Patents by Inventor Martin G. Pomper

Martin G. Pomper has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20160106866
    Abstract: The presently disclosed subject matter generally relates to genetic constructs and methods for their use in cancer imaging, cancer treatment, and combined imaging and treatment protocols. In particular, the presently disclosed subject matter relates to tripartite cancer theranostic nucleic acid constructs that permit simultaneous cancer specific viral replication, expression of a diagnostic gene product, and expression of a therapeutic gene.
    Type: Application
    Filed: June 4, 2014
    Publication date: April 21, 2016
    Inventors: Paul B. FISHER, Swadesh K. Das, Mitchell E. MENEZES, Devanand Sarkar, Martin G. Pomper
  • Publication number: 20160082132
    Abstract: Compositions and methods for chemical exchange saturation transfer (CEST) based magnetic resonance imaging (MRI) or frequency labeled exchange (FLEX) imaging are disclosed. Beta-hydroxycarboxylate and beta-aminocarboxylate derivatives including salicylic acid, salicylates, salicylic acid prodrugs, N-alkyl/aryl/acyl/sulfonyl-anthranilic acid analogs, and any aromatic compound with OH/NH group ortho to the carboxylic acid group are disclosed. Such compounds can be used as general MRI organic contrast agents and produce significantly improved contrast in MR images detectable through CEST or FLEX.
    Type: Application
    Filed: May 16, 2014
    Publication date: March 24, 2016
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: XING YANG, XIAOLEI SONG, SANGEETA RAY, MARTIN G. POMPER, MICHAEL T. MCMAHON
  • Publication number: 20160075667
    Abstract: The invention features novel heterocyclic compounds that are useful as MRI contrast agents. Specifically, the invention relates to a novel class of MRI contrast agents that produce significantly improved contrast in MR images that is detectable through chemical exchange saturation transfer (CEST) or frequency labeled exchange (FLEX) imaging. The MRI contrast agents of the invention include those delineated in the formulae provided herein. The invention also relates to various methods in which the MRI contrast agents are employed. Kits and pharmaceutical compositions thereof are also provided.
    Type: Application
    Filed: May 1, 2014
    Publication date: March 17, 2016
    Inventors: Xing Yang, Xiaolei Song, Sangeeta Ray, Martin G. Pomper, Michael T. McMahon
  • Patent number: 9233178
    Abstract: Translocator protein (TSPO) targeting compounds are described. Methods of making the compounds, and uses of the compounds for imaging are also described.
    Type: Grant
    Filed: July 14, 2014
    Date of Patent: January 12, 2016
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Martin G. Pomper, Haofan Wang, Tomas R. Guilarte
  • Patent number: 9226981
    Abstract: Prostate-specific membrane antigen (PSMA) binding compounds having radioisotope substituents are described, as well as chemical precursors thereof. Compounds include pyridine containing compounds, compounds having phenylhydrazine structures, and acylated lysine compounds. The compounds allow ready incorporation of radionuclides for single photon emission computed tomography (SPECT) and positron emission tomography (PET) for imaging, for example, prostate cancer cells and angiogenesis.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: January 5, 2016
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Martin G. Pomper, Ronnie Charles Mease, Ying Chen
  • Publication number: 20150369738
    Abstract: A detectable substrate for aldehyde dehydrogenase (ALDH) can be used for selecting cells that express ALDH. The detectable substrate can have a fluorescent moiety that has an excitation wavelength, an emission wavelength, or both, that does not overlap with the excitation wavelength, emission wavelength, or both, of green fluorescent protein.
    Type: Application
    Filed: February 21, 2014
    Publication date: December 24, 2015
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: MARTIN G. POMPER, HAOFAN WANG, IL MINN, STEVEN D. LEACH, RONNIE C. MEASE
  • Publication number: 20150246144
    Abstract: The prostate-specific membrane antigen (PSMA) is increasingly recognized as a viable target for imaging and therapy of cancer. Various 99mTc/Re-labeled compounds were prepared by attaching known Tc/Re chelating agents to an amino-functionalized PSMA inhibitor with or without a variable length linker moiety. Ex vivo biodistribution and in vivo imaging demonstrated the degree of specific binding to engineered PSMA+PC3 PIP tumors.
