Patents by Inventor Martin Hentemann

Martin Hentemann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SUBSTITUTED 2,3-DIHYDROIMIDAZO[1,2-C]QUINAZOLINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS
    Publication number: 20130261113
    Abstract: This invention relates to novel 2,3-dihydroimidazo[1,2-c]quinazoline compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for phosphotidylinositol-3-kinase (PI3K) inhibition and treating diseases associated with phosphotidylinositol-3-kinase (PI3K) activity, in particular treating hyper-proliferative and/or angiogenesis disorders, as a sole agent or in combination with other active ingredients.
    Type: Application
    Filed: June 3, 2013
    Publication date: October 3, 2013
    Inventors: Martin HENTEMANN, Jill WOOD, William SCOTT, Martin MICHELS, Ann-Marie CAMPBELL, Ann BULLION, Ronald ROWLEY, Aniko REDMAN
  • Substituted 2,3-dihydroimidazo[1,2-c]quinazoline derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis
    Patent number: 8466283
    Abstract: This invention relates to novel 2,3-dihydroimidazo[1,2-c]quinazoline compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for phosphotidylinositol-3-kinase (PI3K) inhibition and treating diseases associated with phosphotidylinositol-3-kinase (PI3K) activity, in particular treating hyper-proliferative and/or angiogenesis disorders, as a sole agent or in combination with other active ingredients.
    Type: Grant
    Filed: December 5, 2007
    Date of Patent: June 18, 2013
    Assignee: Bayer Intellectual Property GmbH
    Inventors: Martin Hentemann, Jill Wood, William Scott, Martin Michels, Ann-Marie Campbell, Ann-Marie Bullion, Bruce R. Rowley, Aniko Redman
  • 5H-cyclopenta[D]pyrimidines as AKT protein kinase inhibitors
    Patent number: 8329709
    Abstract: Compounds of Formula I are useful for inhibiting AKT protein kinases. Methods using compounds of Formula I and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed. Formula (I).
    Type: Grant
    Filed: January 9, 2009
    Date of Patent: December 11, 2012
    Assignees: Genentech, Inc., Array BioPharma Inc.
    Inventors: Anna L. Banka, Josef R. Bencsik, James Blake, Martin Hentemann, Nicholas C. Kallan, Jun Liang, Ian S. Mitchell, Stephen T. Schlachter, Eli M. Wallace, Rui Xu, Tony P. Tang
  • SULFONE SUBSTITUTED 2,3-DIHYDROIMIDAZO [1,2-C] QUINAZOLINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES WITH ANGIOGENESIS
    Publication number: 20110190281
    Abstract: This invention relates to novel sulfone 2I3-dihydroimidazo[1,2-c]quinazoline compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for phosphotidylinositol-3-kinase (PI3K) inhibition and treating diseases associated with phosphotidylinositol-3-kinase (PI3K) activity, in particular treating hyper-proliferative and/or angiogenesis mediated disorders, as a sole agent or in combination with other active ingredients.
    Type: Application
    Filed: January 13, 2009
    Publication date: August 4, 2011
    Applicant: BAYER SCHERING PHARMA AKTIENGESELLSCHAFT
    Inventors: Martin Hentemann, William Scott, Jill Wood, Jeffrey Johnson, Aniko Redman, Ann-Marie Bullion, Leatte Guernon
  • Indole acetic acid derivatives and their use as pharmaceutical agents
    Patent number: 7964622
    Abstract: This invention is directed to indole acetic acid derivatives and their use in pharmaceutical compositions for the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic disease. The invention is also directed to intermediates useful in preparation of indole acetic derivatives and to methods of preparation.
    Type: Grant
    Filed: July 23, 2009
    Date of Patent: June 21, 2011
    Assignee: Bayer Healthcare LLC
    Inventors: Xin Ma, Louis-David Cantin, Soongyu Choi, Roger Clark, Martin Hentemann, Joachim Rudolph, Rico Lavoie, Zhonghua Zhang
  • Substituted 2,3-dihydroimidazo[1,2-c]quinazoline Derivatives Useful for Treating Hyper-Proliferative Disorders and Diseases Associated with Angiogenesis
    Publication number: 20110083984
    Abstract: This invention relates to novel 2,3-dihydroimidazo[1,2-c]quinazoline compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for phosphotidylinositol-3-kinase (PI3K) inhibition and treating diseases associated with phosphotidylinositol-3-kinase (PI3K) activity, in particular treating hyper-proliferative and/or angiogenesis disorders, as a sole agent or in combination with other active ingredients.
    Type: Application
    Filed: December 5, 2007
    Publication date: April 14, 2011
    Applicant: BAYER SCHERING PHARMA AKTIENGESELLSCHAFT
    Inventors: Martin Hentemann, Jill Wood, William Scott, Martin Michels, Ann-Marie Campbell, Ann-Marie Bullion, Bruce R. Rowley, Aniko Redman
  • Benzofuran derivatives useful for treating hyper-proliferative disorders
    Patent number: 7659412
    Abstract: The invention relates to novel benzofuran derivatives, processes for their preparation and their use for preparing medicaments for the treatment or prophylaxis of disorders, especially of hyperproliferative disorders.
    Type: Grant
    Filed: August 29, 2008
    Date of Patent: February 9, 2010
    Assignee: Bayer Healthcare LLC
    Inventors: Chengzhi Zhang, Jacques Dumas, Gaetan Ladouceur, Qian Zhao, Martin Hentemann, Sharad Verma, Qingming Zhu, Rico Lavoie, Jianmei Fan, Barton Phillips
  • Indole acetic acid derivatives and their use as pharmaceutical agents
    Publication number: 20090298854
    Abstract: This invention is directed to indole acetic acid derivatives and their use in pharmaceutical compositions for the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic disease. The invention is also directed to intermediates useful in preparation of indole acetic derivatives and to methods of preparation.
