Patents by Inventor Martin Brenner
Martin Brenner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20250034267Abstract: Materials and methods for using polypeptides containing fragments and variants of the antibody(ies) or portion(s) thereof that bind CD25 to treat cancer alone or in combination with other anti-neoplastic agents.Type: ApplicationFiled: September 4, 2024Publication date: January 30, 2025Inventors: Dillon Phan, Martin Brenner, Brian Berquist, Peter Kipp, Tam Phuong, Kevin Babilonia, Tom Hsu, Lufei Hu, James Talmage Taylor, JR., Cory Schwartz
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Publication number: 20250019457Abstract: Provided herein are anti-Trop 2 antibodies or binding fragments thereof that bind Trop 2, e.g., human Trop 2. The anti-Trop 2 antibodies of the disclosure are useful for the treatment of proliferative disorders or cells that express Trop 2 or mutant Trop 2. Also provided herein are methods of use for the anti-Trop 2 antibodies or binding fragments thereof, as well as bi-valent or multi-valent anti-Trop 2 antibodies or binding fragments thereof that may form complexes that attract immune effectors or binding to other cells, such as, a second antibody, antigen-binding of the second antibody or fragment thereof; a target-binding protein, a cytokine; a lectin; or a toxin.Type: ApplicationFiled: June 28, 2024Publication date: January 16, 2025Inventors: Dillon Phan, Cory Schwartz, Matthew P. Greving, Cody A. Moore, Tam Thi Thanh Phuong, Matthew Dent, Alexander T. Taguchi, Jiang Chen, Tom Sih-Yuan Hsu, Domyoung Kim, Martin Brenner
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Patent number: 12129302Abstract: Materials and methods for using polypeptides containing fragments and variants of the antibody(ies) or portion(s) thereof that bind CD25 to treat cancer alone or in combination with other anti-neoplastic agents.Type: GrantFiled: August 22, 2022Date of Patent: October 29, 2024Assignee: iBio, Inc.Inventors: Dillon Phan, Martin Brenner, Brian Berquist, Peter Kipp, Tam Phuong, Kevin Babilonia, Tom Hsu, Lufei Hu, James Talmage Taylor, Jr., Cory Schwartz
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Publication number: 20240228637Abstract: Provided herein are anti-CCR8 antibodies or antigen binding fragment thereof, which bind to CCR8, wherein the CCR8 is a human CCR8 and the antibody does not bind human CCR4. The anti-CCR8 antibodies or antigen binding fragment of the disclosure are useful for the treatment of cancer diseases through the elimination of regulatory T cells. Also provided herein are methods of use for the anti-CCR8 antibodies or antigen binding fragment thereof.Type: ApplicationFiled: October 19, 2023Publication date: July 11, 2024Inventors: Dillon Phan, Tom Sih-Yuan Hsu, Tam Thi Thanh Phuong, Matthew P. Greving, Alexander Tomoaki Taguchi, Cory Schwartz, Jiang Chen, Gao Liu, Martin Brenner, Matthew William Dent, Cody Allen Moore
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Publication number: 20240132604Abstract: Provided herein are anti-CCR8 antibodies or antigen binding fragment thereof, which bind to CCR8, wherein the CCR8 is a human CCR8 and the antibody does not bind human CCR4. The anti-CCR8 antibodies or antigen binding fragment of the disclosure are useful for the treatment of cancer diseases through the elimination of regulatory T cells. Also provided herein are methods of use for the anti-CCR8 antibodies or antigen binding fragment thereof.Type: ApplicationFiled: October 18, 2023Publication date: April 25, 2024Inventors: Dillon Phan, Tom Sih-Yuan Hsu, Tam Thi Thanh Phuong, Matthew P. Greving, Alexander Tomoaki Taguchi, Cory Schwartz, Jiang Chen, Gao Liu, Martin Brenner, Matthew William Dent, Cody Allen Moore
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Publication number: 20240117056Abstract: Provided herein are anti-EGFRvII antibodies and binding fragments thereof. The anti-EGFRvIII antibodies of the disclosure are useful for the treatment of cancers through, e.g., antibody-dependent cell cytotoxicity (ADCC). Also provided herein are methods of making and using the anti-EGFRvIII antibodies for the treatment of cancer, and polynucleotides that encode the same.Type: ApplicationFiled: October 11, 2023Publication date: April 11, 2024Inventors: Dillon Phan, Tom Sih-Yuan Hsu, Matthew P. Greving, Martin Brenner, Tam Thi Thanh Phuong, Alexander Tomoaki Taguchi, Cory Schwartz, Gao Liu, Jiang Chen
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Publication number: 20230159646Abstract: Materials and methods for using polypeptides containing fragments and variants of the antibody(ies) or portion(s) thereof that bind CD25 to treat cancer alone or in combination with other anti-neoplastic agents.Type: ApplicationFiled: August 22, 2022Publication date: May 25, 2023Inventors: Dillon Phan, Martin Brenner, Brian Berquist, Peter Kipp, Tam Phuong, Kevin Babilonia, Tom Hsu, Lufei Hu, James Talmage Taylor, JR., Cory Schwartz
