Patents by Inventor Martial Hervy
Martial Hervy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12173311Abstract: A cell culture article includes a substrate having a polymer coating that is conducive to colony passaging of cells cultured on the coating. Example polymer coatings are formed from polygalacturonic acid (PGA), alginate, or combinations thereof. Cells cultured on the polymer coating can be separated from the substrate as a colony or layer of cells by exposing the polymer coating to (i) a chelating agent, (ii) a proteinase-free enzyme, or (iii) a chelating agent and a proteinase-free enzyme.Type: GrantFiled: July 26, 2023Date of Patent: December 24, 2024Assignee: CORNING INCORPORATEDInventors: Ye Fang, Ann MeeJin Ferrie, Vasiliy Nikolaevich Goral, David Henry, Martial Hervy, Corinne Walerack, Yue Zhou
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Publication number: 20240026287Abstract: A cell culture article includes a substrate having a polymer coating that is conducive to colony passaging of cells cultured on the coating. Example polymer coatings are formed from polygalacturonic acid (PGA), alginate, or combinations thereof. Cells cultured on the polymer coating can be separated from the substrate as a colony or layer of cells by exposing the polymer coating to (i) a chelating agent, (ii) a proteinase-free enzyme, or (iii) a chelating agent and a proteinase-free enzyme.Type: ApplicationFiled: July 26, 2023Publication date: January 25, 2024Inventors: Ye Fang, Ann MeeJin Ferrie, Vasiliy Nikolaevich Goral, David Henry, Martial Hervy, Corinne Walerack, Yue Zhou
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Patent number: 11746322Abstract: A cell culture article includes a substrate having a polymer coating that is conducive to colony passaging of cells cultured on the coating. Example polymer coatings are formed from polygalacturonic acid (PGA), alginate, or combinations thereof. Cells cultured on the polymer coating can be separated from the substrate as a colony or layer of cells by exposing the polymer coating to (i) a chelating agent, (ii) a proteinase-free enzyme, or (iii) a chelating agent and a proteinase-free enzyme.Type: GrantFiled: September 16, 2020Date of Patent: September 5, 2023Assignee: CORNING INCORPORATEDInventors: Ye Fang, Ann MeeJin Ferrie, Vasiliy Nikolaevich Goral, David Henry, Martial Hervy, Corinne Walerack, Yue Zhou
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Publication number: 20220235320Abstract: A cell culture article is provided. The cell culture article includes a substrate of a polygalacturonic acid compound crosslinked with a divalent cation, the polygalacturonic acid compound being selected from at least one of: pectic acid; partially esterified pectic acid, partially amidated pectic acid and salts thereof. The substrate is digestible by digestion reagents into components including of galacturonic acid monomers and the divalent cation. Methods of harvesting cells from the cell culture article are also provided. The methods include performing a series of wash and/or centrifugation cycles to reduce components in the harvest solution.Type: ApplicationFiled: June 2, 2020Publication date: July 28, 2022Inventors: Martial Hervy, Liepin Huang, Jinlin Peng, Ryann Loren Russell, Jeffery Joseph Scibek, Yue Zhou
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Publication number: 20220186178Abstract: A cell culture article, including: a substrate comprising a polygalacturonic acid compound selected from at least one of: pectic acid; partially esterified pectic acid having a degree of esterification from 1 to 40 mol %, or salts thereof; and an adhesion polymer on the surface of the polygalacturonic acid compound. A method of making and using the article are also disclosed.Type: ApplicationFiled: December 22, 2021Publication date: June 16, 2022Inventors: David Henry, Martial Hervy, Corinne Walerack
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Publication number: 20210062142Abstract: A cell culture article includes a substrate having a polymer coating that is conducive to colony passaging of cells cultured on the coating. Example polymer coatings are formed from polygalacturonic acid (PGA), alginate, or combinations thereof. Cells cultured on the polymer coating can be separated from the substrate as a colony or layer of cells by exposing the polymer coating to (i) a chelating agent, (ii) a proteinase-free enzyme, or (iii) a chelating agent and a proteinase-free enzyme.Type: ApplicationFiled: September 16, 2020Publication date: March 4, 2021Inventors: Ye Fang, Ann MeeJin Ferrie, Vasiliy Nikolaevich Goral, David Henry, Martial Hervy, Corinne Walerack, Yue Zhou
