge that is engageable with a proximal end of a delivery catheter that is routed to a desired location in a patient's body. An advancement mechanism is provided for advancing the medical device out of the cartridge and into the delivery catheter for deploying the medical device at the desired location in the patient's body.
    Type: Grant
    Filed: January 8, 2008
    Date of Patent: December 13, 2011
    Assignee: Cardiac Dimensions, Inc.
    Inventors: Lucas S. Gordon, Mark L. Mathis, Gregory Nieminen
  • Patent number: 8062358
    Abstract: An anchor anchors a therapeutic device having an elongated body within a body lumen. The anchor includes a fixation member carried on the device which is adjustable from a first configuration that permits placement of the device in the body lumen to a second configuration that anchors the device within the body lumen. The anchor further includes a lock that locks the fixation member in the second configuration. The fixation member may be locked in any one of a plurality of intermediate points between the first configuration and a maximum second configuration.
    Type: Grant
    Filed: November 19, 2004
    Date of Patent: November 22, 2011
    Assignee: Cardiac Dimensions, Inc.
    Inventors: Mark L. Mathis, Leonard Kowalsky, David G. Reuter, Cruz Beeson
  • Publication number: 20110106117
    Abstract: A tissue shaping device adapted to be deployed in a lumen to modify the shape of target tissue adjacent to the lumen. In one embodiment the device includes first and second anchors; a connector disposed between the first and second anchors; and a focal deflector disposed between the first and second anchors and may be adapted to extend away from the lumen axis and toward the target tissue and/or away from the lumen axis and away from the target tissue when the device is deployed in the lumen. The invention is also a method of modifying target tissue shape. The method includes the steps of providing a tissue shaping device comprising proximal and distal anchors, a connector disposed between the proximal and distal anchors, and a focal deflector; placing the tissue shaping device in a lumen adjacent the target tissue; applying a shaping force from the focal deflector against a lumen wall to modify the shape of the target tissue; and expanding the proximal and distal anchors to anchor the device in the lumen.
    Type: Application
    Filed: January 11, 2011
    Publication date: May 5, 2011
    Applicant: Cardiac Dimensions, Inc.
    Inventors: Mark L. Mathis, David Reuter, Lucas Gordon, Cruz Beeson, Garrett Beget, Frederick Stewart
  • Publication number: 20110066234
    Abstract: The invention is a tissue shaping system, including a tissue shaping device with an expandable anchor and a lock; a delivery catheter; a delivery mechanism adapted to deliver the tissue shaping device from outside a patient to a target site within a lumen within the patient via the delivery catheter; and an actuator adapted to deliver an actuation force to the lock to lock the anchor in an expanded configuration. The invention is also a system adapted to percutaneously deliver and deploy a tissue shaping device at a target site within a lumen of a patient. The system includes: a handle; a delivery mechanism supported by the handle and adapted to deliver the tissue shaping device from outside the patient to the treatment site via a delivery catheter; and an actuator supported by the handle and adapted to deliver an actuation force to lock an anchor of the tissue shaping device in an expanded configuration.
    Type: Application
    Filed: November 22, 2010
    Publication date: March 17, 2011
    Inventors: Lucas S. Gordon, Mark L. Mathis, Gregory Nieminen, Leonard Kowalsky, Ryan Braxtan, Brian J. Doll
  • Patent number: 7887582
    Abstract: A tissue shaping device adapted to be deployed in a lumen to modify the shape of target tissue adjacent to the lumen. In one embodiment the device includes first and second anchors; a connector disposed between the first and second anchors; and a focal deflector disposed between the first and second anchors and may be adapted to extend away from the lumen axis and toward the target tissue and/or away from the lumen axis and away from the target tissue when the device is deployed in the lumen. The invention is also a method of modifying target tissue shape. The method includes the steps of providing a tissue shaping device comprising proximal and distal anchors, a connector disposed between the proximal and distal anchors, and a focal deflector; placing the tissue shaping device in a lumen adjacent the target tissue; applying a shaping force from the focal deflector against a lumen wall to modify the shape of the target tissue; and expanding the proximal and distal anchors to anchor the device in the lumen.
