Abstract: To provide a novel and excellent method for treating and/or preventing prostatic cancer, benign prostatic hyperplasia, acne, seborrhea, hirsutism, baldness, alopecia, precocious puberty, adrenal hypertrophy, polycystic ovary syndrome, breast cancer, lung cancer, endometriosis, leiomyoma and the like based on selective inhibitory activity against 17?HSD type 5. It was found that an N-sulfonylindole derivative, where the indole ring is substituted by a carboxy group, a carboxy-substituted lower alkyl group or a carboxy-substituted lower alkenyl group at its carbon atom, has potent selective inhibitory activity against 17?HSD type 5 and may become a therapeutic agent and/or preventive agent for benign prostatic hyperplasia, prostatic cancer and the like without accompanying adverse drug reactions due to a decrease in testosterone, and the present invention has thus been completed.

Abstract: The present invention relates to an optical fiber which has a structure for further increasing an FOM (=|dispersion|/loss) and which can be applied to a dispersion compensation module. The optical fiber is mainly composed of silica glass and has a core region including a center of an optical axis, a depressed region surrounding the core region, a ring region surrounding the depressed region, and a cladding region surrounding the ring region and doped with F. As compared with the refractive index of pure silica glass, a relative refractive index difference of the core region is greater than 2% but less than 3%, a relative refractive index difference of the depressed region is ?1% or more but ?0.5% or less, a relative refractive index difference of the ring region is 0.01% or more but 0.24% or less, and a relative refractive index difference of the cladding region is ?0.3% or more but ?0.1% or less. The FOM at the wavelength of 1550 nm is 250 ps/nm/dB or more.

Abstract: A method includes a first step of joining a multimode fiber to a first end of an optical fiber being a specimen, allowing light to propagate from the multimode fiber to the specimen, measuring an intensity of light from a second end of the specimen, and determining a first power spectrum; a second step of joining the multimode fiber to a first end of a reference fiber having bending loss higher than that of the specimen, allowing light to propagate from the multimode fiber to the reference fiber, measuring an intensity of light from a second end of the reference fiber, and determining a second power spectrum; a third step of determining a difference spectrum by subtracting the second power spectrum from the first power spectrum; and a fourth step of determining a higher-order mode cutoff wavelength of the specimen on the basis of a shape of the difference spectrum.

Abstract: In a glass processing method according to the invention, in the case of performing chemical vapor deposition or diameter shrinkage of a substrate glass tube G by relatively moving a heating furnace 20 comprising a heating element 21 for annularly enclosing the circumference of the substrate glass tube in a longitudinal direction of the substrate glass tube G with respect to the substrate glass tube G in which an outer diameter is 30 mm or more and a wall thickness is 3 mm or more and is less than 15 mm and an ovality of the outer diameter is 1.0% or less using a glass processing apparatus 1, a temperature of at least one of the heating element 21 and the substrate glass tube G is measured and the amount of heat generation of the heating element 21 is adjusted based on the measured temperature.

Abstract: An optical fiber and a broadband light source that can generate SC light having a broader bandwidth. A broadband light source 1 is equipped with a seed light source 11 and an optical fiber 12. The seed light source 11 outputs light having a central wavelength in the wavelength range of 1500 nm to 1650 nm. The optical fiber 12 outputs supercontinuum light a result of input of the light output from the seed light source. The optical fiber 12, which has a zero dispersion wavelength in the wavelength range of 1300 nm to 1500 nm and an effective area of 12 ?m2 or less at the central wavelength, outputs supercontinuum light having a wavelength bandwidth expanded to 1000 nm or more.

Abstract: The chromatic dispersion of an optical component is measured with high accuracy using a simple set-up, which includes a pump light source, a probe light source, and a measuring means. Pump light having a wavelength ?pump and probe light having a wavelength ?probe is propagated through an optical component, with the wavelength ?probe being apart from the wavelength ?pump by a given frequency. The generation efficiency of the idler light with respect to the wavelength ?pump is calculated by measuring the power of idler light having a wavelength ?idler output from the optical component, and by seeking the pump light wavelength for making the generation efficiency a local extreme value, the chromatic dispersion of the optical component is calculated from the result of calculation of phase mismatch among the pump light wavelength having such wavelength as sought, the corresponding probe light wavelength, and the corresponding the idler light wavelength.

