Patents by Inventor Martin Rosenberg

Martin Rosenberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ribG
    Publication number: 20040265872
    Abstract: The invention provides ribG polypeptides and polynucleotides encoding ribG polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribG polypeptides to screen for antibacterial compounds.
    Type: Application
    Filed: April 14, 2004
    Publication date: December 30, 2004
    Applicant: SmithKline Beecham Corporation
    Inventors: Michael Terence Black, Martin Karl Russell Burnham, Jason Craig Fedon, John Edward Hodgson, David Justin Charles Knowles, Michael Arthur Lonetto, Richard Oakley Nicholas, Leslie Marie Palmer, Julie M. Pratt, Raymond Winfield Reichard, Martin Rosenberg, Christopher Michael Traini, Judith M. Ward, Richard Lloyd Warren
  • Methods of capturing, detecting and quantifying RNA:DNA hybrids and a modified RNase H useful therein
    Publication number: 20040229242
    Abstract: Methods for specific RNA capture, detection and quantification are presented utilizing a protein that selectively binds RNA:DNA hybrids, preferably an RNase H that is modified to reduce degradation of the nucleic acid molecules and enhance specific detection of mixed RNA:DNA nucleic acid hybrids. Labeling of the RNA and/or amplification is not required to perform these methods. Modified RNase H enzymes useful in such methods are disclosed.
    Type: Application
    Filed: December 18, 2003
    Publication date: November 18, 2004
    Inventors: Richard H. Carter, Martin Rosenberg, Daniel R. Gentry, Nigel Grinter
  • Identification of targets of antimicrobial compounds
    Publication number: 20040029201
    Abstract: A method of determining the cellular or genetic target of an antimicrobial compound includes cloning of a bacterial gene into an expression vector with an inducible promoter and determining whether increasing expression of the cloned gene in the cell will result in resistance to an antimicrobial compound. Also, the method can include incorporation of every gene of a bacterial strain into expression vectors having an inducible promoter, induction, treating with an antimicrobial compound, isolating the gene clone that confers cells resistant to the compound, and determining the identity of the resistant gene by various methods including DNA microarrays and gene sequencing.
    Type: Application
    Filed: July 11, 2003
    Publication date: February 12, 2004
    Applicant: SmithKline Beecham Corporation and SmithKline Beecham p.I.c.
    Inventors: Frank Fan, Yiping He, Jianzhong Huang, Xinhe Jiang, Damien McDevitt, Martin Rosenberg, Annemarie C. St, John
  • Human cartilage glycoprotein
    Publication number: 20030215847
    Abstract: Nucleic acid sequences for HC gp-39L are provided. Methods of detecting altered expression of tissue remodeling proteins and diagnosing tissue remodeling disorders are also provided.
    Type: Application
    Filed: February 27, 2003
    Publication date: November 20, 2003
    Applicant: SmithKline Beecham Corp.
    Inventors: Robert B. Kirkpatrick, Martin Rosenberg
  • Method of generating conditionally expressed mutant cells using expressible antisense sequences
    Publication number: 20030124507
    Abstract: The present invention provides a method for determining pathogen sensitivity to varying levels of reduction of a gene product using an expression vector system having a promoter that is essentially off in vitro and turns on selectively during the infection process in vivo. Genes and gene products identified by this method as essential to growth of infection of a selected pathogen are also provided. In addition, therapeutic compositions designed to target genes identified by this method are provided.
    Type: Application
    Filed: March 13, 2002
    Publication date: July 3, 2003
    Applicant: SmithKline Beecham Corporation
    Inventors: Andrea Marra, Martin Rosenberg, Yinduo Ji
  • Methods of treating viral diseases with il-18 and il-18 combinations
    Publication number: 20030113292
    Abstract: The present invention relates generally to the use of compositions comprising IL-18, also known as interferon-&ggr;-inducing factor (IGIF), and IL-18 in combination with other agents, for the prevention and/or treatment of viral diseases caused by HIV, HSV, HPV, HAV, HBV, and HCV.
