Patents by Inventor Martial Hervy

Martial Hervy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12173311
    Abstract: A cell culture article includes a substrate having a polymer coating that is conducive to colony passaging of cells cultured on the coating. Example polymer coatings are formed from polygalacturonic acid (PGA), alginate, or combinations thereof. Cells cultured on the polymer coating can be separated from the substrate as a colony or layer of cells by exposing the polymer coating to (i) a chelating agent, (ii) a proteinase-free enzyme, or (iii) a chelating agent and a proteinase-free enzyme.
    Type: Grant
    Filed: July 26, 2023
    Date of Patent: December 24, 2024
    Assignee: CORNING INCORPORATED
    Inventors: Ye Fang, Ann MeeJin Ferrie, Vasiliy Nikolaevich Goral, David Henry, Martial Hervy, Corinne Walerack, Yue Zhou
  • Publication number: 20240026287
    Abstract: A cell culture article includes a substrate having a polymer coating that is conducive to colony passaging of cells cultured on the coating. Example polymer coatings are formed from polygalacturonic acid (PGA), alginate, or combinations thereof. Cells cultured on the polymer coating can be separated from the substrate as a colony or layer of cells by exposing the polymer coating to (i) a chelating agent, (ii) a proteinase-free enzyme, or (iii) a chelating agent and a proteinase-free enzyme.
    Type: Application
    Filed: July 26, 2023
    Publication date: January 25, 2024
    Inventors: Ye Fang, Ann MeeJin Ferrie, Vasiliy Nikolaevich Goral, David Henry, Martial Hervy, Corinne Walerack, Yue Zhou
  • Patent number: 11746322
    Abstract: A cell culture article includes a substrate having a polymer coating that is conducive to colony passaging of cells cultured on the coating. Example polymer coatings are formed from polygalacturonic acid (PGA), alginate, or combinations thereof. Cells cultured on the polymer coating can be separated from the substrate as a colony or layer of cells by exposing the polymer coating to (i) a chelating agent, (ii) a proteinase-free enzyme, or (iii) a chelating agent and a proteinase-free enzyme.
    Type: Grant
    Filed: September 16, 2020
    Date of Patent: September 5, 2023
    Assignee: CORNING INCORPORATED
    Inventors: Ye Fang, Ann MeeJin Ferrie, Vasiliy Nikolaevich Goral, David Henry, Martial Hervy, Corinne Walerack, Yue Zhou
  • Publication number: 20220235320
    Abstract: A cell culture article is provided. The cell culture article includes a substrate of a polygalacturonic acid compound crosslinked with a divalent cation, the polygalacturonic acid compound being selected from at least one of: pectic acid; partially esterified pectic acid, partially amidated pectic acid and salts thereof. The substrate is digestible by digestion reagents into components including of galacturonic acid monomers and the divalent cation. Methods of harvesting cells from the cell culture article are also provided. The methods include performing a series of wash and/or centrifugation cycles to reduce components in the harvest solution.
    Type: Application
    Filed: June 2, 2020
    Publication date: July 28, 2022
    Inventors: Martial Hervy, Liepin Huang, Jinlin Peng, Ryann Loren Russell, Jeffery Joseph Scibek, Yue Zhou
  • Publication number: 20220186178
    Abstract: A cell culture article, including: a substrate comprising a polygalacturonic acid compound selected from at least one of: pectic acid; partially esterified pectic acid having a degree of esterification from 1 to 40 mol %, or salts thereof; and an adhesion polymer on the surface of the polygalacturonic acid compound. A method of making and using the article are also disclosed.
    Type: Application
    Filed: December 22, 2021
    Publication date: June 16, 2022
    Inventors: David Henry, Martial Hervy, Corinne Walerack
  • Publication number: 20210062142
    Abstract: A cell culture article includes a substrate having a polymer coating that is conducive to colony passaging of cells cultured on the coating. Example polymer coatings are formed from polygalacturonic acid (PGA), alginate, or combinations thereof. Cells cultured on the polymer coating can be separated from the substrate as a colony or layer of cells by exposing the polymer coating to (i) a chelating agent, (ii) a proteinase-free enzyme, or (iii) a chelating agent and a proteinase-free enzyme.
    Type: Application
    Filed: September 16, 2020
    Publication date: March 4, 2021
    Inventors: Ye Fang, Ann MeeJin Ferrie, Vasiliy Nikolaevich Goral, David Henry, Martial Hervy, Corinne Walerack, Yue Zhou
  • Patent number: 10808221
    Abstract: A cell culture article includes a substrate having a polymer coating that is conducive to colony passaging of cells cultured on the coating. Example polymer coatings are formed from polygalacturonic acid (PGA), alginate, or combinations thereof. Cells cultured on the polymer coating can be separated from the substrate as a colony or layer of cells by exposing the polymer coating to (i) a chelating agent, (ii) a proteinase-free enzyme, or (iii) a chelating agent and a proteinase-free enzyme.