Abstract: Provided is a novel and excellent method for treating and/or preventing benign prostatic hyperplasia, prostate cancer, and the like based on selective inhibitory activity against 17?HSD type 5. It was found that an indole or benzimidazole derivative, where a nitrogen atom of the indole ring or benzimidazole ring is substituted with a phenyl group substituted with COOH, has a potent selective inhibitory activity against 17?HSD type 5 and may become an agent for treating and/or an agent for preventing a disease associated with 17?HSD type 5, such as benign prostatic hyperplasia, prostate cancer and the like, without accompanying adverse effects due to a decrease in testosterone; and the present invention has thus been completed.

Abstract: Compounds useful as GnRH receptor antagonists are provided. The present inventors have further examined propane-1,3-dione derivatives and confirmed as a result that a propane-1,3-dione having 2-(1,3-dihydro-2H-benzimidazol-2-ylidene), or a compound which has benzene or thiophene ring substituted with a group derived from 1-hydroxymethyl, shows excellent availability, in addition to its excellent GnRH receptor antagonism, thereby accomplishing the invention. Since the compound of the invention shows excellent availability, in addition to its strong GnRH receptor antagonism, it can be expected that it exerts superior drug effect in the living body, and it is useful for the treatment of sex hormone dependent diseases such as prostate cancer, breast cancer, endometriosis, uterine leiomyoma, benign prostatic hypertrophy and the like.

Abstract: Highly accurate measurement of chromatic dispersions of a device under test that is an optical component is enabled with a simple structure comprising: propagating pump light having a wavelength ?pump and probe light having a wavelength ?probe through the device; calculating the generation efficiency of the idler light with respect to the wavelength ?pump by measuring the power of idler light having a wavelength ?idler output from the device according to four-wave mixing generated in the device; seeking the frequency difference or wavelength difference between the pump light and the probe light that makes an extremum of generation efficiency of the idler light; calculating phase mismatch among the pump light wavelength having such frequency difference or wavelength difference, the probe light wavelength, and the idler light wavelength; and on the basis of such calculation results, calculating the chromatic dispersion of the device at the wavelength ?pump.

Abstract: Compounds useful as GnRH receptor antagonists are provided. The present inventors have further examined propane-1,3-dione derivatives and confirmed as a result that a propane-1,3-dione having 2-(1,3-dihydro-2H-benzimidazol-2-ylidene), or a compound which has benzene or thiophene ring substituted with a group derived from 1-hydroxymethyl, shows excellent availability, in addition to its excellent GnRH receptor antagonism, thereby accomplishing the invention. Since the compound of the invention shows excellent availability, in addition to its strong GnRH receptor antagonism, it can be expected that it exerts superior drug effect in the living body, and it is useful for the treatment of sex hormone dependent diseases such as prostate cancer, breast cancer, endometriosis, uterine leiomyoma, benign prostatic hypertrophy and the like.

Abstract: In a glass processing method according to the invention, in the case of performing chemical vapor deposition or diameter shrinkage of a substrate glass tube G by relatively moving a heating furnace 20 comprising a heating element 21 for annularly enclosing the circumference of the substrate glass tube in a longitudinal direction of the substrate glass tube G with respect to the substrate glass tube G in which an outer diameter is 30 mm or more and a wall thickness is 3 mm or more and is less than 15 mm and an ovality of the outer diameter is 1.0% or less using a glass processing apparatus 1, a temperature of at least one of the heating element 21 and the substrate glass tube G is measured and the amount of heat generation of the heating element 21 is adjusted based on the measured temperature.

Abstract: In a glass processing method according to the invention, in the case of performing chemical vapor deposition or diameter shrinkage of a substrate glass tube G by relatively moving a heating furnace 20 comprising a heating element 21 for annularly enclosing the circumference of the substrate glass tube in a longitudinal direction of the substrate glass tube G with respect to the substrate glass tube G in which an outer diameter is 30 mm or more and a wall thickness is 3 mm or more and is less than 15 mm and an ovality of the outer diameter is 1.0% or less using a glass processing apparatus 1, a temperature of at least one of the heating element 21 and the substrate glass tube G is measured and the amount of heat generation of the heating element 21 is adjusted based on the measured temperature.

Abstract: Provided is a pharmaceutical composition containing a propane-1,3-dione derivative as the active ingredient, particularly a GnRH receptor antagonist. Also, provided is a propane-1,3-dione derivative having a GnRH antagonistic effect.