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Patent number: 10808221Abstract: A cell culture article includes a substrate having a polymer coating that is conducive to colony passaging of cells cultured on the coating. Example polymer coatings are formed from polygalacturonic acid (PGA), alginate, or combinations thereof. Cells cultured on the polymer coating can be separated from the substrate as a colony or layer of cells by exposing the polymer coating to (i) a chelating agent, (ii) a proteinase-free enzyme, or (iii) a chelating agent and a proteinase-free enzyme.Type: GrantFiled: December 16, 2015Date of Patent: October 20, 2020Assignee: Corning IncorporatedInventors: Ye Fang, Ann MeeJin Ferrie, Vasiliy Nikolaevich Goral, David Henry, Martial Hervy, Corinne Walerack, Yue Zhou
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Publication number: 20200291348Abstract: A dissolvable foam scaffold for cell culture is provided herein. The dissolvable foam scaffold includes an ionotropically crosslinked polygalacturonic acid compound selected from at least one of: pectic acid; partially esterified pectic acid, partially amidated pectic acid and salts thereof, and at least one first water-soluble polymer having surface activity.Type: ApplicationFiled: November 20, 2018Publication date: September 17, 2020Inventors: Marie-Maud Bear, David Henry, Martial Hervy, Marylène Denise Madeleine Pécheul, Corinne Walerack
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Publication number: 20180051247Abstract: A cell culture article includes a substrate having a polymer coating that is conducive to colony passaging of cells cultured on the coating. Example polymer coatings are formed from polygalacturonic acid (PGA), alginate, or combinations thereof. Cells cultured on the polymer coating can be separated from the substrate as a colony or layer of cells by exposing the polymer coating to (i) a chelating agent, (ii) a proteinase-free enzyme, or (iii) a chelating agent and a proteinase-free enzyme.Type: ApplicationFiled: December 16, 2015Publication date: February 22, 2018Inventors: Ye Fang, Ann MeeJin Ferrie, Vasiliy Nikoleavich Goral, David Henry, Martial Hervy, Corinne walerack, Yue Zhou
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Patent number: 9873786Abstract: A composition for forming a polymeric cell culture surface includes (i) a pre-polymer comprising a polymer backbone, a cationic moiety conjugated to the backbone, and a cross-linker moiety conjugated to the backbone; and (ii) a peptide-polymer comprising a polymer backbone and cell adhesive peptide conjugated to the backbone. Cross-linked coatings for cell culture that have a suitable amount of cell adhesive peptide and cationic moiety may be formed from the pre-polymer and peptide-polymer.Type: GrantFiled: April 13, 2012Date of Patent: January 23, 2018Assignee: Corning IncorporatedInventors: David Henry, Martial Hervy, Marylène Denise Madeleine Pécheul, Corinne Walerack
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Publication number: 20160145567Abstract: A cell culture article, including: a substrate comprising a polygalacturonic acid compound selected from at least one of: pectic acid; partially esterified pectic acid having a degree of esterification from 1 to 40 mol %, or salts thereof; and an adhesion polymer on the surface of the polygalacturonic acid compound. A method of making and using the article are also disclosed.Type: ApplicationFiled: June 23, 2014Publication date: May 26, 2016Inventors: David Henry, Martial Hervy, Corinne Walerack
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Patent number: 9115238Abstract: A cell culture microcarrier includes a polymer formed from copolymerization of a mixture including (i) an uncharged hydrophilic unsaturated monomer having a hydroxyl group; (ii) a hydrophilic carboxylic acid containing unsaturated monomer; and (iii) a hydrophilic multifunctional unsaturated monomer. The microcarrier may further include a polypeptide, such as a polypeptide that promotes cell adhesion, conjugated to the surface of the microcarrier; e.g. via the carboxyl group from the hydrophilic carboxylic acid containing unsaturated monomer. Some of the microcarriers support attachment of human embryonic stem cells.Type: GrantFiled: May 27, 2010Date of Patent: August 25, 2015Assignee: Corning IncorporatedInventors: Sophie Deshayes, David Henry, Martial Hervy
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Patent number: 9068182Abstract: A cell culture polysaccharide microcarrier includes (1) a cross-linked polysaccharide microcarrier base having a neutral or negative charge at pH 7, and (ii) a polypeptide conjugated to the base. The polypeptide may contain a cell adhesive sequence, such as RGD. Cells cultured with such microcarriers exhibit peptide-specific binding to the microcarriers.Type: GrantFiled: July 28, 2010Date of Patent: June 30, 2015Assignee: Corning IncorporatedInventors: Sophie Deshayes, David Henry, Martial Hervy
