Patents by Inventor Martijn Kleefstra

Martijn Kleefstra has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11186861
    Abstract: This invention pertains to the general field of microbiology, and more specifically to transfer, inoculation and/or streaking of micro-organisms, e.g. for the purpose of obtaining individual colonies. Provided is a method for streaking a microbial sample onto a solid carrier, comprising the steps of: a) contacting at least one ferromagnetic particle with a solid carrier, followed or preceded by providing the particle with at least part of said sample, and b) applying a magnetic field gradient to allow for magnetically controlled motion of said particle on said surface, such that at least part of the sample is streaked onto the solid carrier. Also provided is an apparatus for carrying out such method in an (semi-)automated fashion.
    Type: Grant
    Filed: August 1, 2018
    Date of Patent: November 30, 2021
    Assignee: BD KIESTRA B.V.
    Inventors: Trienko Marten Van Der Kaap, Martijn Kleefstra, Ingela Marie Sofie Edlund Tjernberg, Jetze Botma
  • Patent number: 11136544
    Abstract: A picktool manipulator device collects a specimen from a culture medium. In a first mode of operation, a picktool is allowed to move in an axial direction relative to support structure of the device. A detector may generate a signal in response to movement of the body in the axial direction so as to determine a height at which the picktool contacts the medium. The device may operate in the first mode when collecting a specimen from a culture medium. A second mode of operation constrains or precludes axial movement of the picktool. In some cases, the device may operate in the second mode when receiving a new picktool or discarding a used picktool.
    Type: Grant
    Filed: December 2, 2019
    Date of Patent: October 5, 2021
    Assignee: BD KIESTRA B.V.
    Inventors: Martijn Xander Berntsen, Jurjen Sinnema, Martijn Kleefstra
  • Publication number: 20210270862
    Abstract: The present invention describes an integrated incubator and image capture module that regulates the incubator atmosphere and obtains high-resolution digital images of sample specimens. The incubator has a cabinet type enclosure that enables the provision of a controlled environment to the contents of the incubator by having at least three ports on one face of the cabinet for the passage of sample containers. Additionally, an image capture module is located immediately adjacent to the incubator. In this regard, using at least three separate access/egress points for the sample containers streamlines operation of the system and enhances preservation of the incubator environment. Furthermore, locating the image capture module directly adjacent to the incubator reduces the amount of time a sample container is exposed to the external environment, thereby reducing the extent to which samples are exposed to potential contaminants and reducing the exchange of the lab and ambient atmospheres.
    Type: Application
    Filed: May 14, 2021
    Publication date: September 2, 2021
    Applicant: BD KIESTRA B.V.
    Inventors: Martijn Kleefstra, Martijn Xander Berntsen, Jan Bart Van Der Vijver, Tsjerk Nauta, Andrej Girgenson
  • Publication number: 20210269759
    Abstract: The present disclosure describes systems and methods for centering a circular object, such as a petri dish, between a plurality of pins. For example, in one embodiment, a method comprises placing a circular object on a rotatable platform surrounded by three moveable pins. In order to roughly center the circular object, the method further comprises moving, for a first time, all of the pins toward the circular object until at least two out of the three pins are touching the circular object. In order to more accurately center the circular object, the method further comprises: moving all of the pins away from the circular object so that it can be rotated without substantial inference; rotating the platform approximately 60 degrees, wherein rotating the platform causes the circular object to also rotate by approximately 60 degrees; and moving, for a second time, all of the pins toward the circular object.
    Type: Application
    Filed: July 10, 2019
    Publication date: September 2, 2021
    Inventors: Wouter Kuiper, Harm W. van der Dong, Jan Bart Van Der Vijver, Martijn Kleefstra
  • Publication number: 20210239582
    Abstract: The present invention describes an automated platform for inoculating a variety of receptacles with biological samples for testing and analysis. The lab automation system includes a plurality of modules used to automate the inoculation of media for subsequent analysis. In this regard, the lab automation system has one module to enter specimen/order information and store an inventory of petri dishes. Another module is used to label the sample receptacles with a unique identifier that associates the receptacles with the sample. Yet another module includes a robot for retrieving sample and inoculating the receptacles. The sample inoculation module also includes an apparatus that will receive slides, inoculate those slides, and further process the slides for analysis. Finally, the lab automation system includes a module that streaks the culture media with the sample. Thus, the automated lab system described herein provides consistent samples with minimal input from a lab operator.
    Type: Application
    Filed: April 20, 2021
    Publication date: August 5, 2021
    Applicant: BD KIESTRA B.V.