    Type: Application
    Filed: July 23, 2009
    Publication date: December 3, 2009
    Inventors: Xin Ma, Louis-David Cantin, Soongyu Choi, Roger Clark, Martin Hentemann, Joachim Rudolph, Rico Lavoie, Zhonghua Zhang
  • Indole acetic acid derivatives and their use as pharmaceutical agents
    Patent number: 7592361
    Abstract: This invention is directed to indole acetic acid derivatives and their use in pharmaceutical compositions for the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic disease. The invention is also directed to intermediates useful in preparation of indole acetic derivatives and to methods of preparation.
    Type: Grant
    Filed: April 28, 2004
    Date of Patent: September 22, 2009
    Assignee: Bayer Pharmaceuticals Corporation
    Inventors: Xin Ma, Louis-David Cantin, Soongyu Choi, Roger Clark, Martin Hentemann, Joachim Rudolph, Rico Lavoie, Zhonghua Zhang
  • BENZOFURAN DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS
    Publication number: 20090023783
    Abstract: The invention relates to novel benzofuran derivatives, processes for their preparation and their use for preparing medicaments for the treatment or prophylaxis of disorders, especially of hyperproliferative disorders
    Type: Application
    Filed: August 29, 2008
    Publication date: January 22, 2009
    Inventors: Chengzhi Zhang, Jacques Dumas, Gaetan H. Ladouceur, Qian Zhao, Martin Hentemann, Sharad K. Verma, Qingming Zhu, Rico C. Lavoie, Jianmei Fan, Barton Phillips
  • Pyrimidine derivatives for treatment of hyperproliferative disorders
    Publication number: 20070117817
    Abstract: Pyrimidine derivatives of formula (I) in which J and Y represent aromatic or heteroaromatic rings; R2, G, G?, and G? represent substituent groups and R2a represents H or halogen; L represents a linking group; and M represents CH or N. Pharmaceutical compositions containing these compounds, and methods of using these compounds in treatment of hyperproliferative diseases such as cancer are also disclosed and claimed.
    Type: Application
    Filed: October 8, 2004
    Publication date: May 24, 2007
    Applicant: Bayer Pharmaceuticals Corporation
    Inventors: Julie Dixon, Dhanapalan Nagarathnam, Lei Zhang, Chunguang Wang, Lin Yin, Yuanwei Chen, Jianqing Chen, Brian Bear, Michael Brands, Alexander Hillisch, Donald Bierer, Ming Wang, Wenlang Fu, Martin Hentemann, Ann-Marie Bullion
  • Indole acetic acid derivatives and their use as pharmaceutical agents
    Publication number: 20060264486
    Abstract: This invention is directed to indole acetic acid derivatives and their use in pharmaceutical compositions for the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic disease. The invention is also directed to intermediates useful in preparation of indole acetic derivatives and to methods of preparation.
    Type: Application
    Filed: April 28, 2004
    Publication date: November 23, 2006
    Inventors: Xin Ma, Louis-David Cantin, Soongyu Choi, Roger Clark, Martin Hentemann, Joachim Rudolph, Rico Lavoie, Zhonghua Zhang
  • Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation
    Publication number: 20060084680
    Abstract: This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic derivatives and to methods of preparation.
    Type: Application
    Filed: December 19, 2003
    Publication date: April 20, 2006
    Applicant: Bayer Pharmaceuticals Corporation
    Inventors: Louis-David Cantin, Soongyu Choi, Roger Clark, Martin Hentemann, Xin Ma, Joachim Rudolph, Sidney Liang, Christiana Akuche, Rico Lavoie, Libing Chen, Dyuti Majumdar, Philip Wickens
  • Pyrimidine derivatives for treatment of hyperproliferative disorders
    Publication number: 20050277640
    Abstract: Pyrimidine derivatives of formula (I) in which J and Y represent aromatic or heteroaromatic rings; R2, G, G?, and G? represent substituent groups and R2a represents H or halogen; L represents a linking group; and M represents CH or N. Pharmaceutical compositions containing these compounds, and methods of using these compounds in treatment of hyperproliferative diseases such as cancer are also disclosed and claimed.
    Type: Application
    Filed: March 10, 2005
    Publication date: December 15, 2005
    Applicant: Bayer Pharmaceuticals Corporation
    Inventors: Julie Dixon, Dhanapalan Nagarathnam, Lei Zhang, Chunguang Wang, Lin Yi, Yuanwei Chen, Jianqing Chen, Brian Bear, Michael Brands, Alexander Hillisch, Donald Bierer, Ming Wang, Wenlang Fu, Martin Hentemann, Ann-Marie Bullion, Manoj Patel
  • Substituted 2,3-dihydroimidazo[1,2-c]quinazoline derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis
    Patent number: RE46856
    Abstract: This invention relates to novel 2,3-dihydroimidazo[1,2-c]quinazoline compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for phosphotidylinositol-3-kinase (PI3K) inhibition and treating diseases associated with phosphotidylinositol-3-kinase (PI3K) activity, in particular treating hyperproliferative and/or angiogenesis disorders, as a sole agent or in combination with other active ingredients.
    Type: Grant
    Filed: January 5, 2017
    Date of Patent: May 22, 2018
    Assignee: Bayer Intellectual Property GMBH
    Inventors: Martin Hentemann, Jill Wood, William Scott, Martin Michels, Ann-Marie Campbell, Ann-Marie Bullion, Bruce R. Rowley, Aniko Redman