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Publication number: 20170284707Abstract: An absorption chiller may include an absorbent circuit in which a liquid absorbent circulates and a working medium circuit in which a liquid working medium circulates. The absorbent circuit may include an absorber and a desorber. The working medium circuit may include an evaporator and a condenser. The absorption chiller may also include a low pressure membrane arrangement and a high pressure membrane arrangement each being permeable to a working medium vapour, impermeable to the liquid working medium and the liquid absorbent, and arranged between the evaporator and the absorber such that it is in contact with the working medium and the absorbent. At least one of the low pressure membrane arrangement and the high pressure membrane arrangement may include a working medium membrane and an absorbent membrane.Type: ApplicationFiled: March 28, 2017Publication date: October 5, 2017Inventors: Martin Brenner, Georg Feldhaus, Marco Lorenz, Mario Wallisch
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Patent number: 8647788Abstract: A fuel cell module (1) with a fuel cell (2), a residual gas burner (4) and a heat exchanger (6). The service life of the module (1) can be improved by at least one compensator (27) for establishing a flow-carrying connection between the residual gas burner (4) and the heat exchanger (6).Type: GrantFiled: February 9, 2010Date of Patent: February 11, 2014Assignees: Eberspächer Climate Control Systems GmbH & Co KG, Behr GmbH & Co KGInventors: Andreas Kaupert, Markus Münzner, Klaus Luz, Martin Brenner
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Patent number: 7987801Abstract: The present invention relates to a device and a method for monitoring a thread wound on a bobbin during operation in a sewing machine that reduces the expenditure on apparatus and production technology with increased monitoring reliability wherein at least three different marking states are provided in the area of the bobbin (3) and are coupled to an optical device (8) in such a manner that movement of the bobbin (3) produces a change in marking which can be detected in the optical device (8) which can be evaluated in a logic unit connected to the optical device (8), that the marking (10) in the area of the bobbin (3) comprises more than two states, wherein at least one state is defined by at least one true color (g, r, b) or a mixture of the primary colors.Type: GrantFiled: March 28, 2006Date of Patent: August 2, 2011Assignee: RSG Rombold System GmbH & Co., KGInventors: Andreas Ecker, Martin Brenner
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Publication number: 20080261163Abstract: The invention relates to a duct burner (1), particularly for a fuel cell system (2), in which two media are brought together, mixed and combusted to generate heat. To this end, the duct burner (1) has a number of nozzles (9), which are distributed over a surface and via which the media are fed to a burn-out chamber (8). Before feeding to the nozzles (9), the first medium in a first distributing chamber (5) and the second medium in a separate second distributing chamber (7) are each distributed onto a surface that corresponds approximately to the surface (F) of the burn-out chamber (8).Type: ApplicationFiled: July 11, 2005Publication date: October 23, 2008Inventors: Martin Brenner, Herbert Damsohn, Thomas Heckenberger, Klaus Luz, Conrad Pfender
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Publication number: 20070053809Abstract: The invention relates to a mixing device for mixing at least two media comprising at least one mixing chamber (177). The inventive device is characterised in that the wall (104, 110) of the mixing chamber is provided with at least one temperature control channel.Type: ApplicationFiled: April 6, 2004Publication date: March 8, 2007Inventors: Martin Brenner, Herbert Damsohn, Conrad Pfender
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Patent number: 7108053Abstract: The invention relates to a plate-type heat exchanger having a plate block comprising partition plates which delimit flow channel layers between the plates. According to the invention, the partition plates have a solid or folded edge, which projects out of the plane of at least one main side of the partition plates at the edge side, along closed-edge regions which are spaced apart from one another in the peripheral direction by means of intervening open-edge regions. In the plate block, this solid or folded edge is joined in a fluid-tight manner to the opposite edge region of an adjoining partition plate and functions as a lateral boundary for the associated flow channel layer. Such heat exchangers may be used, for example, in automobiles and reactors of fuel cell systems.Type: GrantFiled: April 14, 2004Date of Patent: September 19, 2006Assignee: Behr GmbH & Co.Inventors: Martin Brenner, Herbert Damsohn, Conrad Pfender
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Publication number: 20040194939Abstract: The invention relates to a plate-type heat exchanger having a plate block comprising partition plates which delimit flow channel layers between the plates. According to the invention, the partition plates have a solid or folded edge, which projects out of the plane of at least one main side of the partition plates at the edge side, along closed-edge regions which are spaced apart from one another in the peripheral direction by means of intervening open-edge regions. In the plate block, this solid or folded edge is joined in a fluid-tight manner to the opposite edge region of an adjoining partition plate and functions as a lateral boundary for the associated flow channel layer. Such heat exchangers may be used, for example, in automobiles and reactors of fuel cell systems.Type: ApplicationFiled: April 14, 2004Publication date: October 7, 2004Applicant: BEHR GmbH & Co.Inventors: Martin Brenner, Herbert Damsohn, Conrad Pfender
