Patents by Inventor Martin Karl Russel Burnham

Martin Karl Russel Burnham has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Purified polypeptides from
    Patent number: 7250285
    Abstract: The invention provides novel polypeptides and polynucleotides encoding such polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing such polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: April 13, 2006
    Date of Patent: July 31, 2007
    Assignee: Affinium Pharmaceuticals, Inc.
    Inventors: Michael Terence Black, John Edward Hodgson, David Justin Charles Knowles, Michael Arthur Lonetto, Richard O Nicholas, Robert King Stodola, Martin Karl Russel Burnham
  • Host cells comprising Streptomyces clavuligerus chromosomal DNA fragments encoding enzymes for ?-lactam antibiotic biosynthesis
    Patent number: 6964865
    Abstract: DNA sequences obtained from S. clavuligerus ATCC 27064, recombinant vectors incorporating such sequences and hosts transformed with such vectors are disclosed. The DNA comprises one or more genes coding for one or more enzymes involved in the biosynthesis of penicillin and cephalosporin ?-lactams and such enzymes are expressed by hosts into which the recombinant vectors are transformed. The DNA and the enzymes encoded thereby have utility in the preparation of penicillins and cephalosporins, both known and novel, possessing pharmacological, especially antimicrobial, activity.
    Type: Grant
    Filed: March 31, 2003
    Date of Patent: November 15, 2005
    Assignee: Beecham Group plc
    Inventors: Martin Karl Russel Burnham, Ian David Normansell, John Edward Hodgson
  • Novel compounds
    Publication number: 20040002133
    Abstract: DNA sequences obtained from S. clavuligerus ATCC 27064, recombinant vectors incorporating such sequences and hosts transformed with such vectors are disclosed.
    Type: Application
    Filed: March 31, 2003
    Publication date: January 1, 2004
    Applicant: Beecham Group plc
    Inventors: Martin Karl Russel Burnham, Ian David Normansell, John Edward Hodgson
  • Novel compounds
    Publication number: 20030180834
    Abstract: DNA sequences obtained from S. clavuligerus ATCC 27064, recombinant vectors incorporating such sequences and hosts transformed with such vectors are disclosed.
    Type: Application
    Filed: March 21, 2003
    Publication date: September 25, 2003
    Applicant: Beecham Group plc
    Inventors: Martin Karl Russel Burnham, Ian David Normansell, John Edward Hodgson
  • Polynucleotide encoding spo0J1 of Staphylococcus aureus
    Patent number: 6524813
    Abstract: The invention provides spo0J1 polypeptides and polynucleotides encoding spo0J1 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing spo0J1 polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: March 18, 1998
    Date of Patent: February 25, 2003
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventors: Martin Karl Russel Burnham, Andrew Fosberry, John Hodgson, Deborah Jaworski, Elizabeth Lawlor, Martin Rosenberg, Lisa Kathleen Shilling, Min Wang, Judith Ward
  • ndp
    Publication number: 20030017532
    Abstract: The invention provides ndp polypeptides and polynucleotides encoding ndp polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ndp polypeptides to screen for antibacterial compounds.
    Type: Application
    Filed: July 27, 2001
    Publication date: January 23, 2003
    Inventors: SanJoy Biswas, James Raymond Brown, Martin Karl Russel Burnham, Alison Francis Chalker, David John Holmes, Karen Anne Ingraham, Thomas B. Mathie, Richard Lloyd Warren, Magdalena Zalacain
  • Novel tig
    Publication number: 20020150956
    Abstract: The invention provides tig polypeptides and polynucleotides encoding tig polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing tig polypeptides to screen for antibacterial compounds.
    Type: Application
    Filed: April 6, 2001
    Publication date: October 17, 2002
    Inventors: Martin Karl Russel Burnham, Andrew Fosberry, John Edward Hodgson, Deborah Dee Jaworski, Elizabeth J. Lawlor, Martin Rosenberg, Christopher Michael Traini, Min Wang, Judith Ward, Richard Warren
  • Compounds
    Patent number: 6465621
    Abstract: The invention provides ERA polypeptides and DNA (RNA) encoding ERA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ERA polypeptide for the protection against infection, particularly bacterial infections.
    Type: Grant
    Filed: August 3, 2000
    Date of Patent: October 15, 2002
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventors: Michael Terence Black, John Edward Hodgson, David Justin Charles Knowles, Raymond Winfield Reichard, Richard O Nicholas, Martin Karl Russel Burnham, Julie M Pratt, Martin Rosenberg, Judith M Ward
  • Fibronectin binding proteins
    Patent number: 6461614
    Abstract: The invention provides Fibronectin Binding Protein polypeptides and DNA (RNA) encoding Fibronectin Binding Protein polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing Fibronectin Binding Protein polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: January 21, 2000
    Date of Patent: October 8, 2002
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham PLC
    Inventors: John Edward Hodgson, Martin Karl Russel Burnham
  • Member of ATP dependent protease family, clpL
    Patent number: 6447773
    Abstract: The invention provides clpL polypeptides and DNA (RNA) encoding clpL polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: October 13, 1999
    Date of Patent: September 10, 2002
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventors: Michael Terence Black, John Edward Hodgson, David Justin Charles Knowles, Raymond Winfield Reichard, Richard Oakley Nicholas, Martin Karl Russel Burnham, Julie M Pratt, Martin Rosenberg, Judith M Ward, Andrew Fosberry, Elizabeth J Lawlor
  • dexB
    Publication number: 20020123047
    Abstract: The invention provides dexB polypeptides and polynucleotides encoding dexB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing dexB polypeptides to screen for antibacterial compounds.
