Abstract: Disclosed are inhibitors of human galactokinase of formula (1) that are useful in treating or preventing a galactokinase mediated disease or disorder, e.g., galactosemia. Also disclosed are a composition comprising a pharmaceutically acceptable carrier and at least one inhibitor of the invention, and a method of treating or preventing such disease or disorder in a mammal.

Abstract: This document discloses molecules having the following formula (“Formula One”): and processes related thereto.

Abstract: This document discloses molecules having the following formula (“Formula One”): and processes related thereto.

Abstract: This document discloses molecules having the following formula (“Formula One”): and processes related thereto.

Abstract: Disclosed are pyruvate kinase M2 activators which are compounds of Formula (I), including those of Formula (II), wherein A1, A2, L, R, R1 to R3, X1 to X3, k, n, and m are as defined herein, that are useful in treating a number of diseases that are treatable by the activation of PKM2, for example, cancer. A1-NR-L-A2 (I).

Abstract: The invention related to compounds for formula I useful for inhibiting phosphodiesterase-4.

Abstract: A system and method are disclosed for canceling the leakage from a speaker.

Abstract: A method and apparatus for producing continuous lengths of compression-molded material containing thermoplastic resin. Discrete lengths of extruded material are indexed through a compression mold. The mold forms, hardens, and integrally joins two successive extruded segments of material. A first molded segment is indexed forward leaving a trailing portion in the mold. A subsequent segment is extruded into the mold, and is integrally joined to the trailing portion by compressing the mold. Subsequent segments can be joined to produce a continuous profiled length formed from recycled thermoplastic material, while avoiding damage and downtime caused by contaminants in recycled material.

Abstract: A fire resistant bearing compartment cover (86) for a gas turbine engine features a fluid tight outer wall (106) comprised of an axially extending, radially converging support shell (90) and an axially extending piston ring carrier (92) joined to the support shell by a circumferentially continuous fluid tight joint (104). A heatshield (110) joined to the inner end of the support shell by another circumferentially continuous fluid tight joint (118) and slidably engaging the outer end of the support shell at an expansion joint (128) defines a stagnant air cavity (112). The arrangement reduces the likelihood that any oil leaking out of the bearing compartment will accumulate and be ignited by turbine cooling air (45) which leaks into the cavity.

Abstract: A fuel supply system 32 for a rotary machine 10 is disclosed. Various construction details are developed which enable operation of a plurality of fuel injectors 28 in the machine at a low pressure drop with a wide range of fuel and water fuel rates. In one embodiment, an auxiliary water supply system supplies water at a location in close proximity to the fuel injector.

Abstract: A fuel supply system 32 for a rotary machine 10 is disclosed. Various construction details are developed which enable operation of a plurality of fuel injectors 28 in the machine at a low pressure drop with a wide range of fuel and water fuel rates. In one embodiment, an auxiliary water supply system supplies water at a location in close proximity to the fuel injector.

Abstract: Method and apparatus are disclosed for producing various materials and products of a thermoplastic nature. In the method, thermoplastic material is subjected to a high intensity mixing and melting step to form a material which is a non-flowable and self-sustaining mass, having a temperature low enough to prevent it from being readily flowable, in a subsequent step, the method involves placing the material between a fixed rigid surface and a moving rigid surface to force air from the mass and to densify, compress and convert it to a flowable form whereafter it is passed through a restricted opening. There is provided a combination of a high intensity mixer and melter in which the product produced is then fed into a gear-pump where the material is passed between a fixed rigid surface and a moving surface.