Patents by Inventor Mary Ann Brow

Mary Ann Brow has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nucleic acid detection compositions
    Patent number: 7407782
    Abstract: The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the nucleic acid cleavage structure in a site-specific manner. The structure-specific nuclease activity of a variety of enzymes is used to cleave the target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.
    Type: Grant
    Filed: April 12, 2005
    Date of Patent: August 5, 2008
    Assignee: Third Wave Technologies, Inc.
    Inventors: James R. Prudent, Jeff G. Hall, Victor I. Lyamichev, Mary Ann Brow, James L. Dahlberg
  • Methods and Compositions for Nucleic Acid Analysis
    Publication number: 20080160529
    Abstract: The present invention relates to improved methods and composition for nucleic acid analysis. In particular, the present invention provides improved methods and compositions for carrying out nucleic acid analysis using modified nucleotides.
    Type: Application
    Filed: October 28, 2007
    Publication date: July 3, 2008
    Applicant: Promega Corporation
    Inventors: Mary Ann Brow, David A. Casimir
  • Methods and compositions for nucleic acid analysis
    Patent number: 7282333
    Abstract: The present invention relates to improved methods and composition for nucleic acid analysis. In particular, the present invention provides improved methods and compositions for carrying out nucleic acid analysis using modified nucleotides.
    Type: Grant
    Filed: October 20, 2004
    Date of Patent: October 16, 2007
    Assignee: Promega Corporation
    Inventors: Mary Ann Brow, David A. Casimir
  • Invasive cleavage of nucleic acids
    Publication number: 20070003942
    Abstract: The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the nucleic acid cleavage structure in a site-specific manner. The structure-specific nuclease activity of a variety of enzymes is used to cleave the target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.
    Type: Application
    Filed: July 15, 2005
    Publication date: January 4, 2007
    Inventors: James Prudent, Jeff Hall, Victor Lyamichev, Mary Ann Brow, James Dahlberg
  • Cleavage of nucleic acids
    Publication number: 20060292580
    Abstract: The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the nucleic acid cleavage structure in a site-specific manner. The structure-specific nuclease activity of a variety of enzymes is used to cleave the target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.
    Type: Application
    Filed: July 15, 2005
    Publication date: December 28, 2006
    Inventors: James Prudent, Jeff Hall, Victor Lyamichev, Mary Ann Brow, James Dahlberg
  • Cleavage of nucleic acids
    Publication number: 20060154269
    Abstract: The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the nucleic acid cleavage structure in a site-specific manner. The structure-specific nuclease activity of a variety of enzymes is used to cleave the target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.
    Type: Application
    Filed: July 15, 2005
    Publication date: July 13, 2006
    Inventors: James Prudent, Jeff Hall, Victor Lyamichev, Mary Ann Brow, James Dahlberg
  • Cleavage of nucleic acids
    Publication number: 20060040299
    Abstract: The present invention relates to means for cleaving a nucleic acid cleavage structure in a site-specific manner. Enzymes, including 5? nucleases and 3? exonucleases, are used to detect and identify nucleic acids derived from microorganisms. Methods are provided which allow for the detection and identification of bacterial and viral pathogens in a sample.
    Type: Application
    Filed: August 5, 2005
    Publication date: February 23, 2006
    Inventors: James Dahlberg, Mary Ann Brow, Victor Lyamichev
  • Cleavage of nucleic acids
    Publication number: 20060035256
    Abstract: The present invention relates to means for cleaving a nucleic acid cleavage structure in a site-specific manner. Enzymes, including 5? nucleases and 3? exonucleases, are used to detect and identify nucleic acids derived from microorganisms. Methods are provided which allow for the detection and identification of bacterial and viral pathogens in a sample.
    Type: Application
    Filed: August 5, 2005
    Publication date: February 16, 2006
    Inventors: James Dahlberg, Mary Ann Brow, Victor Lyamichev
  • Methods and compositions for detecting target sequences
    Patent number: 6913881
    Abstract: The present invention relates to compositions and methods for the detection and characterization of nucleic acid sequences and variations in nucleic acid sequences. The present invention relates to methods for forming a nucleic acid cleavage structure on a target sequence and cleaving the nucleic acid cleavage structure in a site-specific manner. For example, in some embodiments, a 5? nuclease activity from any of a variety of enzymes is used to cleave the target-dependent cleavage structure, thereby indicating the presence of specific nucleic acid sequences or specific variations thereof.
    Type: Grant
    Filed: November 15, 2000
    Date of Patent: July 5, 2005
    Assignee: Third Wave Technologies, Inc.
    Inventors: Brian D. Aizenstein, Eric B. Rasmussen, Jeff G. Hall, Poonam Agarwal, David Arco, Myrta W. Atiles, Deborah E. Burris, Monika de Arruda Indig, Scott M. Law, Andrea L. Mast, David J. Marshall, Carolyn W. Miller, Mary C. Oldenberg, James R. Prudent, Jennifer M. Schneiders, Mary Ann Brow, Victor Lyamichev
  • Target-dependent reactions using structure-bridging oligonucleotides
    Publication number: 20050014163
    Abstract: The present invention relates to methods and compositions for analyzing nucleic acids. In particular, the present invention provides methods and compositions for the detection and characterization of nucleic acids and sequence changes. The methods of the present invention permit the detection and/or identification of genetic polymorphism such as those associated with human disease and permit the identification of pathogens (e.g., viral and bacterial strain identification).
    Type: Application
    Filed: September 4, 2003
    Publication date: January 20, 2005
    Inventors: Fang Dong, Victor Lyamichev, James Prudent, Lance Fors, Bruce Neri, Mary Ann Brow, Todd Anderson, James Dahlberg