    Type: Application
    Filed: April 27, 2001
    Publication date: September 5, 2002
    Inventor: Martin Karl Russel Burnham
  • nadE
    Publication number: 20020115075
    Abstract: The invention provides nadE polypeptides and polynucleotides encoding nadE polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing nadE polypeptides to screen for antibacterial compounds.
    Type: Application
    Filed: May 15, 2001
    Publication date: August 22, 2002
    Inventors: Sanjoy Biswas, Martin Karl Russel Burnham, Alison Francis Chalker, Karen Anne Ingraham, Christopher Michael Traini, Patrick Vernon Warren, Magdalena Zalacain
  • metK
    Publication number: 20020102700
    Abstract: The invention provides metK polypeptides and polynucleotides encoding metK polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing metK polypeptides to screen for antibacterial compounds.
    Type: Application
    Filed: March 14, 2001
    Publication date: August 1, 2002
    Inventors: Sanjoy Biswas, Raymond Brown, Martin Karl Russel Burnham, Alison Francis Chalker, David John Holmes, Karen Anne Ingraham, Chi Young So, Richard Lloyd Warren, Magdalena Zalacain, Stephanie Van Horn
  • nusB
    Publication number: 20020091237
    Abstract: The invention provides nusB polypeptides and polynucleotides encoding nusB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing nusB polypeptides to screen for antibacterial compounds.
    Type: Application
    Filed: May 24, 2001
    Publication date: July 11, 2002
    Inventors: Sanjoy Biswas, James Raymond Brown, Martin Karl Russel Burnham, Alison Francis Chalker, David John Holmes, Karen Anne Ingraham, Chi Young So, Richard Lloyd Warren, Magdalena Zalacain
  • Novel prokaryotic polynucleotides, polypeptides and their uses
    Publication number: 20020082234
    Abstract: The invention provides novel polypeptides and polynucleotides encoding such polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing such polypeptides to screen for antibacterial compounds.
    Type: Application
    Filed: August 27, 2001
    Publication date: June 27, 2002
    Inventors: Michael Terence Black, John Edward Hodgson, David Justin Charles Knowles, Raymond Winfield Reichard, Richard O. Nicholas, Martin Karl Russel Burnham, Julie M. Pratt, Martin Rosenberg, Judith M. Ward, Michael Arthur Lonetto
  • Novel glucosaminidase
    Publication number: 20020076766
    Abstract: The invention provides glucosaminidase polypeptides and DNA (RNA) encoding glucosaminidase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing glucosaminidase polypeptides to screen for antibacterial compounds.
    Type: Application
    Filed: January 25, 2001
    Publication date: June 20, 2002
    Inventors: Michael Terence Black, John Edward Hodgson, David Justin Charles Knowles, Raymond Winfield Reichard, Richard O. Nicholas, Martin Karl Russel Burnham, Julie M. Pratt, Martin Rosenberg, Judith M. Ward, Simon J. Foster
  • inFB
    Patent number: 6399343
    Abstract: The invention provides infB polypeptides and polynucleotides encoding infB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing in polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: May 19, 2000
    Date of Patent: June 4, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Sanjoy Biswas, James Raymond Brown, Martin Karl Russel Burnham, Alison Francis Chalker, Richard Lloyd Warren, Magdalena Zalacain, Chi Young So, Christopher M Traini, David John Holmes, Karen Anne Ingraham, Thomas B Mathie
  • Novel histidinol dehydrogenase
    Publication number: 20020064848
    Abstract: The invention provides histidinol dehydrogenase polypeptides and DNA (RNA) encoding histidinol dehydrogenase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing histidinol dehydrogenase polypeptides to screen for antibacterial compounds.
    Type: Application
    Filed: March 14, 2001
    Publication date: May 30, 2002
    Inventors: Michael Terence Black, John Edward Hodgson, David Justin Charles Knowles, Raymond Winfield Reichard, Richard O. Nicholas, Martin Karl Russel Burnham, Julie M. Pratt, Martin Rosenberg, Judith M. Ward, Michael Arthur Lonetto, Patrick Vernon Warren
  • Spo-rel
    Patent number: 6365159
    Abstract: spo-rel polypeptides and DNA (RNA) encoding such spo-rel and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such spo-rel for the treatment of infection, particularly bacterial infections. Antagonists against such spo-rel and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of spo-rel nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding the relA/spoT gene family and for detecting the polypeptide in a host.
    Type: Grant
    Filed: June 30, 1999
    Date of Patent: April 2, 2002
    Inventors: Martin Karl Russel Burnham, Daniel Robert Gentry, John Edward Hodgson, Elizabeth Jane Lawlor
  • M protein
    Patent number: 6358704
    Abstract: The invention provides M Protein polypeptides and DNA (RNA) encoding M Protein polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing M Protein polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: January 28, 1999
    Date of Patent: March 19, 2002
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham, PLC
    Inventors: Stephen Dudley Holmes, Martin Karl Russel Burnham