Abstract: Various methods, systems, and devices for treating tissue ablation are disclosed. Some embodiments disclosed herein pertain to methods of treating tumors, systems used for irradiating tissue and tumors with electromagnetic radiation, components and devices of that system, and kits for providing systems used for irradiating tissue and tumors with electromagnetic radiation. In some embodiments, the system provides sub-ablative infrared radiation that is absorbed by nanoparticles. In some embodiments, the nanoparticles absorb the radiation converting it into heat energy. In some embodiments, though the infrared radiation itself may be sub-ablative, the heat energy generated by the nanoparticles is sufficient to cause thermal coagulation, hyperthermia, and/or tissue ablation.

Abstract: A system that may include a rigid bus bar body portion having one or more first conductive pathways, and a flexible bus bar body portion extending from the rigid bus bar body portion and having a lower modulus of elasticity than the rigid bus bar body portion, the flexible bus bar body portion including one or more second conductive pathways. The one or more first conductive pathways and the one or more second conductive pathways may be configured to be conductively coupled with a first electronic device to form a conductive connection between the first electronic device and at least a second electronic device.

Abstract: A pressure compensation member, an irrigation drip emitter, drip lines and methods relating to same, are provided for delivering irrigation water from a supply tube to an emitter outlet at a reduced and relatively constant flow rate. The pressure compensation member being suitable for use in conventional emitters or alternate emitters being provided having either a uniform elastomeric emitter body configuration or a poly-material emitter body utilizing an elastomeric pressure compensation member. Various methods are also disclosed herein relating to the pressure compensation member, emitters and/or drip line using such pressure compensating members and/or emitters.

Abstract: Methods and systems are provided for an engine component assembly having one or more fastener retention apparatuses. In one example, a system may include each of the one or more fastener retention apparatuses including a rigid limiter and an integrated fastener retention feature adhered to an inner surface of an interior passage of the rigid limiter. Further, one or more fasteners may be held captive by each of the one or more fastener retention apparatuses capturing one fastener of the one or more fasteners.

Abstract: An electrical power delivery system includes a module stack, a conductive bus bar, and one or more energy storage devices. The module stack includes multiple modules stacked side by side along a stack axis. Each of the modules has a respective housing and internal electrical components within the housing. The conductive bus bar is oriented along a plane parallel to the stack axis. The bus bar is mounted along a side of the module stack and electrically connected to one or more of the modules. The one or more energy storage devices are electrically connected to the bus bar and extend from a side of the bus bar facing away from the module stack such that the bus bar is disposed between the one or more energy storage devices and the module stack.

Abstract: A pressure compensation member, an irrigation drip emitter, drip lines and methods relating to same, are provided for delivering irrigation water from a supply tube to an emitter outlet at a reduced and relatively constant flow rate. The pressure compensation member being suitable for use in conventional emitters or alternate emitters being provided having either a uniform elastomeric emitter body configuration or a poly-material emitter body utilizing an elastomeric pressure compensation member. Various methods are also disclosed herein relating to the pressure compensation member, emitters and/or drip line using such pressure compensating members and/or emitters.

Abstract: A mounting system includes a chassis, guide rods, and lifting elements. The guide rods extend from a back wall of the chassis and are suspended above a support platform of the chassis. A first guide rod is spaced a designated height above the support platform to be received within a channel of a module while the module is disposed on the support platform. The first guide rod guides movement of the module towards the back wall. As the module approaches the back wall, a first lifting element engages the module at an angled contact interface to lift the module off the support platform responsive to additional movement of the module towards the back wall. When the module is fully loaded, the module is supported by the back wall, the first lifting element, and/or the first guide rod, and is spaced apart from the support platform by a gap.

Abstract: Systems and methods are provided for continuously monitoring a user to determine when cardiovascular events are likely occurring and to responsively provide a prompt to a user to engage in additional physiological assessment of the putative cardiovascular event. Additional assessment can include the user engaging an additional sensor to provide signals that are more accurate, lower noise, or otherwise improved relative to a continuously-monitoring sensor used to initially detect the cardiovascular event. Detection of cardiovascular events includes using a cardiovascular classifier to determine, based on the output of such a continuously-monitoring sensor, whether the event is likely occurring. Such a classifier can be received from a cloud computing service or other remote system based on sensor outputs sent to such a system.

Abstract: Various methods, systems, and devices for treating tissue ablation are disclosed. Some embodiments disclosed herein pertain to methods of treating tumors, systems used for irradiating tissue and tumors with electromagnetic radiation, components and devices of that system, and kits for providing systems used for irradiating tissue and tumors with electromagnetic radiation. In some embodiments, the system provides sub-ablative infrared radiation that is absorbed by nanoparticles. In some embodiments, the nanoparticles absorb the radiation converting it into heat energy. In some embodiments, though the infrared radiation itself may be sub-ablative, the heat energy generated by the nanoparticles is sufficient to cause thermal coagulation, hyperthermia, and/or tissue ablation.

