Patents by Inventor Martin Allan

Martin Allan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240309084
    Abstract: The present disclosure features bifunctional compounds for the degradation of extracellular targets, as well as compositions and related methods thereof.
    Type: Application
    Filed: January 18, 2022
    Publication date: September 19, 2024
    Inventors: Martin ALLAN, Jeffrey BAGDANOFF, David Weninger BARNES, John BLANKENSHIP, James BRADNER, Kevin CLAIRMONT, Brian GRANDA, Guido JUNGE, Thomas SMITH, Elisabetta TRAGGIAI, Max WARNCKE
  • Publication number: 20240182456
    Abstract: The present invention relates to compounds of formula (I) as activators of glucagon-like peptide 1 (GLP1) receptor for the treatment of obesity, type 2 diabetes mellitus, insulin resistance, hyperinsulinemia, glucose intolerance, hyperglycemia, one or more diabetic complications, diabetic nephropathy, dyslipidemia, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), hypertension, atherosclerosis, peripheral arterial disease, stroke, cardiomyopathy, atrial fibrillation, heart failure, coronary heart disease and neuropathy. Preferred compounds are e.g. 2-((4-((S)-2-(4-chloro-2-fluorophenyl)-2-methylbenzo[d][1,3]dioxol-4-yl)piperidin-1-yl)methyl)-1-(((S)-oxetan-2-yl)methyl)-1H-imidazole derivatives and similar compounds, such as e.g. C-1, C-2, C-3, C-4 and other compounds.
    Type: Application
    Filed: April 11, 2022
    Publication date: June 6, 2024
    Inventors: Martin ALLAN, Matthew CARSON, Thomas CAYA, Lara CZABANIUK, Ming QIAN, Daniel SMITH, Troy SMITH, Liansheng SU, Chung-Yeh WU, Lihua YANG, Chun ZHANG, Ping ZHANG, Xilin ZHOU
  • Publication number: 20230398224
    Abstract: The present invention is directed to the bifunctional compounds and the use of such bifunctional compounds to lower plasma levels of extracellular target molecules by lysosomal degradation. Such bifunctional compounds have a cell surface receptor ligand covalently linked to a ligand that is capable of binding to an extracellular target molecule (such as a ligand for a growth factor, a cytokine, a chemokine, a hormone, a neurotransmitter, a capsid, a soluble receptor, an extracellular secreted protein, an antibody, a lipoprotein, an exosome, a virus, a cell, or a plasma membrane protein), where the cell surface receptor is associated with receptor mediated endocytosis, including asialoglycoprotein receptor (ASGPR) mediated lysosomal degradation and mannose-6-phosphate (M6PR) mediated lysosomal degradation.
    Type: Application
    Filed: February 4, 2021
    Publication date: December 14, 2023
    Inventors: Martin Allan, Jeffrey T. BAGDANOFF, David Weninger Barnes, Kevin Clairmont, Thomas Smith, Shuangxi Wang
  • Publication number: 20200016360
    Abstract: Device and method of use are described in which a housing is configured and coupled to an aerosol generator which delivers aerosol into an oxygen stream transporting both to a patient via a nasal cannula, in a way to minimize condensation at low liters per minute flow rate.
    Type: Application
    Filed: July 11, 2018
    Publication date: January 16, 2020
    Inventor: Martin Allan MORRIS
  • Publication number: 20190381126
    Abstract: The invention provides methods to prepare protein conjugates from proteins having at least four accessible cysteine residues. In one embodiment, an antibody with four reducible disulfide linkages is reduced to provide four pairs of free cysteines. Each pair of free cysteines is reacted with a 1,3-dihaloacetone or similar reactant, linking the sulfur atoms of each pair together though a 3-carbon tether with a reactive ketone. A pair of these reactive ketones are linked together with and used to attach a single payload molecule, thus conjugating the antibody to two payload groups. This method gives a stabilized antibody conjugate with high selectivity for a ratio of two payloads per antibody.
    Type: Application
    Filed: July 29, 2019
    Publication date: December 19, 2019
    Inventors: Qi-Ying HU, Martin ALLAN
  • Patent number: 10471227
    Abstract: A housing and method of using the same is configured and coupled to an aerosol generator which delivers aerosol into an oxygen stream transporting both to a patient via a nasal cannula, in a way to minimize condensation at low liters per minute flow rate.
