Publication number: 20090142806
Abstract: The present invention provides isolated and purified polynucleotides and polypeptides related to the IL-17F signaling pathway. The invention also provides antibodies to IL-17F homodimers and IL-17A/IL-17F heterodimers, and methods of isolating and purifying members of the IL-17 family, including IL-17A/IL-17F heterodimers, from a natural source. The present invention also is directed to novel methods for diagnosing, prognosing, monitoring the progress of, and treating and/or preventing disorders related to IL-17F signaling, i.e., IL-17F-associated disorders, including, but not limited to, inflammatory disorders, such as autoimmune diseases (e.g., arthritis (including rheumatoid arthritis), psoriasis, systemic lupus erythematosus, and multiple sclerosis), respiratory diseases (e.g., COPD, cystic fibrosis, asthma, allergy), transplant rejection (including solid organ transplant rejection), and inflammatory bowel diseases or disorders (IBDs, e.g., ulcerative colitis, Crohn's disease).
Type:
Application
Filed:
August 21, 2008
Publication date:
June 4, 2009
Applicant:
WYETH
Inventors:
BEATRIZ M. CARRENO, MARY COLLINS, JILL F. WRIGHT, NEIL M. WOLFMAN, MAYA ARAI, KENNETH JACOBS, ZHIJIAN LU, YONGJING GUO, YONGCHANG QIU