    Type: Application
    Filed: December 2, 2002
    Publication date: June 19, 2003
    Inventors: Klaus M Esser, Martin Rosenberg, Ruth Tal-Singer, Gary Woodnutt, Francis V Chisari, Susan B Dillon
  • Human cartilage glycoprotein
    Patent number: 6576427
    Abstract: Nucleic acid sequences for HC gp-39L is provided. Methods of detecting altered expression of tissue remodeling proteins and diagnosing tissue remodeling disorders are also provided.
    Type: Grant
    Filed: May 2, 1997
    Date of Patent: June 10, 2003
    Assignee: SmithKline Beecham Corporation
    Inventors: Robert B Kirkpatrick, Martin Rosenberg
  • Polynucleotide encoding spo0J1 of Staphylococcus aureus
    Patent number: 6524813
    Abstract: The invention provides spo0J1 polypeptides and polynucleotides encoding spo0J1 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing spo0J1 polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: March 18, 1998
    Date of Patent: February 25, 2003
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventors: Martin Karl Russel Burnham, Andrew Fosberry, John Hodgson, Deborah Jaworski, Elizabeth Lawlor, Martin Rosenberg, Lisa Kathleen Shilling, Min Wang, Judith Ward
  • Novel tig
    Publication number: 20020150956
    Abstract: The invention provides tig polypeptides and polynucleotides encoding tig polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing tig polypeptides to screen for antibacterial compounds.
    Type: Application
    Filed: April 6, 2001
    Publication date: October 17, 2002
    Inventors: Martin Karl Russel Burnham, Andrew Fosberry, John Edward Hodgson, Deborah Dee Jaworski, Elizabeth J. Lawlor, Martin Rosenberg, Christopher Michael Traini, Min Wang, Judith Ward, Richard Warren
  • Compounds
    Patent number: 6465621
    Abstract: The invention provides ERA polypeptides and DNA (RNA) encoding ERA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ERA polypeptide for the protection against infection, particularly bacterial infections.
    Type: Grant
    Filed: August 3, 2000
    Date of Patent: October 15, 2002
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventors: Michael Terence Black, John Edward Hodgson, David Justin Charles Knowles, Raymond Winfield Reichard, Richard O Nicholas, Martin Karl Russel Burnham, Julie M Pratt, Martin Rosenberg, Judith M Ward
  • Member of ATP dependent protease family, clpL
    Patent number: 6447773
    Abstract: The invention provides clpL polypeptides and DNA (RNA) encoding clpL polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: October 13, 1999
    Date of Patent: September 10, 2002
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventors: Michael Terence Black, John Edward Hodgson, David Justin Charles Knowles, Raymond Winfield Reichard, Richard Oakley Nicholas, Martin Karl Russel Burnham, Julie M Pratt, Martin Rosenberg, Judith M Ward, Andrew Fosberry, Elizabeth J Lawlor
  • ribB
    Patent number: 6448036
    Abstract: The invention provides ribB polypeptides and polynucleotides encoding ribB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribB polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: November 25, 1997
    Date of Patent: September 10, 2002
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventors: Michael Terence Black, Martin Karl Russell Burnham, Jason Craig Fedon, John Edward Hodgson, David Justin Charles Knowles, Michael Arthur Lonetto, Richard Oakley Nicholas, Leslie Marie Palmer, Julie M Pratt, Raymond Winfield Reichard, Martin Rosenberg, Christopher Michael Traini, Judith M Ward, Richard Lloyd Warren
  • Ribonuclease III from Streptococcus pneumoniae
    Patent number: 6444208
    Abstract: The invention provides rnc polypeptides and DNA (RNA) encoding rnc polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing rnc polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: December 16, 1998
    Date of Patent: September 3, 2002
    Assignee: SmithKline Beecham Corporation
    Inventors: Michael Arthur Lonetto, Martin Rosenberg
  • pth
    Publication number: 20020106776
    Abstract: The invention provides pth polypeptides and polynucleotides encoding pth polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing pth polypeptides to screen for antibacterial compounds.