    Type: Grant
    Filed: August 21, 2018
    Date of Patent: November 12, 2019
    Inventor: Martin Allan Morris
  • Patent number: 10406198
    Abstract: The invention provides methods to prepare protein conjugates from proteins having at least four accessible cysteine residues. In one embodiment, an antibody with four reducible disulfide linkages is reduced to provide four pairs of free cysteines. Each pair of free cysteines is reacted with a 1,3-dihaloacetone or similar reactant, linking the sulfur atoms of each pair together though a 3-carbon tether with a reactive ketone. A pair of these reactive ketones are linked together with and used to attach a single payload molecule, thus conjugating the antibody to two payload groups. This method gives a stabilized antibody conjugate with high selectivity for a ratio of two payloads per antibody.
    Type: Grant
    Filed: May 22, 2015
    Date of Patent: September 10, 2019
    Assignee: Novartis AG
    Inventors: Qi-Ying Hu, Martin Allan
  • Publication number: 20170095572
    Abstract: The invention provides methods to prepare protein conjugates from proteins having at least four accessible cysteine residues. In one embodiment, an antibody with four reducible disulfide linkages is reduced to provide four pairs of free cysteines. Each pair of free cysteines is reacted with a 1,3-dihaloacetone or similar reactant, linking the sulfur atoms of each pair together though a 3-carbon tether with a reactive ketone. A pair of these reactive ketones are linked together with and used to attach a single payload molecule, thus conjugating the antibody to two payload groups. This method gives a stabilized antibody conjugate with high selectivity for a ratio of two payloads per antibody.
    Type: Application
    Filed: May 22, 2015
    Publication date: April 6, 2017
    Inventors: Qi-Ying HU, Martin ALLAN
  • Patent number: 8858783
    Abstract: A hydrocarbon synthesizer system for the production of petroleum fractions from a feedstock. Methods of synthesizing hydrocarbons from a feedstock.
    Type: Grant
    Filed: September 22, 2010
    Date of Patent: October 14, 2014
    Assignee: Neo-Petro, LLC
    Inventor: Martin Allan Morris
  • Patent number: 8519134
    Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5 and n are defined herein. The invention also relates to a method for manufacturing compounds of the invention, and their therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
    Type: Grant
    Filed: November 16, 2010
    Date of Patent: August 27, 2013
    Assignee: Novartis AG
    Inventors: Martin Allan, Sylvie Chamoin, Qi-Ying Hu, Hidetomo Imase, Julien Papillon
  • Patent number: 8338437
    Abstract: The present invention relates to compounds that are useful as inhibitors of protein arginine methyltransferase that have a formula selected from Formula (I), Formula (II) and Formula (III), as well as racemic mixtures, diastereomers, enantiomers and tautomers thereof and N-oxides, hydrates, solvates, pharmaceutically acceptable salts, prodrugs and complexes thereof as defined herein. The compound are useful as inhibitors of PRMTs and/or CARM-I. The invention further relates to compositions comprising such compounds and methods for their use.
    Type: Grant
    Filed: February 28, 2008
    Date of Patent: December 25, 2012
    Assignee: MethylGene Inc.
    Inventors: Amal Wahhab, Eric Therrien, Martin Allan, Sukhdev Manku
  • Publication number: 20120316195
    Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5 and n are defined herein. The invention also relates to a method for manufacturing compounds of the invention, and their therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
    Type: Application
    Filed: November 16, 2010
    Publication date: December 13, 2012
    Applicant: NOVARTIS AG
    Inventors: Martin Allan, Sylvie Chamoin, Qi-Ying Hu, Hidetomo Imase, Julien Papillon
  • Patent number: 8207362
    Abstract: A method of producing biodiesel from a source of triglycerides. The source of triglycerides is reacted with a blended alcohol composition in the presence of a catalyst to form a mixture of at least one fatty acid alcohol ester and glycerin. The fatty acid alcohol ester is then separated from the glycerin and is purified to produce a biofuel. The blended alcohol composition comprises at least one lower alcohol, a ketone and ethyl acetate. The use of the blended alcohol composition allows the transesterification process to proceed under ambient temperature and pressure conditions within a relatively short reaction time.