    Type: Grant
    Filed: December 16, 2015
    Date of Patent: October 20, 2020
    Assignee: Corning Incorporated
    Inventors: Ye Fang, Ann MeeJin Ferrie, Vasiliy Nikolaevich Goral, David Henry, Martial Hervy, Corinne Walerack, Yue Zhou
  • Publication number: 20200291348
    Abstract: A dissolvable foam scaffold for cell culture is provided herein. The dissolvable foam scaffold includes an ionotropically crosslinked polygalacturonic acid compound selected from at least one of: pectic acid; partially esterified pectic acid, partially amidated pectic acid and salts thereof, and at least one first water-soluble polymer having surface activity.
    Type: Application
    Filed: November 20, 2018
    Publication date: September 17, 2020
    Inventors: Marie-Maud Bear, David Henry, Martial Hervy, Marylène Denise Madeleine Pécheul, Corinne Walerack
  • Publication number: 20180051247
    Abstract: A cell culture article includes a substrate having a polymer coating that is conducive to colony passaging of cells cultured on the coating. Example polymer coatings are formed from polygalacturonic acid (PGA), alginate, or combinations thereof. Cells cultured on the polymer coating can be separated from the substrate as a colony or layer of cells by exposing the polymer coating to (i) a chelating agent, (ii) a proteinase-free enzyme, or (iii) a chelating agent and a proteinase-free enzyme.
    Type: Application
    Filed: December 16, 2015
    Publication date: February 22, 2018
    Inventors: Ye Fang, Ann MeeJin Ferrie, Vasiliy Nikoleavich Goral, David Henry, Martial Hervy, Corinne walerack, Yue Zhou
  • Patent number: 9873786
    Abstract: A composition for forming a polymeric cell culture surface includes (i) a pre-polymer comprising a polymer backbone, a cationic moiety conjugated to the backbone, and a cross-linker moiety conjugated to the backbone; and (ii) a peptide-polymer comprising a polymer backbone and cell adhesive peptide conjugated to the backbone. Cross-linked coatings for cell culture that have a suitable amount of cell adhesive peptide and cationic moiety may be formed from the pre-polymer and peptide-polymer.
    Type: Grant
    Filed: April 13, 2012
    Date of Patent: January 23, 2018
    Assignee: Corning Incorporated
    Inventors: David Henry, Martial Hervy, Marylène Denise Madeleine Pécheul, Corinne Walerack
  • Publication number: 20160145567
    Abstract: A cell culture article, including: a substrate comprising a polygalacturonic acid compound selected from at least one of: pectic acid; partially esterified pectic acid having a degree of esterification from 1 to 40 mol %, or salts thereof; and an adhesion polymer on the surface of the polygalacturonic acid compound. A method of making and using the article are also disclosed.
    Type: Application
    Filed: June 23, 2014
    Publication date: May 26, 2016
    Inventors: David Henry, Martial Hervy, Corinne Walerack
  • Patent number: 9115238
    Abstract: A cell culture microcarrier includes a polymer formed from copolymerization of a mixture including (i) an uncharged hydrophilic unsaturated monomer having a hydroxyl group; (ii) a hydrophilic carboxylic acid containing unsaturated monomer; and (iii) a hydrophilic multifunctional unsaturated monomer. The microcarrier may further include a polypeptide, such as a polypeptide that promotes cell adhesion, conjugated to the surface of the microcarrier; e.g. via the carboxyl group from the hydrophilic carboxylic acid containing unsaturated monomer. Some of the microcarriers support attachment of human embryonic stem cells.
    Type: Grant
    Filed: May 27, 2010
    Date of Patent: August 25, 2015
    Assignee: Corning Incorporated
    Inventors: Sophie Deshayes, David Henry, Martial Hervy
  • Patent number: 9068182
    Abstract: A cell culture polysaccharide microcarrier includes (1) a cross-linked polysaccharide microcarrier base having a neutral or negative charge at pH 7, and (ii) a polypeptide conjugated to the base. The polypeptide may contain a cell adhesive sequence, such as RGD. Cells cultured with such microcarriers exhibit peptide-specific binding to the microcarriers.