    Type: Grant
    Filed: May 5, 2004
    Date of Patent: February 15, 2011
    Assignee: Cardiac Dimensions, Inc.
    Inventors: Mark L. Mathis, David Reuter, Lucas Gordon, Cruz Beeson, Garrett Beget, Frederick Stewart
  • Patent number: 7857846
    Abstract: An intravascular support device includes a support or reshaper wire, a proximal anchor and a distal anchor. The support wire engages a vessel wall to change the shape of tissue adjacent the vessel in which the intravascular support is placed. The anchors and support wire are designed such that the vessel in which the support is placed remains open and can be accessed by other devices if necessary. The device provides a minimal metal surface area to blood flowing within the vessel to limit the creation of thrombosis. The anchors can be locked in place to secure the support within the vessel.
    Type: Grant
    Filed: May 2, 2003
    Date of Patent: December 28, 2010
    Assignee: Cardiac Dimensions, Inc.
    Inventors: Clifton A. Alferness, John M. Adams, Mark L. Mathis, David G. Reuter, Cruz Beeson, Leonard Kowalsky
  • Publication number: 20100305715
    Abstract: Elongate implant structures can be introduced into an airway system to a target airway axial region, often to apply lateral bending and/or compression forces against the lung tissue from within the airways for an extended period of time. Structures or features of the implants may inhibit tissue reactions that might otherwise allow portions of the device to eventually traverse through the wall of the airway. The devices may enhance the area bearing laterally on the tissue of a surrounding airway lumen wall. Embodiments may have features which increase the device friction with the airway to allow the device to grip the surrounding airway as the device is deployed. An appropriate adhesive may be introduced around the device in the lung. Hydrophilic material may inhibit biofilm formation, or features which induce some tissue ingrowth (stimulation of tissue growth) may enhance implanted device supported.
    Type: Application
    Filed: May 18, 2010
    Publication date: December 2, 2010
    Applicant: PneumRx, Inc.
    Inventors: Mark L. Mathis, Patrick Wu, David Lehrberg, Jaime Vasquez, Erin McGurk, Ronald Dieck, Andrew Stein
  • Patent number: 7837729
    Abstract: The invention is a tissue shaping system, including a tissue shaping device with an expandable anchor and a lock; a delivery catheter; a delivery mechanism adapted to deliver the tissue shaping device from outside a patient to a target site within a lumen within the patient via the delivery catheter; and an actuator adapted to deliver an actuation force to the lock to lock the anchor in an expanded configuration. The invention is also a system adapted to percutaneously deliver and deploy a tissue shaping device at a target site within a lumen of a patient. The system includes: a handle; a delivery mechanism supported by the handle and adapted to deliver the tissue shaping device from outside the patient to the treatment site via a delivery catheter; and an actuator supported by the handle and adapted to deliver an actuation force to lock an anchor of the tissue shaping device in an expanded configuration.
    Type: Grant
    Filed: September 20, 2004
    Date of Patent: November 23, 2010
    Assignee: Cardiac Dimensions, Inc.
    Inventors: Lucas S. Gordon, Mark L. Mathis, Gregory Nieminen, Leonard Kowalsky, Ryan Braxtan, Brian J. Doll
  • Patent number: 7828841
    Abstract: An intravascular support device includes a support or reshaper wire, a proximal anchor and a distal anchor. The support wire engages a vessel wall to change the shape of tissue adjacent the vessel in which the intravascular support is placed. The anchors and support wire are designed such that the vessel in which the support is placed remains open and can be accessed by other devices if necessary. The device provides a minimal metal surface area to blood flowing within the vessel to limit the creation of thrombosis. The anchors can be locked in place to secure the support within the vessel.
    Type: Grant
    Filed: December 21, 2007
    Date of Patent: November 9, 2010
    Assignee: Cardiac Dimensions, Inc.
