Patents by Inventor Mark Samuel Jonathan Briggs

Mark Samuel Jonathan Briggs has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20180181709
    Abstract: Disclosed is a method for optimising an ex-vivo autologous cell culture procedure, said method including the steps of: obtaining and storing a patient's bioinformatic data; comparing said patient's bioinformatic data with known data in the form of bioinformatic data collected from other patients and/or other predetermined data such as genomic or proteomic data; and selecting ex-vivo cell culture procedure parameters based on the comparison between said patient's bioinformatic data and said known data. The selection can also be influenced by using the better data and/or culture parameter indicators determined by monitoring the outcome of plural cellular therapy attempts.
    Type: Application
    Filed: June 29, 2016
    Publication date: June 28, 2018
    Inventors: Mark Samuel Jonathan Briggs, Nicholas Thomas
  • Patent number: 7662973
    Abstract: Disclosed is a method for increasing the fluorescence of a Cyanine dye molecule comprising at least one NO2 group characterized by the reduction of the at least one NO2 group to NHOH or NH2 by the action of a nitroreductase. The cyanine dye molecule comprising at least one NO2 group can be used as a substrate for detecting nitroreductase enzyme activity in a composition and allows for the use of a nitroreductase enzyme in an enzyme-reporter system for the detection of analytes, binding reactions or gene expression.
    Type: Grant
    Filed: February 1, 2001
    Date of Patent: February 16, 2010
    Assignee: GE Healthcare UK Limited
    Inventors: Nicholas Thomas, Nigel Paul Michael, Valerie Millar, Beth Davies, Mark Samuel Jonathan Briggs
  • Publication number: 20040262585
    Abstract: A novel form of dendrimer, polybranched molecule, is described in which fluorescent dyes of the structure exist in a micro environment that affects their fluorescent properties. Within the dendrimer, poly-branched molecules are cleavage sites. When these cleavage sites are treated with a suitable chemical or enzyme which cleaves selective bonds the dyes of the structure are released and a change in their optical properties is effected, notably an increase in fluorescent signal. Methods of using the dendrimer, poly-branched molecule in assays of biological molecules are also described.
    Type: Application
    Filed: August 6, 2004
    Publication date: December 30, 2004
    Inventors: William J. Cummins, Alan L. Hamilton, Mark Bradley, John Ellard, Thomas Zollitsch, Mark Samuel Jonathan Briggs
  • Publication number: 20030186348
    Abstract: Disclosed is a method for increasing the fluorescence of a Cyanine dye molecule comprising at least one NO2 group characterised by the reduction of the at least one NO2 group to NHOH or NH2 by the action of a nitroreductase. The cyanine dye molecule comprising at least one NO2 group can be used as a substrate for detecting nitroreductase enzyme activity in a composition and allows for the use of a nitroreductase enzyme in an enzyme-reporter system for the detection of analytes, binding reaction or gene expression.
    Type: Application
    Filed: October 16, 2002
    Publication date: October 2, 2003
    Inventors: Nicholas Thomas, Nigel Paul Michael, Valerie Millar, Beth Davies, Mark Samuel Jonathan Briggs
  • Patent number: 6294667
    Abstract: The present invention discloses a method of separating or distinguishing carbohydrate substances. More particularly the method includes using fluorescent labeling reagents which have a positive charge when bound to a carbohydrate, involves separating the labeled carbohydrate substances, such as by performing electrophoresis to cause differential migration of different labeled carbohydrate substances, or by isoelectric focusing in a pH gradient. The fluorescent labeling reagents are preferably cyanine dyes.
    Type: Grant
    Filed: June 10, 1999
    Date of Patent: September 25, 2001
    Assignee: Amersham International PLC
    Inventors: Peter Jackson, William Jonathan Cummins, Richard West, John Anthony Smith, Mark Samuel Jonathan Briggs
  • Patent number: 6166202
    Abstract: Benzophenoxazine compounds have formula (I) where X is O or NH, Y is NR.sup.1 R.sup.2 or H, R.sup.1 and R.sup.2 are alkyl or -L-A, L is a linker and A may be a reactive group by means of which the compound is linked to a biomolecule. The compounds can be used as fluorescent dyes for labelling biomolecules.
    Type: Grant
    Filed: January 15, 1999
    Date of Patent: December 26, 2000
    Assignee: Amersham Pharmacia Biotech UK Limited
    Inventors: Adrian Simmonds, James N Miller, Christopher John Moody, Elizabeth Swann, Mark Samuel Jonathan Briggs, Ian Edward Bruce
  • Patent number: 6140494
    Abstract: Novel squarate dyes are described, and adducts of these dyes with biologically significant chemical species such as nucleosides or nucleotides. The adducts have useful properties for fluorescent nucleic acid sequencing methods.
    Type: Grant
    Filed: May 12, 1999
    Date of Patent: October 31, 2000
    Assignee: Amersham Pharmacia Biotech UK Limited
    Inventors: Alan Lewis Hamilton, Richard Martin West, William Jonathan Cummins, Mark Samuel Jonathan Briggs, Ian Edward Bruce