    Inventors: Martijn Xander BERNTSEN, Martijn Kleefstra, Roger Petri, Tino Walter Van Der Zee
  • Publication number: 20210199546
    Abstract: An automated method for preparing a sample suspension. The sample suspension can be used for both MALDI and antimicrobial susceptibility (AST). A suspension is prepared, and a portion of that suspension is removed for a first analysis (e.g. MALDI), leaving a remaining volume. The turbidity of the remaining volume is measured. If the turbidity is below a first threshold, the suspension is not used for a second analysis (e.g. AST) and is subjected to a concentration protocol to raise the turbidity of the suspension. If the turbidity is within a predetermined range, a volume of the suspension is calculated that will deliver a predetermined amount of sample to a vessel for the second analysis. If the turbidity of the suspension is above the predetermined range, and the suspension has not been diluted a predetermined number of times, the suspension is diluted according to a dilution protocol.
    Type: Application
    Filed: June 24, 2019
    Publication date: July 1, 2021
    Applicant: BD KIESTRA B.V.
    Inventors: Timothy Roy Hansen, Martijn Kleefstra, Michael Bois, Timothy M. Wiles, Charles Chak Cheung Yu
  • Patent number: 11041871
    Abstract: The present invention describes an integrated incubator and image capture module that regulates the incubator atmosphere and obtains high-resolution digital images of sample specimens. The incubator has a cabinet type enclosure that enables the provision of a controlled environment to the contents of the incubator by having at least three ports on one face of the cabinet for the passage of sample containers. Additionally, an image capture module is located immediately adjacent to the incubator. In this regard, using at least three separate access/egress points for the sample containers streamlines operation of the system and enhances preservation of the incubator environment. Furthermore, locating the image capture module directly adjacent to the incubator reduces the amount of time a sample container is exposed to the external environment, thereby reducing the extent to which samples are exposed to potential contaminants and reducing the exchange of the lab and ambient atmospheres.
    Type: Grant
    Filed: April 15, 2015
    Date of Patent: June 22, 2021
    Assignee: BD KIESTRA B.V.
    Inventors: Martijn Kleefstra, Martijn Xander Berntsen, Jan Bart Van Der Vijver, Tsjerk Nauta, Andrej Girgenson
  • Patent number: 11016007
    Abstract: The present invention describes an automated platform for inoculating a variety of receptacles with biological samples for testing and analysis. The lab automation system includes a plurality of modules used to automate the inoculation of media for subsequent analysis. In this regard, the lab automation system has one module to enter specimen/order information and store an inventory of petri dishes. Another module is used to label the sample receptacles with a unique identifier that associates the receptacles with the sample. Yet another module includes a robot for retrieving sample and inoculating the receptacles. The sample inoculation module also includes an apparatus that will receive slides, inoculate those slides, and further process the slides for analysis. Finally, the lab automation system includes a module that streaks the culture media with the sample. Thus, the automated lab system described herein provides consistent samples with minimal input from a lab operator.
    Type: Grant
    Filed: March 31, 2015
    Date of Patent: May 25, 2021
    Assignee: BD KIESTRA B.V.
    Inventors: Martijn Xander Berntsen, Martijn Kleefstra, Roger Petri, Tino Walter Van Der Zee
  • Publication number: 20210116471
    Abstract: A method and automated apparatus for locating and selecting a colony of microorganisms on a culture dish and subjecting the obtained sample to a plurality of downstream tests including a test to identify the microorganism and a test to identify the susceptibility of the microorganism to antibiotics. The method includes the automated steps of locating and selecting a colony of microorganisms on a culture dish; obtaining a sample of the selected colony of microorganisms; preparing a suspension of a sample of microorganisms automatically by submerging the pick tool with the sample in a suspension, after which the pick tool is vibrated in at least the vertical direction to release the sample from the pick tool in the suspension. The turbidity of the suspension is monitored to ensure that the concentration of microorganism in suspension is sufficient so that the suspension is used a source for sample for both identification and antibiotic susceptibility of the microorganisms in the sample.
    Type: Application
    Filed: December 29, 2020
    Publication date: April 22, 2021
    Applicant: BD KIESTRA B.V.
    Inventors: Timothy R. Hansen, Rick Holtz, Martijn Kleefstra, Raphael Rodolphe Marcelpoil, Rick Pierpont, Brent Ronald Pohl, Alyssa Shedlosky, Scott Shindledecker, Edward Skevington, Kerry Lynn Smith, Timothy Wiles
  • Publication number: 20210055318
    Abstract: A method and apparatus for locating and selecting a colony of microorganisms on a culture dish and identifying microorganisms in said selected colony using MALDI. The method comprises the automated steps of locating and selecting a colony of microorganisms on a culture dish; obtaining a sample of said selected colony of microorganisms; depositing at least some of said sample of said selected colony of microorganisms on a target plate; and transferring said target plate with said sample in an apparatus for performing MALDI for identification of said sample of said selected colony of microorganisms. A sample of a colony of microorganisms is automatically deposited on a depositing spot such that the sample covers at most approximately half of said one of the depositing spots of the target plate.
