Abstract: ApoC-II mimetic peptides of 19-35 amino acids including one or two helical domains with one or more covalent linkages joining at least two non-contiguous amino acids of the peptide, wherein at least one of the helical domains is an amphipathic helical domain, are provided. Methods of treating dyslipidemic disorders, such as hypertriglyceridemia or hypercholesterolemia, using the peptides are also provided.

Abstract: A method for calorimetric determination of the exogenous lipoprotein lipase activity in preheparin human plasma is disclosed to be used for monitoring rate of lipolysis in the plasma. The method is suitable for example in determining the influence of added regulators on the LPL reaction in plasma and for comparing rate of lipolysis in plasma samples from various patients and control individuals.

Abstract: A method for calorimetric determination of the lipoprotein lipase activity in human plasma comprising steps of preparing a reagent, obtaining and preparing human plasma sample, filling the isothermal titration calorimetry cell withe prepared human plasma sample, injecting LPL to the cell from the syringe-stirrer, changing the heat rate as a result of injection of LPL into ITC cell with human plasma, increasing LPL concentration in the ITC cell by at least one injection, performing isothermal titration calorimetry measurements, recording total hydrolysis of plasma lipids by LPL, recording differences in how well LPL can get access to the lipids, determing the influence of added regulators on the LPL reaction in plasma.