    Type: Application
    Filed: June 8, 2001
    Publication date: August 8, 2002
    Inventors: Sanjoy Biswas, Martin K. Burnham, Andrew P. Fosberry, John E. Hodgson, Elizabeth J. Lawlor, Tong Li, Damien McDevitt, Christopher Michael Traini, Martin Rosenberg, Judith Ward, Richard Lloyd Warren, Magdalena Zalacain
  • Identification of targets of antimicrobial compounds
    Publication number: 20020086310
    Abstract: A method of determining the cellular or genetic target of an antimicrobial compound includes cloning of a bacterial gene into an expression vector with an inducible promoter and determining whether increasing expression of the cloned gene in the cell will result in resistance to an antimicrobial compound. Also, the method can include incorporation of every gene of a bacterial strain into expression vectors having an inducible promoter, induction, treating with an antimicrobial compound, isolating the gene clone that confers cells resistant to the compound, and determining the identity of the resistant gene by various methods including DNA microarrays and gene sequencing.
    Type: Application
    Filed: August 30, 2001
    Publication date: July 4, 2002
    Inventors: Frank Fan, Yiping He, Jianzhong Huang, Xinhe Jiang, Damien McDevitt, Martin Rosenberg, Annemarie C. St. John
  • Novel era
    Publication number: 20020086385
    Abstract: The invention provides era polypeptides and DNA (RNA) encoding era polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing era polypeptides to screen for antibacterial compounds.
    Type: Application
    Filed: March 29, 2001
    Publication date: July 4, 2002
    Inventors: Michael Terence Black, John Edward Hodgson, David Justin Charles Knowles, Michael Arthur Lonetto, Richard Oakley Nicholas, Leslie Marie Palmer, Robert Reid, Martin Rosenberg, Phillip Zarfos
  • Novel prokaryotic polynucleotides, polypeptides and their uses
    Publication number: 20020082234
    Abstract: The invention provides novel polypeptides and polynucleotides encoding such polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing such polypeptides to screen for antibacterial compounds.
    Type: Application
    Filed: August 27, 2001
    Publication date: June 27, 2002
    Inventors: Michael Terence Black, John Edward Hodgson, David Justin Charles Knowles, Raymond Winfield Reichard, Richard O. Nicholas, Martin Karl Russel Burnham, Julie M. Pratt, Martin Rosenberg, Judith M. Ward, Michael Arthur Lonetto
  • Novel glucosaminidase
    Publication number: 20020076766
    Abstract: The invention provides glucosaminidase polypeptides and DNA (RNA) encoding glucosaminidase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing glucosaminidase polypeptides to screen for antibacterial compounds.
    Type: Application
    Filed: January 25, 2001
    Publication date: June 20, 2002
    Inventors: Michael Terence Black, John Edward Hodgson, David Justin Charles Knowles, Raymond Winfield Reichard, Richard O. Nicholas, Martin Karl Russel Burnham, Julie M. Pratt, Martin Rosenberg, Judith M. Ward, Simon J. Foster
  • Novel histidinol dehydrogenase
    Publication number: 20020064848
    Abstract: The invention provides histidinol dehydrogenase polypeptides and DNA (RNA) encoding histidinol dehydrogenase polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing histidinol dehydrogenase polypeptides to screen for antibacterial compounds.
    Type: Application
    Filed: March 14, 2001
    Publication date: May 30, 2002
    Inventors: Michael Terence Black, John Edward Hodgson, David Justin Charles Knowles, Raymond Winfield Reichard, Richard O. Nicholas, Martin Karl Russel Burnham, Julie M. Pratt, Martin Rosenberg, Judith M. Ward, Michael Arthur Lonetto, Patrick Vernon Warren
  • Prokaryotic polynucleotides polypeptides and their uses
    Patent number: 6348582
    Abstract: The invention provides novel polypeptides and polynucleotides encoding such polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing such polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: September 23, 1997
    Date of Patent: February 19, 2002
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventors: Michael Terence Black, John Edward Hodgson, David Justin Charles Knowles, Raymond Winfield Reichard, Richard O Nicholas, Martin Karl Russel Burnham, Julie M Pratt, Martin Rosenberg, Judith M Ward, Michael Arthur Lonetto