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Patent number: 6739385Abstract: The invention relates to a plate-type heat exchanger having a plate block comprising partition plates which delimit flow channel layers between the plates. According to the invention, the partition plates have a solid or folded edge, which projects out of the plane of at least one main side of the partition plates at the edge side, along closed-edge regions which are spaced apart from one another in the peripheral direction by means of intervening open-edge regions. In the plate block, this solid or folded edge is joined in a fluid-tight manner to the opposite edge region of an adjoining partition plate and functions as a lateral boundary for the associated flow channel layer. Such heat exchangers may be used, for example, in automobiles and reactors of fuel cell systems.Type: GrantFiled: August 31, 2001Date of Patent: May 25, 2004Assignee: Behr GmbH & Co.Inventors: Martin Brenner, Herbert Damsohn, Conrad Pfender
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Publication number: 20020023741Abstract: The invention relates to a plate-type heat exchanger having a plate block comprising partition plates which delimit flow channel layers between the plates. According to the invention, the partition plates have a solid or folded edge, which projects out of the plane of at least one main side of the partition plates at the edge side, along closed-edge regions which are spaced apart from one another in the peripheral direction by means of intervening open-edge regions. In the plate block, this solid or folded edge is joined in a fluid-tight manner to the opposite edge region of an adjoining partition plate and functions as a lateral boundary for the associated flow channel layer. Such heat exchangers may be used, for example, in automobiles and reactors of fuel cell systems.Type: ApplicationFiled: August 31, 2001Publication date: February 28, 2002Applicant: BEHR GmbH & Co.Inventors: Martin Brenner, Herbert Damsohn, Conrad Pfender
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Patent number: 6318456Abstract: The invention relates to a heat exchanger of the crosscurrent type, through which at least two fluids flow, consisting of plates which are stacked one on the other between two cover plates and which are spaced from one another in regions and are in contact in regions, so that fluid paths are formed between them in a heat transfer region, and of inlet ducts and outlet ducts which are arranged laterally in duct regions and which are formed from inlet duct openings and outlet duct openings in the plates, at least one inlet duct and one outlet duct being fluidically connected to a group of fluid paths which are next but one. The object of the invention is to develop a heat exchanger of the type initially mentioned, in such a way that, while having at least the same operating reliability, it can be produced more efficiently and more cost-effectively and has a lower weight.Type: GrantFiled: March 6, 2000Date of Patent: November 20, 2001Assignee: Behr GmbH & Co.Inventors: Martin Brenner, Klaus Luz, Herbert Damsohn, Conrad Pfender
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Patent number: 6071712Abstract: An enzymatic process for hydrolyzing the 7-position acyl ester of certain cephalosporin compounds to the corresponding alcohol is disclosed.Type: GrantFiled: September 18, 1997Date of Patent: June 6, 2000Assignee: SmithKline Beecham CorporationInventors: Vedanthadesikan Renganathan, Martin Brenner
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Patent number: 5911273Abstract: Heat transfer device of a stacked plate construction has a stacked plate construction consisting of alternately stacked flow duct plate units with flow duct openings and connection duct openings as well as connection cover plate units with connection duct openings provided such that two separate fluid flow systems are formed. The equal-sided connection duct openings overlap only by means of an interior portion with the equal-sided ends of the flow duct openings, whereas, by means of an exterior portion, while forming a respective connection conduit, they extend in the area outside the flow duct openings. This implements a compact plate stack construction with an optimal connection geometry for very low pressure losses.Type: GrantFiled: September 18, 1997Date of Patent: June 15, 1999Assignee: Behr GmbH & Co.Inventors: Martin Brenner, Conrad Pfender, Walter Wolf
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Patent number: 4340601Abstract: A new series of compounds having renal vasodilating activity described. The compounds are 2-allyl-8-halo-4-(p-hydroxyphenyl)-1,2,3,4-tetrahydroisoquinolines.Type: GrantFiled: July 8, 1980Date of Patent: July 20, 1982Assignee: SmithKline CorporationInventor: L. Martin Brenner