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Patent number: 8426176Abstract: A cell culture microcarrier includes a polymer formed from copolymerization of a mixture including (i) an uncharged hydrophilic unsaturated monomer having a hydroxyl group; (ii) a hydrophilic carboxylic acid containing unsaturated monomer; and (iii) a hydrophilic multifunctional unsaturated monomer. The microcarrier may further include a polypeptide, such as a polypeptide that promotes cell adhesion, conjugated to the surface of the microcarrier; e.g. via the carboxyl group from the hydrophilic carboxylic acid containing unsaturated monomer.Type: GrantFiled: May 27, 2010Date of Patent: April 23, 2013Assignee: Corning IncorporatedInventors: Sophie Deshayes, David Henry, Martial Hervy
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Publication number: 20120282697Abstract: A composition for forming a polymeric cell culture surface includes (i) a pre-polymer comprising a polymer backbone, a cationic moiety conjugated to the backbone, and a cross-linker moiety conjugated to the backbone; and (ii) a peptide-polymer comprising a polymer backbone and cell adhesive peptide conjugated to the backbone. Cross-linked coatings for cell culture that have a suitable amount of cell adhesive peptide and cationic moiety may be formed from the pre-polymer and peptide-polymer.Type: ApplicationFiled: April 13, 2012Publication date: November 8, 2012Inventors: David Henry, Martial Hervy, Marylène Denise Madeleine Pécheul, Corinne Walerack
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Publication number: 20120058554Abstract: A cell culture polysaccharide microcarrier includes (1) a cross-linked polysaccharide microcarrier base having a neutral or negative charge at pH 7, and (ii) a polypeptide conjugated to the base. The polypeptide may contain a cell adhesive sequence, such as RGD. Cells cultured with such microcarriers exhibit peptide-specific binding to the microcarriers.Type: ApplicationFiled: July 28, 2010Publication date: March 8, 2012Inventors: Sophie Deshayes, David Henry, Martial Hervy
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Publication number: 20100317113Abstract: A cell culture microcarrier includes a polymer formed from copolymerization of a mixture including (i) an uncharged hydrophilic unsaturated monomer having a hydroxyl group; (ii) a hydrophilic carboxylic acid containing unsaturated monomer; and (iii) a hydrophilic multifunctional unsaturated monomer. The microcarrier may further include a polypeptide, such as a polypeptide that promotes cell adhesion, conjugated to the surface of the microcarrier; e.g. via the carboxyl group from the hydrophilic carboxylic acid containing unsaturated monomer.Type: ApplicationFiled: May 27, 2010Publication date: December 16, 2010Inventors: SOPHIE DESHAYES, DAVID HENRY, MARTIAL HERVY
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Publication number: 20100304482Abstract: A cell culture microcarrier includes a polymer formed from copolymerization of a mixture including (i) an uncharged hydrophilic unsaturated monomer having a hydroxyl group; (ii) a hydrophilic carboxylic acid containing unsaturated monomer; and (iii) a hydrophilic multifunctional unsaturated monomer. The microcarrier may further include a polypeptide, such as a polypeptide that promotes cell adhesion, conjugated to the surface of the microcarrier; e.g. via the carboxyl group from the hydrophilic carboxylic acid containing unsaturated monomer. Some of the microcarriers support attachment of human embryonic stem cells.Type: ApplicationFiled: May 27, 2010Publication date: December 2, 2010Inventors: Sophie Deshayes, David Henry, Martial Hervy
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Publication number: 20090286720Abstract: A pharmaceutical composition for the treatment, prevention or diagnosis of a tumoral pathology comprising an active agent which stabilizes an actin network of a cellular cytoskeleton.Type: ApplicationFiled: April 20, 2009Publication date: November 19, 2009Applicants: Bioalliance Pharma, Ecole Normale Superieure de Cachan, Institut Gustave Roussy - IGR, Centre National de la Recherche Scientifique - CNRSInventors: Christian Auclair, Valerie Amsellem, Martial Hervy, Frederic Subra
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Publication number: 20040191230Abstract: A pharmaceutical composition for the treatment, prevention or diagnosis of a tumoral pathology comprising an active agent which stabilizes an actin network of a cellular cytoskeleton.Type: ApplicationFiled: December 18, 2003Publication date: September 30, 2004Applicants: Bioalliance Pharma, a corporation of France, Ecole Normale Superieure de Cachan, a corporation of France, Institut Gustave Roussy - IGR, a corporation of France, Centre National de la Recherche Scientifique - CNRS, a corporation of FranceInventors: Christian Auclair, Valerie Amsellem, Martial Hervy, Frederic Subra