Abstract: The present invention relates to derivatives of formula (I) wherein Ring A, W, X, Y, Z, R1, R2, R3 and R4 are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as C5a receptor modulators.

Abstract: A vehicle electrical power system includes a phase module assembly of a multi-phase inverter. The phase module assembly includes first and second flat laminated busbars extending in orthogonal planes. The phase module assembly also includes one or more transistors that convert direct current into one phase of a multi-phase alternating current of the multi-phase inverter, and to output the phase of the multi-phase alternating current to the load. The phase module assembly also includes one or more capacitors conductively coupled with the internal positive and negative terminal connectors and with the external positive and negative bushings configured to be conductively coupled with the power source of direct current. The assembly can be useful for vehicles because the components of the system are configured to carry large amounts of current in a more reliable and sustainable manner.

Abstract: Systems and methods are provided for continuously monitoring a user to determine when cardiovascular events are likely occurring and to responsively provide a prompt to a user to engage in additional physiological assessment of the putative cardiovascular event. Additional assessment can include the user engaging an additional sensor to provide signals that are more accurate, lower noise, or otherwise improved relative to a continuously-monitoring sensor used to initially detect the cardiovascular event. Detection of cardiovascular events includes using a cardiovascular classifier to determine, based on the output of such a continuously-monitoring sensor, whether the event is likely occurring. Such a classifier can be received from a cloud computing service or other remote system based on sensor outputs sent to such a system.

Abstract: Systems and methods are provided for determining the frequency of a cardiovascular pulse based on a first physiological signal that is continuously available and a second physiological signal that is less available and that is more accurate or otherwise improved relative to the first signal with respect to pulse rate estimation. When the second signal is available it controls the determination of the pulse rate. When the second signal is unavailable, the first signal is used to determine the pulse rate. This can include using the first signal to estimate the pulse rate until the second signal is available, at which point the pulse rate is estimated based on the second physiological signal. Alternatively, the first signal could be used to determine a number of candidate pulse rates, and the second signal could be used to select a pulse rate from the set of candidate pulse rates.

Abstract: A vehicle electrical power system includes a phase module assembly of a multi-phase inverter. The phase module assembly includes first and second flat laminated busbars extending in orthogonal planes. The phase module assembly also includes one or more transistors that convert direct current into one phase of a multi-phase alternating current of the multi-phase inverter, and to output the phase of the multi-phase alternating current to the load. The phase module assembly also includes one or more capacitors conductively coupled with the internal positive and negative terminal connectors and with the external positive and negative bushings configured to be conductively coupled with the power source of direct current. The assembly can be useful for vehicles because the components of the system are configured to carry large amounts of current in a more reliable and sustainable manner.

Abstract: The present invention relates to derivatives of formula (I) wherein Ring A, X, Y, Z, RA, R1, R2, R3 and R4 are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as C5a receptor modulators.

Abstract: The present invention relates to derivatives of formula (I) wherein ring A, X, Y, Z, R1, R2, R3 and R4 are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as C5a receptor modulators.

Abstract: A mounting system includes a chassis, guide rods, and lifting elements. The guide rods extend from a back wall of the chassis and are suspended above a support platform of the chassis. A first guide rod is spaced a designated height above the support platform to be received within a channel of a module while the module is disposed on the support platform. The first guide rod guides movement of the module towards the back wall. As the module approaches the back wall, a first lifting element engages the module at an angled contact interface to lift the module off the support platform responsive to additional movement of the module towards the back wall. When the module is fully loaded, the module is supported by the back wall, the first lifting element, and/or the first guide rod, and is spaced apart from the support platform by a gap.

Abstract: A module panel and method include an exterior housing, at least one heat sink disposed in the housing, a power delivery circuit disposed in the housing and coupled to one side of the at least one heat sink, and a controller circuit disposed in the housing and coupled to an opposite side of the at least one heat sink. The power delivery circuit operates using one or more different voltages than the controller circuit.

Abstract: An electrical power delivery system includes a conductive plane, multiple electrical energy storage devices, and a support structure. The electrical energy storage devices are mounted to and electrically connected to the conductive plane. The electrical energy storage devices project from a common side of the conductive plane. The support structure is spaced apart from the conductive plane. The support structure engages and at least partially surrounds each of the electrical energy storage devices such that the support structure mechanically supports each of the electrical energy storage devices along at least two support directions that are orthogonal to each other.