    Type: Application
    Filed: May 18, 2015
    Publication date: September 3, 2015
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: MARTIN G. POMPER, SANGEETA RAY, RONNIE C. MEASE, CATHERINE ANNE FOSS
  • Patent number: 9044468
    Abstract: The prostate-specific membrane antigen (PSMA) is increasingly recognized as a viable target for imaging and therapy of cancer. Various 99mTc/Re-labeled compounds were prepared by attaching known Tc/Re chelating agents to an amino-functionalized PSMA inhibitor with or without a variable length linker moiety. Ex vivo biodistribution and in vivo imaging demonstrated the degree of specific binding to engineered PSMA+ PC3 PIP tumors.
    Type: Grant
    Filed: June 26, 2008
    Date of Patent: June 2, 2015
    Assignee: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Martin G. Pomper, Ray Sangeeta, Ronnie C. Mease, Catherine Foss
  • Publication number: 20150104387
    Abstract: Prostate-specific membrane antigen (PSMA) targeting compounds are described. Uses of the compounds for imaging, therapy, cell sorting, and tumor mapping are also described.
    Type: Application
    Filed: April 2, 2014
    Publication date: April 16, 2015
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: MARTIN G. POMPER, RONNIE C. MEASE, YING CHEN, Sangeeta Ray
  • Publication number: 20140369931
    Abstract: Prostate-specific membrane antigen (PSMA) binding compounds having radioisotope substituents are described, as well as chemical precursors thereof. Compounds include pyridine containing compounds, compounds having phenylhydrazine structures, and acylated lysine compounds. The compounds allow ready incorporation of radionuclides for single photon emission computed tomography (SPECT) and positron emission tomography (PET) for imaging, for example, prostate cancer cells and angiogenesis.
    Type: Application
    Filed: March 14, 2014
    Publication date: December 18, 2014
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: MARTIN G. POMPER, RONNIE CHARLES MEASE, YING CHEN
  • Publication number: 20140322133
    Abstract: Translocator protein (TSPO) targeting compounds are described. Methods of making the compounds, and uses of the compounds for imaging are also described.
    Type: Application
    Filed: July 14, 2014
    Publication date: October 30, 2014
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: MARTIN G. POMPER, HAOFAN WANG, TOMAS R. GUILARTE
  • Patent number: 8778304
    Abstract: Translocator protein (TSPO) targeting compounds are described. Methods of making the compounds, and uses of the compounds for imaging are also described.
    Type: Grant
    Filed: February 24, 2011
    Date of Patent: July 15, 2014
    Assignee: The Johns Hopkins University
    Inventors: Martin G. Pomper, Haofan Wang, Tomas R. Guilarte
  • Patent number: 8691186
    Abstract: The instant invention provides a method for diagnosing an infection in a subject by administering to the subject a compound suitable for imaging which binds to a thymidine kinase present in the infecting organism, and obtaining an image of the subject to determine the presence and location of the compound, wherein a localization of the compound is indicative that the subject has an infection.
    Type: Grant
    Filed: August 28, 2012
    Date of Patent: April 8, 2014
    Assignee: The Johns Hopkins University
    Inventors: Martin G. Pomper, Chetan Bettegowda, Catherine Foss, Shibin Zhou, Kenneth Kinzler, Bert Vogelstein
  • Publication number: 20130064767
    Abstract: The instant invention provides a method for diagnosing an infection in a subject by administering to the subject a compound suitable for imaging which binds to a thymidine kinase present in the infecting organism, and obtaining an image of the subject to determine the presence and location of the compound, wherein a localization of the compound is indicative that the subject has an infection.