    Type: Grant
    Filed: July 28, 2010
    Date of Patent: June 30, 2015
    Assignee: Corning Incorporated
    Inventors: Sophie Deshayes, David Henry, Martial Hervy
  • Patent number: 8426176
    Abstract: A cell culture microcarrier includes a polymer formed from copolymerization of a mixture including (i) an uncharged hydrophilic unsaturated monomer having a hydroxyl group; (ii) a hydrophilic carboxylic acid containing unsaturated monomer; and (iii) a hydrophilic multifunctional unsaturated monomer. The microcarrier may further include a polypeptide, such as a polypeptide that promotes cell adhesion, conjugated to the surface of the microcarrier; e.g. via the carboxyl group from the hydrophilic carboxylic acid containing unsaturated monomer.
    Type: Grant
    Filed: May 27, 2010
    Date of Patent: April 23, 2013
    Assignee: Corning Incorporated
    Inventors: Sophie Deshayes, David Henry, Martial Hervy
  • Publication number: 20120282697
    Abstract: A composition for forming a polymeric cell culture surface includes (i) a pre-polymer comprising a polymer backbone, a cationic moiety conjugated to the backbone, and a cross-linker moiety conjugated to the backbone; and (ii) a peptide-polymer comprising a polymer backbone and cell adhesive peptide conjugated to the backbone. Cross-linked coatings for cell culture that have a suitable amount of cell adhesive peptide and cationic moiety may be formed from the pre-polymer and peptide-polymer.
    Type: Application
    Filed: April 13, 2012
    Publication date: November 8, 2012
    Inventors: David Henry, Martial Hervy, Marylène Denise Madeleine Pécheul, Corinne Walerack
  • Publication number: 20120058554
    Abstract: A cell culture polysaccharide microcarrier includes (1) a cross-linked polysaccharide microcarrier base having a neutral or negative charge at pH 7, and (ii) a polypeptide conjugated to the base. The polypeptide may contain a cell adhesive sequence, such as RGD. Cells cultured with such microcarriers exhibit peptide-specific binding to the microcarriers.
    Type: Application
    Filed: July 28, 2010
    Publication date: March 8, 2012
    Inventors: Sophie Deshayes, David Henry, Martial Hervy
  • Publication number: 20100317113
    Abstract: A cell culture microcarrier includes a polymer formed from copolymerization of a mixture including (i) an uncharged hydrophilic unsaturated monomer having a hydroxyl group; (ii) a hydrophilic carboxylic acid containing unsaturated monomer; and (iii) a hydrophilic multifunctional unsaturated monomer. The microcarrier may further include a polypeptide, such as a polypeptide that promotes cell adhesion, conjugated to the surface of the microcarrier; e.g. via the carboxyl group from the hydrophilic carboxylic acid containing unsaturated monomer.
    Type: Application
    Filed: May 27, 2010
    Publication date: December 16, 2010
    Inventors: SOPHIE DESHAYES, DAVID HENRY, MARTIAL HERVY
  • Publication number: 20100304482
    Abstract: A cell culture microcarrier includes a polymer formed from copolymerization of a mixture including (i) an uncharged hydrophilic unsaturated monomer having a hydroxyl group; (ii) a hydrophilic carboxylic acid containing unsaturated monomer; and (iii) a hydrophilic multifunctional unsaturated monomer. The microcarrier may further include a polypeptide, such as a polypeptide that promotes cell adhesion, conjugated to the surface of the microcarrier; e.g. via the carboxyl group from the hydrophilic carboxylic acid containing unsaturated monomer. Some of the microcarriers support attachment of human embryonic stem cells.
    Type: Application
    Filed: May 27, 2010
    Publication date: December 2, 2010
    Inventors: Sophie Deshayes, David Henry, Martial Hervy
  • Publication number: 20090286720
    Abstract: A pharmaceutical composition for the treatment, prevention or diagnosis of a tumoral pathology comprising an active agent which stabilizes an actin network of a cellular cytoskeleton.
    Type: Application
    Filed: April 20, 2009
    Publication date: November 19, 2009
    Applicants: Bioalliance Pharma, Ecole Normale Superieure de Cachan, Institut Gustave Roussy - IGR, Centre National de la Recherche Scientifique - CNRS
    Inventors: Christian Auclair, Valerie Amsellem, Martial Hervy, Frederic Subra
  • Publication number: 20040191230
    Abstract: A pharmaceutical composition for the treatment, prevention or diagnosis of a tumoral pathology comprising an active agent which stabilizes an actin network of a cellular cytoskeleton.
    Type: Application
    Filed: December 18, 2003
    Publication date: September 30, 2004
    Applicants: Bioalliance Pharma, a corporation of France, Ecole Normale Superieure de Cachan, a corporation of France, Institut Gustave Roussy - IGR, a corporation of France, Centre National de la Recherche Scientifique - CNRS, a corporation of France
    Inventors: Christian Auclair, Valerie Amsellem, Martial Hervy, Frederic Subra