    Inventors: Mark L. Mathis, Leonard Kowalsky, David G. Reuter, Cruz Beeson
  • Publication number: 20100280602
    Abstract: A mitral valve annulus reshaping device includes at least a portion that is formed of a biocompatible shape memory alloy SMA having a characteristic temperature, Af, that is preferably below body temperature. The device is constrained in an unstable martensite (UM) state while being introduced through a catheter that passes through the venous system and into the coronary sinus of the heart. The reshaping device is deployed adjacent to the mitral valve annulus of the heart as it is forced from the catheter. When released from the constraint of the catheter, the SMA of the device at least partially converts from the UM state to an austenitic state and attempts to change to a programmed shape that exerts a force on the adjacent tissue and modifies the shape of the annulus. The strain of the SMA can be varied when the device is within the coronary sinus.
    Type: Application
    Filed: July 16, 2010
    Publication date: November 4, 2010
    Applicant: Cardiac Dimensions, Inc.
    Inventor: Mark L. Mathis
  • Patent number: 7814635
    Abstract: A tissue shaping device adapted to be deployed in a vessel to reshape tissue adjacent to the vessel. In some embodiments the device includes first and second anchors and a connector disposed between the first and second anchors, with the connector being integral with at least a portion of the first anchor. The invention is also a method of making a tissue shaping device including the steps of removing material from a blank to form a connector and an integral anchor portion; and attaching a non-integral anchor portion to the integral anchor portion.
    Type: Grant
    Filed: May 12, 2006
    Date of Patent: October 19, 2010
    Assignee: Cardiac Dimensions, Inc.
    Inventors: Lucas Gordon, Mark L. Mathis, Nathan Aronson
  • Patent number: 7794496
    Abstract: A tissue shaping device adapted to be deployed in a vessel to reshape tissue adjacent to the vessel. In some embodiments the device includes first and second anchors and a connector disposed between the first and second anchors, with the connector being integral with at least a portion of the first anchor. The invention is also a method of making a tissue shaping device including the steps of removing material from a blank to form a connector and an integral anchor portion; and attaching a non-integral anchor portion to the integral anchor portion.
    Type: Grant
    Filed: December 19, 2003
    Date of Patent: September 14, 2010
    Assignee: Cardiac Dimensions, Inc.
    Inventors: Lucas Gordon, Mark L. Mathis, Nathan Aronson
  • Patent number: 7758639
    Abstract: A mitral valve annulus reshaping device includes at least a portion that is formed of a biocompatible shape memory alloy SMA having a characteristic temperature, Af, that is preferably below body temperature. The device is constrained in an unstable martensite (UM) state while being introduced through a catheter that passes through the venous system and into the coronary sinus of the heart. The reshaping device is deployed adjacent to the mitral valve annulus of the heart as it is forced from the catheter. When released from the constraint of the catheter, the SMA of the device at least partially converts from the UM state to an austenitic state and attempts to change to a programmed shape that exerts a force on the adjacent tissue and modifies the shape of the annulus. The strain of the SMA can be varied when the device is within the coronary sinus.
    Type: Grant
    Filed: January 18, 2007
    Date of Patent: July 20, 2010
    Assignee: Cardiac Dimensions, Inc.
    Inventor: Mark L. Mathis
  • Publication number: 20100168847
    Abstract: An intravascular support device includes a support or reshaper wire, a proximal anchor and a distal anchor. The support wire engages a vessel wall to change the shape of tissue adjacent the vessel in which the intravascular support is placed. The anchors and support wire are designed such that the vessel in which the support is placed remains open and can be accessed by other devices if necessary. The device provides a minimal metal surface area to blood flowing within the vessel to limit the creation of thrombosis. The anchors can be locked in place to secure the support within the vessel.
    Type: Application
    Filed: March 8, 2010
    Publication date: July 1, 2010
    Inventors: Clifton A. Alferness, John M. Adams, Mark L. Mathis, David G. Reuter, Cruz Beeson, Leonard Kowalsky