    Type: Application
    Filed: August 28, 2012
    Publication date: March 14, 2013
    Applicant: The Johns Hopkins University
    Inventors: Martin G. Pomper, Chetan Bettegowda, Catherine Foss, Shibin Zhou, Kenneth Kinzler, Bert Vogelstein
  • Patent number: 8273326
    Abstract: The instant invention provides a method for diagnosing an infection in a subject by administering to the subject a compound suitable for imaging which binds to a thymidine kinase present in the infecting organism, and obtaining an image of the subject to determine the presence and location of the compound, wherein a localization of the compound is indicative that the subject has an infection.
    Type: Grant
    Filed: June 20, 2005
    Date of Patent: September 25, 2012
    Assignee: The Johns Hopkins University
    Inventors: Martin G. Pomper, Chetan Bettegowda, Catherine Foss, Shibin Zhou, Kenneth Kinzler, Bert Vogelstein
  • Publication number: 20110212025
    Abstract: Translocator protein (TSPO) targeting compounds are described. Methods of making the compounds, and uses of the compounds for imaging are also described.
    Type: Application
    Filed: February 24, 2011
    Publication date: September 1, 2011
    Applicant: The Johns Hopkins University
    Inventors: Martin G. Pomper, Haofan Wang, Tomas R. Guilarte
  • Publication number: 20110200677
    Abstract: The invention provides a nanoparticle composition that is decorated with a urea-based small-molecule peptidomimetic inhibitor of prostate specific membrane antigen (PSMA), which is expressed by almost all solid tumors. This strategy takes advantage of both the avidity of the functionalized nanoparticle for binding to PSMA and the ability of the nanoparticle to be retained for longer periods of time in the tumor due to enhanced leakage via EPR into the tumor interstitium and poor clearance due to underdeveloped or non-existent lymphatics within the tumor.
    Type: Application
    Filed: November 26, 2008
    Publication date: August 18, 2011
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Sachin S. Chandran, Sangeeta Ray, Martin G. Pomper, Samuel R. Denmeade, Ronnie C. Mease
  • Publication number: 20110176998
    Abstract: The present invention features compositions and methods for detecting, selecting a treatment method for, monitoring, and treating a neoplasia associated with a viral infection.
    Type: Application
    Filed: October 13, 2010
    Publication date: July 21, 2011
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Martin G. Pomper, Richard Ambinder, Jun O. Liu, Curtis R. Chong, Jianmeng Chen
  • Publication number: 20100034741
    Abstract: The present invention relates to radiolabelled compounds particularly 1-azabicyclo[2.2.2]octane compounds (i.e., quinuclidine compounds) which are labeled with one or more radioisotopes and which are suitable for imaging or therapeutic treatment of tissues, organs, or tumors which express the ?7-nicotinic cholinergic receptor. In another embodiment, the invention relates to methods of imaging tissues, organs, or tumors using radiolabeled compounds of the invention, particularly tissues, organs, or tumors which express ?7-nicotinic cholinergic receptor to which the compounds of the invention have an affinity.
    Type: Application
    Filed: January 26, 2009
    Publication date: February 11, 2010
    Applicants: The Johns Hopkins University
    Inventors: Martin G. Pomper, John L. Musachio, Hong Fan, Robert F. Dannals, Catherine Foss, Eifion Phillips, John Gordon, Dennis McCarthy, Richard Keith, Mark Smith, Richard Heys, Peter N. Dorff
  • Publication number: 20090010844
    Abstract: The instant invention provides a method for diagnosing an infection in a subject by administering to the subject a compound suitable for imaging which binds to a thymidine kinase present in the infecting organism, and obtaining an image of the subject to determine the presence and location of the compound, wherein a localization of the compound is indicative that the subject has an infection.
    Type: Application
    Filed: June 20, 2005
    Publication date: January 8, 2009
    Applicant: The John Hopkins University
    Inventors: Martin G. Pomper, Chetan Bettegowda, Catherine Foss, Shibin Zhou, Kenneth Kinzler, Bert Vogelstein