    Type: Application
    Filed: November 10, 2020
    Publication date: February 25, 2021
    Applicant: BD KIESTRA B.V.
    Inventors: Jetze Botma, Martijn Kleefstra, Tino Walter Van der Zee
  • Patent number: 10921336
    Abstract: A method and automated apparatus for locating and selecting a colony of microorganisms on a culture dish and subjecting the obtained sample to a plurality of downstream tests including a test to identify the microorganism and a test to identify the susceptibility of the microorganism to antibiotics. The method includes the automated steps of locating and selecting a colony of microorganisms on a culture dish; obtaining a sample of the selected colony of microorganisms; preparing a suspension of a sample of microorganisms automatically by submerging the pick tool with the sample in a suspension, after which the pick tool is vibrated in at least the vertical direction to release the sample from the pick tool in the suspension. The turbidity of the suspension is monitored to ensure that the concentration of microorganism in suspension is sufficient so that the suspension is used a source for sample for both identification and antibiotic susceptibility of the microorganisms in the sample.
    Type: Grant
    Filed: May 27, 2016
    Date of Patent: February 16, 2021
    Assignee: BD KIESTRA B.V.
    Inventors: Timothy Roy Hansen, Rick Holtz, Martijn Kleefstra, Raphael R. Marcelpoil, Rick Pierpont, Brent Ronald Pohl, Alyssa Shedlosky, Scott Shindledecker, Edward Skevington, Kerry Lynn Smith, Timothy M. Wiles
  • Patent number: 10859588
    Abstract: A method and apparatus for locating and selecting a colony of microorganisms on a culture dish and identifying microorganisms in said selected colony using MALDI. The method comprises the automated steps of locating and selecting a colony of microorganisms on a culture dish; obtaining a sample of said selected colony of microorganisms; depositing at least some of said sample of said selected colony of microorganisms on a target plate; and transferring said target plate with said sample in an apparatus for performing MALDI for identification of said sample of said selected colony of microorganisms. A sample of a colony of microorganisms is automatically deposited on a depositing spot such that the sample covers at most approximately half of said one of the depositing spots of the target plate.
    Type: Grant
    Filed: October 30, 2019
    Date of Patent: December 8, 2020
    Assignee: BD KIESTRA B.V.
    Inventors: Jetze Botma, Martijn Kleefstra, Tino Walter Van der Zee
  • Publication number: 20200166532
    Abstract: An apparatus for conveying a plurality of articles includes a transport belt, a bumper stopper, and a rotator. A motor moves the transport belt which is adapted to rotate the rotator as the belt conveys the plurality of articles. The stopper can move between first and second positions relative to the transport belt wherein the bumper stopper guides one article toward the rotator when the bumper stopper is in the first position. The bumper stopper allows the article to be conveyed to another location when the bumper stopper is in the second position. The transport belt can continue to convey other articles while the one article is temporarily held in place by the bumper stopper. The rotator is configured to rotate the article conveyed by the transport belt. The article can remain in contact with the transport belt while the rotator is rotating the article.
    Type: Application
    Filed: January 28, 2020
    Publication date: May 28, 2020
    Inventors: Jurjen Sinnema, Roger Petri, Martijn Xander Berntsen, Martijn Kleefstra
  • Publication number: 20200102532
    Abstract: A picktool manipulator device collects a specimen from a culture medium. In a first mode of operation, a picktool is allowed to move in an axial direction relative to support structure of the device. A detector may generate a signal in response to movement of the body in the axial direction so as to determine a height at which the picktool contacts the medium. The device may operate in the first mode when collecting a specimen from a culture medium. A second mode of operation constrains or precludes axial movement of the picktool. In some cases, the device may operate in the second mode when receiving a new picktool or discarding a used picktool.
    Type: Application
    Filed: December 2, 2019
    Publication date: April 2, 2020
    Inventors: Martijn Xander BERNTSEN, Jurjen SINNEMA, Martijn Kleefstra
  • Patent number: 10585107
    Abstract: An apparatus for conveying a plurality of articles (10) includes a transport belt (6), a bumper stopper (14), and a rotator (12). A motor moves the transport belt which is adapted to rotate the rotator as the belt conveys the plurality of articles. The stopper can move between first and second positions relative to the transport belt wherein the bumper stopper guides one article toward the rotator when the bumper stopper is in the first position. The bumper stopper allows the article to be conveyed to another location when the bumper stopper is in the second position. The transport belt can continue to convey other articles while the one article is temporarily held in place by the bumper stopper. The rotator is configured to rotate the article conveyed by the transport belt. The article can remain in contact with the transport belt while the rotator is rotating the article.