Abstract: It is intended to provide a compound useful as a GnRH receptor antagonist. The inventors further investigated propane-1,3-dione derivatives. As a result, they confirmed that a compound having a benzene ring or a thiophene ring substituted with a group represented by —SO2—R3 in a propane-1,3-dione derivative having 2-(1,3-dihydro-2H-benzimidazol-2-ylidene) has an excellent GnRH receptor antagonistic effect and accomplished the present invention. Because the compound of the present invention has a potent GnRH receptor antagonistic effect, it is useful for the treatment of sex hormone-dependent diseases, particularly GnRH-related diseases. Further, because the compound of the present invention has an excellent metabolic stability in human and few drug interactions, therefore it has preferable characteristics as a pharmaceutical used for the above-mentioned diseases.

Abstract: To provide a novel and excellent method for treating and/or preventing prostatic cancer, benign prostatic hyperplasia, acne, seborrhea, hirsutism, baldness, alopecia, precocious puberty, adrenal hypertrophy, polycystic ovary syndrome, breast cancer, lung cancer, endometriosis, leiomyoma and the like based on selective inhibitory activity against 17?HSD type 5. It was found that an N-sulfonylindole derivative, where the indole ring is substituted by a carboxy group, a carboxy-substituted lower alkyl group or a carboxy-substituted lower alkenyl group at its carbon atom, has potent selective inhibitory activity against 17?HSD type 5 and may become a therapeutic agent and/or preventive agent for benign prostatic hyperplasia, prostatic cancer and the like without accompanying adverse drug reactions due to a decrease in testosterone, and the present invention has thus been completed.

Abstract: The present invention relates to an analyzing apparatus and the like having a structure for enabling spectrometry and the like up to a longer frequency region while being excellent in practicality. The analyzing apparatus comprises a light source section and a light-detecting section. The light source section includes a seed light source emitting laser light, and a solid highly nonlinear optical fiber generating SC light in response to the input of the laser light, and thereby emitting the SC light as irradiation light to an object. The light-detecting section detects light to be detected from the object irradiated with the irradiation light. Here, the seed light source in the light source section emits pulsed light having a center wavelength within the range of 1.3 ?m to 1.8 ?m.

Abstract: A container for an optical fiber coil and an optical fiber module including the container is provided, wherein an excess length portion of a pigtail fiber is accommodated in the container and the remaining portion can be drawn out from the container. The container includes a first part for accommodating a coil having a functional optical fiber, and a second part disposed on an outer periphery side of the first part and windingly accommodating a pigtail fiber that is optically connected to the functional optical fiber. The second part has a gap that extends over the entirety of the outer periphery, and communicates with the exterior. The optical fiber module includes the container, the coil having the functional optical fiber accommodated in the first part of the container, and the pigtail fiber that is optically connected to the functional fiber and that has a portion windingly accommodated in the second part.

Abstract: An optical fiber and a broadband light source that can generate SC light having a broader bandwidth. A broadband light source 1 is equipped with a seed light source 11 and an optical fiber 12. The seed light source 11 outputs light having a central wavelength in the wavelength range of 1500 nm to 1650 nm. The optical fiber 12 outputs supercontinuum light a result of input of the light output from the seed light source. The optical fiber 12, which has a zero dispersion wavelength in the wavelength range of 1300 nm to 1500 nm and an effective area of 12 ?m2 or less at the central wavelength, outputs supercontinuum light having a wavelength bandwidth expanded to 1000 nm or more.

Abstract: The present invention relates to an optical fiber for light pulse expansion in which the ratio (?3/?2) of the third derivative ?3 to the second derivative ?2 is negative, the absolute value thereof is large, and the absolute value of the second derivative ?2 is also large. Such an optical fiber comprises at least a central core portion having a maximum refractive index N1 and an outer diameter 2a, a depressed portion, provided on the outer periphery of the central core portion, having a minimum refractive index N2 and an outer diameter 2b, and a cladding portion, provided on the outer periphery of the depressed portion, having a maximum refractive index N3. The respective maximum refractive indices of the central core portion, the depressed portion and the cladding portion satisfy the relationship “N1>N3>N2”.

Abstract: An optical fiber and an optical fiber device, which can suppress generation of the stimulated Brillouin scattering while maintaining large nonlinearity. The fiber includes a central core which is made of SiO2 as a main component and contains Al2O3 at concentration of 15 wt % or more. The fiber is allowed to propagate only a fundamental mode and has an absolute value of chromatic dispersion of 5 ps/nm/km or less at a predetermined wavelength. The device includes the fiber having the above composition. The fiber guides first light and second light having different wavelengths to propagate therethrough such that the first light and the second light interact with each other by a nonlinear optical phenomenon during the propagation, thus causing the fiber to output the first light or the second light modulated by the nonlinear optical phenomenon or third light newly produced by the nonlinear optical phenomenon and having a different wavelength.