    Type: Grant
    Filed: November 21, 2008
    Date of Patent: June 26, 2012
    Assignee: Bio-Alternative, LLC
    Inventor: Martin Allan Morris
  • Publication number: 20120060411
    Abstract: A mobile biodiesel production facility comprising a shear mixer, a centrifuge, a control unit, and a plurality of pumps needed to pump the feedstocks and reactants. Upon mixing, the feedstock and reactant mixture becomes a reaction product. A residence tank collects the reaction product, where it rests for some time and self-converts to a residence product. The residence product is then pumped to the centrifuge, where the centrifuge separates the residence product into biodiesel and a heavy phase product. The control unit coordinates the operations of the shear mixer, centrifuge, and plurality of pumps.
    Type: Application
    Filed: February 10, 2010
    Publication date: March 15, 2012
    Inventors: Martin Allan Morris, Tony Khan, Michael J. Henneman, Jim Vollrath
  • Publication number: 20110067305
    Abstract: A hydrocarbon synthesizer system for the production of petroleum fractions from a feedstock. Methods of synthesizing hydrocarbons from a feedstock.
    Type: Application
    Filed: September 22, 2010
    Publication date: March 24, 2011
    Inventor: Martin Allan Morris
  • Publication number: 20100043280
    Abstract: A method of producing biodiesel from a source of triglycerides. The source of triglycerides is reacted with a blended alcohol composition in the presence of a catalyst to form a mixture of at least one fatty acid alcohol ester and glycerin. The fatty acid alcohol ester is then separated from the glycerin and is purified to produce a biofuel. The blended alcohol composition comprises at least one lower alcohol, a ketone and ethyl acetate. The use of the blended alcohol composition allows the transesterification process to proceed under ambient temperature and pressure conditions within a relatively short reaction time.
    Type: Application
    Filed: November 21, 2008
    Publication date: February 25, 2010
    Inventor: Martin Allan Morris
  • Patent number: 7553982
    Abstract: A method of producing biodiesel from a source of triglycerides. The source of triglycerides is reacted with a blended alcohol composition in the presence of a catalyst to form a mixture of at least one fatty acid alcohol ester and glycerin. The fatty acid alcohol ester is then separated from the glycerin and is purified to produce a biofuel. The blended alcohol composition comprises at least one lower alcohol, a ketone and ethyl acetate. The use of the blended alcohol composition allows the esterfication process to proceed under ambient temperature and pressure conditions within a relatively short reaction time.
    Type: Grant
    Filed: August 13, 2007
    Date of Patent: June 30, 2009
    Assignee: Bio-Alternative, LLC
    Inventor: Martin Allan Morris
  • Publication number: 20080280925
    Abstract: The present invention relates to compounds that are useful as inhibitors of protein arginine methyltransferase that have a formula selected from Formula (I), Formula (II) and Formula (III), as well as racemic mixtures, diastereomers, enantiomers and tautomers thereof and N-oxides, hydrates, solvates, pharmaceutically acceptable salts, prodrugs and complexes thereof as defined herein. Said compound are useful as inhibitors of PRMTs and/or CARM-I. The invention further relates to compositions comprising such compounds and methods for their use.
    Type: Application
    Filed: February 28, 2008
    Publication date: November 13, 2008
    Inventors: Amal Wahhab, Eric Therrien, Martin Allan, Sukhdev Manku
  • Publication number: 20070293530
    Abstract: This invention relates to compounds for the inhibition of histone deacetylase. More particularly, the invention provides for compounds of formula (I), and racemic and scalemic mixtures, diastereomers and enantiomers thereof: or an N-oxide, hydrate, solvate, pharmaceutically acceptable salt, prodrug or complex thereof, wherein Y, L, Z, W, M, Ra, Rb and Rc are as defined in the specification.
    Type: Application
    Filed: June 14, 2007
    Publication date: December 20, 2007
    Applicant: METHYLGENE INC.
    Inventors: David Smil, Silvana Leit, Alain Ajamian, Martin Allan, Yves Chantigny, Robert Deziel, Eric Therrien, Amal Wahhab, Sukhdev Manku
  • Publication number: 20070155730
    Abstract: This invention relates to compounds for the inhibition of histone deacetylase. More particularly, the invention provides for compounds of formula (I) wherein A, B, D, E, X1, X2, X3, X4 and n are as defined in the specification.
    Type: Application
    Filed: August 25, 2006
    Publication date: July 5, 2007
    Applicant: METHYLGENE, INC.
    Inventors: Silvana Leit, Amal Wahhab, Martin Allan, David Smil, Pierre Tessier, Robert Deziel, Yves Chantigny