    Type: Grant
    Filed: February 4, 2016
    Date of Patent: March 10, 2020
    Assignee: BD KIESTRA B.V.
    Inventors: Jurjen Sinnema, Roger Petri, Martijn Xander Berntsen, Martijn Kleefstra
  • Publication number: 20200064361
    Abstract: A method and apparatus for locating and selecting a colony of microorganisms on a culture dish and identifying microorganisms in said selected colony using MALDI. The method comprises the automated steps of locating and selecting a colony of microorganisms on a culture dish; obtaining a sample of said selected colony of microorganisms; depositing at least some of said sample of said selected colony of microorganisms on a target plate; and transferring said target plate with said sample in an apparatus for performing MALDI for identification of said sample of said selected colony of microorganisms. A sample of a colony of microorganisms is automatically deposited on a depositing spot such that the sample covers at most approximately half of said one of the depositing spots of the target plate.
    Type: Application
    Filed: October 30, 2019
    Publication date: February 27, 2020
    Applicant: BD KIESTRA B.V.
    Inventors: Jetze Botma, Martijn Kleefstra, Tino Walter Van der Zee
  • Patent number: 10557113
    Abstract: A picktool manipulator device collects a specimen from a culture medium. In a first mode of operation, a picktool is allowed to move in an axial direction relative to support structure of the device. A detector may generate a signal in response to movement of the body in the axial direction so as to determine a height at which the picktool contacts the medium. The device may operate in the first mode when collecting a specimen from a culture medium. A second mode of operation constrains or precludes axial movement of the picktool. In some cases, the device may operate in the second mode when receiving a new picktool or discarding a used picktool.
    Type: Grant
    Filed: March 30, 2016
    Date of Patent: February 11, 2020
    Assignee: BD KIESTRA B.V.
    Inventors: Martijn Xander Berntsen, Jurjen Sinnema, Martijn Kleefstra
  • Patent number: 10495655
    Abstract: A method and apparatus for locating and selecting a colony of microorganisms on a culture dish and identifying microorganisms in said selected colony using MALDI. The method comprises the automated steps of locating and selecting a colony of microorganisms on a culture dish; obtaining a sample of said selected colony of microorganisms; depositing at least some of said sample of said selected colony of microorganisms on a target plate; and transferring said target plate with said sample in an apparatus for performing MALDI for identification of said sample of said selected colony of microorganisms. A sample of a colony of microorganisms is automatically deposited on a depositing spot such that the sample covers at most approximately half of said one of the depositing spots of the target plate.
    Type: Grant
    Filed: August 8, 2018
    Date of Patent: December 3, 2019
    Assignee: BD KIESTRA B.V.
    Inventors: Jetze Botma, Martijn Kleefstra, Tino Walter Van der Zee
  • Publication number: 20180364264
    Abstract: A method and apparatus for locating and selecting a colony of microorganisms on a culture dish and identifying microorganisms in said selected colony using MALDI. The method comprises the automated steps of locating and selecting a colony of microorganisms on a culture dish; obtaining a sample of said selected colony of microorganisms; depositing at least some of said sample of said selected colony of microorganisms on a target plate; and transferring said target plate with said sample in an apparatus for performing MALDI for identification of said sample of said selected colony of microorganisms. A sample of a colony of microorganisms is automatically deposited on a depositing spot such that the sample covers at most approximately half of said one of the depositing spots of the target plate.
    Type: Application
    Filed: August 8, 2018
    Publication date: December 20, 2018
    Applicant: BD KIESTRA B.V.
    Inventors: Jetze Botma, Martijn Kleefstra, Tino Walter Van der Zee
  • Publication number: 20180340205
    Abstract: This invention pertains to the general field of microbiology, and more specifically to transfer, inoculation and/or streaking of micro-organisms, e.g. for the purpose of obtaining individual colonies. Provided is a method for streaking a microbial sample onto a solid carrier, comprising the steps of: a) contacting at least one ferromagnetic particle with a solid carrier, followed or preceded by providing the particle with at least part of said sample, and b) applying a magnetic field gradient to allow for magnetically controlled motion of said particle on said surface, such that at least part of the sample is streaked onto the solid carrier. Also provided is an apparatus for carrying out such method in an (semi-)automated fashion.
    Type: Application
    Filed: August 1, 2018
    Publication date: November 29, 2018
    Applicant: BD KIESTRA B.V.
    Inventors: Trienko Marten Van Der Kaap, Martijn Kleefstra, lngela Marie Sofie Edlund Tjernberg, Jetze Botma